Oligodendroglioma: Lɛ wi lan bɔt dis kayn bren tumor insay simpul wɔd dɛn

Bɔku tɛm yu kin gɛt ed pen fɔ natin? Ɔ yu dɔn gɛt sik wantɛm wantɛm fɔ di fɔs tɛm na yu layf? Sɔntɛnde, di siriɔs rizin bihayn dɛn tin ya na wan bren tumor. Ivin we wi yɛri dɛn wɔd ya kin mek wi fred bad bad wan, nɔto so? Bɔt tide wi go tɔk bɔt wan kayn bren tumbu we nɔ kin apin smɔl, bɔt we kin ansa fayn fayn wan to tritmɛnt. Dat na oligodendroglioma.

Fɔ tɔk am simpul wan, wetin na oligodendroglioma?

Oligodendroglioma na wan tכmכro we de divεlכp na di bren. na sכm tεm, i kin divεlכp bak na di spεnal kכd. dis tכmכro dεm de divεlכp frכm wan spεshal tכp sεl na wi nεv sεstem we dεn kכl glial sεl dεm. fכ bi prεsis, frכm sεl dεm we dεn kכl ‘oligodendrocytes’ bitwin dεn glial sεl dεm.

Naw yu kin de wɔnda wetin na dɛn glial sɛl ya, we na oligodendrocytes. Imajin se wi nervɔs sistɛm na big kɔmni. di men wok we de insay de na wokman dεm we dεn kכl nyuron dεm de du am. Dɛn kin kɛr mɛsej frɔm di bren to di bɔdi ɛn frɔm di bɔdi to di bren. So wan grup de we de ɛp dɛn nyuron dɛn ya, protɛkt dɛn, ɛn gi dɛn di it we dɛn nid. Na dɛn wan ya na di glial sɛl dɛn .

So wetin na dɛn oligodendrocytes ya?

Dis nem de saund likl strenj, no bi so? I mek am wit bɔku Grik wɔd dɛn.

• Oligo (Oligo-): smɔl
• Dendro (-dendro-): lɛk tik
• Sayt dεm (-sayt dεm): sεl dεm

Fɔ tɔk am simpul wan, i min "smɔl sɛl dɛn we gɛt branch dɛn lɛk tik." Di wok we dɛn sɛl ya de du rili impɔtant. wi nyuron dεm gεt wan lכng an we dεn kכl aksכn. Dis na di say we ilɛktrik signal dɛn kin travul. Jɔs lɛk ilɛktrik waya. So wan sheath de we de protɛkt am rawnd dis aksɔn. Dɛn kɔl am di maylin sheath. Dis de mek shɔ se di signal dɛn de travul kwik ɛn nɔ de lik. Da maylin sεt de na dεn sεl dεm ya we dεn kכl oligodεndrכsayt dεm . wan oligodεndrכsayt sεl kin mek wan maylin sεl rawnd di aksכn fכ lεk 30-40 nyuron dεm na di tכp εn bכtכm. Na dat mek dɛn se i gɛt branch dɛn lɛk tik.

so, oligodendroglioma na tכmכro we de divεlכp frכm di divεlכpmεnt we dεn nכ kכntrol di oligodεndrכsayt sεl dεm, we de du da valyu wok de.

Yu tink se difrɛn kayn nɛt dɛn de?

Yɛs. Di Wol Wɛlbɔdi Ɔganayzeshɔn (WHO) dɔn sheb dɛn tumbu ya to stej (grɛd) bay aw dɛn siriɔs. Fɔ fala dis, tu men kayn oligodendroglioma de. Lɛ wi luk dis insay wan izi we fɔ ɔndastand am.

Wetin na di sayn dɛm fɔ oligodendroglioma?

Bɔrku tɛm, di sayn dɛm fɔ di bren tכmכro kin apin we di tכmכro gro big fכ bigin fכ prεs di bren tisu we de rawnd am. di tu tin dεm we kin sho se yu gεt oligodendroglioma na ed we de at εn we yu de sכk . Infakt, lɛk 80% pan di pipul dɛm wae gɛt dis sik kin gɛt sik wae de mɛk dɛn sik.

dis na biכs dis kayn tכmכro kin divεlכp bכku tεm na di sεribra kכtεks, we na di כda pat pan wi bren we gεt wrinkled. Dis eria gɛt di sɛnta dɛn we gɛt fɔ du wit di wok we wi de du ɛvride, lɛk fɔ si, fɔ tɔk, ɛn fɔ kɔntrol di mɔsul dɛn. We tumbu de mek dɛn say dɛn ya wok, pɔsin kin gɛt sik we de mek pɔsin sik.

apat frכm di sik dεm we de sik, "focal symptoms" kin apin bak, we de sho se prכblεm de na wan spεsifi k εria na di bren. Dɛn tin ya na:

• Di mɔsul dɛn wik ɔ paralayz na wan say na di bɔdi ɔ wan say na di fes .
• I nɔ de yɛri fayn igen.
• I nɔ kin izi fɔ tɔk ɔ ɔndastand wetin ɔda pipul dɛn se (aphasia).
• Wik vishɔn, dɛbul vishɔn, blurred vishɔn.
• Prɔblɛm fɔ mɛmba tin dɛn.
• I nɔ kin izi fɔ tink ɛn pe atɛnshɔn.

Wetin na di rizin we mek dis kayn tin de apin?

Dis na pɔynt we rili impɔtant. fכ no se yu gεt oligodendroglioma, tu jεnεtik chenj dεm fכ de.

Imajin se wan big buk de we de sho aw fɔ mek it we de sho di sɛl dɛn we de na wi bɔdi. Wi de kɔl am DNA. di tin dεm we dis DNA de kכyl insay dεn kכl dεm kromozom. We di sɛl dɛn sheb, dɛn kin kɔpi dis rɛsipɛkt buk. Sɔntɛnde, mistek kin apin we dɛn de kɔpi da tɛm de. Wɛl, tu mistek dɛn lɛk dis na di rizin fɔ dis.

1. 1p/19q ko-dilit: tu sכm pat dεm na wi kromozom nכmba 1 εn nכmba 19 dεn de dilit. dis na di men jεnεtik mak na dεn tכmכro dεm ya.

2. IDH1 כ IDH2 mכtεshכn: chenj de apin na wan jin we de mek wan εnzym we de εp fכ mεtabolism na wi bכdi.

So fa, dɛn nɔr dɔn no ɔda risk factor fɔ dis kɔndishɔn.

Us prɔblɛm dɛn dis kin mek?

di komplikashכn dεm we di bren tכmכro kin gεt dipכnt pan di say we i de εn di sayz we i de. Sɔm pan di men wan dɛn we yu fɔ wach na:

• Malignant transfכmeshכn: sכmtεm, wan lכw grεd (Grεd 2) tכmכro kin chenj as tεm εn bi hכy grεd (Grεd 3) kεnsar.
• Kכndishכn dεm we lεk strכk: As di tכmכro de gro, prεshכn insay di bren de go כp, we de mek di blכd vεsul dεm bulge, we de mek i gεt kכndyushכn dεm we lεk strכk.
• di chenj dεm we de apin na di bon dεm na di sכkul: dεn tכmכro dεm ya kin at biכs di kalsiכm dεm we de dכn. Tumɔs we de gro sloslo kin afɛkt di bon dɛn na di skel bak.

Aw fɔ no bɔt dis sik?

We yu go to yu dɔktɔ we yu gɛt sɔm sayn dɛn, i go fala sɔm tin dɛn.

1. Fɔ chɛk yu bɔdi ɛn yu nervɔs sistɛm: Di dɔktɔ go chɛk yu balans, yu mɔsul trɛnk, yu si, ɛn aw yu de riflɛs.

2. Diagnostic imaging: Dɛn kin du skan fɔ luk insay di ed.

• CT scan (Computed Tomography): Bɔku tɛm, dis na di fɔs tin we dɛn kin du we sɔntin lɛk we pɔsin de sik. Dɛn kin si dɛn tumbu ya fayn fayn wan pan CT skan bikɔs dɛn gɛt kalsiɔm.
• MRI skan (Magnetic Resonance Imaging): Dis kin mek yu no mɔ bɔt di bren tisu, di sayz, ɛn usay di tumbu de.

3. 3. .Bren Bayopsi: Dis na di tɛst we de kɔnfyus di sik 100% . Skan nɔmɔ nɔ go ebul fɔ no fɔ tru se na oligodendroglioma. We dɛn de du bayɔpsi, wan dɔktɔ we de mɛn nyuro kin ɔpreshɔn wan rili smɔl pat pan di tumbu ɛn sɛn am na di lɛbɔtri. Na de, dɛn kin luk di sɛl dɛn wit maykroskɔp. dεn de chεk bak fכ di prεsεns fכ di jεnεtik chenj dεm we wi bin tכk bכt, di 1p/19q kכ-dilishכn εn di IDH mכtεshכn . If dɛn tu de, i go mɔs bi se na oligodendroglioma.

Wetin na di tritmɛnt dɛn? Yu tink se i pɔsibul fɔ mɛn am kpatakpata?

Di gud nyus na dat, we yu kɔmpia am wit ɔda kayn bren tɔŋ dɛm, oligodendroglioma na wan pan di tumbu dɛm we dɛn kin trit ɛn we dɛn kin mɛn. Bɔrku tɛm, dɛn kin trit am wit kɔmbayn tritmɛnt dɛm.

Ɔpreshɔn

Di fɔs ɛn impɔtant gol na fɔ pul bɔku pan di tumbu as i pɔsibul tru ɔpreshɔn. Sɔntɛnde, dɛn kin pul di tumbu kpatakpata. Dis kin dipen pan bɔku tin dɛn, lɛk aw di tumbu de saiz, usay i de, ɛn di ɛkspiriɛns we yu dɔktɔ gɛt.

Kimotɛrapi

Dɛn kin gi kemotɛrapi fɔ kil ɛni sɛl we go lɛf afta dɛn dɔn du di ɔpreshɔn. Bɔku fayn fayn mɛrɛsin dɛn de fɔ oligodendroglioma.

• PCV tritmɛnt rijim: Dis na tri mɛrɛsin dɛn we dɛn jɔyn: procarbazine, lomustine, ɛn vincristine.
• Temozolomide: Sɔntɛnde dɛn kin yuz dis mɛrɛsin insted ɔf PCV bikɔs i nɔ gɛt bɛtɛ sayd ɛfɛkt ɛn i rili fiba di we aw i de wok lɛk PCV.

Rɛdieshɔn Tɛrapi

dis involv fכ tכk di hכy εnεji rayt dεm (we fiba di εks-ray) to di tכmכro sayt, fכ pwεl εni kεnsar sεl dεm we rεst we dεn de sכmtεm di damej to di hεlty tisu dεm we de rawnd.

Yu dɔktɔ ɛn di mɛdikal tim go disayd togɛda us tritmɛnt fayn fɔ yu, aw lɔng i go las, ɛn if yu nid kemotɛrapi ɔ redyushɔn tritmɛnt afta dɛn dɔn du yu ɔpreshɔn.

Aw layf go tan lɛk wit dis sik? (Autluk) .

I ɔndastand fɔ mek ɛnibɔdi fred ɛn shɔk we i yɛri bɔt bren tumor. Bɔt oligodendroglioma nɔto kɔndishɔn fɔ lɔs op pan.

di fayv ia rεt we de liv - di pasεnshכn fכ pipul dεm we de alayv 5 ia afta dεn no di sik - de bitwin 69% εn 90% fכ lכw grεd tכmכro dεm. ivin fכ hכy grεd tכmכro dεm, i de bitwin 45% εn 76%. Dis na jɔs statystik, ɛn yu sityueshɔn kin bɛtɛ pasmak.

Dɔn bak, dɛn de du risach naw bɔt nyu mɛrɛsin dɛn we de tɔch dɛn tumbu ya wit di IDH muteshon, so wi kin gɛt gud op fɔ tumara bambay.

Tin dɛn we yu kin du ɛn kwɛstyɔn dɛn fɔ aks yu dɔktɔ

If yu gɛt dis sik, i impɔtant fɔ fala di instrɔkshɔn dɛn we yu mɛdikal tim dɔn gi yu. I impɔtant fɔ go na tritmɛnt di rayt tɛm ɛn tek yu mɛrɛsin kɔrɛkt wan. Di tritmɛnt kin gɛt sayd ɛfɛkt. Nɔr frayd fɔ tɔk to yu dɔktɔ bɔt dɛn ɛn lan bɔt wetin dɛn kin du bɔt dɛn.

Nɔ shem fɔ aks yu dɔktɔ dɛn kwɛstyɔn ya:

• Us stej (grɛd) na mi tumbu?
• Usay dis de na di bren? Us abiliti dɛn i go afɛkt?
• Us tritmɛnt opshɔn dɛn a gɛt?
• Yu tink se dɛn kin pul dis tumbu kpatakpata we dɛn du ɔpreshɔn?
• Wetin na di sayd ɛfɛkt ɔ kɔmplikeshɔn dɛm wae de kam wit de tritmɛnt?
• A nid kemotɛrapi, redyushɔn tɛrapi, ɔ ɔl tu?
• Aw di tritmɛnt schedule tan lɛk?
• Us sayn dɛn a fɔ go to dɔktɔ fɔ di tritmɛnt ɔ afta di tritmɛnt? (e.g., ed we de at bad bad wan, we yu de siz bak).