Yu liva tu fat? Lɛ wi lan bɔt MASH (Mɛtabolik Dysfunshɔn-Asɔsiet Steatohepatitis)!

Yu dɔn ɛva yɛri bɔt wan sik we fat kin gɛda na di liva? Sɔmtɛm, dis sik kin bi siriɔs wan wae nɔr gɛt ɛni big big sayn. Tide, wi go tɔk bɔt wan pan dɛn kayn sik dɛn de we kin afɛkt wi liva kwayɛt wan. dεn kכl dis MASH (Mεtabolik Disfכnkshכn-Asכsiet Steatohepatitis).

Wetin na MASH (Mɛtabolik Dysfunkshɔn-Asɔsiet Steatohepatitis)?

Fɔ tɔk am simpul wan, MASH na wan sik we yu liva gɛt bɔku fat, we kin mek yu gɛt inflamɛns , wan sik we fiba we yu wund. Tink bɔt dis we: we yu gɛt injuri, di say kin rɛd, swel, ɛn wam, ɛn di sem tin kin apin insay di liva. di nem fכ dis kכndyushכn na NASH (non-alcoholic steatohepatitis).

dis kכndyushכn we dεn kכl MASH na pat pan wan big grup fכ liva sik dεm we dεn kכl MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease). Dis kin apin bikɔs di fat kin gɛda na di liva fɔ ɔda rizin dɛn pas fɔ drink rɔm.

Di tin we impɔtant pas ɔl na dat if dɛn nɔ trit dis fayn, as tɛm de go i kin mek pɔsin gɛt tin dɛn lɛk sirosis, we kin mek di liva at ɛn gɛt skata, ɔ ivin sik dɛn we denja lɛk liva kansa. So, i rili impɔtant fɔ mek wi no bɔt dis.

Wetin na di tin dɛn we kin mek pɔsin gɛt MASH? Udat dɛn de pan denja?

di men tin we de mek MASH na we di fεt we de kכmכt pasmak na di liva, we de pwεl di liva εn mek di liva inflameshn. Dis kכndyushכn kin apin we prכblεm de wit di mεtabolism fכ shuga εn fεt na wi bכdi. Lɛ wi tek wan luk pan di men tin dɛm wae kin mek wi gɛt dis sik ɛn di tin dɛm wae kin mek wi gɛt dis sik:

• Fɔ fat ɔ fɔ fat pasmak: Dis na di men tin we kin mek pɔsin fat.
• Tayp 2 dayabitis: Pipul dɛn we gɛt dayabitis kin gɛt mɔ risk fɔ gɛt MASH.
• Ay kɔlɔstrel: Di bad bad kɔlɔstrel we de na di blɔd kin bɔku.
• High triglycerides: Dis na wan kayn fat bak we de na di blɔd. If dɛn tin ya bɔku bak nɔ fayn.
• Ay blɔd prɛshɔn: Wi kin kɔl am prɛshɔn.
• Insulin resistance: We di bɔdi in sɛl dɛn nɔ de ansa fayn fayn wan to insulin. Dis na wan sik wae kin kam bifo yu gɛt shuga.

Mɛmba se, sɔmtɛm ivin if yu gɛt nɔmal wet, if yu gɛt ay kɔlɔstrel, ay blɔd prɛshɔn, ɔ kɔndishɔn lɛk dayabitis, yu kin gɛt sɔm risk fɔ gɛt MASH. So, if yu gɛt ɛni wan pan dɛn tin ya we kin mek yu gɛt prɔblɛm, i go fayn fɔ mek yu go to yu dɔktɔ ɛn chɛk fɔ si if yu gɛt MASH.

Wetin na di sayn dɛm fɔ MASH? Aw yu no am?

Na dis na di prɔblɛm: Bɔku tɛm, MASH nɔ kin sho ɛni klia simptom we i bigin.Dis sik kin kam smɔl smɔl fɔ lɔng tɛm. Sɔm sayn dɛn kin jɔs bigin fɔ sho afta di liva dɔn pwɛl bad bad wan. We di sayn dɛn kin sho, dɛn kin bi:

• Taya: Fɔ fil taya ivin we yu nɔ du natin.
• Diskɔmfɔt ɔ pen na yu ɔp rayt bɛlɛ: Rayt usay di liva de.
• We yu de lɔs yu wet we yu nɔ ɛksplen.
• Di mɔsul dɛn we wik ɔ di mɔsul dɛn we de lɔs.
• Bɛlɛ ɔ leg dɛn we dɔn swel.
• Wae de sik kin tranga, yu yay ɛn yu skin kin yɔlɔ (jaundice): Dis na wetin sɔmtɛm wi kin kɔl janda.

Bikɔs nɔr simptom nɔr de na di fɔs stej, i rili impɔtant fɔ de chɛk-ap ɔltɛm, mɔ if yu gɛt tin dɛm wae kin mek yu gɛt dis sik lɛk fɔ fat, dayabitis, ɛn ay kɔlɔstrel. Na da tɛm de nɔmɔ yu go ebul fɔ no dis sik kwik kwik wan.

Us ɔda kɔmplikɛshɔn dɛn kin apin bikɔs ɔf MASH?

If dɛn nɔ trit MASH fayn, i kin mek i gɛt siriɔs prɔblɛm dɛn we kin mek pɔsin in layf de pan denja. Na dis na wetin dɛn bi:

• Liva fibrosis: Dis na skata na di liva. As tɛm de go, dis skata kin bɔku, ɛn dis kin mek pɔsin gɛt sirosis.
• Sirosis: Dis na sik we di liva kin gɛt bad bad skata ɛn i nɔ kin wok fayn. Bɔrku tɛm dis kin bi pɔrsin wae de apun, wae min se i nɔr kin izi fɔ rivɛns.
• Liva we nɔ de wok fayn: Di liva kin stɔp fɔ wok fayn fayn wan. Dis kin apin wantɛm wantɛm. If dis apin, yu kin nid fɔ go to dɔktɔ wantɛm wantɛm ɔ fɔ transplant yu liva.
• Hepatocellular carcinoma: MASH de mek di risk fɔ gɛt dis kɔmɔn kayn liva kansa.
• At sik: Pipul wae gɛt MASH kin gɛt bɔrku sik wae gɛt fɔ du wit at lɛk at atak ɛn strok.

Jɔs tink bɔt, ɔltin kin bigin wit smɔl fat na di liva. Na dat mek wi se, nɔ ignore ivin di smɔl tin.

Aw dɔktɔ dɛn kin no se yu gɛt MASH sik?

Bikɔs MASH nɔ kin mek yu gɛt di sik fɔs, sɔm tin dɛn de we yu nid fɔ du fɔ no if i gɛt am. Dɔktɔ go du fɔs ɛgzam fɔ di bɔdi. Dɔn dɛn go aks yu bɔt ɔda mɛrɛsin dɛn we kin mek yu gɛt mɔ chans fɔ gɛt MASH (e.g., dayabitis, kɔlɔstrel). Apat frɔm dat, dɛn kin du dɛn tɛst ya:

Blɔd tɛst dɛn

Yu dɔktɔ go ɔda fɔ mek dɛn du blɔd tɛst fɔ chɛk fɔ si if di liva dɔn pwɛl ɔ if i gɛt inflamɛns. Dɛn tin ya kin bi:

• CBC (Kɔmplit Blɔd Kɔnt): Kɔmplit blɔd sɛl kɔnt.
• BMP (Bεsik Mεtabolik Panεl): Bεsik mεtabolik prכsεs tεst.
• Lipid panεl: Chεk di fεt lεvεl lεk kכlestכl εn triglisεrayd.
• Ɛmoglobin A1C: Na tɛst fɔ no aw pɔsin kin kɔntrol dayabitis.

Test dɛn fɔ tek imej

Dɛn tɛst ya kin tek pikchɔ (imej) fɔ di insay pat pan yu liva. Yu dɔktɔ go luk dɛn pikchɔ ya fɔ chɛk fɔ ɛni chenj na yu liva we gɛt fɔ du wit MASH stetɔs. Dɛn kin du tɛst dɛn lɛk dɛn wan ya:

• CT skan (CT skan - Kɔmpyuta Tomografi skan) .
• Ultrasound skan we dɛn kin yuz
• FibroScan®: Dis na spɛshal kayn ɔltra saund we de mɛzhɔ aw di liva stif. Dis kin gi yu aidia bɔt liva fibrosis.
• magnεtik rεsכnans εlastografi εn protכn dεnsiti fεt frakshכn (MRE-PDFF): dis kin mכsu di fεt we de na di liva kכrekt wan.

Liva bayɔpsi

Sɔntɛnde, yu dɔktɔ kin nid fɔ tek smɔl smɔl tisu frɔm yu liva we dɛn kɔl liva bayɔpsi. Wan dɔktɔ we de mɛn di sik go chɛk di sampul ɔnda maykroskɔp fɔ chɛk fɔ si if i gɛt fat, if i gɛt inflamɛns, ɛn if i gɛt skata na di liva. Liva bayɔpsi na di bɛst we fɔ no di MASH kɔrɛkt wan.

Apat frɔm dat, yu dɔktɔ kin du ɔda tɛst dɛn bak fɔ no if yu gɛt ɔda sik na yu liva.

Wetin na di tritmɛnt dɛm fɔ MASH?

Di men tin we dɛn kin pe atɛnshɔn pan fɔ trit MASH na fɔ mek yu bɔdi gɛt mɔ mɛtabolik wɛlbɔdi ɛn fɔ mek yu liva nɔ pwɛl mɔ. Yu tritmɛnt plan kin gɛt fɔ du wit:

Di we aw pipul dɛn de liv dɛn layf kin chenj

Fɔ kɔntrol MASH, i impɔtant fɔ adopt wɛlbɔdi it, bi aktif, ɛn lɔs weit. Yu dɔktɔ kin tɛl yu fɔ chenj yu layf lɛk:

• It fayn it: Wan gud it plan we de ɛp fɔ kɔntrol MASH na di Mɛditarenian it ɔ it we nɔ gɛt bɔku kab . Fɔ tɔk am simpul wan, it mɔ vɛjitebul, frut, ligɛm, fayv grens, gud kwaliti prɔtin (fish, chukchuk), ɛn fayn fayn fat (avokado, ɔliv ɔyl, nɛt). Yu fɔ ridyus swit, it dɛn we gɛt fat, ɛn fast fud dɛn as yu ebul.
• Fɔ bi aktif: at le wan tɛm insay di wikTray fɔ gɛt 150 to 300 minit fɔ du mɔdaret-intɛnsity aerobic ɛksɛsayz. Sɔm ɛgzampul dɛn na fɔ waka kwik kwik wan, fɔ rɔn, fɔ rayd baysikul, ɛn fɔ swim.
• Nɔ drink rɔm ɔltogɛda: Ivin smɔl rɔm kin mek yu liva strɛs, so i impɔtant fɔ lɛ yu nɔ drink rɔm kpatakpata.

Mɛrɛsin we dɛn kin gi

Yu dɔktɔ kin gi yu sɔm mɛrɛsin fɔ ɛp fɔ ridyus di sayn dɛm, lɛk skata, we MASH kin kam wit. Fɔ ɛgzampul:

• Resmetiron (Rezdiffra®): Dis mɛrɛsin kin ɛp fɔ ridyus ɔ rivɛns di skata na di liva we MASH kin mek. Na di wan ol mɛrɛsin we di U.S. Food and Drug Administration (FDA) dɔn gri fɔ fɔ trit MASH insay stej 2 ɛn 3 pan fibrosis.
• GLP-1 agonists: Dɛn drɔgs ya de ɛp fɔ ridyus inflamɛns ɛn fat na di liva. Sɔm ɛgzampul dɛn na liraglutayd (Victoza®, Saxenda®), sɛmaglutayd (Ozempic®, Wegovy®), ɛn tirzepatide (Mounjaro®, Zepbound®). Bɔku tɛm dɛn kin yuz dɛn tin ya bak fɔ mɛn dayabitis.

Apat frɔm dat, yu dɔktɔ kin gi yu ɔda mɛrɛsin ɔ sɔpɔtmɛnt. Fɔ ɛgzampul, dɛn kin tɛl yu fɔ tek wan mɛrɛsin fɔ dayabitis we dɛn kɔl pioglitazone (Actoplus Met XR®) ɔ wan supamakit lɛk vaytamɛn E.

Naw, di wan dɛn we de du risach de du klinik trial fɔ fɛn nyu mɛrɛsin fɔ MASH. Yu kin tɔk to yu dɔktɔ bɔt if yu go fit fɔ tek pat pan dis kayn trial.

Ɔpreshɔn fɔ lɔs yu wet (Bariatric ɔpreshɔn) .

If yu fat bad bad wan ɛn yu gɛt siriɔs liva sik, ɔpreshɔn fɔ lɛf fɔ it bɔku bɔku it (bariatric ɔpreshɔn) na ɔda tritmɛnt we yu kin du. Gastrik sliv ɔpreshɔn (we dɛn pul pat pan di bɛlɛ) ɔ gastric bypass ɔpreshɔn (we dɛn ridyus di bɛlɛ) kin gi dɛn bɛnifit ya:

• I de ɛp fɔ ridyus di bɔdi wet.
• Di damej we di liva kin gɛt we MASH kin mek kin ridyus to sɔm mak, ɛn sɔntɛm dɛn kin ivin rivɛns am.
• I de ridyus di risk fɔ gɛt sirosis, liva kansa, ɛn nid fɔ gɛt liva transplant bad bad wan.

Yu tink se MASH kin wɛl ɔltogɛda?

MASH nɔ kin mɛn ɔltɛm. Bɔt if dɛn no di sik kwik kwik wan ɛn bigin fɔ trit am kwik, sɔntɛnde dɛn kin chenj am ɔ mek i nɔ wɔs. Dis min se chans de fɔ mek dɛn nɔ pwɛl di liva mɔ.

Aw lɔŋ pɔsin we gɛt MASH kin liv?

Di layf we yu go liv de dipen pan aw MASH dɔn pwɛl yu liva. If dɛn no di sik ɛn trit am kwik, bɔku pipul dɛn kin liv nɔmal layf.Bɔt as di sik de go bifo to mɔ advans stej, di risk fɔ day kwik bikɔs ɔf kɔmplikeshɔn lɛk we di liva nɔ de wok fayn ɛn di liva kansa de go ɔp. Bɔt, tritmɛnt kin mek di sik nɔ go bifo kwik kwik wan ɛn i kin mek in layf bɛtɛ. Fɔ bigin tritmɛnt kwik kwik wan na di bɛst we fɔ gɛt di bɛst rizɔlt.

Ustɛm a fɔ go to dɔktɔ?

If yu fil taya ɔltɛm, gɛt pen ɔr nɔr de fil fayn na yu bɛlɛ ɔp rayt pat, ɔr gɛt sayn dɛm lɛk fɔ lɔs yu bɔdi we yu nɔr ɛksplen, i impɔtant fɔ go to dɔktɔ. Dɛn tin ya kin bi sayn dɛn we de sho se sɔntin nɔ fayn na yu liva. Yu dɔktɔ go rɔn tɛst fɔ si if na MASH ɔ ɔda liva sik.

Mɛmba se sɔm kayn mɛrɛsin, lɛk fɔ fat pasmak ɛn fɔ gɛt tayp 2 dayabitis, kin mek yu gɛt MASH. If yu gɛt ɛni wan pan dɛn sik ya, yu dɔktɔ go de chɛk yu liva ɔltɛm bak.

Fɔ dɔn, di tin dɛn we impɔtant pas ɔl we yu fɔ mɛmba

We dɛn no se yu gɛt MASH (metabolic dysfunction-associated steatohepatitis), yu kin fil bɔku bɔku shɔk ɛn fred. If yu gɛt tin dɛn lɛk fɔ fat, fɔ gɛt ay blɔd prɛshɔn, ɔ fɔ gɛt ay kɔlɔstrel, yu go de wɔnda se, "Na mi gɛt fɔ ansa fɔ dis?"

Bɔt mɛmba wan tin. Nɔn pan dɛn kɔndishɔn ya, inklud MASH, nɔto yu fɔlt. Yu mɛdikal tim de pe atɛnshɔn pan di tin dɛn we de apin naw, nɔto di tin dɛn we dɔn pas. Dɛn go ɛksplen to yu us step yu kin tek fɔ manej MASH. Ɛn dɛn go de wit yu ɛvri step we yu de waka. So nɔ fred.

De tin wae impɔtant pas ɔl na fɔ no bɔt de sik wae de kam, du wɛl mɛdikal tɛst if pɔrsin gɛt dis sik, ɛn fala dɔktɔ advays. Dɔn wi kin sev wi liva frɔm dis ɛnimi we nɔ de tɔk.

` MASH, fat liva, sirosis, liva kansa, dayabitis, fat, kɔlɔstrel