Sɔntɛnde, yu kin fil taya ɛn taya fɔ natin? Ɔ dɔktɔ dɔn ɛva luk yu blɔd tɛst ripɔt ɛn tɔk sɔntin lɛk, "Smɔl chenj dɔn chenj na di shep fɔ yu rɛd blɔd sɛl dɛn?" na dεn tεm ya, wan pan di wכd dεm we wi kin yεri na `(Poikilocytosis)` (dεn kin pronכns am: poi-ki-lo-say-to-sis). Nɔ fred tumɔs we yu yɛri dis nem. Dis nɔto sik, bɔt i kin bi sayn fɔ sho se ɔda tin de apin insay wi bɔdi. So, i rili impɔtant fɔ no bɔt dis.
Wetin rili na `(Poikilocytosis)`?
fכ simpul wan, ``Poikilocytosis`` min se wan siknifikant nכmba (dat na, mכr dan 10%) pan di rεd bכdi sεl dεm na wi bכdi na di shep dεm we nכ sכmtεm. Naw yu kin de tink se, "So wetin mek di shep fɔ di rɛd blɔd sɛl dɛn impɔtant?"
Jɔs tink bɔt dat, ɔl ɔda sɛl, tisu, ɛn ɔgan dɛn na wi bɔdi nid ɛnaji fɔ liv ɛn wok. Na ɔksijɛn de gi da ɛnaji de. Udat no, dis ɔksijɛn, lɛk fɔ kam wit gas silinda na os, dɛn kin kɛr am go ɔlsay na di bɔdi? Dat na wi rɛd blɔd sɛl dɛn. Nɔmal wan, if yu tek wan wɛlbɔdi rɛd blɔd sɛl, dɛn ɔl gɛt di sem saiz ɛn shep. Lɛk rawnd kɔyn (lɛk disk) we kɔnkav smɔl na ɔl tu di say dɛn.
so, if di shep fכ dεn rεd bכdi sεl dεm chenj (`(Poikilocytosis)`) כ di sayz chenj (כda wan de we dεn kכl `(Anisocytosis)`), dεn nכ kin kכri כksijεn fayn fayn wan. Na da tɛm de wi kin gɛt kɔndishɔn lɛk anemia (blɔd nɔ de na di blɔd). Dat min se di sɛl dɛn na di bɔdi nɔ de gɛt bɛtɛ ɔksijɛn, we min se dɛn gɛt ɛnaji.
Wetin na di abnɔmal shep dɛm fɔ di rɛd blɔd sɛl dɛm? (Poikilɔsayt dɛn) .
dכkta dεm de klas dεn rεd bכdi sεl dεm ya we nכ shep (dεn kכl dεm bak `Poikilocytes`) bay aw dεn de luk. If yu gɛt `(Poikilocytosis)` na blɔd sɛmpul, yu kin si wan ɔ mɔ pan dɛn tin ya:
- Akantosayt / Spur sεl dεm : Dis dεm lεk tכn branch. dεn gεt lכng, wayd, spayk lεk protrushכn dεm we de kכmכt frכm di sεl mεmbran.
- di kodosayt dεm / di tכgεt sεl dεm : dεn ya de lεk di tכgεt bכd. Wan dak sɛklɔ de na di midul.
- Dakrosayt / Tiadrɔp sɛl dɛn : Dɛn shep lɛk tiadrɔp. Wan say na di sɛl tan ɛn i gɛt pɔynt.
- Drepanocytes / Sickle cells : Dis na tin, sikle-shaped sel dεm we yu kin si pan pipul dεm we gεt sikl sεl sik.
- Echinocytes : lεk si כchin, di sεl de kכba wit spayna dεm we de ikwal distans כlsay.
- εliptosayt / Ovalsayt כ Siga sεl dεm : dεn wan ya shep lεk oval εn dεn lכng we nכ sכmtεm. Dɛn kin gɛt sayz frɔm we tan lɛk eg to we tan lɛk siga.
- Schistocytes : Dis na pat dεm na di rεd bכdi sεl dεm. Bɔku tɛm dɛn kin gɛt rɔf, brok brok, bɔt dɛn kin gɛt ɛni shep.
- Sfɛrosayt dɛn: Sfɛrikal. Lɛk smɔl bɔl.
Ɛni wan pan dɛn kayn tin ya kin gɛt fɔ du wit sɔm patikyula sik dɛn we pɔsin kin gɛt.
Wetin na di sayn dɛm fɔ dis sik?
di simptom dεm fכ ``Poikilocytosis`` de difrεn dipכnt pan di kכz, bכt dεn kin bi di sem lεk dεn wan dεm we dεn kin si pan anemia.
Na sɔm sayn dɛn we de sho se pɔsin nɔ gɛt bɛtɛ blɔd:
- Wik ɔ taya pasmak (jɔs fil taya).
- Difεlεns fכ brith (dyspnea) – sכt brith ivin wit sכm sכm wok dεm.
- At bit fast ɔ i nɔ de bit ɔltɛm (arithmia).
- Sɔntɛnde yu kin yɛri "whooshing" sawnd na yu yes (`(pulsatile tinnitus)`).
- Ed de at .
- Diziz we pɔsin kin gɛt .
- Pale skin .
- Chɛst pen .
If yu gɛt wan ɔ mɔ pan dɛn sayn ya, i go fayn fɔ mek yu go to dɔktɔ.
Wetin mek dis de apin? Wetin na di rizin dɛn?
Dɛn kin sheb di tin dɛn we kin mek dɛn rɛd blɔd sɛl dɛn ya we nɔ fayn, dɛn kin sheb dɛn to tu men tin dɛn: we pɔsin kin gɛt frɔm in mama ɛn papa ɛn we pɔsin kin gɛt . Sɔm tin dɛm lɛk Myelodysplastic Syndrome kin mek dɛn tu tin ya.
Di Kɔndishɔn dɛn we dɛn kin gɛt frɔm dɛn mama ɛn papa
Bɔku tɛm, di tin dɛn we kin apin we pɔsin bɔn kin kam bikɔs ɔf wan mistek we de na di jɛnɛtik infɔmeshɔn (DNA) we di rɛd blɔd sɛl nid fɔ gro, wok, ɛn liv fayn fayn wan. Rɛd blɔd sɛl dɛn we gɛt dɛn kayn abnɔmal strɔkchɔ ya kin brok kwik kwik wan bifo di bɔdi ebul fɔ mek nyu sɛl dɛn. Dɛn kɔl dis ɛmolaytik anemia .
sכm kכndyushכn dεm we dεn bכn wit we de mek `(Poikilocytosis)`:
- `(Hɛridit Ɛliptosaytɔsis)`
- `(Hɛridit Sfɛrosaytɔsis)`
- `(Makliɔd Sindrom)`
- `(Pyruvate kinase Dɛfisiɛns)`
- `(Sikl Sεl Sik)` (Sikl Sεl Sik)
- `(Talasɛmia)`
Bɔku tɛm, dɛn tin ya na tin dɛn we pipul dɛn kin pas fɔ lɔng lɔng tɛm.
Di Kɔndishɔn dɛn we dɛn dɔn gɛt
As tɛm de go, sɔm mɛrɛsin dɛn kin mek bak di shep fɔ di rɛd blɔd sɛl dɛn chenj. Fɔ ɛgzampul, if di bɔdi nɔ gɛt di tin dɛn we i nid fɔ mek di rɛd blɔd sɛl dɛn we gɛt wɛlbɔdi, lɛk vaytamɛn B12, folate, ɛn ayɔn, difrɛn kayn anemia kin apin. Poikilocytosis na wan kכmכn sayn fכ dεn nyutrishכn dεfishכn dεm ya. I kin kam bak bikɔs ɔf sik dɛn we kin ambɔg di we aw dɛn de mek rɛd blɔd sɛl, lɛk sɔm kansa dɛn.
sכm pan di leta kכndishכn dεm we de mek `(Poikilocytosis)` na:
- Awtoimyun Ɛmolaytik Anemia
- Bɔn (if i bɔku) .
- `(Siliak Sik)`
- Difrɛn infɛkshɔn dɛn
- Anemia we nɔ gɛt ayɔn
- Kidni Sik we pɔsin kin gɛt
- Lukimiya (blɔd kansa) .
- Liva Sik we pɔsin kin gɛt
- Megaloblastic anemia (bikɔs ɔf vaytamɛn B12 ɔ fɔlet we nɔ de) .
- `(Maylɔfibrosis)`
- Pɔyzin (e.g. lid) .
- Riakshɔn we dɛn transfyuz pɔsin blɔd
- Riakshɔn we dɛn pul di splɛn
- Snek we dɛn de bit am
Us prɔblɛm dɛn dis kin mek?
bכku kכndyushכn dεm we de mek poikilocytosis dεn kin mεnεj wit tritmεnt, εn sכm kin kכl kכmplit wan. Bɔt if dɛn nɔ trit sɔm tin dɛn we kin apin kin rili siriɔs ɛn ivin kin mek pɔsin in layf de pan denja. Fɔ ɛgzampul, if yu gɛt anemia, yu kin fil so taya dat yu nɔ go ebul fɔ du di tin dɛn we yu de du ɛvride. If yu lɔs inof wɛlbɔdi rɛd blɔd sɛl dɛn as tɛm de go, i kin mek yu gɛt tin dɛn lɛk we yu ɔgan dɛn nɔ de wok fayn .
Ɛspɛshali pan yɔŋ pikin dɛn, if anemia we dɛn nɔ trit, i kin afɛkt dɛn growth ɛn divɛlɔpmɛnt.
So, we yu dɔktɔ dɔn no di rayt tin we mek yu gɛt Poikilocytosis, i go gi yu di tritmɛnt we yu nid fɔ mek yu nɔ gɛt prɔblɛm dɛn lɛk dis.
Aw yu kin no dis ɛksaktɔli? (Diagnosis) .
Di men tɛst we dɔktɔ kin yuz fɔ no if pɔsin gɛt poikilocytosis na we dɛn kin du peripheral blood smear (PBS) . Dis kin min se wan lab tɛknishian tek wan drop pan yu blɔd sɛmpul ɛn luk am ɔnda maykroskɔp. Dɔn dɛn kin si ɔmɔs pan yu rɛd blɔd sɛl dɛn gɛt ɔda kayn shep ɛn us kayn shep dɛn.
sכm kayn sεl dεm kin kכmכn mכr pan spεshal sik kכndishכn dεm. Bɔt ivin insay di sem sik kɔndishɔn, difrɛn kayn sɛl dɛn kin de. fכ egzampl, insay kכndishכn dεm lεk `(Hemolytic Anemia)`, `(Megaloblastic Anemia)`, `(Myelofibrosis)`, `(Thalassemia)`, yu kin si sεvεra abnכmal sεl tכp dεm.
Yu dɔktɔ dɛn kin nid fɔ du sɔm ɔda tɛst fɔ no wetin de mek yu gɛt poikilocytosis.
adishכnal tεst dεm fכ fכnshכn di kכz fכ `(Poikilocytosis)`
Bɔku tɛm dɛn kin du kɔmplit blɔd kɔnt (CBC) wit PBS. di CBC kin gi bכku infכmeshכn bכt di sεl dεm na yu bכdi, inklud dεn lεvεl εn saiz. sכm pan di valyu dεm na di CBC kin gi mכr infכmeshכn bכt di rεd bכdi sεl dεm, we kin εp fכ no wetin mek di Poikilocytosis de kכmכt. Dɛn valyu dɛn ya na:
- `Mean Corpuscular Volume (MCV)` : di avrej saiz fכ yu rεd bכdi sεl dεm.
- `Mean Corpuscular Hemoglobin (MCH)` : di avrej amoun fכ hεmoglobin na yu rεd bכdi sεl dεm.
- ``Min Kכpכskul Hεmoglobin Kכnsantreshכn (MCHC)''.: Di avrej valyu fɔ di ɛmoglobin kɔnsɛntreshɔn na yu rɛd blɔd sɛl dɛn.
- `Rεd Sεl Distribushכn Width (RDW)` : Aw difrεn yu rεd bכdi sεl dεm de in saiz.
Apat frɔm dat, yu dɔktɔ kin chɛk yu vaytamɛn B12, folate, ɛn ayɔn lɛvɛl, ɛn i kin ɔda bak fɔ mek dɛn tɛst yu liva fɔ wok.
Wetin na di tritmɛnt dɛm fɔ dis?
Di tritmɛnt de dipen pan de kɔz fɔ yu poikilocytosis ɛn aw yu sik dɛn kin tranga.
Mɛmba se if di tin we mek dis sik na we yu nɔ gɛt bɛtɛ it (e.g. ayɔn, vaytamɛn B12 we yu nɔ gɛt), we yu tek di rilevɛns nyutrishɔn sɔpɔtmɛnt dɛn, ɔ chenj to it we gɛt vaytamɛn B12 ɔ folate, bɔku tɛm i kin sɔlv dis `(Poikilocytosis)` kɔndishɔn.
Bɔku pan di tin dɛn we kin apin we pɔsin bɔn kin nid fɔ tek tɛm wach am . Yu go nid fɔ tek blɔd ɔltɛm fɔ mek shɔ se yu gɛt inof wɛlbɔdi rɛd blɔd sɛl. Ɔ yu kin jɔs nid tritmɛnt bay if yu gɛt sɔm sayn dɛn.
Yu tink se dɛn go ebul fɔ mek dis tin nɔ apin?
Wi nɔ kin ebul fɔ protɛkt di tin dɛn we kin mek wi bɔn wit ``Poikilocytosis.`` Bɔt wi kin ridyus di risk fɔ sɔm tin dɛn we kin bigin leta.
Wan pan di bɛst we fɔ kia fɔ yu rɛd blɔd sɛl na fɔ gɛt di tin dɛn we yu bɔdi nid fɔ mek dɛn. Mek shɔ se yu gɛt inof B vaytamɛn, folate, ɛn ayɛn . Dɛn tin ya na di men tin dɛn we yu bɔdi nid fɔ mek yu gɛt wɛlbɔdi rɛd blɔd sɛl. I kin ɛp bak fɔ mek yu nɔ drink bɔku rɔm . If yu drink pasmak, dat kin mek i nɔ izi fɔ yu bɔdi fɔ tek dɛn tin ya.
Wetin go apin tumara bambay? (Autluk) .
in jεnarכl, if di kכz fכ `(Poikilocytosis)` na kכndyushכn we de bigin leta, di prכgnosis kin bi gud. insay kes dεm fכ di kכz we dεn bכn, di prכgnosis de difrεn dipכnt pan di כndalayn kכndishכn. Fɔ ɛgzampul, pan ɔl we dɛn kin tek di layf we pipul dɛn we gɛt `(Sickle Cell Disease)` kin liv fɔ shɔt, nyu tritmɛnt dɛn dɔn mek am pɔsibul naw fɔ liv fɔ pas 50 ia we dɛn de kɔntrol di sayn dɛm.
Ustɛm yu fɔ go to dɔktɔ?
If yu gɛt sayn dɛm fɔ anemia (tin dɛm we wi bin dɔn tɔk bɔt, lɛk taya ɛn wik), fɔ tru to dɔktɔ.
Ivin if yu fil se yu gɛt wɛlbɔdi ɛn yu nɔ gɛt ɛni sayn, i impɔtant fɔ mek yu chɛk-ap ɛvri ia. Yu dɔktɔ kin chɛk yu blɔd sɛl dɛn bak. Wan simpul blɔd tɛst, lɛk fɔ kɔnt blɔd kɔmplit wan (CBC), kin ɛp fɔ no ɛn trit wɛlbɔdi prɔblɛm bifo dɛn bi siriɔs.
dis ``Poikilocytosis'' na siriכs kכndyushכn?
`(Poikilocytosis)` insɛf nɔ siriɔs. Bɔt, iE kin bi sayn fɔ wan ɔndalayn mɛdikal kɔndishɔn we kin mek yu gɛt prɔblɛm if dɛn nɔ trit am. fכ dat, i imכtant fכ כndastand εksεkshכn wetin de mek `(Poikilocytosis)` εn go fכ tritmεnt if nid de.
Poikilocytosis kin saund lεk wan siriכs kכndyushכn, bכt nכto so. Na jɔs wan kwaliti fɔ yu rɛd blɔd sɛl dɛm we dɔktɔ dɛn kin yuz fɔ asɛs yu wɛlbɔdi. If yu kam fɔ no se yu rɛd blɔd sɛl nɔ de wok fayn, nɔ shek fɔ aks yu dɔktɔ bɔt dat. I kin tɛl yu if e de afɛkt yu wɛl bɔdi ɛn if na so i bi, wetin yu kin du fɔ ɔl tu nɔr de pan de sik ɔr de kɔntrol de sik wae de ɔnda yu.
Di impɔtant tin dɛn we wi nid fɔ mɛmba (Take-Home Message) .
Okay, so, di men pɔynt dɛm fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt na dɛn wan ya:
- Poikilocytosis na we mכr dan 10% pan yu rεd bכdi sεl dεm de shep abnכmal.
- Dis nɔto sik, bɔt i kin bi sayn fɔ wan sik we de ɔnda am.
- Yu kin si di simptom dɛm fɔ anemia (taya, wik, paleness) bak na dis kes.
- di tin dεm we kin mek dεn kin kכz dεn kin bi we dεn bכn am כ we dεn gεt am (nutritional deficiencies, sכm sik dεm).
- dis kin bi wit simpul bכdi tεst (`PBS`, `CBC`).
- Di tritmɛnt dipen pan di tin we mek i gɛt am, bɔt bɔku tɛm dɛn kin ebul fɔ kɔntrol am.
- If yu it fayn it, dat kin ɛp fɔ mek yu nɔ gɛt sɔm pan di tin dɛn we kin mek yu bigin fɔ it leta.
- If yu gɛt sɔm sayn dɛn ɔ yu gɛt ɛni dawt bɔt dis, i go fayn fɔ mek yu go to dɔktɔ fɔ advays.
So, a op se dis infɔmeshɔn go yusful to yu. Stay wit wɛlbɔdi!
` Poikilocytosis, Rεd Blɔd Sεl, Blɔd Sεl Shep, Anemia, Blɔd Tεst, Wεlth, Anemia, Rεd Blɔd Sεl, Blɔd Tεst
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