Yu liva tu fat? Lɛ wi lan bɔt di nyu nem fɔ fat liva sik (Steatotic Liver Disease)!

“O, dɔktɔ, a gɛt fat dipɔsit na mi liva...” Yu dɔn yɛri sɔntin lɛk dis? Ɔ yu gɛt dis sik bak? Nɔ wɔri. Tide wi de tɔk bɔt dis sik we de mek fat de na di liva, ɔ in ɔda wɔd, Steatotic Liver Disease. Trade, wi bin de kɔl dis “fat liva.” Wetin rili na dis? Wetin mek dɛn gi am nyu nem? Lɛ wi tɔk bɔt ɔl dis simpul wan.

Wetin mek di nem "Fatty Liver" chenj?

Wi bin de kɔl dis sik “fat liva sik.” Bɔt insay 2023, masta sabi bukman dɛn we sabi bɔt mɛrɛsin bin disayd fɔ chenj di nem to “steatotic liver disease.” Tu men rizin dɛn de fɔ dis. Wan pan dɛn na dat di nyu nem de tɔk mɔ bɔt di tin dɛn we kin mek pɔsin gɛt dis sik. Fɔ ɛgzampul, pan ɔl we fɔ fat na wan tin we kin mek pɔsin fat, ɔda tin dɛn de we kin mek pɔsin gɛt prɔblɛm we nɔ gɛt natin fɔ du wit in wet. Wan ɔda rizin na dat, sɔmtɛm di wɔd “fat liva” kin shem ɛn stigmatiz fɔ pipul dɛm wae gɛt dis sik, so fɔ chenj di nem ɛp fɔ de-emphasize dat. Fɔ tɔk am simpul wan, “steatosis” na wɔd we dɔktɔ dɛn kin yuz fɔ tɔk bɔt aw fat kin gɛda na wan ɔgan (bɔku tɛm na di liva). Liva we gɛt wɛlbɔdi ɛn we de wok fayn, gɛt smɔl fat. dis fεt we de kכmכt de bi prכblεm if i pas 5% pan di liva in wet.

Wetin na di kayn fat liva sik (SLD)?

Dɔktɔ dɛn kin klas SLD bay di tin dɛn we kin mek i apin ɛn di kɔndishɔn dɛn we gɛt fɔ du wit am. Lɛ wi tek wan luk pan di men kayn dɛn.

1. Liva sik we gɛt fɔ du wit rɔm (ALD) .

Wetin kin apin na dat if yu drink bɔku rɔm, fat kin bɔku na yu liva. Tink bɔt am, we yu de drink rɔm, na yu liva de filta am. We dɛn de du dis, sɔm pan di liva sɛl dɛn kin day. Nɔmal wan, di liva kin mek nyu sɛl dɛn fɔ tek di ples fɔ di wan dɛn we dɔn lɔs. Bɔt if yu kɔntinyu fɔ drink tumɔs rɔm, di liva nɔ go ebul fɔ du dis wok fayn fayn wan. Na da tɛm de fat kin bigin fɔ bɔku na yu liva, we na wan sik we dɛn kɔl steatosis .

2. mεtabolik disfכnkshכn-asכsiet stεatotik liva sik (MASLD) .

Fɔs, dɛn bin de kɔl dis sik we nɔ gɛt rɔm we gɛt fat liva (NAFLD). Dis na bikɔs di fat we de na di liva nɔ kin kɔmɔt frɔm we pɔsin de drink pasmak. di nyu nem se di men tin dεm we de mek di fεt liva divεlכp na di kכdivaskyul εn mεtabolik risk factor dεm . Fɔ tɔk am simpul wan, i kin kam bikɔs ɔf sɔm tin dɛn ɛn sɔm kayn tin dɛn we kin afɛkt di wɛlbɔdi na yu at.

Di men tin dɛn we kin mek pɔsin gɛt MASLD na:

• Fat
• Tayp 2 Dayabitis
• Di ay blɔd prɛshɔn
• di lipid abnכmaliti – Dis na di imbalans na di kayn fεt dεm na yu bכdi, lεk kכlestכl εn triglisεrayd.

Ivin if yu drink smɔl rɔm insay di wik, dat na, nɔ rich 140 gram insay di wik fɔ uman ɛn less dan 210 gram fɔ wan wik fɔ man, dɛn kin stil tek yu as MASLD. (Fɔ ɛgzampul, na Amɛrika, wan tin we dɛn kin yuz fɔ mek bia we gɛt 12 ɔns kin gɛt lɛk 14 gram rɔm.)

3. fεt dεposit dεm εn inflameshn na di liva bikoz fכ mεtabolik disfכnkshכn (Mεtabolik-associated steatohepatitis – MASH) .

MASH na wan we we rili siriɔs fɔ MASLD. insay dis kכndishכn, di liva kin swεla εn inflam bikoz fכ fεt we de kכmכt na di liva. Dɔn, di liva tisu kin pwɛl ɛn bigin fɔ gɛt skata (fibrosis) . Bifo dis tɛm, dɛn bin de kɔl dis nɔ-alcoholic steatohepatitis (NASH).

4. MASLD ɛn fɔ yuz rɔm pasmak (MetALD) .

If yu gɛt MetALD, i min se ɔl tu di mɛtabolik risk factor dɛm ɛn di we aw yu de drink rɔm dɔn ɛp fɔ mek di fat we de na yu liva gɛda. If na so i bi, yu gɛt tin dɛn we kin mek yu gɛt prɔblɛm wit yu at ɛn yu bɔdi, ɛn yu kin drink pas 140 gram rɔm ɛvri wik fɔ uman dɛn ɛn pas 210 gram fɔ man dɛn.

If rɔm ɔr mɛtabolik risk factors kin mek di fat gɛda na di liva kin difrɛn frɔm wan pɔsin to ɔda pɔsin.

5. Ɔda kayn SLD dɛn

SLD kin apin if yu nɔ yuz rɔm ɔ yu nɔ gɛt ɛnitin fɔ du wit di mɛtabolik risk. Fɔ ɛgzampul, sɔm mɛrɛsin ɛn ɔda sik dɛn kin mek fat bɔku na di liva. Sɔntɛnde, dɔktɔ dɛn nɔ kin ebul fɔ fɛn klia rizin. SLD we nɔ gɛt klia kɔz dɛn kɔl am kriptojɛnik SLD .

Yu tink se fat liva sik (SLD) na siriɔs prɔblɛm?

Bɔku tɛm, di fat we de na di liva nɔ kin mek ɛni big prɔblɛm ɔ i kin ambɔg di nɔmal wok we di liva de du. Bɔt sɔntɛnde dis sik kin wɔs smɔl smɔl ɛn tɔn to liva sik. Dis kin apin insay sɔm stej dɛm:

• Epataytis : Di liva we kin ful-ɔp wit fat fɔs, kin swel ɛn inflam. Dis inflameshn de damej di liva tisu. Dɛn kɔl dis sik stiatohepatitis. Fɔ ɛgzampul, MASLD kin bi MASH lɛk aw i de dɔŋ ya.
• Faybrosis: Ska tisu de bigin fכm na di εria dεm we di liva dεn dכn pwεl we inflameshn de kכz. Dis kin mek di liva stif smɔl. Dɛn kɔl dis prɔses fibrosis .
• Sirosis na di liva: Dis na we di liva tisu we gɛt wɛlbɔdi de tek bɔku bɔku skata tisu in ples. Dis na we wi kin kɔl am sirosis na di liva. If dɛn nɔ trit am fayn, sirosis kin mek pɔsin gɛt prɔblɛm dɛn we kin mek pɔsin in layf de pan denja lɛk we di liva nɔ de wok fayn ɛn we i gɛt kansa na di liva. Fɔ ɛgzampul, lɛk 90% pan di pipul dɛn we gɛt ɛpatocellular carcinoma (HCC) , we na wan kayn kansa na dɛn liva, kin gɛt sirosis.

Wetin na di sayn dɛm fɔ fat liva sik (SLD)?

Nɔto ɔlman wae gɛt SLD go gɛt dis sik. Sɔntɛnde, if di sayn dɛn kin apin, dɛn kin bi:

• Bɛlɛ de pen ɔ fil se yu ful-ɔp na di ɔp rayt pat na di bɛlɛ.
• Fɔ fil se yu taya pasmak ɔ yu wik (taya).

Bɔt bɔku pipul dɛn kin jɔs notis di sayn dɛn afta SLD dɔn go bifo to sirosis . We sirosis de kam, sɔm sayn dɛm lɛk:

• Vɔmit.
• Di it nɔ de te.
• Fɔ bi tin fɔ no rizin.
• Di skin kin yɔlɔ ɛn di yay kin wayt (jaundice).
• Ascites – Dis min se di bɛlɛ ful-ɔp wit wata.
• Swel (edema) na di leg, an, ɔ ankles.
• Blɔd (dɔktɔ kin si dis na yu εsophagus, bɛlɛ, ɔ rεktum).

Wetin na di tin dɛm wae kin mek pɔrsin gɛt fat liva sik (SLD)?

Bɔku rizin dɛn de we mek SLD kin divɛlɔp. Bɔt if yu gɛt tin dɛn we kin mek yu gɛt prɔblɛm wit yu at ɛn yu bɔdi , if yu de yuz rɔm di we we nɔ fayn fɔ yu, ɔ if yu gɛt ɔl tu, yu go gɛt SLD.

Yu de pan big risk fɔ gɛt SLD if yu gɛt dɛn tin ya:

• Dizayd fɔ yuz rɔm – dat na fɔ drink rɔm ɔltɛm ɔ fɔ drink pasmak.
• mεtabolik sεndrכm – Dis inklud insulin rεsistεns, hεy blכd prεshכn, hεy kכlestכl, εn hεy triglisεrayd lεvεl.
• Tayp 2 dayabitis.
• כvaweit – Dis min se yu bכdi mas indeks (BMI) de bitwin 25 εn 29.9 kg/m2.
• Fat pasmak – BMI na 30 kg/m2 ɔ mɔ.
• Polisistik ovari sindrom (PCOS).
• Obstruktiv slip apnɛa.
• Di sik we dɛn kɔl haypotayroyd.
• di pituitary hכmon lεvεl dεm we de dכn (Hypopituitarism).
• Di ɔmon dɛn we de na di sɛks we de go dɔŋ (Hypogonadism).
• Kɔntinyu fɔ tek sɔm mɛrɛsin dɛn. Fɔ ɛgzampul, Amiodarone (Amiodarone – Cordarone®), Diltiazem (Diltiazem – Cardizem®), Tamoxifen (Tamoxifen – Nolvadex®) ɔ stɛroyd. (Sɔm mɛrɛsin kin mek di fat bɔku na di liva as sayd ɛfɛkt.)

Wetin na di prɔblɛm dɛn we pɔsin kin gɛt we i gɛt SLD?

If dɛn nɔ trit am, di steatotic liva kin go to sirosis , we kin mek di liva nɔ wok fayn, i kin mek i gɛt kansa na di liva, ɛn ɔda kansa dɛn we nɔ de na di liva. Pipul wae gɛt MASLD kin gɛt at sik mɔr. I impɔtant fɔ mɛmba se at sik, nɔto liva sik, na in de mek pipul dɛn we gɛt MASLD day.

Aw dɛn kin no bɔt fat liva sik (SLD)?

Bikɔs SLD nɔ kin gɛt ɛni sayn, yu dɔktɔ kin bi di fɔs pɔsin fɔ notis di prɔblɛm. If yu liva ɛnzaym dɛn go ɔp we yu de du blɔd tɛst fɔ ɔda tin dɛn, dat kin bi sayn fɔ wɔn yu. di εnzym dεm na di liva we de εlevεt kin min se yu liva dεn dכn pwεl.

Fɔ no if yu gɛt di sik, yu dɔktɔ kin du dɛn tin ya:

• Mɛdikal istri: Fɔ aks bɔt yu mɛrɛsin, ɔmɔs rɔm yu de drink, ɛn us mɛrɛsin yu de yuz.
• Fɔ chɛk yu bɔdi: Chɛk fɔ si if yu gɛt sayn dɛn we de sho se yu gɛt sirosis, lɛk we yu liva big ɛn yu gɛt janda .
• Di we aw dɛn kin tek pikchɔ: Dɛn kin yuz tɛst lɛk ɔltra saund , CT skan (Computed Tomography scan) , ɔ MRI (Magnetic Resonance Imaging) skan fɔ luk fɔ inflamɛns ɛn skata na di liva. Dɛn kin yuz spɛshal ɔltra saund tɛst we dɛn kɔl FibroScan® fɔ no ɔmɔs fat ɛn ska tisu de na di liva.
• Liva bayɔpsi: Dɛn kin du dis tɛst fɔ no aw di liva sik dɔn go bifo. di onli we fכ kכrekt difrεns bitwin MASLD εn MASH na fכ du liva bayopsi .

Aw dɛn kin trit fat liva sik (SLD)?

Nɔr patikyula tritmɛnt ɔ mɛrɛsin nɔr de fɔ dis sik. Bifo dat, dɔktɔ dɛn kin pe atɛnshɔn fɔ ɛp yu fɔ kɔntrol di tin dɛn we kin mek yu gɛt dis sik. Dis inklud fɔ chenj yu layf we go mek yu gɛt wɛlbɔdi.

Yu dɔktɔ kin tɛl yu fɔ du dɛn tin ya:

• Stɔp fɔ drink rɔm ɔltogɛda: Ivin if yu SLD nɔto bikɔs yu de drink rɔm, nɔ drink rɔm ɔltogɛda.
• Lɔs yu wet: Ɛksesaiz, chenj di it we yu de it ɔnda di sɔpɔtishɔn fɔ di wan we sabi bɔt it, ɛn sɔm mɛrɛsin dɛn lɛk GLP-1RA, kin ɛp yu fɔ lɛf fɔ it bɔku bɔku it. Yu kin tink bak fɔ du ɔpreshɔn fɔ mek yu nɔ gɛt bɔku bɔku bɔdi.(Bariatric surgery) kin fit bak.
• Tek mɛrɛsin fɔ kɔntrol di mɛtabolik kɔndishɔn: Tek di mɛrɛsin dɛn we yu dɔn tɛl yu fɔ kɔntrol dayabitis, kɔlɔstrel, ɛn blɔd fat (triglycerides). Sɔntɛnde, yu kin nid bak fɔ tek vaytamɛn E ɛn thiazolidinediones (mɛrɛsin fɔ dayabitis lɛk Actos® ɛn Avandia® ).
• Gɛt vaysin agens Epataytis A ɛn Epataytis B : Dɛn vayral infɛkshɔn ya kin rili denja if yu dɔn ɔlrɛdi gɛt liva sik.

If wan mɛrɛsin we yu de tek de mek di fat bɔku na yu liva, yu dɔktɔ kin chenj di mɛrɛsin we yu de gi.

Aw fɔ mek yu nɔ gɛt fat liva sik (SLD)?

Di bɛst we fɔ avɔyd SLD na fɔ mek yu kɔntinyu fɔ gɛt wɛlbɔdi:

• Ɛksesaiz ɔltɛm.
• Limit yu rɔm we yu de drink.
• Mek yu gɛt wɛlbɔdi wet fɔ yu.
• If yu gɛt tayp 2 dayabitis ɔ mɛtabolik sindrom, tek di mɛrɛsin we dɛn gi yu jɔs lɛk aw dɛn tɛl yu fɔ tek.

Yu tink se fat liva sik (SLD) kin mɛn?

Dipen pan aw yu sik tranga, dɛn kin chenj SLD ɛn dɛn kin ivin mek sɔm skata dɛn. Yu liva gɛt wɔndaful pawa fɔ mɛn insɛf. If yu fala yu dɔktɔ in tritmɛnt plan di rayt we, yu kin ridyus di fat ɛn inflamɛns na yu liva. Yu kin mek di damej nɔr wɔs, ɛn sɔm tɛm, yu kin ivin rivɛns di liva we dɔn pwɛl kwik kwik wan.

SLD kin mek pɔsin day?

Fɔ bɔku pipul dɛn, SLD nɔ kin gɛt big prɔblɛm pas i go bifo to advans sirosis . Bɔrku pipul dɛm wae gɛt SLD de liv nɔrmal layf span.

Bɔt if dɛn nɔ trit di sik we dɛn kɔl sirosis na di liva , dat kin mek di liva nɔ wok fayn ɔ i kin mek i gɛt kansa na di liva. Di liva na impɔtant ɔgan fɔ yu. Na dat mek i rili impɔtant fɔ protɛkt yu liva if yu kam fɔ no se yu gɛt SLD.

Wetin na gud it fɔ pɔsin we gɛt SLD?

If yu SLD gɛt fɔ du wit di wet we yu de gɛt, fala di tin dɛn we yu de it fɔ lɛ yu nɔ gɛt bɔku bɔku bɔdi smɔl smɔl bɔt ɔltɛm. Bɔku tɛm, dɔktɔ dɛn kin se yu fɔ avɔyd it dɛn we gɛt shuga. Dɛn kin se bak fɔ tray di it dɛn we dɛn kin it na di Mɛditarenian . I gɛt bɔku vɛjitebul, frut, ɛn gud fat. Dɔn bak, tin dɛn lɛk nɛt, ligɛm, ɔl gren, fish, ɛn chukchuk na gud it fɔ pipul dɛn we gɛt SLD. I rili impɔtant bak fɔ avɔyd fɔ it tumɔs rɛd mit ɛn drink drink dɛn we gɛt shuga.

Kwɛstyɔn dɛn we dɛn kin Aks Bɔku tɛm (FAQ) .

Kwɛstyɔn: Aw bɔku damej dɔn apin to mi liva?

Ansa: Yu dɔktɔ kin tɛl yu fɔ tru. I go du blɔd tɛst, skan (Ultrasound, FibroScan) fɔ chɛk ɔmɔs fat de na yu liva ɛn if ɛni skata de. Dɔn i go ɛksplen to yu di tin we apin.

Kwɛshɔn: Aw lɔng i kin tek fɔ mek di liva we dɔn pwɛl bak?

Ansa:I rili dipen pan yu kɔndishɔn ɛn di tray we yu de tray. If na di fɔs stej, if yu kɔntrol yu it ɛn lɔs yu wet, yu kin si gud chenj insay sɔm mɔnt. If i tranga, lɛk sirosis, i nɔ kin izi fɔ mɛn am ɔl, bɔt yu kin stɔp am fɔ mek i nɔ wɔs.

Kwɛshɔn: Di mɛrɛsin dɛn we a de tek kin afɛkt SLD?

Ansa: Yɛs, i kin ebul. Sɔm mɛrɛsin, fɔ ɛgzampul, Amiodarone ɛn Diltiazem, kin afɛkt di liva. Na dat mek yu fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek. Dɔn i go chɛk fɔ si if prɔblɛm de wit dɛn mɛrɛsin dɛn de.

Kwɛstyɔn: Wetin na wɛlbɔdi wet fɔ mi?

Ansa: I dipen pan yu ayt ɛn yu ej. Jɛnɛral wan i bɛtɛ fɔ mek yu BMI nɔ rich 25. Bɔt di bɛst tin fɔ du na fɔ aks yu dɔktɔ ɔ pɔsin we sabi bɔt it bɔt di rayt wet fɔ yu. Ivin if yu lɔs smɔl wet, dat kin mek yu liva rili fil fayn.

Kwɛstyɔn: A kin mit wit pɔsin we sabi bɔt it fɔ lan bɔt aw fɔ it fayn?

Ansa: Na tru tru wan! Dat na di bɛst tin fɔ du. Wan pɔsin we sabi bɔt it kin ɛp yu fɔ mek wan list fɔ di it dɛn we fayn fɔ yu. Dɛn kin tɛl yu bɔt tin dɛn lɛk di Mɛditarenian it ɛn it dɛn we izi fɔ mek. If yu aks yu dɔktɔ, i kin rifer yu.

Kwɛshɔn: Aw a go gɛt tritmɛnt fɔ di sik we de mek a nɔ de drink rɔm?

Ansa: If yu de gɛt prɔblɛm fɔ lɛf fɔ drink, nɔ shem. Na nɔmal tin. Di bɛst tin fɔ du na fɔ tɔk to yu dɔktɔ bɔt am. I kin ɛp yu, ɛn if nid de, rifer yu to kɔyl savis ɔ spɛshal pɔsin. Mɛmba se fɔ de fa frɔm rɔm rili impɔtant fɔ mek yu sev yu liva.