Yu kin gɛt rash bɔku tɛm na yu bɔdi? Lɛ wi lan bɔt dis (Marginal Zone Lymphoma - MZL)?

Sɔntɛnde yu kin gɛt lumps lɛk dis na yu bɔdi? Ɔ yu kin fil taya fɔ natin, ɔ yu kin fil lɛk se yu de lɔs yu wet? Bɔrku tɛm, dis kin bi nɔrmal tin, bɔt sɔmtɛm dɛn kin bi sayn fɔ wan sik wae nid sɔm atɛnshɔn. Tide wi go tɔk bɔt wan kayn limfoma we nɔ kin bɔku we dɛn kɔl `(Marginal Zone Lymphoma - MZL)` we wi ɔl nid fɔ no bɔt. Nɔ wɔri, wi go tɔk bɔt dis simpul wan ɛn di we we yu go ɔndastand.

Wetin na `(Marginal Zɔn Limfoma - MZL)`? Fɔ tɔk am simpul wan...

Marginal Zone Lymphoma na wan kɔmɔn nem fɔ sɔm kayn limfoma we nɔ kin bɔku we kin gro sloslo, we min se dɛn nɔ kin skata kwik kwik wan, ɛn dɛn kin de pan wan grup fɔ kansa we dɛn kɔl Nɔn-Hɔdgkin Limfoma. Dɛn tin ya kin apin na di limfoyd tisu, we na pat pan wi bɔdi in imyun sistɛm . Dɛn tisu ya gɛt wan kayn wayt blɔd sɛl we dɛn kɔl B sɛl. Yu no se di B sɛl dɛn tan lɛk di bɔdi in sɛntinɛl dɛn, we na wan kayn sɛl we de ɛp fɔ protɛkt wi frɔm sik? dεn kin fכn mכst na wi limf no dεm (dεn kin kכl dεm bak limf no dεm) εn splin.

naw luk, insay wi limf no dεm de sכm sכm εria dεm we dεn kכl `(lymphoid follicles)`. dis `(limfoyd fכlikul dεm)` gεt tu zon - wan dεn kכl am `(mantle zone)` εn di כda wan dεn kכl am `(marginal zone)`. jכs lεk we yu ad כda layt pan kek, dis `(marginal zone)` de rawnd di `(mantle zone)`. `(Marginal Zone Lymphoma)` de fכm we di `(B sel dεm)` sεl dεm na da `(marginal zone)` de bi mכtayshכn , dat min se dεn de כnda sכm chenj, bi abnכmal sεl dεm, εn bigin fכ mכltiply we dεn nכ kכntro.

dis kכndyushכn, ``Marginal Zone Lymphoma'', dεn kin si am bכku pan pipul dεm we pas 60. I kin kכmכn sכmtεm bak pan man dεm pas uman dεm.

Wetin na di men kayn `(Marginal Zone Lymphoma)`?

Tri men kayn `(MZL)` de. Lɛ wi si wetin dɛn bi:

1. Mucosa-assisted lymphoid tissue (MALT) lymphoma: Dis na di kayn MALT we kכmכn pas כl. Sɔntɛnde, dɔktɔ dɛn kin kɔl am ɛkstranodal marginal sɛl limfoma. "Ekstranodal" min se i de stat na do na di limf no dεm. dis kayn limfoma kin stat na di layn na di bεlε (gastric MALT), כ na di lכng, skin, tayroyd, saliva gland, intestin, כ di εria dεm we de rawnd di yay (non-gastric MALT).

2. Nodal marginal zone lymphoma: Dis kayn we de afɛkt yu limf no dɛm . Dat min se, yu limf no dɛm. Bɔt sɔntɛnde, yu kin si am bak na yu bon mɛrɔ.

3. Splenic marginal zone lymphoma: Dis na wan kayn we we nɔ kin apin so ɔltɛm. I kin afɛkt yu splin, blɔd, ɛn bon mɛrɔ.

Wetin na di sayn dɛm fɔ `(Marginal Zone Lymphoma)`?

Bɔku tɛm, Marginal Zone Lymphoma na sik we kin gro sloslo . So, yu kin gɛt dis sik fɔ lɔng tɛm ɛn nɔr gɛt ɛni sayn. Di sayn dɛm kin difrɛn difrɛn wan bay di kayn limfoma. In jɛnɛral, Marginal Zone Lymphoma kin mek yu gɛt sɔm kayn sik lɛk:

• Fiva (fiva we kin kam pan pɔsin we nɔ gɛt rizin) .
• We yu de swet pasmak na nɛt (sote di bed sheet dɛn kin wet) .
• We yu de lɔs yu wet fɔ no rizin (if yu lɔs yu wet we yu nɔ tray) .

Sɔntɛnde wi kin kɔl dɛn "B trayt dɛm."

Di simptom dɛm fɔ `(MALT)` Limfoma

di simptom dεm fכ `(Extranodal marginal zone lymphoma)` כ `(MALT)` limfoma de difrεn dipכnt pan usay di limfoma de. fכ egzampl, if yu gεt `(MALT)` lymphoma na yu bεlε, yu kin gεt simptom dεm lεk dis:

• Nɔs ɛn vɔmit
• Bɛlɛ de pen ɔ nɔ de fil fayn
• Fɔ fil ful ivin afta yu dɔn it smɔl it

if di limfoma de כda say pas na di bεlε (non-gastric MALT), fכ egzampl na di yay, dεn kin si chenj dεm na di kכnjunktiva כ di lakrimal gland dεm.

Di simptom dɛm fɔ `(Nodal marginal zone lymphoma)`

pan dis kayn, di men sayn na di tεstikul dεm we de swel. Apat frɔm dat, di kɔmɔn sayn dɛm we wi bin dɔn tɔk bɔt kin apin bak:

• Fiva
• Nayt swet dɛn
• We yu de lɔs yu wet fɔ natin

Di simptom dɛm fɔ `(Splenik marginal zon limfoma)`

Dis kayn kansa na di splin kin mek yu gɛt sɔm sayn dɛm lɛk:

• Taya ɛn taya
• di splin we big (i kin fil hεvi כ ful na di כp pat na di lεft pat na di bכdi) .
• Nayt swet dɛn
• We yu de lɔs yu wet fɔ natin

Wetin na di kɔz dɛm fɔ `(Marginal Zone Lymphoma)`?

Bɔrku tɛm, pipul dɛm wae gɛt Marginal Zone Lymphoma gɛt famili histri fɔ lymphoma, ɔr dɛn kin gɛt infekshɔn ɔltɛm, ɔr kin gɛt ɔtoimyun sik dɛm. Bɔt sɔm patikyula tin dɛn de we kin mek ɛni sɔbtayp de apin.

• MALT lymphoma: Dis kin kכmכn fכ baktriyal infεkshכn, spεshal wan H. pylori. Yu go dɔn yɛri se na dis baktri kin mek yu gɛt gastritis bak. Apat frɔm dat, sik dɛn we pɔsin kin gɛt we i de fɛt insɛf lɛk Hashimoto’s disease (wan sik we kin afɛkt di tayroyd gland) ɔ Sjögren’s syndrome (wan sik we kin dray di salivary ɛn tear glands), ɛn di famili histri bɔt lymphoma kin bi bak wan risk factor.
• Splenic marginal zone lymphoma: Dis kin gɛt fɔ du wit ɛpatitis C vayrɔs infɛkshɔn ɛn ɔtoimyun sik dɛn.
• Nodal marginal zone lymphoma: Dɛn dɔn si bak se dis gɛt fɔ du wit Epatitis C infɛkshɔn.

Impɔtant:Nɔto ɔlman de divɛlɔp `(MZL)` fɔ dɛn rizin ya. Dɔn bak, sɔm pipul dɛn kin gɛt am we dɛn nɔ gɛt ɛni wan pan dɛn rizin ya. Dis na jɔs tin dɛn we kin mek pɔsin gɛt prɔblɛm.

Wetin na di risk factor dɛm fɔ `(Marginal Zone Lymphoma)`?

As wi bin dɔn tɔk, di men tin dɛn we kin mek pɔsin gɛt limfoma, sɔm infɛkshɔn dɛn na in famili (lɛk H. pylori, Epatitis C), ɛn sik dɛn we pɔsin kin gɛt we i de fɛt insɛf (Hashimoto in sik, Sjögren’s syndrome).

Aw dɛn kin no se pɔsin gɛt Marginal Zone Lymphoma?

Yu dɔktɔ go aks yu sɔm kwɛstyɔn dɛn fɔs fɔ no bɔt dis sik. Dis kin inklud us sayn dɛm yu gɛt, yu mɛdikal histri, ɛn if ɛnibɔdi na yu famili dɔn gɛt dis kayn sik.

Afta dat, dɛn go gɛt fɔ du bɔku tɛst fɔ no if pɔsin gɛt di sik.

Wetin na di tɛst dɛn we dɛn kin du fɔ no if pɔsin gɛt sik?

di tεst dεm we dεn kin du kin difrεn sכmtεm dipכnt pan di sכbtayp fכ limfoma, bכt in jεnarכl, dεn tεst dεm ya kin du:

• Kɔmplit Blɔd Kɔnt (CBC): I de chɛk di nɔmba fɔ difrɛn kayn sɛl dɛn (rɛd sɛl, wayt sɛl, pletlɛt) na di blɔd.
• `(LDH - Lactate Dehydrogenase)` tεst: Dis na εnzym we de inkrεs na di bכdi we di sεl dεm dכn pwεl.
• `(Beta-2 microglobulin)`: Dɛn kin yuz dis as indikɛtɔ pan blɔd kansa.
• Test fɔ di wok we di liva de du .
• Tɛst fɔ di we aw di rεnal (kidni) de wok .
• di sεrum protin immunofixation (IFX): na tεst fכ luk fכ chenj dεm na di protin dεm na di bכdi.
• Tεst fכ sכm baktri εn vayral infεkshכn dεm (e.g., `(H. pylori)`, `(Epatitis C)`).
• `(CT scan)`: Tek ditayl pikchɔ dɛm fɔ di insay pat na di bɔdi. Si tin dεm lεk di limf no dεm we swεla εn wan spεlin we big.
• Nidul bayɔpsi: Dɛn kin pul smɔl smɔl tisu frɔm wan limf no we dɔn swel ɔ ɔda say wit nidul ɛn chɛk am ɔnda maykroskɔp. dis na di onli we fכ no fכ sכri if di limfoma sεl dεm de.
• Bon mכro bayopsi: sכmtεm dεn kin du dis tεst fכ si if di limfoma dכn spre to di bon mכro.
• כda `(Biopsy)` tεst dεm: fכ tek sεmpl fכ sεl כ tisu frכm eni εria na di bכdi we dεn tink se i afekt εn tεst am.

Wetin na di stej dɛm fɔ kansa na `(MZL)`?

Fɔ stej kansa na we fɔ no aw fa di kansa dɔn skata na di bɔdi. Dis impɔtant fɔ plan tritmɛnt ɛn gɛt aydia bɔt aw di sik go kam tumara bambay. Di stej dɛm fɔ MZL kin bi lɛk dis:

• Stej I: Di kansa de na wan limf node rijyכn nכmכ.
• Stej II: .di kansa de na tu כ mכr limf node rijyכn dεm na di sem say, oba כ dכn di dayafragm (di mכsul we de separet wi chεst εn bεlε).
• Stej III: di kansa dכn spre to mכltipכl limf no dεm we de oba εn dכn di dayafragm, we min se limf no dεm de na di tu say dεm.
• Stej IV: Di kansa dɔn spre ausayd di limfatik sistɛm to wan ɔ mɔ ɔda ɔgan dɛn, lɛk di liva, lɔng, ɔ bon mɛro.

Wetin na di tritmɛnt dɛm fɔ `(Marginal Zone Lymphoma)`?

Bikɔs Marginal Zone Lymphoma na sik we de gro sloslo, sɔm pipul dɛn nɔ kin nid fɔ bigin tritmɛnt wantɛm wantɛm. Sɔntɛnde, dɔktɔ dɛn kin tɔk bɔt wan tritmɛnt we dɛn kɔl "watchful waiting" ɔ "active surveillance." Dis min se dɛn kin wach yu ɔltɛm te di sik sho ɔr di sik wɔs.

If dɛn nid tritmɛnt, di tritmɛnt we dɛn go gi go difrɛn difrɛn wan bay di sɔbtayp fɔ di limfoma. Di tritmɛnt dɛn we dɛn kin yuz na:

• Antibayɔtik: Ɛspɛshali if di limfoma na di baktri we nem H. pylori, dɛn kin gi am antibayɔtik fɔ kil di baktri. Bɔrku tɛm, dis kin mɛn di lymphoma.
• Kimotɛrapi: Na drɔgs we dɛn kin gi fɔ kil kansa sɛl dɛn.
• Radieshɔn tɛrapi: Na di we aw dɛn de yuz rayt we gɛt bɔku ɛnaji fɔ pwɛl di kansa sɛl dɛn. Dɛn kin yuz dis we di limfoma de na di say we i de.
• Targeted therapy: Dis na nyu kayn mɛrɛsin wae de woke bay wae dɛn de target sɔm patikyula mɔlyul dɛm na di kansa sɛl dɛm.
• Immunotherapy: I de mek di bɔdi in yon imyun sistɛm fɔ fɛt di kansa sɛl dɛn.

Yu tink se `(Marginal Zone Lymphoma)` kin wɛl ɔltogɛda?

Dis rili dipen pan di kayn lymphoma, di stej, ɛn yu ɔl wɛl bɔdi. fכ egzampl, gastric (MALT) lymphoma we H. pylori infεkshכn kכz gεt hכy chans fכ kכl am kכmplit wit antibaytik tritmεnt.

Na ɔda kayn, tritmɛnt kin put di sik insay ``rɛmishɔn'' . ``Rɛmishɔn'' min se di sayn dɛm dɔn dɔnawe ɛn tɛst nɔr sho ɛni pruf fɔ di sik. כltu, ``Marginal Zone Lymphoma'' kin kam bak sכmtεm (``recur'') afta tritmεnt. So, dɔktɔ dɛn go kɔntinyu fɔ wach yu.

Wetin na di rεt we de liv fכ `(Marginal Zone Lymphoma)`?

Di nɔmba fɔ pipul dɛn we nɔ day na jɔs sɔm statystik. Dɛn kin sho di pasɛnt pan pipul dɛm wae de alayv fayv ia afta dɛn dɔn no bɔt dɛn sik. Bɔt dɛn kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Yu ɛkspiriɛns kin difrɛn.

Wan stɔdi sho se:

• Na lɛk 88% pan di pipul dɛm we gɛt ɛkstranodal marginal zone lymphoma (MALT) de alayv fayv ia afta dɛn dɔn no se dɛn gɛt di sik.
• כlmost 79% pan di pipul dεm we gεt spεlin marginal zon limfoma de alayv fayv ia afta dεn no di sik.
• Na lɛk 76.5% pan di pipul dɛm we gɛt nodal marginal zone lymphoma de alayv fayv ia afta dɛn dɔn no se dɛn gɛt di sik.

Mɛmba se: Dɛn tin ya na jɔs avrej. Bikɔs Marginal Zone Lymphoma kin apin to ol pipul dɛm, bɔrku pan dɛn pipul ya kin day pan ɔda tin dɛm pas lymphoma. Na yu dɔktɔ nɔmɔ go ebul fɔ gi yu di bɛst infɔmeshɔn bɔt di tin we de apin to yu. So, nɔ fred fɔ dɛn statystik ya nɔmɔ.

Yu tink se dɛn kin ebul fɔ protɛkt Marginal Zone Lymphoma?

Wi nɔ kin ebul fɔ kɔntrol sɔm pan di tin dɛn we kin mek dis sik kam, lɛk di sik dɛn we pɔsin kin gɛt we i de fɛt insɛf ɔ di tin dɛn we kin apin to pɔsin in jɛnɛtiks. Bɔt if infɛkshɔn de wit `(H. pylori)`, i kin ridyus to sɔm mak bay we yu tek di rayt tritmɛnt ɛn tek stɛp fɔ protɛkt yusɛf frɔm infɛkshɔn lɛk `(Epatitis C)`.

Ustɛm a fɔ go to mi dɔktɔ?

If dɛn dɔn no se yu gɛt ``Marginal Zone Lymphoma'', mek shɔ se yu go to yu dɔktɔ if:

• If yu notis chenj na yu bɔdi we yu tink se kin bi di sayn dɛm fɔ Marginal Zone Lymphoma (e.g., nyu lump de apia, wan we dɔn de go big, fiva, swet na nɛt, we yu de lɔs).
• If yu sik dɛn de wɔs we yu de gɛt tritmɛnt .
• If yu de na remission ɛn yu bigin fɔ si sayn dɛm fɔ se di sik de kam bak, e kin bi wan kes wae de kam bak .

Aw a fɔ kia fɔ mi wɛlbɔdi biznɛs?

We yu de liv wit sik lɛk MZL, fɔ kia fɔ yusɛf rili impɔtant. Na sɔm tin dɛn we yu kin du:

• Manej strɛs: Sɔm pipul dɛm wae gɛt MZL nɔr kin gɛt sɔm kayn sik ɛn nɔr kin nid tritmɛnt. Wail dat na gud tin, yu kin stil de wori se "wetin e go wos?" Ɛksesaiz, lisin to myuzik, du yoga, ɔ du sɔntin we yu lɛk fɔ du, dat kin ɛp yu fɔ rilaks.
• Drink inof wata: Di tritmɛnt fɔ kansa ɛn di sayd ɛfɛkt dɛm kin mek yu bɔdi nɔ gɛt wata, so tray fɔ drink at le 8 glas wata ɛvride.
• It fayn it: Put tin dɛn we gɛt fayn fayn tin dɛn lɛk frut, vɛjitebul, nɛt, ɛn tin dɛn we dɛn mek wit milk insay yu it. It smɔl it dɛn instead fɔ it big it dɛn.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

Yu kin aks di dɔktɔ kwɛstyɔn dɛn lɛk dɛn wan ya:

• Us kayn ``Marginal Zone Lymphoma'' a gɛt?
• Wetin na di stej fɔ mi sik?
• A nid tritmɛnt wantɛm wantɛm?
• If dɛn nid tritmɛnt, us tritmɛnt yu go se ɛn wetin mek?
• Wetin na di bad tin dɛn we dɛn tritmɛnt ya kin du?
• Ɛni klinik trial de we a kin tek pat pan?
• Wetin yu kin tɛl mi bɔt di prɔgnosis fɔ mi sik?

Fɔ dɔn, wetin fɔ mɛmba (Take-Home Message) .

Marginal Zone Lymphoma (MZL) na wan kayn limfoma we nɔ kin bɔku, we kin gro sloslo we kin fɔdɔm insay di kategori fɔ Nɔn-Hɔdgkin Limfoma. Bɔku kayn limfoma de, ɛn di sayn dɛm, di tritmɛnt, ɛn di prɔgnosis kin difrɛn difrɛn wan bay di kayn. Di tin we impɔtant pas ɔl na dat, bikɔs di sik kin go bifo smɔl smɔl, sɔm pipul dɛn nɔ kin nid tritmɛnt fɔ lɔng lɔng tɛm. Fɔ ɔda pipul dɛn, tritmɛnt kin put di sik na rɛmishɔn.

If yu gɛt dis sik, i go fayn fɔ mek yu nɔ fred, bɔt yu fɔ tɔk to yu dɔktɔ ɛn gɛt infɔmeshɔn we fit yu sityueshɔn. Yu dɔktɔ go ɛksplen to yu aw dis sik kin afɛkt yu bɔdi ɛn di tritmɛnt dɛn we yu kin gɛt. Mɛmba se nɔto yu wangren de, ɛn dɔktɔ dɛn ɛn pipul dɛn we yu lɛk de we go ɛp yu.

` Marginal Zɔn Limfoma, MZL, Nɔn-Hɔdgkin Limfoma, Limfoma, Kansa, MALT Limfoma, B sɛl dɛn, H. pylori, Kimotɛrapi, Limf no dɛm