Lɛ wi lan bɔt Lynch Syndrome, wae kin mek yu gɛt kansa mɔr.

Yu dɔn ɛva yɛri bɔt di wɔd ``Lynch Syndrome''? Dis kin bi nyu wɔd to yu. Bɔt i impɔtant fɔ lɛ wi ɔl no. Fɔ tɔk am simpul wan, Lynch Syndrome na wan sik wae de mek wi gɛt kansa bikɔs ɔf sɔm chenj dɛm na wi jin dɛm. Speshal, i de mek di risk fɔ gɛt kansa bifo i ol 50. So, lɛ wi tɔk bɔt dis smɔl mɔ, nɔto so?

Wetin rili na Lynch Syndrome? Udat kin gɛt am?

Lynch syndrome na wan sik we pɔsin kin gɛt frɔm in mama ɛn papa . Dat min se na bikɔs ɔf wan chenj we de na di jɛnɛtiks we wi gɛt frɔm wi mama ɔ papa. Imajin se we wi sɛl dɛn sheb, sɔntɛnde, smɔl mistek dɛn kin apin. Wi bɔdi gɛt spɛshal jin dɛn we de no ɛn kɔrɛkt dɛn mistek ya. dεn kכl dεn tin ya ‘Mismatch Repair genes’ (MMR jin dεm). Pɔsin we gɛt Lynch syndrome gɛt difrɛns pan wan ɔ mɔ pan dɛn ‘MMR’ jin ya. Dɔn, dɛn nɔ go ebul fɔ kɔrɛkt di ɔda mistek dɛn we dɛn sɛl dɛn de sheb. Dɛn sɛl dɛn ya we dɔn pwɛl kin gɛda ɛn bi kansa .

Dis kin apin to ɛnibɔdi. Na bikɔs na tin we pɔsin kin gɛt frɔm in jɛnɛtiks. Sɔntɛnde, ivin if nɔbɔdi na di famili nɔ bin dɔn gɛt dis sik bifo, pɔsin kin gɛt am bikɔs ɔf wan random jenɛtik mutation. Dis min se jɔs bikɔs famili istri nɔ de, i nɔ min se i nɔ go apin.

Statistikin na Amɛrika sho se na lɛk wan pan ɛvri 279 pipul dɛn kin gɛt Lynch syndrome. Dɛn se na lɛk 4,000 pipul dɛn we gɛt kɔlorektal kansa ɛn lɛk 1,800 pipul dɛn we gɛt kansa na di ɛndometrial kin gɛt Lynch sindrom ɛvri ia. I rili impɔtant fɔ no bɔt dis kɔndishɔn na Sri Lanka bak.

Wetin na di sayn dɛm wae de sho se yu gɛt Lynch syndrome?

De sayn dɛm kin difrɛn difrɛn wan bay aw de sik tranga ɛn di kayn kansa wae de mek pɔrsin gɛt am. Di sayn dɛm wae kin kam wit kɔlorektal kansa na:

• Blɔd na yu stɔl.
• Banbɛlɛ .
• Bɛlɛ pen ɔ kramp.
• Dayarɛa ɔ stɔl we smɔl pas aw i kin bi.
• Frɛkuɛnt filin fɔ taya pasmak (`Fatigue`).
• Fɔ fil ful ɔ blo.
• Nɔs ɔ vɔmit.

Di impɔtant tin na dat sɔm pipul dɛn nɔ kin sho ɛni sayn te di kansa dɔn rili go bifo. So if yu gɛt ɛni wan pan dɛn sik ya, yu fɔ go to dɔktɔ wantɛm wantɛm .

Us kayn kansa kin kam wit Lynch syndrome?

Dis kin rili afɛkt bɔku ɔgan dɛn. Na sɔm kayn kansa wae kin kam wit Lynch syndrome:

• Bren kansa
• Kɔlɔn ɛn rɛktal kansa - Dis na di men wan.
• Kansa na di gal blad
• Kansa na di liva
• Kansa na ovarian
• Kansa na di pankrias
• Prɔstat kansa
• Kansa na di skin
• Smɔl intestinal kansa
• Bɛlɛ kansa
• Kansa na di urinary tract we de ɔp
• uterin (endometrial) cancer - Na כda kayn kεnsar we kin kכmכn fכ fכm uman dεm.

di mכtayshכn we di jin (`jin`) de de de sho us כgan de pan hכy risk fכ kεnsar. Fayv men jin dεm de we gɛt fɔ du wit di Lynch syndrome. Dɛn na: `MLH1`, `MSH2`, `MSH6`, `PMS2` ɛn `EPCAM`.

di kכlon kεnsar we di Lynch sεndrכm kin kכz kin kam bifo (insay 1-2 ia) pas di jεnarכl pipul dεm. Bɔku tɛm, i kin tek lɛk 10 ia so fɔ mek kansa na di kɔlon. Dɔn bak, pɔsin we dɔn gɛt kansa na in kɔlon kin gɛt di kansa bak . Na lɛk 15% risk de insay 10 ia afta dɛn du di ɔpreshɔn fɔ di fɔs kansa, lɛk 40% risk insay 20 ia, ɛn lɛk 60% risk afta 30 ia.

Wetin kin mek pɔsin gɛt Lynch syndrome?

as wi bin dכn tכk, di men kכz fכ dis na di jεnεtik mכtεshכn insay wan כ mכr pan di fayv jin dεm we de kכrekt mistek dεm na wi DNA (di ``mismatch ripa jin`` כ ``MMR jin``). Dɛn fayv jin dɛn de na:

• `MLH1`
• `MSH2`
• `MSH6`
• `PMS2`
• `EPCAM`

if yu gεt Lynch syndrome, yu `MMR` jin dεm nכ de gεt di instrכkshכn dεm we dεn nid fכ pul di sεl dεm we dεn dכn pwεl. Dɔn dɛn sɛl dɛn de we dɔn pwɛl kin gɛda na di tisu dɛn ɛn mek dɛn gɛt kansa.

Aw dis kin kɔmɔt frɔm jɛnɛreshɔn to jɛnɛreshɔn?

Lynch sεndrכm na ``autosomal dominant`` kכndishכn. Fɔ tɔk am simpul wan, ilɛksɛf na wan mama ɔ papa nɔmɔ gɛt di jin we dɔn chenj, di pikin kin gɛt am . Dis min se 50% chans de fɔ mek di pikin sɛf gɛt di sik.

If dɛn dɔn no se yu gɛt Lynch syndrome, i impɔtant fɔ tɛl yu famili ɛn ɛnkɔrej dɛn fɔ go to advays bɔt yu jɛnɛtiks . Fɔ advays yu ɛn yu famili fɔ no bɔt di sik ɛn di prɔblɛm we yu pikin gɛt fɔ gɛt am. Dɛn kin du jɛnɛtik tɛst bak fɔ si if yu gɛt di Lynch syndrome jin muteshon.

Aw dɛn kin no se pɔsin gɛt di sik we dɛn kɔl Lynch syndrome?

Yu dɔktɔ kin no if yu gɛt Lynch sindrom bay we i de du tɛst bifo yu bɔn pikin ɛn tɛst yu jɛnɛtiks. Dɛn kin du di jɛnɛtik tɛst bak afta dɛn bɔn yu pikin.

jεnεtik tεst involv fכ tek bכdi sεmpl כ bכkal swab fכ chεk fכ mכtεshכn insay di jin dεm we wi bin dכn tכk bכt `MLH1`, `MSH2`, `MSH6`, `PMS2` כ `EPCAM`. If dɛn du jenɛtik tɛst fɔ no se dis kayn muteshon de, di dɔktɔ go no se i gɛt Lynch syndrome.

Us tɛst dɛn kin yuz fɔ no di kansa dɛn we gɛt fɔ du wit Lynch syndrome?

If dɛn no se yu gɛt Lynch syndrome, bɔku tɛm yu dɔktɔ go tɛl yu fɔ du bɔku tɛst fɔ chɛk if yu gɛt kansa. Di tɛst dɛn we dɛn kin du mɔ na:

• Kolonoskopi: dis involv fכ put wan tכb (skop) wit kεmεra we dεn tay tru di an fכ egzamin insay di big intestin εn rεktum. Bɔku tɛm, dɛn kin du dis wan tɛm insay di ia ɔ ɛvri tu ia.
• transvaginal ultrasound: dεn de put sכmכl instrכmεnt (probe) tru di vagina fכ egzamin di ovaria dεm εn di uterus. Dɛn kin advays bak fɔ du dis wan ɔ tu tɛm insay di ia.
• Urinalysis: Dɛn kin tek wan sampul pan yu urine fɔ chɛk fɔ tin dɛn lɛk kidni tumor. Bɔku tɛm, dɛn kin du dis wan tɛm insay di ia.
• Tumɔr bayɔpsi: If yu dɔktɔ sɔprayz se yu gɛt tumbu sɔmsay na yu bɔdi, dɛn go tek smɔl pat pan am ɛn tɛst am na di lɛb fɔ si if i gɛt kansa sɛl dɛn.
• כp εndoskopi כ kapsul εndoskopi: Na we dεn de yuz sכm tכn tכb (skop) כ maykroskכpik kεmεra (sכm sכm tכn tכb we dεn sכlow lεk pil) fכ luk fכ kεnsar na di bεlε εn sכmכl intestin. Dɛn kin aks yu fɔ du dis ɛvri tri to fayv ia.

Aw dɛn kin trit Lynch syndrome?

di ki fכ trit Lynch syndrome na fכ no di tכmכro dεm kwik kwik wan εn כpεrayshכn fכ pul di tכmכro dεm . Dis min se fɔ gɛt skrinin ɔltɛm ɛn fɔ kech kansa kwik, if i de.

Udat de trit dis?

I bɛtɛ fɔ go to tritmɛnt frɔm wan tim we gɛt spɛshal dɔktɔ dɛn fɔ wan sik lɛk dis.Bikɔs Lynch syndrome kin afɛkt bɔku ɔgan sistɛm dɛn, di tritmɛnt tim kin gɛt difrɛn spɛshal pipul dɛn, lɛk gastroenterologist, surgeon, gynecologic oncologist, urologist, dermatologist, gynecologist, praymari kia dɔktɔ, jenɛtiks, jenɛtik kɔlnɔ, ɛn onkolɔg.

Yu tink se kansa kin kam bak afta dɛn dɔn trit am?

Yɛs, ivin if dɛn du ɔpreshɔn fɔ pul di kansa, chans de fɔ mek di kansa kam bak . Na dat mek i impɔtant fɔ kɔntinyu fɔ tɛst.

Sɔm pipul dɛm we gɛt Lynch syndrome, bikɔs dɛn gɛt ay risk fɔ gɛt kansa, dɛn kin disayd fɔ du ɔpreshɔn fɔ pul di uterus (hysterectomy), ovary (oophorectomy), ɔ pat pan di intestinal (colectomy ɔ bowel resection surgery) kwik kwik wan. Dis na big tin we pɔsin kin disayd fɔ du, ɛn i fɔ du am bay di advays we dɔktɔ gi am.

Yu tink se dɛn go ebul fɔ mek dɛn nɔ gɛt di sik we dɛn kɔl Lynch syndrome?

Bɔt i sɔri fɔ no se, Lynch syndrome na wan sik we pɔsin kin gɛt we i kam pan jɛnɛtiks, so dɛn nɔ kin ebul fɔ avɔyd am kpatakpata . Bɔt dɛn kin chɛk pipul dɛn we gɛt Linch sindrom fɔ gɛt kansa ɔl dɛn layf, frɔm we dɛn big, so dat dɛn go ebul fɔ no kansa kwik if i kam .

Wetin kin apin if yu gɛt Lynch syndrome? Wetin yu go ɛkspɛkt?

Naw, no mɛrɛsin nɔ de fɔ mɛn di sik we dɛn kɔl Lynch syndrome. Bɔt di bɛst tin kin apin if dɛn fɛn di kansa ɛn pul am kwik, bifo i go na ɔda pat dɛn na di bɔdi . So, i rili impɔtant fɔ mek pipul dɛn we gɛt Lynch syndrome gɛt ɛni ia skrinin tɛst, lɛk fɔ du kɔlon skɔpi.

Yu tink se Lynch syndrome go mek tumor na mi kɔlon?

Pipul dεm we gεt Lynch sεndrכm kin gεt sεvεra ‘adenomas’, we na wan kayn we we nכ de gro na dεn kכlon כ rεktum. If dɛn nɔ no dɛn ‘polyps’ ya ɛn pul dɛn, dɛn kin bi kansa. Na dat mek i impɔtant fɔ gɛt kɔlonɔskɔpi ɔltɛm fɔ chɛk fɔ dɛn tin ya ɛn pul dɛn if dɛn de.

Ustɛm a fɔ go to dɔktɔ?

If yu gɛt Lynch syndrome, i impɔtant fɔ mek yu chɛk-ap ɛn chɛk tɛst ɛvri ia ɔltɛm .

If yu notis ɛni lumps, nyu growth, ɔ skin chenj ɛnisay na yu bɔdi, go to dɔktɔ wantɛm wantɛm , bikɔs dɛn tin ya kin bi sayn fɔ kansa.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

• Aw ɔltɛm a fɔ du tɛst fɔ no if pɔsin gɛt kansa?
• Dis lump na mi skin kansa?
• Us jin muteshon a gɛt?
• A kin du tɛst fɔ mek a gɛt bɛlɛ bifo a plan fɔ gɛt bɛlɛ?

Yu tink se Lynch Syndrome ɛn HNPCC na di sem tin?

sכmtεm dεn kin yuz Lynch sεndrכm εn ``Hεreditary Non-Polyposis Colorectal Cancer`` (``HNPCC``) intachεnj fכ rifer to di sem kכndishכn. Bɔt smɔl difrɛns de bitwin dɛn tu pan di we aw dɛn kin pas dɛn frɔm jɛnɛreshɔn dɛn.

Lynch sεndrכm de kכz bay wan mכtεshכn na di `MMR` jin. di sem jin mכtεshכn de afekt pipul dεm we gεt `HNPCC` bak. Bɔt dɛn kin gi di nem `HNPCC` we dis kɔndishɔn apin wit famili histri . Dat min se `HNPCC` de ɔltɛm gɛt frɔm jɛnɛreshɔn to jɛnɛreshɔn. Sɔntɛnde, di Lynch syndrome kin apin we nɔbɔdi nɔ gɛt am na di famili, ɛn i kin apin bak bikɔs ɔf wan random jin muteshon. Na dat mek bɔku pipul dɛn de yuz di nem Lynch syndrome naw.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Nɔbɔdi nɔ lɛk fɔ yɛri di wɔd dɛn we se, "Yu gɛt kansa." We yu kam fɔ no se yu gɛt Lynch syndrome, yu kin gɛt fɔ yɛri dɛn wɔd dɛn de frɔm yu dɔktɔ. Bɔt i nɔ nid fɔ bi bad tin.

Wae dɛn dɔn no se yu gɛt Lynch syndrome, yu dɔktɔ go woke wit yu fɔ sɛtul fɔ du skreynin tɛst ɔltɛm fɔ ɛp fɔ no kansa kwik kwik wan. Fɔ no am kwik kwik wan ɛn fɔ trit yu na di bɛst we fɔ mek yu gɛt mɔ chans fɔ liv . Dɔn yu go ebul fɔ liv fayn layf ɛn gɛt wɛlbɔdi.

So, bifo yu fred dis infɔmeshɔn, na fɔ no, go to dɔktɔ if nid de, ɛn tray fɔ liv fayn layf . If ɛnibɔdi na yu famili gɛt dis sik, i rili impɔtant fɔ tɛl dɛn bɔt dis bak.

` Lynch syndrome, HNPCC, kansa, jεnεtik mכtεshכn, hεriditri sik dεm, kכlon kεnsar, uterin kεnsar