Bɔku tɛm yu kin gɛt alɛji wit rɛd spat ɛn it ɔlsay na yu bɔdi? Dis kin bi Mastocytosis!

Bɔku tɛm yu kin gɛt rɛd, it, ɛn sɔntɛnde yu kin gɛt siriɔs rash na yu bɔdi? Ɔ yu kin gɛt siriɔs alɛji fɔ ivin di smɔl tin fɔ sɔm dez? Yu kin tink se, "A de gɛt ɔda alɛji riakshɔn." Bɔt sɔmtɛm biɛn dɛn sik ya, sɔm kayn tin kin de wae nɔr kin bɔrku wae wi nɔr dɔn yɛri bɔt. wan pan dεn kכndyushכn dεm ya na `(Mastocytosis)`. Pan ɔl we di nem kin tan lɛk se i strenj smɔl, lɛ wi tɔk bɔt am simpul wan.

Wetin na Mastocytosis? Fɔ tɔk am simpul wan...

Imajin, insay wi bɔdi, sɛl dɛn de we tan lɛk smɔl smɔl sikyɔriti dɛn. Wi kin kɔl dɛm ``mast cells.`` Dɛn ``mast cells`` ya na pat pan wi ``immune system.`` Dɛn tan lɛk di sikyɔriti fɔs dɛm na wi kɔntri. we enimi dεm lεk jεm, baktri dεm, εn alergen dεm de kam insay di bכdi, dεn ``mast sεl dεm`` ya de kam fכ fכd εn fכt.

we dεn `(mast sεl dεm)` dεn de ansa to εnimi dεm, dεn de rilis wan kεmikכl we dεn kכl `(histamine).` Dis `(histamine)` na in de mek wi gεt alerjik simptom dεm na wi bכdi (fכ egzampl, it, rεd fכ di skin, swεla). dεn `(mast sεl dεm)` dεm de εp bak fכ prodyuz asid na di bεlε.

nכmal wan, dεn `(mast sεl)` dεm de du dεn wok εn kכntrכl di εnimi dεm εn afta dat dεn kin silεnt bak. כltu, wetin de apin na di bכdi fכ pכsin we gεt `(Mastocytosis)` na dat dεn `(mast sεl dεm)` dεm de inkrεs abnכmal wan εn we dεn nכ de kכntro. we dεn de inkrεs lεk dis, dεn sεl dεm ya de rilis tu mכch `(histamine).` na we yu gεt big alerji to ivin di sכm sכm tin, כ we yu gεt alerji, i de wכs pas nכmal pכsin, εn i de las fכ lכng.

Di tin we impɔtant pas ɔl na dat, ɔlman we gɛt Mastocytosis kin gɛt mɔ risk fɔ gɛt anafilaksis , we na wan alɛji we kin apin wantɛm wantɛm, we kin rili bad ɛn we kin mek i day . So, i impɔtant fɔ mek wi no bɔt dis.

Pan ɔl we dɔktɔ dɛn nɔ kin ebul fɔ mɛn Mastocytosis ɔltogɛda, dɛn kin kɔntrol di sayn dɛm ɛn trit ɛni prɔblɛm we kin kam.

Wetin na di men kayn Mastocytosis?

Tu men kayn dis sik de:

1. Cutaneous Mastocytosis: Dis kin apin pan bεlε pikin dεm εn yכŋ pikin dεm . Bɔt, i kin apin bak pan big pipul dɛn. wetin de apin ya na dat abnכmal ``mast sεl dεm`` de kכmכt na di skin, we de mek i it rεd, dak rεd, brawn, כ miks kכla blista εn spat. I tan lɛk se smɔl pikin kin gɛt bɔku rɛd spat dɛn na dɛn bɔdi wantɛm wantɛm ɛn dɛn kin skrach dɛn ɔltɛm.

2. Sistem Mastocytosis: dis kayn we dεn kin si am mכst pan big pipul dεm.na ya, abnכmal ``mast sεl dεm`` de kכmכt na di intanεt כgan dεm lεk di bon mכro, bon dεm, wi dijestiv sistεm, εn lכng dεm. Imajin, if dɛn sɛl ya gɛda pasmak na di bon mɛro, dat kin afɛkt di we aw wi blɔd sɛl dɛn de mek. Dɔn bak, if dɛn sɛl ya bɔku na di bɛlɛ, dɛn kin mek bɔku bɔku asid na di bɛlɛ ɛn mek ɔlsa na di bɛlɛ.

Dis na sik we pipul dɛn kin gɛt?

Nɔ, dis na rili sik we nɔ kin apin so ɔltɛm. Akɔdin to sɔv, dɛn se na wan pan ɛvri tɛn tawzin (10,000) ɔ wan pan ɛvri twɛnti tawzin (20,000) pipul dɛn de sɔfa wit dis sik. So, na nɔmal tin fɔ mek nɔto ɔlman no bɔt am.

Wetin na di poshubul simptom dɛm fɔ Mastocytosis?

as dεn ``mast sεl dεm`` de inkrεs abnכmal, difrεn simptom dεm kin apin. Pan ɔl we dɛn sik ya kin rili smɔl fɔ sɔm pipul dɛn, dɛn kin tranga fɔ ɔda pipul dɛn.

• Bon pen: Fɔ fil lɛk se yu bon dɛn de at.
• Daya (bɛlɛ de at): Na fɔ go na di bafa bɔku tɛm.
• Fɔ fɔdɔm (lɛk fɔ lɛ yu nɔ no natin): Wantɛm wantɛm, di yay dɛn kin tɔn blu ɛn i kin tan lɛk se yu nɔ kin no natin.
• Wae yu de wɔri ɛn frayd ɔltɛm: Fɔ fil fɔ wɔri fɔ natin.
• Flushing: Di skin kin rɛd wantɛm wantɛm ɔlsay na di bɔdi.
• Itchy blisters ɔ spat na di skin: As wi bin dɔn tɔk bɔt bifo.
• Ɛd we de at: Ed kin at ɔltɛm.
• Diziz we kin kam bikɔs yu blɔd prɛshɔn smɔl: Na di filin fɔ diziz we yu tinap we yu tinap.
• Jɔyn pen: Jɔyn pen.
• Rɛd ɔ brawn spat na di skin: Dɛn tin ya kin it ɔ nɔ kin it.

na us ej Mastocytosis de stat?

I kin difrɛn difrɛn wan bay di kayn sik. Jɛnɛral wan:

• Cutaneous Mastocytosis: Dis kin afɛkt ivin pikin dɛn we dɛn jɔs bɔn.
• Sistem Mastocytosis: i kin afekt big pipul dεm we pas 50 ia.

Wetin na di rizin fɔ dis?

`(Mastocytosis)` nɔto sɔntin we dɛn bɔn wi wit. i de kכz fכ mכtεshכn dεm na di jin dεm we dεn kכl `(KIT jin dεm)`. dis `(KIT jin dεm)` na jin dεm we de εp sכm kayn sεl dεm, lεk wi bכdi sεl dεm, `(mast sεl dεm)`, fכ gro. insay `(Mastocytosis), dεn mכtayt `(KIT jin dεm)` de gi di rכng signal to `(mast sεl dεm)` fכ "proliferate pasmak εn gro we dεn nכ kכntro."

Wetin na di tin dɛn we kin mek pɔsin gɛt mastocytosis?

Dis kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Nɔto ɔlman gɛt di sem tin dɛn we kin mek pɔsin want fɔ du sɔntin. Bɔt sɔm tin dɛn de we kin mek yu gɛt mɔ sik:

• Fɔ rɔb ɔ skrach di skin: Dis kin apin bak to sɔm pipul dɛn jɔs we dɛn wɛr tayt klos.
• Ɛksesaiz ɛn fɔ du tin dɛn we yu de du pasmak.
• Insɛkt dɛn we de sting ɔ bit:Ɛspɛshali animal dɛn lɛk ant, wasp, ɛn bi.
• Fɔ drink rɔm.
• Sɔm it dɛn: Ɛspɛshali it dɛn we gɛt spays ɛn we gɛt bɔku sizin.
• Sɔm mɛrɛsin dɛm: Fɔ ɛgzampul, pen kil dɛm we dɛn kɔl ``NSAIDs`` (Nonsteroidal anti-inflammatory drugs), mɔsul rilaksant dɛm, ɛn anestetik dɛm ``(anestesia)``.
• Di tɛmpracha kin chenj wantɛm wantɛm: Lɛk we yu jomp insay wata we rili kol.
• Stress na yu bɔdi ɔr yu maynd: Bɔrku tɛm dis kin gɛt big impak.

Wetin na di poshubul kɔmplikeshɔn dɛm fɔ Mastocytosis?

Dis sik kin kam wit ɔda wɛl bɔdi prɔblɛm, lɛk:

• Ɔstioporosis: Dis kin mek di bon dɛn wik ɛn i kin brok izi wan.
• Liva prɔblɛm: Na tin we kin mek di liva swel ɛn nɔ de wok fayn.
• Saytopenia: Na di bɔdi we nɔ ebul fɔ mek inof blɔd sɛl.
• Infekshɔn dɛn we kin kam bɔku tɛm.

Aw dɛn kin no bɔt Mastocytosis?

Yu dɔktɔ go aks bɔt yu sik ɛn chɛk yu skin. Apat frɔm dat, dɛn kin du tɛst dɛn lɛk:

• bכdi tεst: Chεk di lεvεl fכ wan εnzym we dεn kכl ``tryptase`` na yu bכdi. dis ``tryptase`` na sכmtin we ``mast sεl dεm`` de rilis we dεn de rεspכnd to εnimi.
• Bon skan: Fɔ chɛk fɔ si if di bon dɔn pwɛl.
• bon mכro bayopsi: dεn tek wan sεmpl fכ bon mכro εn chεk fכ abnכmal mast sεl dεm.
• Jεnεtik tεst dεm: If yu gεt Systemic Mastocytosis, dεn kin tεst yu fכ mכtεshכn dεm na di KIT jin dεm.

Wetin na di tritmɛnt dɛm fɔ Mastocytosis?

Di tritmɛnt we dɛn kin pik kin difrɛn fɔ di kayn sik ɛn di sayn dɛm we yu kin gɛt. Bɔku tɛm, dɔktɔ dɛn kin yuz mɛrɛsin ɛn ɔda tritmɛnt dɛn fɔ mek dɛn nɔ gɛt di sik.

Di kayn drɔgs dɛn we dɛn kin yuz fɔ Mastocytosis:

• Antasid fɔ bɛlɛ prɔblɛm (Antacids - H2 blockers): Fɔ tin dɛm lɛk bɛlɛ inflameshɔn ɛn gastritis.
• Antihistamines: Ridyus di alɛji skin simptom dɛm lɛk it ɛn rɛd.
• Bisfosfonat fɔ ɔstioporosis: I de mek di bon dɛn strɔng.
• Kɔtikosterɔyd: I de ridyus di swel.
• Monoklonal antibodi dεm: spεshal wan dεm lεk omalizumab (Xolair®).
• Mɛrɛsin fɔ mɛn pen .

Ɔda tritmɛnt dɛn:

• Ultraviolet (UV) layt tɛrapi: Ridyus di dak dak spat na di skin.
• Targeted therapy .
• Epinephrine fɔ anafilaksis:Wan imejensi tritmɛnt fɔ wan siriɔs alɛji riakshɔn.
• Kimotɛrapi: Dis nɔ kin apin so ɔltɛm ɛn dɛn kin gi am if Mastocytosis tɔn to kansa.
• allojenik stεm sεl (bon mכro) transplant: dεn kin kכnsidr dis bak insay vεri siriכs, kכmpleks kes dεm fכ mastosaytosis. Bɔku pipul dɛn nɔ nid dis.

Ɛni kɔmplikeshɔn ɔ sayd ɛfɛkt de fɔ di tritmɛnt?

Yes, lεk eni tritmεnt, sכm sayd ifekt dεm de we kin apin wit tritmεnt fכ Mastocytosis. Sɔm pan dɛn kin smɔl, ɛn ɔda wan dɛn kin rili siriɔs. If yu gɛt Mastocytosis, yu dɔktɔ go ɛksplen di tritmɛnt dɛm we yu de gɛt ɛn di sayd ɛfɛkt dɛm we yu kin gɛt.

Yu tink se Mastocytosis kin wɛl ɔltogɛda?

Jɛnɛral wan, dɛn kin tek Mastocytosis as sik we nɔ kin wɛl ɔl, bɔt dɛn kin ebul fɔ kɔntrol am bay we dɛn de kɔntrol di sayn dɛm ɛn trit di kɔmplikeshɔn dɛm .

di onli tritmεnt we kin kכri fכ dis na di ``allogeneic stεm sεl (bon mכro) transplant'' we wi bin dכn mεnshכn bifo. Bɔt ivin dat na fɔ di wan dɛn nɔmɔ we gɛt di sik dɛn we rili siriɔs ɛn we kɔmpleks.

Mastocytosis kin wɔs as tɛm de go?

If dɛn nɔ trit am, di sik kin wɔs as tɛm de go, mɔ pan pɔsin we gɛt sistɛm mastocytosis , as di abnɔmal mast sɛl dɛn kin kɔntinyu fɔ afɛkt di bon mɛrɔ ɛn di ɔgan dɛn we de insay.

Yu tink se dɛn kin mek dɛn nɔ gɛt Mastocytosis?

Bɔt i sɔri fɔ no se, nɔto so. Bikɔs na di chenj dɛn we de apin na di KIT jin dɛn kin mek i apin, no we nɔ de fɔ mek i nɔ apin. Bɔt if yu gɛt Mastocytosis, yu kin kɔntrol yu sik dɛn bay we yu no gud gud wan wetin kin mek yu gɛt alɛji ɛn avɔyd dɛn as yu ebul.

Fɔ ɛgzampul, if yu gɛt sɔntin we de mek yu tek sɔm mɛrɛsin dɛn, i go fayn fɔ mek yu wɛr breslɛt we de sho aw pɔsin kin tek am. Dis go mek ɔda pipul dɛn no us mɛrɛsin yu nɔ fɔ tek if ɛnitin apin.

If yu gɛt Systemic Mastocytosis, i impɔtant fɔ kɛr sirinj we yu kin injɛkt yusɛf ɔltɛm we gɛt epinephrine. Dɛn kin yuz dis fɔ trit bad bad alɛji we kin mek pɔsin in layf de pan denja lɛk anafylaktik shɔk.

Aw a kin kia fɔ misɛf? (Mastocytosis) We yu de liv wit...

Bikɔs Mastocytosis na sik we nɔ go ebul fɔ mɛn ɔl, yu kin gɛt fɔ liv wit am fɔ sɔm tɛm. I kin tranga. Bɔt, na sɔm tin dɛn we go ɛp yu:

• No gud gud wan wetin kin mek yu gɛt di sik.Di tin dɛn we kin mek ɔlman kin trig am difrɛn. Yu kin want fɔ kip yu dayari ɛn rayt ustɛm yu sik dɔn wɔs, wetin yu it ɛn drink, ɛn wetin yu bin du da tɛm de.
• Stret kin mek dɛn sik ya wɔs. If yu nid ɛp fɔ kɔntrol strɛs, aks yu dɔktɔ bɔt di program dɛn fɔ mɛn yu strɛs. Tin dɛn lɛk fɔ tink gud wan ɛn yoga kin ɛp.
• Wear breslɛt we de mek pɔsin no bɔt di mɛrɛsin. I fɔ rayt yu mɛrɛsin ɛn ɛni mɛrɛsin we yu nɔ fɔ tek.
• Ɔltɛm, kɛr wan epinephrine ɔto-injɛkta nidul wit yu. I kin sev layf if pɔsin gɛt siriɔs alɛji.

Ustɛm a fɔ go to mi dɔktɔ?

Yu go de chɛk yu dɔktɔ ɔltɛm . Dɛn go wach yu sayn dɛm ɛn chenj yu tritmɛnt if nid de. If yu gɛt nyu sik, ɔ if yu sik de wɔs, tɛl yu dɔktɔ wantɛm wantɛm.

Ustɛm a fɔ go na di Imejɛnsi Rum?

If yu gɛt wan bad bad alɛji we yu nɔ go ebul fɔ kɔntrol wit mɛrɛsin, go na di imejensi rum wantɛm wantɛm. Dat min se, if yu gɛt sɔm kayn sik lɛk fɔ blo, yu trot tayt, yu ed de tɔn bad bad wan, ɔ yu nɔ de no natin.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

If yu gɛt Mastocytosis, i fayn fɔ aks yu dɔktɔ kwɛstyɔn dɛn lɛk dɛn wan ya:

• Us kayn Mastocytosis a gɛt?
• Us tritmɛnt dɛn de fɔ di kayn we aw a gɛt?
• Yu tink se di tritmɛnt go pul mi sik dɛn kpatakpata?
• Us ɔda sayn dɛn we go sho se mi sik de wɔs?
• A go gɛt fɔ tek tritmɛnt sote go?
• If a gɛt fɔm we rili bad, wetin na mi prɔgnosis?
• Ɛni klinik trial de we a kin tek pat pan?

Fɔ dɔn, wetin fɔ mɛmba (Take-Home Message) .

Mastocytosis na wan kכndyushכn we nכ kin apin we kin mek di mast sεl dεm na di bכdi gro abnכmal, we dεn nכ kin kכntro. I kin afɛkt di skin ɛn di ɔgan dɛn we de insay. Bɔrku pipul kin ebul fɔ kɔntrol dɛn sik bay wae dɛn no ɛn avɔyd di tin dɛm wae kin mek dɛn gɛt dis sik ɛn tek mɛrɛsin. I impɔtant bak fɔ kip wan epinephrine injɛkshɔn na yu an fɔ trit bad bad alɛji.

Pan ɔl we dis na sik we yu nɔ go ebul fɔ wɛl ɔl, if yu gi yu di rayt advays ɛn tritmɛnt, yu kin tray fɔ kɔntrol di sik dɛn ɛn liv nɔmal layf. If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis, nɔ shek fɔ tɔk to yu dɔktɔ. Dɛn go ɛp yu.

` Mastosaytosis, mast sεl dεm, histamin, alerji, sik dεm na di skin, imyun sistεm, anafylaksis