Wetin na POEMS Syndrome? Yu want fɔ no bɔt dis bak?

Yu dɔn ɛva yɛri bɔt POEMS Syndrome? Dis na wan sik wae nɔr kin bɔrku ɛn nɔr kin yɛri bɔt. Bɔt i impɔtant fɔ no smɔl bɔt am bikɔs i kin afɛkt bɔku sistɛm dɛn na wi bɔdi wan tɛm. Fɔ tɔk am simpul wan, na kɔmpleks sik we gɛt fɔ du wit wi blɔd. Tide, wi go tɔk bɔt wetin na POEMS Syndrome, wetin na in sayn dɛm, aw dɛn kin no am, ɛn if tritmɛnt de.

Wetin rili na POEMS Syndrome?

Okay, mek wi si wetin na POEMS Syndrome. Dis na blɔd sik we nɔ kin rili apin. Wi gɛt wan kayn blɔd sɛl we dɛn kɔl plasma sɛl na wi bɔdi. we POEMS sεndrכm de apin, dεn plasma sεl dεm ya de sheb εn mכltiply abnכmal wan, we dεn nכ de kכntro. Dɛn plasma sɛl dɛn ya we nɔ de na di bɔdi kin pul wan spɛshal prɔtin insay wi blɔd. dεn kכl am monoklonal protin, כ M-protein fכ sכt. Naw yu kin imajin, nɔto so? we dεn abnכmal plasma sεl dεm, M-protein, inkrεs tumɔs na di blɔd, i kin pwεl wi nerv dεm εn insay כgan dεm.

Dɛn pul di nem POEMS frɔm di fɔs lɛta dɛn pan di fayv men sayn dɛm fɔ dis sik:

• P - Polyneuropathy: dis de tכk bכt di damej pan di nεv dεm na di כlsay na di bכdi. Insay POEMS, dis damej kin mek yu fil pen ɔ ɔda tin dɛn we nɔ fayn (lɛk fɔ tingling, bɔn, ɛn ɔda tin dɛn) na yu leg, yu an, yu fut, ɛn yu an.
• O - Organomegaly: dis min se di intanεt כgan dεm de bi abnכmal big. Pɔsin we gɛt POEMS kin gɛt ɔgan dɛn we dɔn big lɛk di liva, di splin, ɛn di limf no dɛm.
• E - Endocrinopathy: Fɔ tɔk am simpul wan, dis na ɔmon prɔblɛm. insay POEMS, di כmon dεm we wi εndokrin gland dεm de kכmכt kin bi abnכmal. Sɔm ɔmon dɛn kin kɔmɔt pasmak ɔ smɔl smɔl.
• M - monoklonal protin (M-protein): dis na di spεshal protin we de kכmכt na di bכdi insay POEMS. we wan plasma sel mek bכku kכpi (klon) fכ insεf, εvri wan pan dεn sεl dεm de ad dis M-protein to di bכdi. As tɛm de go, di M-protɛin we de na di blɔd kin go ɔp bad bad wan.
• S - Skin chenj: Pipul dεm wae gεt POEMS kin gεt difrεn chenj dεm na di skin, lεk wae dεn skin dak εn dεn skin de tik.

Dɛn kin kɔl POEMS sindrom bak ɔstiosklerotik mayloma , Crow-Fukase sindrom , PEP sindrom , ɛn Takatsuki sindrom .

Udat kin gɛt di sik we dɛn kɔl POEMS syndrome?

POEMS syndrome na wan sik wae nɔr kin bɔrku. Na smɔl pipul dɛn nɔmɔ i kin afɛkt ɔlsay na di wɔl. Dɛn kin si am mɔ pan pipul dɛn we ol bitwin 50 ɛn 60. I kin afɛkt ɔl tu di man ɛn uman, bɔt i tan lɛk se i kin apin mɔ pan man dɛn.

Wetin na di sayn dɛm fɔ POEMS syndrome?

As wi bin dɔn tɔk, di lɛta dɛn we de na di nem POEMS de sho sɔm pan di men sayn dɛm. Dat min se, Polinyuropathy, Organomegaly, Endocrinopathy, M-protein elevation, ɛn skin chenj na di men sayn dɛm. Klose to ɔlman we gɛt POEMS gɛt polyneuropathy ɛn M-protein elevation. Ɔda sayn dɛm kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin.

Simptom dɛm wae kin kam wit polyneuropathy

Di simptom dɛm we dis nerve damej kin kam wit na dɛn kin mɔs pan POEMS. Bɔrku tɛm, dɛn kin fil de pen mɔr na di leg ɛn fut. Bɔt sɔntɛnde, i kin afɛkt di an ɛn an. Na dis na aw yu kin fil wae yu gɛt dis sik:

• Wik
• Tingling
• Fɔ mek pɔsin nɔ ebul fɔ du natin
• Prickling / Pin-ɛn-nidul sɛnseshɔn
• Fɔ mek yu fil lɛk se yu de bɔn

כrganomegaly - we di כgan dεm we de insay de big

Di we aw dɔktɔ dɛn kin tek pikchɔ kin no if dɛn ɔgan ya dɔn big:

• Liva (Liva - `(Epatomegali)`)
• Spleen (Splenomegaly) we de mek di bɔdi gɛt .
• Limf no dεm (Limf no dεm - `(Lymphadenopathy)`)

Endocrinopathy - prɔblɛm dɛn we gɛt fɔ du wit ɔmon

di men כmon prכblεm we de kam wit POEMS na we di lεvεl fכ di sεks כmon dεm de dכn. dεn kכl dεn sεks כmon dεm ya ``Tεstosterone`` pan man dεm εn ``Estrogen`` pan uman dεm. Apat frɔm dat, yu kin si sɔm sayn dɛn lɛk:

• Prɔblɛm fɔ kɔntrol di blɔd shuga lɛvɛl (e.g. dayabitis) .
• Tayrɔyd prɔblɛm (e.g. Hypothyroidism) .
• Adisin sik (Adrenal insufficiency - `(Addison in sik)`)

di man dεm kin gεt rεdכks fεtiliti εn di brεst kin big (Gynecomastia).

fכ uman dεm , mεnstral kin stכp (`(Amenorrhea)`), di brεst kin big. we uman bεlε, di כmon `(Prolactin)` we de εp fכ mek milk kin kכmכt pasmak. So i pɔsibul fɔ mek milk lik frɔm di nipples ivin if yu nɔ gɛt bɛlɛ.

M-Protein we de go ɔp

wan men tin we de sho se POEMS de na di εlevεt lεvεl fכ M-protein na di bכdi. dis m-protein we pasmak kin mek di tכmכro dεm na di bכdi fכm. כlso, biכs fכ di hכy lεvεl fכ M-protein, yudi bon dεm kin tik εn stif (osteosclerosis) .

Skin kin chenj

Difrɛn chenj dɛn kin apin na di skin, lɛk:

• Skin we dak pasmak
• Skin we tik pasmak
• Wait finga nel dɛn
• Di ia we de gro mɔ ɛn mɔ na yu fes ɛn yu leg
• di blכd vesel dεm we de gro we lεk sכm sכm chεri na di skin na di chεst

Ɔda sayn dɛn we de sho se yu gɛt dis sik

Apat frɔm dis, yu kin si ɔda sayn dɛm:

• An ɛn fut kin swel
• We yu de lɔs yu wet fɔ natin
• Pen na bon ɛn jɔyn dɛn
• Di we aw pɔsin nɔ de si fayn
• I nɔ kin izi fɔ yu fɔ blo
• Taya
• Fiva

Sɔm pipul dɛm wae gɛt POEMS syndrome kin gɛt wan sik bak wae dɛn kɔl Castleman Disease (CD), wae kin afɛkt di limf no dɛm. If yu gɛt sayn dɛm fɔ Castleman Disease, yu dɔktɔ kin sɔprayz bak se POEMS.

Wetin kin mek pɔsin gɛt POEMS sindrom?

We yu gɛt POEMS, yu kin gɛt difrɛn sayn ɛn ifɛkt dɛn bikɔs ɔf wan monoklɔnal plasma sɛl disɔda . Fɔ tɔk am simpul wan, wan plasma sɛl we nɔ de wok fayn kin mek tumɔs kɔpi fɔ insɛf. Di mɔ we dɛn sɛl ya de, na di mɔ dɛn kin pwɛl di tisu dɛn. dis sεl dεm de ad M-protein to di bכdi, we de mek di amount of M-protein na di bכdi de go כp. na dεn εksyכs sεl dεm εn M-protein dεm de pwεl difrεn sistεm dεm na di bכdi.

Bɔt sayɛnsman dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin mek dɛn plasma sɛl dɛn ya kin bigin fɔ gro di rayt we fɔs.

Risach pipul dεm dεn fכnshכn se wan protin we dεn kכl Vascular Endothelial Growth Factor (VEGF) kin de insay. Bɔrku pipul dɛm wae gɛt POEMS syndrome gɛt ay lɛvɛl VEGF na dɛn blɔd. Risach fɔ di rilayshɔn bitwin VEGF ɛn POEMS sindrom stil de go bifo.

Aw dɛn kin no se pɔsin gɛt POEMS sindrom? (Diagnosis) .

Yu dɔktɔ go aks yu fɔs bɔt yu mɛdikal istri ɛn di sik dɛn we yu gɛt naw. Dɔn, dɛn go du wan ɛgzam fɔ dɛn bɔdi fɔ chɛk fɔ si if pɔsin gɛt sayn dɛn we de sho se pɔsin gɛt POEMS sindrom.

Apat frɔm dat, di dɔktɔ kin du bɔku tɛst dɛn bak, lɛk:

• Blɔd ɛn urine tɛst: Dɛn tɛst ya kin ɛp fɔ chɛk fɔ si if di M-protein ɔ VEGF gɛt ay blɔd ɔ yu urine. Dɛn kin chɛk bak fɔ si if di blɔd sɛl dɛn nɔ bɔku ɔ if dɛn gɛt blɔd sɛl dɛn we nɔ tan lɛk. Dɛn tin ya kin bi sayn dɛn fɔ PƆM.
• Imej tɛst: Tɛst lɛk X-ray ɛn CT skan kin sho if yu bon dɛn tik ɔ stif. dis chenj dεm kin apin we di M-protein lεvεl dεm de εlevεt.
• Bon mכro bayopsi: Dis kin fכnכt if yu gεt plasma sεl dεm we de luk abnכmal na yu bon mכro, כ if di nכmba fכ di plasma sεl dεm tu hכy.
• Ilɛktromayogram (EMG): EMG na tɛst we de sho aw di nerv dɛn de wok. I kin ɛp yu dɔktɔ fɔ no se yu gɛt polyneuropathy.

Dipen pan di sayn dɛm we yu gɛt, yu dɔktɔ kin du ɔda tɛst dɛm bak, lɛk fɔ tɛst aw yu de blo, ɛkokardiogram, ɔr ɛndokrin tɛst.

If dɛn dɔn no se yu gɛt wan sik we dɛn kɔl Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) , yu dɔktɔ kin tɛst yu bak fɔ si if yu gɛt POEMS syndrome.

Aw dɛn kin manej ɔ trit POEMS sindrom?

Nɔr mɛrɛsin nɔr de fɔ POEMS syndrome. Bɔt, tritmɛnt kin ɛp fɔ kɔntrol ɛn kɔntrol di sayn dɛm. Di tritmɛnt dɛn we yu kin gɛt na:

• Radieshɔn tɛrapi: Dis kin min fɔ dayrɛkt bɔku bɔku raytin to di abnɔmal plasma sɛl dɛn fɔ pwɛl dɛn.
• Kimotɛrapi: Dɛn kin yuz antikansa drɔgs, we dɛn kin kɔl bak ``Kɛmotɛrapi,'' fɔ kil ɔ slo di grow we di plasma sɛl dɛn we nɔ de wok fayn. Kimotɛrapi fɔ POEMS tan lɛk di tritmɛnt fɔ multiple myeloma. Dɛn tritmɛnt ya kin rili wok ɛn bɔku tɛm dɛn nɔ kin gɛt siriɔs sayd ɛfɛkt.
• כtכlכg stεm sεl transplant: Dis prכsidכs de riples yu abnכmal plasma sεl dεm wit hεlty stεm sεl dεm. stεm sεl dεm na di sεl dεm we de divεlכp to machכ sεl dεm lεk plasma sεl dεm. Insay dis transplant, yu dɔktɔ kin fɔs pul sɔm stem sɛl dɛn we gɛt wɛlbɔdi na yu bɔdi. Dɔn, dɛn kin yuz kemotɛrapi ɔ redyushɔn tɛrapi fɔ pwɛl di plasma sɛl dɛn we nɔ kin fayn. Afta di tritmɛnt, dɛn kin put di stem sɛl dɛn we dɛn pul bak insay yu bɔdi. Dɔn dɛn kin gro ɛn bi wɛlbɔdi plasma sɛl dɛn.
• Fizik tritmɛnt: If yu gɛt prɔblɛm fɔ waka bikɔs ɔf polyneuropathy, dis tritmɛnt kin ɛp.

Apat frɔm dat, di dɔktɔ kin gi yu mɛrɛsin lɛk stɛroyd fɔ mek yu nɔ gɛt di sik ɛn diuretics (wata pils) fɔ mek yu nɔ swel.

Wetin na di kɔmplikɛshɔn dɛm wae gɛt fɔ du wit POEMS syndrome?

Wit POEMS syndrome, di nerve damej ɛn wik kin bɔku as tɛm de go. I kin mek i nɔ izi bak fɔ muf go ɔdasay. If bɔku wata kam nia di lɔng ɔ insay di chɛst, i kin mek yu chɛst pen ɛn i nɔ kin izi fɔ blo.

Bɔt mɛmba se, .If yu trit yu fayn, dat kin stɔp ɔ slo di nerve damej. I kin ɛp bak fɔ pul ɔda sayn dɛm. Ivin di nerve damej kin wɛl smɔl smɔl as tɛm de go.

Sɔm tin dɛn de we kin mek pɔsin gɛt POEMS sindrom?

Naw, dɛn nɔr dɔn no bɔt di risk factor dɛm fɔ divεlכp POEMS sεndrכm.

Yu tink se dɛn kin ebul fɔ protɛkt di sik we dɛn kɔl POEMS syndrome?

Bɔt i sɔri fɔ no se, dɛn nɔ kin ebul fɔ avɔyd POEMS sindrom.

Wetin na di prɔgnosis fɔ pipul dɛm wae gɛt POEMS syndrome?

Yu wɛl bɔdi kin dipen pan bɔku tin, lɛk us pat na yu bɔdi kin afɛkt, aw dɛn kin no di sik kwik kwik wan ɛn bigin fɔ trit yu, ɛn aw yu kin du tritmɛnt.

I impɔtant fɔ gɛt tritmɛnt fɔ POEMS. POEMS syndrome kin mek yu layf de pan denja if yu nɔ trit yu. Bɔt di tritmɛnt dɛn we go wok fayn ɛn we de pwɛl di plasma sɛl dɛn we nɔ de wok fayn, dat kin ɛp yu fɔ liv lɔng. Apat frɔm dat, tritmɛnt kin mek yu nɔ gɛt di sik ɛn mek yu liv bɛtɛ layf.

Di midyan sɔvayv rɛt fɔ bɔku pipul dɛn we gɛt POEMS na lɛk 14 ia. Dat min se lɛk af pan di pipul dɛn nɔ de liv lɔng pas 14 ia, ɛn di ɔda af pipul dɛn de liv lɔng. Yu layf ɛkspɛkt de dipen pan yu patikyula sik ɛkspiriɛns ɛn tritmɛnt.

Aks yu dɔktɔ bɔt yu fiuja as pɔsin we de liv wit POEMS syndrome.

Ustɛm yu fɔ go to dɔktɔ bɔt POEMS syndrome?

If yu gɛt ɛni sayn we gɛt fɔ du wit POEMS syndrome, mɔ we yu wik na yu an ɛn yu fut , go to dɔktɔ wantɛm wantɛm.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ bɔt POEMS syndrome?

Yu kin aks kwɛstyɔn dɛn lɛk dɛn wan ya:

• Aw siriɔs mi sik de?
• Us tritmɛnt opshɔn dɛn a gɛt?
• Wetin a fɔ du fɔ mek a nɔ gɛt bɔku prɔblɛm dɛn ɔ fɔ mek a nɔ ebul fɔ du am?
• Us sɔpɔt savis dɛn de fɔ mi?
• A nid fɔ go to dɔktɔ we spɛshal pan plasma sɛl dizayd fɔ gayd mi tritmɛnt?

Ustɛm a kin go bak to mi nɔmal aktiviti dɛn if a gɛt POEMS syndrome?

POEMS syndrome kin afɛkt yu ebul fɔ du yu woke ɛvride. Yu dɔktɔ go ɛksplen to yu aw dis sik go afɛkt yu ɛvride layf.

Yu tink se POEMS sindrom na ɔtoimyun sik?

POEMS na wan sik we dɛn kɔl paraneoplastic syndrome.I nɔto sik we pɔsin kin gɛt we i de fɛt insɛf. Paraneoplastic syndrome na wan kɔlekɛshɔn fɔ di simptom dɛm wae de kam wit wan ɔndalayn mɛdikal kɔndishɔn. insay POEMS, di כndalayn prכblεm na dat abnכmal plasma sεl dεm de prodyuz tu mכch M-protein na di bכdi (wan monoklonal plasma sεl dizכrd). di simptom dεm fכ POEMS na di abnכmal plasma sεl dεm εn M-protein we de damej di bכdi in tisu dεm.

Yu tink se POEMS syndrome na di sem wit multiple myeloma?

Multiple myeloma na kansa we de afɛkt di plasma sɛl dɛn. POEMS sεndrכm na wan kכlekshכn fכ simptom dεm we de kכz fכ abnכmal plasma sεl dεm εn inkrεs pan M-protein. di rεt fכ sכvayv POEMS sεndrכm bεtε pas di layf εkspεktεns fכ mכltipכl maylכma.

Bɔt bɔku tɛm, di tritmɛnt dɛn we dɛn kin gi fɔ kimotɛrapi fɔ POEMS ɛn mɔltipɛl mayloma kin fiba. Sɔm pan de sayn dɛm bak kin tan lɛk dis.

POEMS syndrome na wan kɔmpleks diagnosis. I kin tek yu dɔktɔ sɔm tɛm fɔ no se na POEMS syndrome de kam wit yu sik ɛn nɔto ɔda sik. Wae dɛn dɔn no se yu gɛt dis sik, woke klos wit yu mɛdikal tim fɔ no us tritmɛnt go gi yu mɔr fridɔm frɔm yu sik. Aks yu dɔktɔ bɔt ɔganayzeshɔn ɔ sɔpɔt grup dɛm wae de ɛp pipul dɛm ɛn famili dɛm wae de dil wit diagnosis lɛk POEMS syndrome.

Mɛsej we dɛn kin kɛr go na os

Okay, so wi don tok plenti boht POEMS Syndrome tide. Di impɔtant tin na fɔ ɔndastand se dis na sik we nɔ kin apin so ɔltɛm, bɔt i kin rili siriɔs . I kin afɛkt bɔku sistɛm dɛn na wi bɔdi.

• di nem POEMS kכmכt frכm di fכs lεta dεm na di Inglish nem dεm fכ fayv men simptom dεm (nεv dizכrd, intanεt כgan dεm we de big, כmon prכblεm, M-protein we de bכku, εn skin chenj).
• di men tin we kin mek dis apin na di plasma sεl dεm we nכ nכmal εn di M-protein we dεn de mek.
• Pan ɔl we no kɔmplit mɛrɛsin nɔ de, fayn tritmɛnt dɛn de fɔ kɔntrol di sik dɛn ɛn fɔ mek yu liv bɛtɛ layf.
• I rili impɔtant fɔ no di sik ɛn bigin fɔ trit am kwik .

If yu gɛt ɛni wan pan dɛn sayn ya, duya go to dɔktɔ. Nɔr frayd, wit de rayt infɔmeshɔn ɛn mɛrɛsin sɔpɔt, yu kin ebul fɔ bia wit dis kayn tin.

` POEMS sεndrכm, bכdi sik, nεv dεm we dεn dכn pwεl, כmon prכblεm, M-protein, skin chenj, plasma sεl dεm