I tan lɛk se nyu blɔd vesel dɛn de fɔm insay yu yay? Wi go tɔk bɔt dis niɔvaskulayzeshɔn na di yay?

Sɔntɛnde, wi yay kin gɛt prɔblɛm dɛn we wi nɔ bin de ɛkspɛkt, nɔto so? Wantɛm wantɛm, wi nɔ kin si fayn, ɔ wi yay kin rɛd ɛn fil pen. Sɔntɛm wan kɔndishɔn de biɛn dɛn tin ya we wi nɔ yɛri bɔku bɔt. Wan pan dɛn kayn tin ya na di ocular neovascularization, ɔ di fɔmɛshɔn fɔ nyu blɔd vesel dɛn insay di yay.

Wetin na di fɔmɛshɔn fɔ nyu blɔd vesel dɛn na di yay? (Niovaskulayzeshɔn fɔ di Ay) .

Fɔ tɔk am simpul wan, dis na we nyu blɔd vesel dɛn kin kam insay di yay. Bɔt dɛn blɔd vesel ya kin gro na say dɛn we dɛn nɔ fɔ gro, di we dɛn we dɛn nɔ fɔ gro, ɛn sɔntɛnde dɛn kin gro pasmak . Dɛn kin gro lɛk gras. nyu fayv tisu dεm kin fכm bak bitwin dεn nyu bכdi vεsul dεm ya. Na da tɛm de di vishɔn bigin fɔ afɛkt.

dis na wetin wi mεdikal kכl ``Neovascularization``, di fכmeshכn fכ nyu, blכd vεsul dεm we wi nכ want insay di yay. Dis kin mek di yay inflamɛns ɛn gɛt skata insay di yay, we kin mek i nɔ ebul fɔ si bɛtɛ ɔ i nɔ kin si igen . Bɔrku tɛm, dis sik kin kam wae pɔrsin gɛt injury ɔr sik wae de kɔntinyu fɔ de .

Usay na di yay dɛn nyu blɔd vesel ya kin mek?

Naw lɛ wi si us pat na di yay dɛn nyu blɔd vesel ya kin afɛkt. Di yay na wan ɔgan we rili kɔmpleks ɛn we nɔ gɛt wan bɔt.

• Choroid: Dis de bitwin di retina ɛn di sklera, we na di wayt pat na di yay. Na dis say bɔku pan di blɔd vesel dɛn we de gi blɔd to di yay de.
• Retina: Dis na di say we di layt we de go insay di yay de chenj to ilɛktrik signal ɛn sɛn am to di bren. Dis na wetin de mek wi ebul fɔ si tin dɛn.
• Makula: Dis de na di sɛntrɔm pan di retina. I de ɛp wi fɔ si tin dɛn we de bifo wi klia wan.
• Ayris: Dis na di pat pan di yay we de gi am in kɔlɔ. Di smɔl blak sɛklɔ we de na di midul, we na di pupil , de bak ya.
• Kɔnia: Dis na di klia pat pan di yay we tan lɛk glas we de bifo, lɛk winda.
• Kɔnjɔktiva: Dis na tin we tan lɛk tin we de protɛkt di yay.

fכmeshכn fכ nyu bכdi vεsul dεm na di vaskulכr layεr `(Choroidal Neovascularization - CNV)`

naw lε wi luk dis `(Choroid)`, dat na di fכmeshכn fכ nyu bכdi vεsul dεm na di vaskulכr layεr. dis dεn kכl am `(Choroidal Neovascularization - CNV)`.

Dis kin mɔs si pan pipul dɛm wae gɛt ej-rilayt makyula dijɛnɛreshɔn (AMD). Dɔktɔ dɛn biliv se di tin we kin mek i apin na we wan kemikal we dɛn kɔl Vascular Endothelial Growth Factor (VEGF) we di pɔsin we gɛt AMD in retina de mek, de bɔku.

Dɛn nyu blɔd vesel ya nɔto nɔmal tin. Dɛn wik bad bad wan, lɛk paip we dɔn brok.Dis kin mek wata, ɛn sɔntɛnde ivin blɔd, lik insay di retina. Tink bɔt am lɛk smɔl balyɔn we ful-ɔp wit wata, ɛn blista kin fɔm na di retina.

dis kכz dεm fכ `(CNV)` kin mek bak nyu bכdi vεsul dεm fכm na di sεntri rεtina (Macular Neovascularization - MNV). Bɔt sɔm tɛm dɛn de `(MNV)` kin apin we nɔ gɛt ɛni rizin. insay dεn kayn kes dεm ya, dεn kin kכl am bak `(Idiopathic)`, we min "fכ kכz we dεn nכ no".

Kכnia Niovaskulεrayzeshn

nεks, lε wi tכk bכt di fכmeshכn fכ nyu bכdi vεsul dεm na di kכnia. Mɛmba se di kɔnia na di klia pat na di yay. Nɔmal wan, i nɔ gɛt blɔd vesel dɛn atɔl. Na dat mek i rili klia. So, if nyu blɔd vesel dɛn fɔm insay de, dat klia kin ambɔg, ɛn i kin tan lɛk fɔg. Dis kin mek yu nɔ de si fayn.

dis ``Kכnia Niovaskulεrayzeshn`` de sho difrεn ay kכndishכn dεm.

Rεtina Niovaskulεrayzεshכn

di rεtina niכvaskulεrayzeshn na di fכmeshכn fכ nyu, abnכmal bכdi vεsul dεm na di rεtina. Mɛmba se na di retina na di say we di sɛl dɛn we de no di layt de. Dis kayn sik kin kam bikɔs ɔf difrɛn sik ɛn injury. Dɛn nyu blɔd vesel ya wik ɛn dɛn kin blɔd ɛn lik wata.

Niovaskularizayshɔn fɔ di Ayris

Iris Niovascularization na di divεlכpmεnt fכ nyu εn abnכmal bכdi vεsul dεm na di ayris – di pat pan di yay we de gi kכla to di yay. Dɛn kin kɔl am bak Rubeosis Iridis. I gɛt fɔ du wit wan bad bad kayn glaukoma we dɛn kɔl Neovascular Glaucoma. Glaukoma na sik we de pwɛl di optik nerve ɛn na big trɛtin fɔ si.

Wetin na di sayn dɛm fɔ dis sik?

Naw lɛ wi si us sayn dɛn wi kin fil ɛn si we nyu blɔd vesel dɛn fɔm insay di yay. Dɛn sayn ya kin difrɛn difrɛn wan bay usay di nyu blɔd vesel dɛn dɔn fɔm.

If nyu bכdi vεsul dεm fכm na di kכroyd εn makula:

• Tin dɛn we yu de si kin tan lɛk se dɛn dɔn chenj ɛn we nɔ fayn , lɛk we yu de luk insay wata ɔ na miro we nɔ fayn.
• We yu luk stret bifo yu, yu go si wan blank ples ɔ blak ples na di midul pan yu vishɔn.

if nyu bכdi vεsul dεm fכm na di kכnia (Corneal Vascularization):

Sɔntɛm yu nɔ go gɛt ɛni sayn atɔl. Bɔt if yu du dat, yu go gɛt dɛn tin ya:

• Ay pen.
• Di yay dɛn we de rɛd.
• Yay dɛn we gɛt wata.
• Sensitivity to light (Photophobia) - Dis min se i nɔ kin izi fɔ luk tin dɛn lɛk san layt ɛn brayt layt.
• If yu wɛr kɔntakt lens, yu nɔ go ebul fɔ wɛr am fɔ pas sɔm awa.

Wetin mek dis de apin? Wetin na di rizin dɛn?

Okay, naw lɛ wi luk wetin mek nyu blɔd vesel dɛn de fɔm insay di yay dis we, ɛn wetin na di tin dɛn we kin mek wi gɛt am. Di rizin fɔ dɛn fɔmɛshɔn ya difrɛn smɔl na ɛni ples.

di tin dεm we de mek nyu bכdi vεsul dεm de fכm na di kכroyd εn makula:

• Macular degeneration: Dis na di men tin we kin mek i apin.
• Fɔ si tin we de nia pasmak.
• Ocular histoplasmosis na fכngal infεkshכn na di yay.
• Ay injury.
• Angioid streaks: dis dεm lεk krak krak dεm we de fכm na wan pan di layεr dεm na di rεtina.
• Yuveitis: Dis na wan grup wae gɛt dis sik wae kin mek yu yay gɛt inflamɛns, rɛd, ɛn yu yay kin fil pen.

Di tin dɛn we kin mek nyu blɔd vesel dɛn fɔm na di kɔnia:

• Sik dεm we dεn kin bכn pikin: Dis na sik dεm we de de we dεn bכn am.
• Ay trauma: Fɔ ɛgzampul, kemikal bɔn.
• Keratitis we kin mek pɔsin gɛt sik.
• Alɛji dɛn we pɔsin kin gɛt.
• Imyun sistɛm ɛn inflammatory dizayd.
• If yu yuz kɔntakt lens fɔ lɔng tɛm, dat kin mek di tisu nɔ gɛt ɔksijɛn (Hypoxia).
• Rijekshכn fכ wan kכnia graft bay di bכdi.

Di tin dɛn we kin mek nyu blɔd vesel dɛn fɔm na di retina:

• Retinitis we gɛt di sik.
• Retinopathy: Dis kin inklud tin dɛm lɛk dayabitis-rilayt retinopathy, sikɛl sɛl retinopathy, ɛn retinopathy of prematurity.
• di bכdi we de fכlכ na di men bכdi we de na yu nεk (carotid arteries) dכn dכn.
• di rεtina vein oklushכn: Dis na di blכd we de blo na di rεtina.

Di tin dɛn we kin mek nyu blɔd vesel dɛn na di ayris:

• Retinopathy we gɛt fɔ du wit dayabitis.
• Sεntrial rεtina vein oklushכn.
• Ocular ischemic syndrome: Na wan sik wae de kam wae blɔd nɔr de go na di yay.
• di rεtina dεtachmεnt: dis na we di rεtina de separet frכm in sכpכt tisu dεm.
• Yuveitis we gɛt di sik.

Aw yu no dis? Wetin na di tɛst dɛn?

Wɛl, if yu gɛt sɔm sayn dɛn lɛk dis, aw dɔktɔ go no di sik klia wan? Bɔku tɛst dɛn de fɔ dat.

• Dilated slit lamp ay ɛgzam:Insay dis, dɛn kin put ay drɔp pan di yay, dɛn kin mek di yay big, ɛn dɛn kin tek tɛm luk insay di yay wit spɛshal tin lɛk maykroskɔp.
• Optical Coherence Tomography (OCT): Dis tan lɛk we dɛn de skan di insay pat pan di yay. i kin tek klia kכros-sekshכnal imej dεm fכ di layεr dεm we de insay di yay. I kin luk fɔ tin dɛn lɛk nyu blɔd vesel ɛn wata we de lik.
• Fluorescein angiography ɔ Indocyanine green angiography: Dis na fɔ injɛkt spɛshal day insay wan vein na yu an ɛn tek pikchɔ fɔ di blɔd vesel dɛn we de insay yu yay. Dis kin sho klia wan tin dɛm lɛk fɔ blok ɛn lik na di blɔd vesel dɛm.

Wetin na di tritmɛnt dɛn?

Di tritmɛnt fɔ dis sik kin difrɛn difrɛn wan fɔ di kɔz ɛn di pat pan di yay we i afɛkt. Dɛn tritmɛnt ya kin inklud mɛrɛsin ɛn/ɔ ablation, we kin pwɛl di nyu, abnɔmal blɔd vesel dɛm.

Di kayn mɛrɛsin dɛn we dɛn kin yuz:

Sɔm pan dɛn na injɛkshɔn we dɛn kin gi insay di yay we dɛn kin gi dairekt insay di yay. Dɛn tin ya kin wok mɔ bay we dɛn de kɔntrol wan kemikal we dɛn kɔl VEGF ɛn ridyus di fɔmɛshɔn fɔ nyu blɔd vesel dɛn.

• `Bevacizumab (Avastin®)` (Dεn de yuz dis `(off-label)`, we min se i nכ de fכ di sik we dεn apruv am fכ, bכt na biכs dεn no se i bεnεfit)
• `Brɔlusizumab (Beovu®)`
• `Aflibersɛpt (Eylea®)`
• `Ranibizumab (Lusɛntis®)`
• Jin tɛrapi: Dis na nyu tritmɛnt we stil de na di risach stej.
• MMP inhibitors: Fכ egzampl, na wan pil we dεn kכl Doxycycline , we dεn kin gi fכ mek nyu bכdi vεsul dεm na di kכnia gro.

Di we dɛn we de pwɛl di tisu dɛn we nɔmal:

• Laser ablashכn tεrapi: Dis de yuz laser bim fכ "bכn" εn pwεl di nyu bכdi vεsul dεm.
• Fɔtodaynamik tɛrapi (PDT): Dis kin min fɔ injɛkt wan mɛrɛsin we de mek layt na di yay, dɔn dɛn kin shayn spɛshal layt na di yay fɔ pik di blɔd vesel dɛn we nɔ de wok.
• Cauterization: Dis we ya de yuz ɔt fɔ trit abnɔmal blɔd vesel dɛn.

Mɛmba bak: Dɛn tritmɛnt ya kin gɛt sayd ɛfɛkt. Fɔ ɛgzampul, stɛroyd ɛn anti-VEGF drɔgs kin gɛt sayd ɛfɛkt we kin afɛkt di wan ol bɔdi. Dɔn bak, we dɛn de pwɛl di blɔd vesel dɛn, sɔntɛnde di tisu dɛn we gɛt wɛlbɔdi kin pwɛl. So, i impɔtant fɔ tɔk to yu dɔktɔ bɔt di gud ɛn bad tin dɛn we ɛni tritmɛnt gɛt ɛn pik di wan we go fayn fɔ yu.

Wetin wi go du fɔ protɛkt wisɛf frɔm dis kayn tin?

Pan ɔl we dɛn nɔ go ebul fɔ avɔyd dis sik kpatakpata, tin dɛn de we wi kin du fɔ kia fɔ wi yay ɛn ridyus di prɔblɛm:

• Bifo yu mek yu yay kɔntaktWash yu an dɛn fayn fayn wan wit sop.
• If yu wɛr kɔntakt lens, fala di kɔrɛkt instrɔkshɔn fɔ yuz ɛn klin am. Nɔ wɛr dɛn fɔ lɔng tɛm pas di tɛm we dɛn tɛl yu fɔ wɛr. Rimov dɛn we yu de slip.
• Aks yu dɔktɔ bɔt it ɛn sɔpɔtmɛnt dɛn we go ɛp fɔ mek yu yay gɛt wɛlbɔdi. Fɔ pipul dɛm wae gɛt AMD, wan kayn supamakit de wae dɛn kɔl AREDS 2 wae kin ɛp fɔ stɔp ɔr kɔntrol aw di sik de go bifo we i bigin.
• Fɔ fala di we aw yu de liv yu layf we gɛt wɛlbɔdi. Dis min se yu fɔ it di rayt it, yu fɔ de du ɛksasaiz ɔltɛm , ɛn yu nɔ fɔ smok. If yu gɛt ɛni sik, lɛk dayabitis ɔ ay blɔd prɛshɔn, kɔntrol am fayn fayn wan.

Wetin wi kin ɛkspɛkt wit dis sityueshɔn?

If dɛn nɔ trit dis nyu blɔd vesel fɔmɛshɔn, yu go de si smɔl smɔl ɛn leta i nɔ go de igen. Dat go rili afɛkt yu layf, nɔto so?

Bɔku tin dɛn de we kin afɛkt if di tritmɛnt go fayn. Dɛn tin ya na usay di blɔd de klɔt, aw i bad, yu ej, ɛn if yu gɛt ɔda wɛlbɔdi prɔblɛm. Di kwik we dɛn no bɔt am ɛn trit am, na di mɔ i go fayn.

Ustɛm a fɔ go to dɔktɔ?

If yu nɔ de si fayn wantɛm wantɛm, yu yay de fil bad bad wan, ɔ yu yay de bɔn we de mek i nɔ izi fɔ si layt, go to dɔktɔ wantɛm wantɛm. Dɔn bak, if yu notis ɛni chenj na yu yay (e.g., yu nɔ de si fayn, blak spat), ɔ ɛni ɔda sayn we yu tink se na prɔblɛm, go to dɔktɔ we de mɛn yu yay wantɛm wantɛm.

I impɔtant bak fɔ mek yu de du yu yay ɛgzam ɔltɛm lɛk aw yu yay dɔktɔ tɛl yu. If yu de pan risk fɔ sɔm kayn yay kɔndishɔn (e.g., dayabitis, yu famili histri fɔ AMD), yu kin nid fɔ go mɔs.

``Neovascularization'' εn ``Angiogenesis'' na tu difrεnt tin dεm?

dis na sכm dip sכbjek, bכt fכ put am sכmtεm, `(Angiogenesis)` na di prכsεs we nyu bכdi vεsul dεm de branch kכmכt frכm di bכdi vεsul dεm we de naw. `(Vasculogenesis)` na di prכsεs we nyu bכdi vεsul dεm de stat frכm sεl dεm (lεk se i de stat frכm skrach). `(Neovascularization)` kin yuz fכ mek nyu bכdi vεsul dεm na di tu we dεm. so `(Neovascularization)` na sכm bכku tεm, εn i kin inklud כl dεn kayn nyu bכdi vεsεl fכmeshכn.

Di tin dɛn we impɔtant pas ɔl we wi nid fɔ mɛmba frɔm dis stori na

so, wi dכn tכk bכku bכt dis kכndyushכn we dεn kכl ``Neovascularization of the Eye'', usay nyu bכdi vεsul dεm de fכm insay di yay. Pan ɔl we dis kin tan lɛk se i de mek pɔsin fred smɔl, if dɛn no am ɛn trit am di rayt tɛm, chans de fɔ mek dɛn ebul fɔ kɔntrol di sik ɛn fɔ mek dɛn nɔ si am fayn.

• If yu gɛt chenj na yu yay wantɛm wantɛm, yu rɛd, yu de fil pen, ɔ yu nɔr kin ebul fɔ si na brayt layt, nɔr de delay. Go to dɔktɔ we de mɛn yu yay wantɛm wantɛm.
• If yu gɛt tin dɛn lɛk dayabitis, haypa ropia, ɔ yu famili histri bɔt AMD, mek dɛn chɛk yu yay ɔltɛm lɛk aw yu dɔktɔ tɛl yu.
• Yuz di mɛrɛsin we yu dɔktɔ gi yu di rayt we, fala wetin i tɛl yu fɔ du, ɛn nɔ stɔp di tritmɛnt midul.
• Nɔ smok kpatakpata. Smok kin rili bad fɔ di yay wɛlbɔdi, mɔ fɔ tin dɛn lɛk AMD ɛn dayabitik ay sik.
• Fɔ it fayn ɛn fɔ du ɛksɛsayz ɔltɛm nɔto jɔs fɔ yu yay, bɔt fɔ yu wan ol bɔdi bak. Put grɛn vɛjitebul, frut, ɛn fish we gɛt bɔku omega-3 insay yu it.

Mɛmba se yu yay rili valyu. Dɛn na di tin dɛn we wi gɛt fɔ si di wɔl we gɛt valyu pas ɔl. So, na yu wok fɔ kia fɔ dɛn gud gud wan. If yu no bifo tɛm ɛn du di tin dɛn we yu nid, yu go avɔyd bɔku prɔblɛm dɛn.

` Niovaskulayzεshכn כf di Ay, Ay Sik, Vishכn, Rεtina, כftalmכlכji, Ay Tritmεnt