Yu no bɔt dis kansa we nɔ kin bɔku? Mek wi tok abaut NUT Carcinoma

Yu don eva yehri boht NUT Carcinoma? Sɔntɛm nɔto so. Na bikɔs na wan kayn kansa we nɔ kin bɔku, we nɔ kin bɔku, ɛn we kin gro kwik kwik wan. Bɔt i rili impɔtant fɔ no bɔt am, bikɔs dis sik kin kam pan ɛnibɔdi. So tide wi go tɔk bɔt am smɔl mɔ, lɛk se wi de tɔk to wi padi.

Wetin na NUT Karsinoma?

Fɔ tɔk am simpul wan, NUT Carcinoma na wan kayn kansa we de gro kwik kwik wan ɛn we de mek pɔsin vɛks . Dɛn kin tek am se na di wan we de agresiv pas ɔl pan di squamous cell carcinomas. Naw yu go de wɔnda wetin na squamous cells. Dis na wan kayn sɛl we de na wi skin. Nɔto dat nɔmɔ, bɔt sɔm pan di insay pat dɛn na wi bɔdi sɛf de kɔba dɛn sɛl dɛn ya.

Dis NUT Carcinoma de kכz bay wan jεnεtik mכtεshכn na wi jin dεm. fכ bi prεsis, i de kכz fכ wan difεkt na wan jin we dεn kכl `NUTm1`. Yu no, dɛn jin ya de gi instrɔkshɔn to wi sɛl dɛn bɔt aw fɔ wok. so, we mistek de na dεn instrכkshכn dεm ya, dat na, wan `mכtεshכn`, ivin hεlty sεl dεm de bigin fכ tכn to `kεnsar sεl dεm`. afta dat dεn kεnsar sεl dεm ya kin gεt εn fכm `tכmכr`.

כltεm, dεn NUT kansa dεm ya de divεlכp na di midul pan wi bכdi, כ along di ``midlayn`` . Na dat mek dɛn bin de kɔl dɛn fɔs NUT-midlayn kansa. Bɔt dɛn tumbu ya kin kam bak na ɔda pat dɛn na di bɔdi.

Usay dɛn kansa tumbu ya kin kam?

Pipul dɛn we dɛn no se gɛt NUT Carcinoma gɛt tumor na dɛn say ya na dɛn bɔdi:

• di ed, spεshal wan na di sayn dεm (dis na di wan we kכmכn pas כl) .
• Na di nɛk (dɛn kin si dis bak) .
• Na di lכng dεm (dis na kכmכn bak) .
• na di midul pat pan di chεst, di spεs we di at εn di lכng dεm de (di `mediastinum`) (dis na kכmכn bak) .
• Pankrias we de na di bɔdi
• Kidni dɛn
• Di adrenal gland dɛn we de na di bɔdi
• Bɛlɛ
• Blada we de na di bɔdi
• Na di bon dɛn (`Bones`) .

Dis kansa we dɛn kɔl NUT Carcinoma , kin gro ɛn spre kwik kwik wan, ilɛksɛf dɛn trit am . Dat na di tin we denja pas ɔl bɔt am.

Aw rare na NUT Carcinoma?

Dɛn kin rili tek dis as kansa we nɔ kin bɔku . Bɔt, di wan dɛn we sik kin bɔku pas aw wi kin tink. Di Intanɛshɔnal NUT Midlayn Karsinoma Rɛjista de ripɔt 20 nyu kes dɛm nɔmɔ ɛvri ia.

Wan rizin fɔ dis lɔw nɔmba na bikɔs i nɔ kin izi fɔ no bɔt dis sik. sayɛnsman dεm nכmכ dכn fכ no di men kכntribyushכn fכ dis kεnsar, di ``mכtεshכn`` insay di ``NUTm1`` jin, insay 2004. So, nכto כl כspitul dεm gεt di ``tεst mεtirial`` we kin dεtekt dis jin.

Tink bɔt am lɛk se yu dɔn fɛn nyu sik. I kin tek sɔm tɛm fɔ mek di rayt tɛst dɛn de ɔlsay.

Dɔn bak, NUT Carcinoma kin izi fɔ kɔnfyus wit ɔda kɔmɔn kayn kansa. i כnli posbul fכ no kכrekt wan if kεnsar na NUT Karsinoma if dεn no di `NUTm1` jin mכtεshכn. Sɔm pipul dɛm wae dɛn no se gɛt `hɛd ɛn nɛk kansa`, `lɔng kansa`, ɛn sɔm ɔda kayn kansa kin rili gɛt dis jin muteshon.

Bɔt naw, bikɔs pipul dɛn dɔn no mɔ bɔt dis kayn kansa, ɛn bikɔs di teknɔlɔji fɔ no dis jenɛtik muteshɔn dɔn impɔtant, i dɔn izi fɔ di wan dɛn we sabi bɔt kansa fɔ no bɔt NUT kansa pas aw i bin de bifo.

Udat kin gɛt NUT Carcinoma?

Bɔku tɛm dɛn kin no dis kansa pan yɔŋ pipul dɛn . Di midyan ej we dɛn no di sik na lɛk 24 ia. Dis min se lɛk af pan di wan dɛn we dɛn kin no se dɛn gɛt dis sik nɔ rich 24 ia yet, ɛn di ɔda af pan dɛn dɔn ol.

Bɔt dis kansa kin kam pan ɛnibɔdi . Dɛn dɔn si am pan pikin dɛn we dɛn jɔs bɔn, ɛn pan pipul dɛn we dɔn pas 80 ia. So i nɔ pɔsibul fɔ tink se i nɔ go apin jɔs bikɔs ɔf di ej.

Wetin na di sayn dɛm fɔ NUT Carcinoma?

Bɔrku tɛm, dis kansa nɔr kin sho ɛni sayn na di fɔs stej . Di sayn dɛm kin bigin fɔ sho we di kansa dɔn gro smɔl ɛn bigin fɔ afɛkt di tisu dɛm we de rawnd di tumbu. Da tɛm de, yu kin fil taya ɛn yu nɔ kin fil fayn.

Bikɔs bɔku tɛm di tɔŋ dɛn kin kam na di sayn dɛn ɛn di lɔng dɛn, di sayn dɛn we dɛn kin ripɔt mɔ kin gɛt fɔ du wit dɛn.

Di sayn dɛn we kin apin:

• Ekstrim taya/taya (`Fatigue`) .
• We yu de lɔs yu wet we yu nɔ ɛksplen
• Wan mas we de mek pɔsin fil pen

Di sayn dɛn we de sho se pɔsin gɛt sayn sist:

• Sayn prɛshɔn, tayt, ɔ pen
• Blɔd we de kɔmɔt na yu nos ɔltɛm
• Nasal kɔnjɛshɔn ɔ stɔf
• Fɔ lɔs yu sɛns fɔ smɛl

Di sayn dɛn we de sho se pɔsin gɛt lɔng tɔŋ:

• Fɔ blo shɔt ɔ fɔ gɛt prɔblɛm fɔ blo
• Kɔf we nɔ de dɔn (na kɔf we nɔ de dɔn we nɔ de go) .

Nɔ fred NUT Carcinoma jɔs bikɔs yu gɛt dɛn sik ya. Bɔt if dɛn sayn ya kɔntinyu, .I rili impɔtant fɔ rili go to dɔktɔ ɛn gɛt advays.

Wetin kin mek pɔsin gɛt NUT Carcinoma?

dis kansa de kכz fכ di kכmbaynshכn fכ tu difrεn jin dεm, we de mek wan strenj haybrid jin (`haybrid jin` כ `fyushכn jin`). pan evri pesin we gεt NUT Carcinoma, di jin `NUTm1` de kam togεda wit כda jin we nכ fכ kכmbayn wit am. di `NUTm1` jin nכ de mek kεnsar insεf, bכt dis nyu haybrid jin we dεn fכm na in de mek di kεnsar sεl dεm gro.

insay lεk 75% pan di pipul dεm we gεt NUT kכrεs, di `NUTm1` jin de kam togεda wit di `BRD4` jin. insay lεk כda 15%, di `NUTm1` jin de kכmbayn wit di `BRD3` jin. Na smɔl tɛm nɔmɔ, dɛn kin jɔyn am wit ɔda jin dɛn.

Sayɛnsman dɛn stil nɔ shɔ wetin kin mek dɛn chenj dɛn ya we de na di jɛnɛtiks. Bɔt wan tin klia: dɛn nɔ gɛt frɔm dɛn gret gret granpa dɛn. I tan lɛk bak se tin dɛn we kin mek pɔsin gɛt kansa, lɛk fɔ smok ɛn fɔ gɛt tin dɛn we kin mek pɔsin gɛt kansa, kin gɛt fɔ du wit am. Dɛn nid fɔ du mɔ risach fɔ ɔndastand wetin kin afɛkt dɛn chenj ya we kin apin na di jɛnɛtiks.

Aw dɛn kin no se yu gɛt NUT Carcinoma?

Dɔktɔ dɛn kin no dis sik tru bayɔpsi. dis involv fכ tek wan sכm tisu sεmpl frכm di tכmכro yuz wan spεshal olo nidul. Dɔn dɛn kin sɛn di sampul to wan lab fɔ mek dɛn tɛst am fɔ si if i gɛt kansa sɛl dɛn.

Yu dɔktɔ go yuz spɛshal imej dɛn bak fɔ luk di tumbu we de insay yu bɔdi ɛn no di stej we i de. kansa stej na di prכsεs fכ no aw di kansa siriכs, bay di saiz fכ di tכmכro, usay i de, εn if i dכn spre (mεtastas) frכm di praymar tכmכro to כda pat dεm na di bכdi. di kansa mεtastas kin apin we di kansa sεl dεm brok kכmכt frכm di כrijinal tכmכro, travul tru di limf fכluid כ bכdi, εn fכm nyu tכmכro dεm na di כgan כ tisu dεm we de fa.

CT skan ɛn MRI skan kin sho usay di tumbu de na di bɔdi. PET skan kin no if di kansa dɔn skata.

Us tɛst dɛn kin du fɔ no dis sik?

wan spεshal tεst we dεn kכl `Immunohistochemistry` dεn de du am na di labכtכri fכ no if di `NUTm1` jin de insay di bayopsi sεmpl. if di `NUTm1` jin de insay di sεmpl (`positiv`), dεn kin no se na NUT Carcinoma.

כda tεst dεm we dεn kin du fכ no dis jin na di Fluorescence In Situ Hybridization (FISH) tεst כ כda spεshal jεnεtik tεst dεm.

Aw dɛn kin trit NUT Carcinoma?

Yu kin pul di tumbu.Sɔntɛm dɛn go nid fɔ du ɔpreshɔn ɛn redyushɔn tɛrapi. If di kansa dɔn skata pas di tumbu, dɛn kin gi am kemotɛrapi bak. Bɔku tɛm, dɛn kin gi wan ɔ mɔ pan dɛn tritmɛnt ya togɛda.

Bɔt fɔ trit NUT kansa na tin we rili tranga. Bɔku tɛm, ivin if tritmɛnt stɔp di kansa fɔ wɔs, i go bigin fɔ gro ɛn spre bak afta sɔm tɛm.

Di tin we impɔtant pas ɔl sɔntɛnde lɛk dis na fɔ kɔntinyu fɔ strɔng. Wi nid fɔ lisin to wetin di dɔktɔ dɛn se ɛn fes dis togɛda wit dɛn.

If dɛn no se yu gɛt NUT Carcinoma, klinik trial kin bi di bɛst tritmɛnt opshɔn . Klinik trial na stɔdi dɛm wae de tɛst nyu tritmɛnt ɔr aw fɔ trit. Naw, sayɛnsman dɛn de du risach bɔt di tritmɛnt we dɛn dɔn tɔk bɔt fɔ NUT Carcinoma. Targeted therapy na tritmɛnt wae de target di jenɛtik mutation wae de mek wan wɛl bɔdi sɛl gɛt kansa.

Wan pan di tεrapi dεm we dεn tכk bכt fכ NUT kכrεs na `BET` inhibito dεm . dis dכg dεm de tכk to tu jin dεm, `BRD4` εn `BRD3`, we kכmכn fכ kכmכn wit di `NUTm1` jin. dis inhibito dεm, we dεn kכmbayn wit da jin de `NUTm1`, de stכp di growth fכ di kεnsar sεl dεm.

Yu tink se dɛn kin mɛn NUT Carcinoma?

I sɔri fɔ no se, no mɛrɛsin nɔ de fɔ NUT Carcinoma. Na kansa we de gro kwik kwik wan ɛn i kin spre kwik kwik wan to ɔda pat dɛn na di bɔdi. Na avrej, pipul dɛm wae gɛt tritmɛnt kin liv fɔ lɛk 10 mɔnt afta dɛn dɔn no se dɛn gɛt dis sik. Tu to tri pan ɛvri tɛn pipul dɛm wae dɛn no se gɛt NUT Carcinoma de liv fɔ tu ia.

Bɔt, lɛk ɛni kansa, yu prɔgnosis, ɔ aw yu go ansa fayn to tritmɛnt, dipen pan bɔku tin dɛn. di say we di tכmכro de, if dεn kin pul am kכmplit wan wit כpεrayshכn כ rεdyushכn tεrapi, εn sכm stכdi dεm dεn sho se כda jin dεm we dεn pe wit di NUTm1 jin dεm de ple rol bak.

Yu dɔktɔ go ɛksplen di gol dɛm fɔ tritmɛnt bay aw yu dɔn no bɔt yu sik.

Aw a kin kia fɔ misɛf?

I impɔtant fɔ rawnd yusɛf wit pipul dɛm we yu trɔst ɛn sɔpɔt insay dis tɛm. Tek advantej pan ɔl di tin dɛm wae de fɔ ɛp yu fɔ no bɔt de chalenj dɛm wae kin kam wit dis diagnosis.

Palliative care frɔm yu dɔktɔLan bɔt di savis dɛn. Palliative care professionals kin ɛp yu fɔ manej di nyu dimand dɛm na yu layf bikɔs ɔf dis diagnosis. Dɛn kin ɛp yu fɔ kɔntrol di sayd ɛfɛkt dɛm wae de kam wit kemotɛrapi ɛn redyushɔn tritmɛnt, ɛn ɛp yu fɔ bia wit de ɛvride rispɔnsibiliti wae kin kam wit kansa.

Mɛmba se nɔto yu wangren de. Nɔ ɛva shem fɔ aks fɔ ɛp ɛn sɔpɔt.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

Bɔku tin dɛn de we yu go want fɔ aks yu dɔktɔ pan tɛm lɛk dis. Na sɔm ɛgzampul dɛn ya:

• Yu tink se di kansa dɔn skata?
• A nid fɔ go to spɛshal dɔktɔ ɔ go na spɛshal ɔspitul fɔ tritmɛnt?
• Us kayn tritmɛnt yu kin advays?
• Wetin na di bɛnifit ɛn di prɔblɛm dɛn we pɔsin kin gɛt we i gɛt tritmɛnt?
• Wetin na di gol dɛm fɔ tritmɛnt?
• Yu kin ɛp mi fɔ gɛt ɔda sɔpɔt savis, inklud palliative care?

Bɔku tɛm, di tritmɛnt fɔ NUT Carcinoma kin tranga. Wit ɔltɛm fɔ go to dɔktɔ we de mɛn kansa ɛn di strɛs we de na ɛvride layf, fɔ bia wit wan kansa we dɛn no se i gɛt kansa kin tranga. Mɛdikal risɔs lɛk palliativ kia kin ɛp. Ɛn we yu go to di wan dɛn we yu lɛk, dat kin mek yu gɛt bɔku trɛnk. Frɔm di tɛm we dɛn dɔn no se yu gɛt di sik, i impɔtant fɔ tɔk opin wan wit yu kansa kia tim fɔ ɔndastand di bɛst kia opshɔn dɛm fɔ go bifo. Ɔlman in kansa ɛkspiriɛns difrɛn. Yu mɛdikal tim de fɔ gayd yu fɔ dis tɛm we nɔ izi.

Impɔtant tin dɛn fɔ mɛmba (Take-Home Message) .

Okay, so lɛ wi sɔma di impɔtant tin dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt:

• NUT Carcinoma na wan kayn kansa we nɔ kin bɔku, bɔt we kin skata kwik kwik wan, we kin mek pɔsin vɛks.
• dis de kכz fכ wan mכtεshכn na di jin ``NUTm1``. Dis nɔto sɔntin we pɔsin kin gɛt frɔm dɛn mama ɛn papa.
• Bɔku tɛm, di sayn dɛn kin apin afta di kansa dɔn go bifo smɔl. Nɔ ignore am, ɛn go to dɔktɔ if yu gɛt ɛni ɔda kayn sik we nɔ kɔmɔn we de kɔntinyu.
• Dɛn nid fɔ du bayɔpsi ɛn spɛshal jenɛtik tɛst fɔ no if pɔsin gɛt di sik.
• I nɔ izi fɔ trit am, bɔt dɛn de du risach bɔt nyu tritmɛnt dɛn. Klinik trial kin bi gud opshɔn.
• Palliative care ɛn de sɔpɔt fɔ yu pipul dɛm we yu lɛk rili impɔtant pan dis joyn.
• Tɔk opin wan bɔt ɔltin wit yu mɛdikal tim.

A op se dis infɔmeshɔn go yusful to yu. If yu no bɔt dis sik, dat go ɛp yu fɔ disayd fɔ du di rayt tin we di tɛm rich.

` NUT Kansa, kansa, jenɛtik muteshon, kansa we nɔ kin bɔku, squamous cell carcinoma, kansa simptom, kansa tritmɛnt