Wit di COVID-19 pandemic, wan wod we klos to ol of wi don hie and we don bi rili klos to wi laif na ‘mRNA vaccine’. Yu go mɛmba se dɛn bin de tɔk bɔt dis wɔd bɔku tɛm wit nem dɛn lɛk Pfizer ɛn Moderna. Sɔm pipul dɛn bin tɔk fayn bɔt am, ɛn ɔda wan dɛn bin de fred smɔl fɔ dis nyu teknɔlɔji. So wetin rili na mRNA vaysin? Aw i de wok insay wi bɔdi? Aw i difrɛn frɔm di vaysin we dɛn kin gi ɔltɛm? Ɛnitin de we wi fɔ fred? Lɛ wi tɔk bɔt ɔl dis simpul wan, di we we yu go ɔndastand.
Wetin na mRNA vaysin, fɔ tɔk am simpul wan?
Fɔ tɔk am simpul wan, mRNA vaysin na tritmɛnt fɔ mek wi nɔ gɛt sik we de tich, ɔ tren wi bɔdi fɔ protɛkt insɛf frɔm sik. Dɔktɔ ɔ tren wɛlbɔdi wokman kin gi yu as injɛkshɔn wit nidul.
Di onli mRNA vaysin we dɛn dɔn gri fɔ yuz na di wɔl te naw na fɔ protɛkshɔn agens COVID-19. Sɔntɛm yu mɛmba dɛn tu nem ya gud gud wan:
- Comirnaty® (dis na di Pfizer-BioNTech vaysin we wi ɔl no)
- Spikevax® (dis na di Moderna vaysin) .
Bɔt dis teknɔlɔji rili pawaful. Sayɛnsman dɛn dɔn ɔlrɛdi de du risach if dɛn kin yuz dis mRNA teknɔlɔji fɔ mek vaysin fɔ ɔda sik dɛn we kin kam pan pɔsin, ɛn bak fɔ sik dɛn lɛk kansa. Dis min se wi kin gɛt bɔku bɛnifit frɔm dis teknɔlɔji tumara bambay.
Okay, so wetin na dis mRNA?
Pan ɔl we dis kin tan lɛk sayɛns smɔl, a go ɛksplen am to una wit wan ɛgzampul we rili simpul.
Tink bɔt di DNA we de na yu bɔdi as buk we rili valyu, we gɛt masta sabi buk we de na big laybri. Dis buk gɛt ɔl di instrɔkshɔn ɛn risɛp dɛn we yu nid fɔ bil yu bɔdi ɛn mek i kɔntinyu fɔ wok. Dis masta buk so valyu dat dɛn nɔ alaw fɔ pul am na laybri, ɛn dɛn nɔ alaw am fɔ kɔpi am. I fɔ kip am sef.
naw na dis mRNA de kam in. mRNA na sכt fכ "mεsenja Ribonuklik Asid." I tan lɛk ‘mɛsenja.’ wetin i de du na we i de go na di men buk (DNA) na di laybri εn rayt dכn pan wan pepa wan kכpi fכ di rεsεp (instrכkshכn) fכ mek di protin we di bכdi nid da tεm de. afta dat i tek da pepa de kכmכt na di laybri, go insay di kichin na di sεl (we wi kכl ribosכm).
di kuk dεm (ribosomes) na di kichin de luk di rεsipi (mRNA) we di mεsenja bכn εn mek di protin jכs lεk aw dεn rayt am. We dɛn dɔn di wok, dɛn kin chɛr di pepa we dɛn rayt di risɛp pan am ɛn trowe am. Dɛn nɔ de kip am.
So, wetin mRNA vaysin de du na fɔ gi wi bɔdi di ‘rɛsipɛkt’ nɔmɔ we de mek wan smɔl pat we pɔsin kin no bɔt pan wan ɔdasay vayrɔs (fɔ ɛgzampul, di COVID-19 vayrɔs).
Aw mRNA vaysin dɛn de wok na wi bɔdi?
Lɛk ɔl ɔda vaysin dɛn, mRNA vaysin de tren wi bɔdi in imyun sistɛm fɔ no ɛnimi (lɛk vayrɔs) ɛn mek di wɛpɔn dɛn we wi nid fɔ fɛt da ɛnimi de.
Lɛ wi si aw dis kin apin na di COVID-19 mRNA vaysin:
1. Gi instrɔkshɔn: We yu gɛt di vaysin, dɛn kin gi yu sɛl dɛn di ‘rɛsipɛkt’ (mRNA) fɔ mek di spayk protin , di pat we tan lɛk spayk pan di SARS-CoV-2 vayrɔs we de mek COVID-19. Mɛmba se dis nɔto di wan ol vayrɔs, ɔ ivin wan pat pan am. Na di ‘instrɔkshɔn’ nɔmɔ fɔ mek am.
2. Sεl dεm de mek di protin: Wi sεl dεm de rid da instrכkshכn de εn bigin fכ mek spayk protin dεm. Dɛn prɔtin ya de sho na di say we wi sɛl dɛn de.
3. Aktivεshכn fכ di imyun sistεm: Naw wi bכdi in difεns (di imyun sistεm) de si dis nyu spayk protin εn de wכri. "Udat na dis strenja? Dis nɔto wan pan wi," i tink, ɛn i de aydentify am as 'invader'.
4. Wɛpɔn: Dɔn di sikyɔriti fɔs dɛn bigin fɔ mek spɛshal wɛpɔn fɔ fɛt dis ɛnimi. Dɛn wɛpɔn ya na wetin wi kɔl antibodi . Dɛn kin mek bak wan kayn ‘mɛmori sɛl’ we kin mɛmba dis ɛnimi.
5. Distrכkshכn fכ di instrכkshכn: Jכs lεk aw wi de rid mεsej εn tear am εn trowe am, wi sεl dεm de tek di instrכkshכn frכm dis mRNA εn dεstroy am kכmplit insay fכ dez. I nɔ de kɔntinyu fɔ de na wi bɔdi, ɛn i nɔ de jɔyn wit wi DNA. Dis na sɔntin we bɔku pipul dɛn nɔ kin ɔndastand.
Naw imajin se di rial COVID-19 vayrɔs dɔn kam insay yu bɔdi. Dis vayrɔs nɔto strenja to yu imyun sistɛm. Dɛn dɔn si di spayk protin fɔ dis vayrɔs ɛn dɛn dɔn rɛdi fɔ fɛt am. So, dɛn kin pwɛl di vayrɔs kwik kwik wan bifo i skata na yu bɔdi. Dis na wetin de protɛkt yu fɔ mek yu nɔ sik bad bad wan.
Wetin na di difrɛns bitwin tradishɔnal vaysin ɛn mRNA vaksin?
Di men difrɛns na di we aw wi imyun sistɛm de no di ɛnimi. Fɔ ɔndastand dis izi wan, lɛ wi luk dis tebul .
| Tayp fɔ di vaysin | Aw i de wok (insay simpul wɔd dɛn) . |
|---|---|
| Tradishɔnal Vaksin dɛn | di כl vayrus, we dεn dεaktiv כ we wik bכku, כ di protin sכbyunit dεm na di vayrus, dεn injεkt dεm dεn wan dεm dεn wan dεm na di bכdi. di imyun sistεm de ansa dis fכrin tin. |
| mRNA Vaksin dɛn | Nɔ pat pan di vayrɔs nɔ de gi di bɔdi. bifo dat, i de כnli gi ‘instrכkshכn' (mRNA) fכ wi כwn sεl dεm fכ mek wan pat we wi kin no pan di vayrus. di imyun sistεm de ansa da protin de bay we i de mek wi yon sεl dεm. |
Na ɔl di vaysin fɔ COVID-19 mRNA?
Nɔ Fɔ ɛgzampul, di COVID-19 vaysin we dɛn kɔl Novavax® nɔto mRNA vaysin. Na wan prɔtin sabyunit vaksin. dat min se i de injεkt pat dεm pan di spayk protin fכ di SARS-CoV-2 vayrus dεn dεn de insay di bכdi.
Wetin kin apin we yu gɛt di vaysin?
Dis prɔses rili simpul, ɛn if yu dɔn gɛt shot bifo, dis na di sem.
1. Wan wɛlbɔdi wokman go klin yu ɔp an (ɔ sɔntɛm yu shɔl fɔ yɔŋ pikin dɛn) wit rɔm.
2. Dɔn dɛn kin gi di injɛkshɔn wit wan rili fayn nidul.
3. Put smɔl plasta na di say we dɛn pank am.
Di tin we impɔtant pas ɔl na dat dɛn go aks yu fɔ de stil fɔ lɛk 15 minit afta dɛn dɔn gi yu di injɛkshɔn. Dis na fɔ chɛk fɔ ɛni alɛji we yu gɛt wantɛm wantɛm. If yu na pɔsin we de fil smɔl diziz ɔ de fred fɔ nidul, i bɛtɛ fɔ sidɔm insay dis tɛm.
Wetin na di bɛnifit dɛn we di mRNA vaysin dɛn gɛt?
Tu men bɛnifit dɛn de we dis teknɔlɔji gɛt.
- Rapid prodakshɔn: Fɔ mek tradishɔnal vaysin, dɛn nid fɔ gro di vayrɔs na lɛbɔtri. Dis kin tek lɔng tɛm. Bɔt insay mRNA vaksin, di vayrɔs nɔ nid fɔ gro. we dεn no di jεnεtik kכd fכ di vayrus, di kכrεspכndεnt mRNA kin kכmכt kwik kwik wan. So, we pandemik kam, dɛn kin mek bɔku bɔku vaysin dɛn insay sɔm wiks, pas fɔ wet fɔ sɔm mɔnt ɔ ia.
- Protekshɔn fɔ nɔ gɛt vaysin: Fɔ gɛt ɛni COVID-19 vaysin, mɔ wan mRNA vaysin, de gi yu dɛn bɛnifit ya we yu kɔmpia am wit pɔsin we nɔ gɛt vaysin:
- Ridyus risk fɔ gɛt COVID-19 infɛkshɔn.
- Ivin if i gɛt di sik, di risk fɔ sik bad bad wan ɛn go na ɔspitul kin ridyus bad bad wan.
- Fɔ ridyus di risk fɔ gɛt lɔng tɛm COVID kɔndishɔn afta yu dɔn wɛl frɔm COVID-19.
Wetin na di risk ɛn sayd ifɛkt dɛm fɔ mRNA vaysin dɛm?
Lɛk ɛni mɛrɛsin, mRNA vaysin dɛn gɛt smɔl sayd ifɛkt ɛn alɛji riakshɔn dɛn we nɔ kin apin so ɔltɛm. I impɔtant fɔ no bɔt dɛn tin ya.
Mɛmba se di sayd ɛfɛkt dɛm we kin apin na gud sayn fɔ se yu imyun sistɛm dɔn bigin fɔ wok ɛn bil difɛns dɛm. Bɔku tɛm, dɛn tin ya kin kɔmɔt kpatakpata insay wan ɔ tu dez.
| Di Kɔmɔn Sayd Ɛfɛkt dɛn | Rare bɔt Siriɔs Alɛji Riakshɔn Sayn dɛn |
|---|---|
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Ustɛm a fɔ go to dɔktɔ?
Dis rili impɔtant.
If yu gɛt ɛni siriɔs alɛji lɛk we yu nɔ ebul fɔ blo, yu gɛt ayv, ɔ yu fes, yu lip, yu tɔŋ, ɔ yu trot de swel , go na di ɔspitul imejensi rum (ETU) we de nia yu ɛn nɔ de te. Dis na mɛdikal imejensi.
If yu gɛt ɛni ɔda kwɛstyɔn bɔt dis vaysin, ɔ if yu nɔ shɔ if dis vaysin go gri wit yu ɔda mɛrɛsin, nɔ shek fɔ tɔk to yu famili dɔktɔ. I go ɛksplen ɔltin to yu ɛn gi yu di rayt advays.
Wetin na di histri fɔ dis mRNA teknɔlɔji?
Pan ɔl we i dɔn bi pɔpul wantɛm wantɛm bikɔs ɔf di COVID-19 pandemik, dis mRNA teknɔlɔji nɔto sɔntin we dɛn bin fɛn yestede. I gɛt bɔku bɔku ia risach istri biɛn am.
- Besik risach pan mRNA teknɔlɔji bigin insay di 1970 dɛm.
- Na insay di 1990 dɛm we sayɛnsman dɛn bin tray fɔ si if dɛn go yuz am fɔ mek vaysin.
- Bɔt big big prɔblɛm dɛn bin de da tɛm de. di mRNA mכlikul na rili fraylayz. We i dɔn de na di bɔdi, wi imyun sistɛm kin pwɛl am. Ɛn no we nɔ bin de fɔ mek i go insay sɛl dɛn.
- Afta we sayɛnsman dɛn dɔn de du risach fɔ pas 20 ia, dɛn dɔn fɛn we fɔ sɔlv dɛn prɔblɛm dɛn ya. Dɛn lan fɔ mek wan kɔtin we gɛt smɔl smɔl fat patikyula dɛn (lipid nanoparticles) fɔ protɛkt di mRNA mɔlyul. Dis na wetin dɛn kin yuz fɔ mek di vaysin dɛn tide.
- Fɔ dɔn, insay 2018, dɛn bin gri fɔ yuz wan mɛrɛsin we dɛn kɔl patisiran fɔ mɛn wan sik we nɔ kin apin na di nyurolɔjik we nɔ kin apin so ɔltɛm. Di sem we we dɛn bin de yuz fɔ gi RNA insay sɛl dɛn leta mek di we fɔ mek kɔmni dɛn lɛk Pfizer ɛn Moderna mek COVID-19 vaysin.
Na nɔmal tin fɔ fred smɔl ɛn nɔ biliv nyu tin, mɔ pan mɛrɛsin. We sɔntin kam we difrɛn frɔm di ol we dɛn we wi dɔn yus to, i nɔ kin izi fɔ mek wi biliv am wantɛm wantɛm. Bɔt dis mRNA teknɔlɔji na sɔntin we bɔku bɔku sayɛnsman dɛn dɔn mek fɔ lɔng lɔng tɛm ɛn dɛn dɔn pruv se i nɔ bad. Dis na di rizin we mek, we siriɔs pandemik kam, wi bin ebul fɔ mek sef, ifɛktiv vaysin dɛn insay sɔm mɔnt, pas fɔ wet fɔ lɔng lɔng tɛm.
Mɛsej we dɛn kin kɛr go na os
- di mRNA vaksin dεm nכ de gεt di vayrus כ pat dεm pan di vayrus. כnli dεn gεt di ‘instrכkshכn' (mRNA) dεm we nid fכ mek wan pat we dεn kin no pan di vayrus.
- Dis instrɔkshɔn kin kɔmɔt na wi sɛl dɛn kpatakpata insay sɔm dez afta dɛn dɔn yuz am. I nɔ de afɛkt wi DNA ɛni we.
- Dɛn vaysin ya rili wok fɔ mek pɔsin nɔ gɛt siriɔs sik, fɔ mek pipul dɛn nɔ go na ɔspitul, ɛn fɔ mek pipul dɛn nɔ day, mɔ bikɔs ɔf sik dɛn lɛk COVID-19.
- Smɔl smɔl sayd ɛfɛkt dɛn lɛk ed we de at ɛn bɔdi we de at afta dɛn dɔn gi yu di vaysin kin bɔku, ɛn dɛn kin sho se yu imyun sistɛm de wok.
- Bɔrku alɛji, lɛk wae yu nɔr kin ebul fɔ blo ɔr yu fes kin swel, nɔr kin bɔrku. Bɔt if dɛn apin, yu fɔ go wantɛm wantɛm na ɔspitul in Imejɛnsi Dipatmɛnt (ETU).
- If yu gɛt ɛni dawt ɔ kwɛstyɔn, nɔ jɔs abop pan di tin dɛn we yu de fɛn na di intanɛt, bɔt go to yu dɔktɔ.
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