Yu nɔ gladi? Yu taya wit ɔltin? Wi kin kɔl dis kɔndishɔn pwɛl hat. So, difrɛn kayn mɛrɛsin de wae dɛn kin gi fɔ trit dis maynd sik wae dɛn kɔl pwɛl hat. Tide wi go tɔk bɔt wan grup fɔ mɛrɛsin dɛn we dɔn ol smɔl ɛn we yu nid fɔ tek tɛm wit we yu de yuz am. Dɛn kɔl dɛn tin ya MAOI, we tinap fɔ Monoamine Oxidase Inhibitors. Pan ɔl we dis nem kin tan lɛk se i kɔmplikt smɔl, lɛ wi tɔk bɔt am simpul wan.
Wetin na dɛn MAOI ya rili?
Fɔ tɔk am simpul wan, MAOI na wan kayn mɛrɛsin wae de ɛp fɔ kɔntrol di sayn dɛm wae de sho se pɔrsin gɛt pwɛl hat. Dis na di fɔs mɛrɛsin dɛn we dɛn dɔn fɛn na di wɔl fɔ mek pɔsin nɔ fil bad . Bɔt, dɔktɔ dɛn nɔ kin gi dis mɛrɛsin izi wan dɛn tɛm ya. Di rizin fɔ dis na bikɔs yu fɔ rili tek tɛm wit wetin yu de it ɛn drink we yu de tek dɛn mɛrɛsin ya, ɛn yu fɔ pe atɛnshɔn bak to sɔm sayd ɛfɛkt ɛn sef.
Bɔku tɛm, dɔktɔ dɛn kin jɔs gi dɛn MAOI as las tin we dɛn kin du we ɔda nyu mɛrɛsin dɛn we de mek pɔsin fil bad (lɛk SSRI) nɔ ebul fɔ mek di sik bɛtɛ.
Us mɛrɛsin dɛn de insay dis kategori?
Na sɔm pan di kayn MAOI dɛm we dɛn kin yuz na di wɔl:
- Isokarboksazid (Marplan®) we dɛn kɔl .
- Fɛnɛlzin (Nardil®) we dɛn kɔl .
- Sɛlɛgilin (Emsam®) we dɛn kɔl .
- Tranilsaypromin (Parnate®) we dɛn kɔl di .
Sɔntɛm yu nɔ sabi dɛn nem ya, bikɔs dɛn nɔ kin yuz dɛn na wi kɔntri. Bɔt i fayn fɔ no.
Us kɔndishɔn dɛn kin trit wit MAOI?
Dɛn dɔn gri fɔ yuz dɛn mɛrɛsin ya fɔ difrɛn sik dɛn.
| Tayp fɔ mɛrɛsin | Men wan we dɛn kin yuz fɔ mɛn sik dɛn |
|---|---|
| Isokarboksazid ɛn Tranilsaypromin | Major Dipreshɔn Disɔda |
| Fɛnalzin we dɛn kɔl | Pwɛl hat sik wae nɔr kin gɛt tritmɛnt, wae pɔrsin kin panik, ɛn wae pɔrsin kin wɔri bɔt ɔda pipul dɛm |
| Selegilin we dɛn kɔl | As adjɔnt tritmɛnt fɔ big big pwɛl hat sik ɛn Pakinsin sik. |
Wetin na "ɔf-lɛbul" yus?
Sɔntɛnde, dɔktɔ dɛn kin yuz wan mɛrɛsin fɔ wan sik we dɛn nɔ ɔfishal gri fɔ. Dɛn kɔl dis "ɔf-lɛbul" yus. Na if di dɔktɔ in ɛkspiriɛns ɛn di tin dɛn we i no se i go bɛnifit di pɔsin we sik. Fɔ ɛgzampul, sɔm tɛm dɛn kin gi Selegiline fɔ ADHD, ɛn sɔm tɛm dɛn kin gi Tranylcypromine fɔ sɔshal wɔri.
Aw dis mɛrɛsin de wok?
Dis rili izi fɔ ɔndastand. Imajin se smɔl smɔl mɛsenja dɛn de insay wi bren. Wi kin kɔl dɛn nyurotransmitta dɛn . Serotonin, Norepinephrine, ɛn Dopamine na di men mɛsenja dɛm we de kɔntrol tin dɛm lɛk gladi at, slip, ɛn mɛmori na wi maynd.
Naw, wan ɔda ɛnzaym de na wi bren we dɛn kɔl monoamine oxidase . di wok we dis εnzym de du na fכ "klin" dεn mεsenja dεm de. Dat min se fɔ brok dɛn dɔŋ ɛn ridyus dɛn lɛvɛl.
wetin MAOI de du na fכ stכp di εnzym we de klin (Monoamine Oxidase) fכ wok. Wetin kin apin da tɛm de? Dɛn gladi gladi mɛsenja dɛn de (lɛk sɛrotonin ɛn dopamin) kin gɛda na di bren instead fɔ brok. Dɛn lɛvɛl dɛn de go ɔp. Dɔn wi maynd kin bɛtɛ ɛn di sayn dɛm fɔ pwɛl hat kin shɔt.
Dis tɛm ya, wan kemikal de bak we dɛn kɔl Tyramine . I de ɛp fɔ kɔntrol blɔd prɛshɔn na wi bɔdi. MAOI drɔgs dɛn kin stɔp bak fɔ brok dis Tyramine. Dis na di big big prɔblɛm we kin kam wit dɛn mɛrɛsin ya . Wi go tɔk bɔt am leta.
Wetin na di sayd ɛfɛkt ɛn risk dɛm fɔ MAOI?
Bɔku sayd ɛfɛkt ɛn siriɔs risk dɛn de we pɔsin kin gɛt we i yuz dɛn mɛrɛsin ya. So, i rili denja fɔ yuz dɛn we yu nɔ gɛt dɔktɔ advays .
Kɔmɔn sayd ɛfɛkt dɛn
- Diziz ɔ layt ed (bikɔs ɔf di low blɔd prɛshɔn) .
- Mɔt we dray (xerostomia) .
- Vɔmit
- Bloating ɔ kɔnstipɛshɔn
- Di we aw pɔsin kin slip
- Nɔ ebul slip
Siriɔs risk ɛn kɔmplikeshɔn dɛn
1. Sεrotonin Sindrכm
Dis na di sik we siriɔs pas ɔl ɛn we kin mek pɔsin in layf de pan denja. i kin apin we di sεrotonin lεvεl na di bכdi tu hכy. Dis risk kin ivin big if yu tek MAOI wit ɔda mɛrɛsin dɛn we de mek di sɛrotonin lɛvɛl go ɔp (e.g., SSRI, sɔm pen kil). Na dat mek i impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek, ivin di vaytamɛn dɛn.
| Simptom dɛm fɔ sɛrotonin sindrom | |
|---|---|
| Jɛnɛral kwaliti dɛn | Nɔ rɛst, nɔs, vɔmit, bɛlɛ at, yay de twit , swet , tret, mɔsul twitch. |
| Di bad bad sayn dɛm (we nid fɔ go na ɔspitul kwik kwik wan) . | Kɔnfyushɔn, tachycardia, ay blɔd prɛshɔn, fiva, siz, lɔs kɔnshɛns. |
If yu gɛt ɛni wan pan dɛn bad bad tin ya, go na di ɔspitul we de nia yu na di Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm . If yu delay di tritmɛnt, dat kin mek yu layf de pan denja.
2. Prɔblɛm wit it (Tyramine interaction) .
Dis na di big prɛktikal prɔblɛm wit MAOI dɛm. As wi bin dɔn tɔk, MAOI dɛn kin stɔp fɔ brok wan kemikal we dɛn kɔl tyramine, we kin de na sɔm it dɛn we natin nɔ de du.
If yu it it dɛn we gɛt bɔku tyramine we yu de tek MAOI, di lɛvɛl we tyramine de na yu blɔd kin rili ay. Dis kin mek di blɔd prɛshɔn go ɔp wantɛm wantɛm ɛn bad bad wan . Dɛn kɔl dis "Tyramine Pressor Response." Sɔntɛnde, dis ay blɔd prɛshɔn kin mek blɔd kɔmɔt na di bren (sɛribra blɔd) ɛn ivin day.
Us it dɛn yu fɔ avɔyd we yu de tek MAOI?
Dis dɔŋ ya na wan list fɔ it dɛm we pɔsin we de tek dis mɛrɛsin fɔ rili avɔyd, bikɔs ɔf dɛn ay lɛvɛl tyramine.
| Di kayn it we dɛn kin it | Diskripshɔn ɛn ɛgzampul dɛn |
|---|---|
| Chiz we dɔn ol | Chiz dɛn lɛk Chɛda, Swis, ɛn Pamɛsan (nyu chiz dɛn lɛk Kɔtej chiz ɛn Mɔzarɛla nɔ gɛt bɛtɛ risk). |
| Soya Sos we dɛn kin yuz | Ɔl di prɔdak dɛn we dɛn mek wit soya. |
| Mit/fish we dɛn dɔn fɛmɛnt ɔ we dɛn dɔn kip | Sosish, salami, dray fish, ɛn ɔda tin dɛn. |
| Liva | Pan ɔl we nyu liva nɔ gɛt tayramin, di tayramin lɛvɛl kin go ɔp bikɔs i kin pwɛl kwik kwik wan. |
| Frut we rili rayp | We frut dɛn lɛk banana, avokado, ɛn fig dɔn rayp. |
| Bia we dɛn dɔn fɛmɛnt | Ɛspɛshali tap bia. |
Di tin we impɔtant pas ɔl: As it de ol, in tayramin lɛvɛl de go ɔp. So, pɔsin we de tek dis mɛrɛsin fɔ avɔyd ɔltɛm fɔ it tin dɛn we lɛf ɛn it tin dɛn we i jɔs kuk .
3. Antidipreshan Diskɔntinyueshɔn Sindrom
Dis sik kin apin if yu stɔp fɔ tek dis mɛrɛsin wantɛm wantɛm afta yu dɔn tek am fɔ pas 6 wik. Sɔm kayn sik lɛk fiva, bɔdi we de at, ed we de at, diziz, nɔ ebul fɔ slip, ɛn we yu nɔ de rɛst kin apin. So, nɔ ɛva stɔp fɔ tek dis mɛrɛsin if yu nɔ go to yu dɔktɔ . If yu stɔp fɔ tek di mɛrɛsin, yu fɔ du am smɔl smɔl fɔ sɔm wiks ɛn na ɔnda yu dɔktɔ in sɔpɔtishɔn nɔmɔ.
4. Tin dɛn we pɔsin kin tink bɔt fɔ kil insɛf
Smɔl risk de fɔ mek dɛn tink mɔ bɔt fɔ kil dɛnsɛf we yɔŋ pipul dɛn we nɔ rich 25 ia yet bigin fɔ tek dis mɛrɛsin. If yu ɔ yu pikin gɛt dɛn tin ya, tɔk to di dɔktɔ we gi yu di mɛrɛsin wantɛm wantɛm.
Ustɛm yu fɔ go to dɔktɔ?
If yu de tek MAOI, yu fɔ go to yu dɔktɔ ɔltɛm fɔ chɛk if di mɛrɛsin de wok ɛn if ɛni prɔblɛm de. Apat frɔm dat, tɔk to yu dɔktɔ bɔt dɛn tin ya bak.
- If yu gɛt sayd ɛfɛkt dɛn we yu nɔ go ebul fɔ bia wit.
- If yu sik nɔr de bɛtɛ, ɔr if dɛn de wɔs.
- If yu fil se yu nid fɔ stɔp fɔ tek di mɛrɛsin.
Mɛsej we dɛn kin kɛr go na os
- MAOI na wan ol klas wae gɛt bɔrku pawaful ɛn denja wae dɛn nɔr kin yuse tide.
- If yu de tek dis mɛrɛsin, yu fɔ kɔntrol di it we yu de it . Yu fɔ avɔyd it dɛn we gɛt bɔku tayramin ɔltogɛda.
- I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin we yu de tek, ɔdasay yu kin gɛt denja sɛrotonin sindrom.
- Nɔ bigin ɔ stɔp fɔ tek dis mɛrɛsin we yu nɔ gɛt dɔktɔ advays fɔ ɛni rizin.
- If yu gɛt siriɔs sik dɛn we de sho se yu gɛt sɛrotonin sindrom ɔ yu de tink bɔt fɔ kil yusɛf, go na ɔspitul imejensi rum (ETU) wantɛm wantɛm.
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