Yu dɔn notis se yu bɔdi dɔn chenj, yu bɛlɛ de pen, ɔ yu blɔd de na yu stɔl dis biɛn tɛm? Nɔ ignore dɛn sayn ya, tink se dɛn nɔrmal. Dɛn kin bi sayn dɛm fɔ kɔlon kansa. Tide, wi de tɔk bɔt wan kayn kɔlon kansa we spɛshal smɔl, bɔt i gɛt smɔl mɔ fɔtunate bak. Dɛn kɔl am MSI-H.
Fɔ tɔk am simpul wan, wetin na dis MSI-H kɔlon kansa?
Fɔ ɔndastand dis, lɛ wi fɔs luk di DNA we de insay wi bɔdi in sɛl dɛn. Tink bɔt wi DNA lɛk wan lɔng chen. Dis chen gɛt di sem kayn bidz dɛn we dɛn kin tay pan am bak ɛn bak. dεn kכl dεn pat dεm ya we de ripit ripit na di DNA maykrosataylayt.
Naw, we wi bɔdi in sɛl dɛn sheb ɛn mek nyu sɛl dɛn, dɛn kin mek kɔpi dɛn fɔ dis DNA chen. Sɔntɛnde, mistek (muteshɔn) kin apin we dɛn mek dɛn kɔpi ya. Bɔt nɔ wɔri, wi bɔdi gɛt sistɛm lɛk ‘polis we de fɛn mistek’. Dɛn kɔl am di Mismatch Ripa (MMR) sistem. I de chɛk fɔ si if mistek de na dɛn DNA kɔpi dɛn de ɛn kɔrɛkt dɛn wantɛm wantɛm.
Bɔt insay sɔm kansa sɛl dɛn, dis MMR sistɛm nɔ de wok fayn. Wi kɔl am dMMR (deficient DNA Mismatch Ripair). Dɔn, bikɔs nɔbɔdi nɔ de fɔ fiks di mistek dɛn we de na dɛn DNA kɔpi dɛn de, mistek dɛn kin gɛda ɛn di DNA nɔ kin stebul bad bad wan. Dat na di kɔndishɔn wit maykrosataylayt dɛn we nɔ stebul pasmak, we wi kɔl MSI-H (Microsatellite Instability-High) .
i sɔprayz se dis "instability" fכ DNA na tru tru sכmtεm na gud tin. MSI-H kansa dεm de rεspכnd bεtεh to wan tritmεnt we dεn kכ l imyuno tεrapi pas כda kayn kεnsar dεm. Apat frɔm dat, di we aw dɛn de si tin kin rili fayn.
Wetin na di poshubul simptom dɛm fɔ MSI-H kansa?
Nɔr kin apun ɔltɛm, bɔt if di sayn dɛm kin sho, dɛn kin fiba di wan dɛm wae kin gɛt kansa na di kɔlon.
| Kategori fɔ di simptom dɛn | Tin dɛn fɔ si |
|---|---|
| Di chenj dɛn we de apin na di bɔdi we de muv | Dayarɛa, kɔnstipɛshɔn, ɔ fil fɔ ful-ɔp afta yu dɔn muv yu bɔdi. |
| Blɔd we de na di stɔl | Dak brawn ɔ blak stɔl, ɔ blɔd we de kɔmɔt na di rɛktum. |
| Bɛlɛ nɔ kin fil fayn | Bɛlɛ de at, i de blo. |
| Ɔda tin dɛn we de apin na di bɔdi | Taya we yu nɔ ebul fɔ ɛksplen, we yu de lɔs yu wet, we yu nɔ want fɔ it. |
Impɔtant: Nɔto ɔlman we gɛt dɛn sik ya gɛt kansa. Bɔt , if yu gɛt blɔd na yu stɔl ɔ yu bɛlɛ de at bad bad wan, go to dɔktɔ wantɛm wantɛm. If ɔda sayn dɛn de fɔ pas tu wiks, yu fɔ rili go to dɔktɔ.
Sɔntɛnde, di fɔs sayn fɔ dis kansa na we dɛn de tɛst di blɔd we de sho se di rɛd blɔd sɛl dɛn nɔ bɔku (anemia). Dis kin bi bikɔs blɔd de kɔmɔt na di insay.
Di tin dɛn we kin mek pɔsin gɛt MSI-H kansa ɛn di tin dɛn we kin mek i gɛt prɔblɛm
di praymar kכz fכ MSI-H kεnsar na di dεfekt dεm na di MMR jin dεm we wi bin tכk bכt bifo. Bɔku tɛm, dɛn tin ya kin apin we pɔsin de liv, fɔ no patikyula rizin.
Bɔt pan lɛk 5% pan di pipul dɛm we gɛt kɔlon kansa, dis jɛnɛtik dɛfekt de pas dɔŋ tru jɛnɛreshɔn dɛm. Wi kɔl dis Linch sindrom . If pɔrsin na yu famili gɛt dis sik, yu kin gɛt bɔrku kɔlon kansa bak.
Apat frɔm dat, tin dɛn de na wi layf we kin mek wi gɛt kansa mɔ ɛn mɔ.
| Risk factors we wi nɔ ebul fɔ kɔntrol | Risk factors we wi kin kɔntrol |
|---|---|
| Bikɔs i dɔn pas 50 ia | Fat |
| Fɔ gɛt famili histri bɔt kɔlon kansa | Tayp 2 dayabitis |
| Sik dɛm we pɔsin kin gɛt frɔm in mama ɛn papa lɛk Lynch syndrome | Fɔ smok |
| Fɔ gɛt sik dɛn lɛk Crohn’s disease | Fɔ drink pasmak |
| Fɔ gɛt polip na di kɔlon | Fɔ it tumɔs rɛd mit ɛn prosɛs mit |
Aw fɔ no di sik?
If yu dɔktɔ saspek kansa bay di sayn dɛm we yu gɛt, i go rifer yu fɔ sɔm tɛst dɛm.
1. Kolonoskopi: dεn de put wan fleksibul tכb we gεt kεmεra we dεn atak tru di an fכ egzamin di כl kכlon. dis tεm, dεn kin tek wan sכm sכm tisu frכm wan say we dεn sכspεkt fכ egzamin. Dɛn kɔl dis bayɔpsi .
2. mכlikul tεst dεm: dεn de du spεshal tεst fכ no di jεnεtik chenj dεm, i.e. MSI-H stetכs, insay di tisu sεmpl we dεn tek frכm di bayopsi. Dɛn kin yuz tɛknɔlɔji dɛn lɛk IHC , PCR , ɛn NGS fɔ dis.
3. Imej tɛst: Dɛn kin du skan lɛk CT ɛn MRI fɔ si if di kansa dɔn skata to ɔda ɔgan dɛn.
Wetin na di tritmɛnt fɔ MSI-H kansa?
Di tritmɛnt dipen pan di stej we di kansa gɛt ɛn aw fa i dɔn skata. Tu men tritmɛnt dɛn de we yu kin du.
Ɔpreshɔn
If di kansa nɔ dɔn skata to ɔda say dɛn, di fɔs tin we yu fɔ du na fɔ pul di tumbu tru ɔpreshɔn. Di kayn ɔpreshɔn kin difrɛn difrɛn wan bay di sayz we di kansa gɛt.
Mɛrɛsin we dɛn kin gi
Dis na di say we di spεsifisiti fכ MSI-H kεnsar de kam in ple.
- Immunotherapy: Dis na di tritmɛnt we impɔtant pas ɔl ɛn we go wok fayn fɔ MSI-H kansa.. Tink bɔt wi imyun sεl dεm lεk we dεn gεt ‘on’/‘off’ switch. Sɔntɛnde, di kansa sɛl dɛn kin yuz sɛns fɔ ɔf dis swich ɛn ayd frɔm di tin dɛn we wi bɔdi de protɛkt. di imyun tεrapi dεm (chεkpכynt inhibito dεm) de tכn da ‘כf’ switch de bak, we de εp di imyun sistεm fכ fכn εn pwεl di kεnsar sεl dεm.
- Kimotɛrapi: Fɔ gi strɔng mɛrɛsin fɔ kil di kansa sɛl dɛn. Sɔntɛnde, dɛn kin yuz am bifo ɔ afta di ɔpreshɔn.
- Targeted Therapy: Fɔ gi drɔgs we de tɔch ɛn stɔp sɔm patikyula prɔtin ɔ prɔses dɛm we de ɛp di kansa sɛl dɛm fɔ gro.
Liv wit MSI-H kansa
I rili impɔtant fɔ mek yu gɛt gud bɔdi ɛn maynd wɛlbɔdi we yu de trit kansa.
- Di it: Afta yu dɔn du di ɔpreshɔn, fala wetin yu dɔktɔ tɛl yu fɔ it ɛn it it we izi fɔ digest ɛn we gɛt bɔku prɔtin. I bεst fכ ridyus di it dεm we de prodyuz gas (e.g., kabij, bins) εn mit dεm we dεn prכsεs.
- Ɛksesaiz: Simpul ɛksesaiz lɛk fɔ waka as yu ebul kin rili bɛnifit yu bɔdi ɛn maynd. Bɔt chɛk wit yu dɔktɔ bifo yu bigin ɛni ɛksesaiz.
- Mental hεlth: Na nɔrmal tin fɔ fil wɔri ɛn frayd pan tɛm lɛk dis. Nɔ kip yu filin dɛn bɔtul insay. Tɔk to pɔsin we yu trɔst, yu famili, ɛn aks fɔ ɛp frɔm pɔsin we de advays yu bɔt yu maynd if nid de.
MSI-H kansa gɛt rili ay rɛt fɔ mɛn we yu kɔmpia am wit ɔda kayn kɔlon kansa, mɔ if dɛn no am kwik, ɛn tritmɛnt dɛn lɛk imyunotɛrapi kin gi rili gud rizɔlt.
Mɛsej we dɛn kin kɛr go na os
- MSI-H na wan spεsifi k tכp kכlon kεnsar we di kεnsar sεl dεm gεt difεkt na dεn DNA ripa sistεm (MMR).
- biכs fכ dis "instability", dεn kεnsar dεm ya de rεspכnd bכku bכku wan to imyun tεrapi.
- If yu gɛt sɔm sayn dɛn we gɛt fɔ du wit kɔlon kansa (we yu de chenj yu stɔl, yu bɛlɛ de pen, yu de blɔd), nɔ ignore dɛn ɛn go to yu dɔktɔ wantɛm wantɛm.
- MSI-H kansa gɛt rili ay chans fɔ wɛl if dɛn no am kwik. So, i impɔtant fɔ mek yu nɔ fred ɛn go to di rayt advays ɛn tritmɛnt we yu go gi yu.
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