Prɔblɛm de wit di bayl dakt dɛn na yu liva? Lɛ wi lan gud gud wan bɔt Praymari Biliary Cholangitis (PBC)!

Oh my, yu de fil tu se yu taya bad bad wan, taya ivin we yu no du enitin? Ɔ sɔntɛnde yu kin fil lɛk se yu de skrach yu skin fɔ natin? Sɔntɛnde, pan ɔl we wi nɔ kin pe atɛnshɔn tumɔs to dɛn tin ya, dɛn kin bi sayn fɔ se wi gɛt prɔblɛm wit di liva, we na wan pan di impɔtant ɔgan dɛn na wi bɔdi. Tide wi go tɔk bɔt dis kayn sik we kin afɛkt di liva, ɛn pan ɔl we di nem kin tan lɛk se i kɔmplikt smɔl, i izi fɔ ɔndastand. Dat na (Primary Biliary Cholangitis) , we dɛn kin kɔl bak (PBC) fɔ shɔt.

Wetin na Praymari Biliary Cholangitis (PBC)? Lɛ wi ɔndastand am simpul wan!

Okay, dis nem luk laik se i long likl, no bi so? Lɛ wi si wetin i min.

"Cholangitis" na inflameshn na yu bayl dakt . Yu no, di wata we dɛn kɔl bayl, we de kɔmɔt na wi liva, de travul tru wan sistɛm we gɛt smɔl smɔl tiub dɛn. Dɛn kɔl dɛn tiub dɛn de bayl dakt. "Biliary" min bak sɔntin we gɛt fɔ du wit dɛn bayl dakt ya. "Praymari" min "bɛsik" ɔ "initial."

Dɔn, we yu put ɔl dis togɛda, Praymari Biliary Cholangitis min se, nɔto bikɔs ɔf ɛni ɔda sik, infɛkshɔn, ɔ blok, bɔt bikɔs ɔf dis sik, di bayl dakt dɛn we de insay yu liva de inflamɛns . Bikɔs dis inflamɛns nɔ de apin fɔ ansa ɛnitin, yu nɔ no ustɛm i go stɔp. So na kɔndishɔn we de go bifo smɔl smɔl.

Fɔs, dɛn bin de kɔl dis sik Primary Biliary Cirrhosis bikɔs leta i kin mek di liva at ɛn gɛt skata, ɛn dis kin mek pɔsin gɛt wan sik we dɛn kɔl cirrhosis .

Aw (PBC) kin afɛkt wi bɔdi?

Imajin, wetin go apin if wan pat na wi bɔdi de inflam ɔltɛm? Bɔrku tɛm, inflamɛns fɔ sɔm tɛm na pat pan di wɛl bɔdi prɔses. Bɔt if dis kayn inflamɛns we nɔ de dɔn kɔntinyu, instead fɔ wɛl, di say kin bigin fɔ gɛt skata.

na dat kin apin to di bayl dakt dεm we de insay yu liva na PBC. Dɛn dakt ya kin smɔl ɛn blok bikɔs dɛn gɛt skata . Dɔn di bayl we di liva de mek nɔ kin ebul fɔ flɔ fayn fayn wan. dis bayl de bigin fכ bak insay di liva. we dis bayl de bכku, i de pwεl di liva sεl dεm εn mek di liva inflameshn. As tεm de go, dis hεlty liva tisu de riples wit ska tisu. Afta sɔm tɛm, di liva nɔ kin ebul fɔ wok fayn, ɛn na dat wi bin dɔn tɔk bɔt bifo tɛm (cirrhosis) .

PBC na siriɔs kɔndishɔn?

Yes, Primary Biliary Cholangitis na sik we nɔ de mɛn ɛn we de go bifo . Dis min se i nɔr kin jɔs bɛtɛ, i kin wɔs as tɛm de go. I nɔ kin wɔs wan tɛm, i kin wɔs smɔl smɔl, tru difrɛn stej dɛm. Yu nɔ go gɛt ɛni sayn fɔs.

Bɔt di tin we denja pas ɔl bɔt dis na dat, leta i kin mek di liva nɔ wok fayn ɛn ivin day if dɛn nɔ transplant di liva .

Bɔt, fɔtunate wan, mɛrɛsin dɛn de we kin mek dis sik nɔ go bifo kwik kwik wan . Ɛn nɔto ɔlman kin go na dis las stej. So nɔ wɔri.

Wetin na di difrɛns bitwin (PBC) ɛn (PSC)?

Yu go dɔn yɛri bɔt ɔda sik we dɛn kɔl Primary Sclerosing Cholangitis, ɔ PSC. Dɛn tu tin ya rili fiba, bɔt sɔm impɔtant tin dɛn de we difrɛn.

• insay PBC , na di bayl dakt dεm we de insay yu liva (intrahεpatik bayl dakt dεm) nכmכ de afekt.
• כltu, insay PSC, di bayl dakt dεm insay di liva εn bak na do na di liva (εkstra hεpatik dakt dεm) de afekt .
• Sɔm difrɛns de bak pan di pipul dɛm we dɛn tu sik ya kin bɔku pan.
• Di impɔtant tin na dat, pan ɔl we mɛrɛsin dɛn de fɔ trit (PBC), dɛn nɔ dɔn fɛn ɛni tritmɛnt we go wok fayn yet fɔ (PSC) .

Udat kin gɛt dis sik (PBC) mɔ?

Pan ɔl we dis kin tan lɛk se i sɔprayz, uman dɛn kin gɛt PBC lɛk tɛn tɛm pas man dɛn (10:1) . Statistikin na Amɛrika sho se na lɛk 60 pan ɛvri 100,000 uman dɛn gɛt dis sik, we yu kɔmpia am to lɛk 15 pan ɛvri 100,000 man dɛn.

Bɔrku pipul dɛn kin gɛt dis sik afta dɛn dɔn ol 40. Dis sik kin bɔrku pasmak na Skɔtland, Skandinevian kɔntri dɛm, ɛn nɔt-ist pat na Ingland.

Dɔn bak, if yu ɔ sɔmbɔdi na yu famili gɛt ɔda sik we de mek yu nɔ ebul fɔ fɛt, yu go gɛt PBC . Dis sho se sɔntɛm sɔntin de we gɛt fɔ du wit di jɛnɛtiks .

Wetin na di sayn dɛm fɔ (PBC) sik?

Bɔrku pipul dɛm wae gɛt PBC nɔr kin gɛt ɛni simptom na di fɔs stej. Na as di sik de go bifo, na in di sayn dɛm we gɛt fɔ du wit di bayl dakt dɛn kin bigin fɔ sho. Di fɔs ɛn kɔmɔn sayn dɛm wae dɛn kin si pan pipul dɛm wae gɛt PBC na:

• Bɔrku taya (lɛk 65% pan pipul dɛm) .
• Skin we de it (lɛk 55% pan pipul dɛn) .

Dɛn sayn ya kin afɛkt ɔlman difrɛn we. Sɔm pipul kin gɛt dɛn kwik kwik wan na di sik, ɛn ɔda wan dɛn kin gɛt dɛn leta. Dɛn kin bi bak mɔr ɔr smɔl pan ɛni stej na di sik. I tan lɛk se big kɔnekshɔn de bitwin aw yu sik dɛn kin tranga ɛn aw de sik dɔn go bifo. Bɔt sɔm risach dɔn sho se pipul dɛm wae gɛt siriɔs sik kwik kwik wan kin gɛt dis sik kwik kwik wan .

Wetin na di prɔblɛm dɛn we kin kam wit di sik dɛn we de na di bayl dakt?

We yu bigin, yu nɔ go notis se yu gɛt prɔblɛm wit yu bayl dakt. Bɔt as di sik de go bifo, difrɛn prɔblɛm dɛn kin bigin fɔ apin. Di bayl we nɔ kin ebul fɔ flɔ fayn, yuI kin bigin fɔ lik insay di blɔd, we kin mek pɔsin gɛt sik. כlso, we di bayl nכ ebul fכ rich di dijestiv sistεm fayn fayn wan, di digεstiv sistεm de ambɔg bak. Bikɔs bayl impɔtant fɔ mek yu ebul fɔ digest it.

Leta, di skata we de na di liva kin afɛkt bak di blɔd vesel dɛn we de pas na di liva, we kin mek pɔsin gɛt wan sik we dɛn kɔl pɔtal haypatɛnshɔn , we min se blɔd prɛshɔn na dɛn vein dɛn de.

1. Fat malabsorpshɔn

If yu dijestiv sistεm nכ gεt inof bayl, i nכ kin brok dכn fayn fayn wan εn abzכp di fεt dεm we de insay yu it. Dis ridyus absכpshכn fכ fεt kin mek dεn tin ya:

• Di bɔku bɔku kɔlɔstrel na di blɔd .
• Fat we de ɔnda di skin .
• Fat poop ɔ dayarɛa .
• We yu de lɔs yu wet .
• di lεvεl dεm fכ di fεt-sכlubul vaytam in A, D, E, εn K dεm dכn dכn.
• Ɔstioporosis na sik we de mek yu bon tan we yu nɔ de tek di vaytamɛn D we de sɔlv di fat.

2. Pɔtal haypatɛnshɔn

we di bכdi vεsul dεm we de pas na di liva de blok bikoz fכ skata, di pכtal haypatεnshכ n we wi bin dכn tכk bכt de apin, we min se di blכd prεshכn na dεn vein dεm εn כda vein dεm we kכnεkt to dεm de go כp. Dis pɔtal haypatɛnshɔn kin mek dɛn kayn tin ya:

• Liva we dɔn big .
• Di splin we dɔn big .
• Kɔl ɔltɛm ɛn ɔda infɛkshɔn (ridyus di imyuniti).
• I izi fɔ brus ɛn blɔd (di blɔd pletlɛt dɛn smɔl - (thrombocytopenia) ).
• di apinεns fכ rεd, lεk spayda bכdi vεsul dεm (spaida angiomas) na di skin sεf.
• di vein dεm we swεl כ kכt na di εsophagus εn bכdi (vεn dεm we swεl - varis) .
• Blɔd we de kɔmɔt na di bɛlɛ .
• Fluid we kin gɛda na di bɛlɛ (ascites) .
• Swel (edema) na di lכw bכdi.
• Sɔntɛnde, di pɔyzin kin kam pan pɔsin in maynd bikɔs ɔf di pɔyzin we de gɛda na di blɔd.

Wetin na di tin dɛm wae kin mek pɔrsin gɛt (PBC)?

insay PBC, yu yon imyun sistεm de atak di sεl dεm we de layn yu liva in bayl dakt dεm . i tan lεk se di imyun sistεm de si dεn sεl dεm ya lεk fכrin invayda dεm. Dis na wetin wi kin kɔl ɔtoimyun sik., ɔ sik dɛn we pɔsin kin gɛt we i de fɛt insɛf. Fɔ no rizin, di imyun sistɛm de pwɛl di sɛl dɛn we gɛt wɛlbɔdi, ɛn no kɔntrol nɔ de fɔ stɔp am. Dis inflameshn we de go bifo na in de mek yu gɛt skata.

Wi nɔr rili no gud gud wan wetin mek dɛn ɔtoimyun sik ya kin kam. Bɔt i tan lɛk se sɔntin de we de mek pɔsin gɛt jɛnɛtiks . Bɔrku pipul dɛm wae gɛt ɔtoimyun sik gɛt famili histri bɔt dis sik, ɛn dɛn kin gɛt pas wan kayn ɔtoimyun sik.

I tan lɛk se sɔntin de bak we de ambɔg di envayrɔmɛnt . Dat min se, sɔntɛm sɔntin we de na di say we wi de kin mek dis sik kam. I kin bi kemikal we yu de gɛt, ɔ i kin bi infekshɔn.

Aw dɛn kin no se pɔsin gɛt PBC?

Yu dɔktɔ go aks yu fɔs bɔt yu mɛdikal istri ɛn di sayn dɛm, du yu bɔdi ɛgzam, dɔn tek blɔd sɛmpul fɔ chɛk fɔ PBC.

Dɛn blɔd tɛst ya kin luk mɔ fɔ sɔm patikyula antibodi dɛn we gɛt fɔ du wit PBC, spɛshal wan antibodi we dɛn kɔl antimitochondrial antibody (AMA) . Dɛn kin luk bak fɔ ɛlevɛt liva ɛnzaym dɛn , spɛshal wan alkaline phosphatase (ALP), we de sho se di liva dɔn pwɛl.

If yu tɛst rizɔlt sho se yu gɛt PBC, yu dɔktɔ go want fɔ luk di pikchɔ dɛn we de sho yu liva ɛn yu biliary system nɛks . Dis kin ɛp fɔ pul ɔda tin dɛm wae kin mek yu gɛt dis sik ɛn si aw de sik dɔn go bifo. Bɔku tɛm, dɛn kin du sɔntin we simpul lɛk fɔ du ɔltrasɔund na di bɛlɛ fɔs. Bɔt sɔntɛnde, dɛn kin nid fɔ du tɛst lɛk MRI (magnetic resonance imaging) fɔ mek dɛn gɛt klia pikchɔ dɛn.

Na lɛk 5% pan di pipul dɛm wae gɛt PBC kin gɛt negatif AMA tɛst, bɔt dɛn kin gɛt ɔda sayn dɛm. If dis apin, yu dɔktɔ kin nid fɔ tek smɔl pat pan yu liva (liva bayɔpsi) fɔ kɔnfɔm PBC. Dɛn kin du dis na di bedsayd bay we dɛn put nidul insay yu liva. di sכmכl sεmpl fכ di tisu we dεn tek frכm di nidul dεn de sεnd am to lab fכ egzamin am כnda maykroskכp.

Wetin na di tritmɛnt fɔ Praymari Biliary Cholangitis?

Dɔktɔ dɛn kin yuz dɛn tin ya fɔ trit PBC:

Mɛrɛsin we dɛn kin gi

PBC nɔ kin ebul fɔ mɛn ɔltogɛda . Bɔt, mɛrɛsin kin kɔntrol aw di sik de go bifo ɛn mek yu sik bɛtɛ .

(Ursodeoksikɔlik asid - UDCA) .Na wan kayn bayl asid. I de ɛp fɔ pul bayl na di liva ɛn ridyus di liva we de pwɛl. Dis mɛrɛsin kin wok fayn fɔ lɛk af pan pipul dɛm wae gɛt PBC, mɔr lɛk wae di sik bigin. Fɔ pipul dɛn we nɔ de du UDCA, sɔntɛnde dɔktɔ dɛn kin tɛl dɛn fɔ yuz ɔda kayn bayl asid we dɛn kɔl obeticholic acid .

Dɔn bak, dɛn kin trit yu wan wan sik dɛn wit difrɛn mɛrɛsin dɛn.

• Fɔ it we di skin de it: dɛn kin gi antihistamin (e.g., diphenhydramine - lɛk Benadryl®), ɔltra vayolɛt layt tɛrapi, ɔ bayl asid sikwɛstant lɛk kɔlestayramin.
• Fɔ mek yu nɔ gɛt sayd ɛfɛkt lɛk we yu nɔ gɛt vaytamɛn ɛn ɔstioporosis: Vitamin sɔpɔtmɛnt kin ɛp.
• Sɔm pipul dɛm wae taya kin bɛnifit frɔm tin dɛm wae de mek dɛn fil fayn lɛk modafinil.

Ɔpreshɔn

If yu sik nɔr bɛtɛ wit mɛrɛsin, ɛn yu liva de kɔntinyu fɔ wok fayn, yu dɔktɔ kin put yu pan di list fɔ wet fɔ mek dɛn transplant yu liva . Pipul dɛn we gɛt PBC kin gɛt rili gud rizɔlt wit liva transplant ɔpreshɔn.

Lεk כda כtoimyun sik dεm, PBC kin kam bak afta dεn transplant di liva, bכt di rεt we di sik de go bifo kin slo bכku di sεkכn tεm. Di layf we pɔsin kin liv afta dɛn dɔn transplant di liva na nɔmal tin.

Wetin yu fɔ ɛkspɛkt we yu de liv wit dis sik?

Bɔrku tɛm, Praymari Biliary Cholangitis kin go bifo smɔl smɔl . If yu no di sik kwik kwik wan ɛn trit am kwik kwik wan, i kin mek yu nɔ gɛt ɔ at ɔl delay di leta stej dɛm fɔ di sik ɛn di prɔblɛm dɛm we i kin gɛt.

Bɔrku pipul kin kɔntrol dɛn sik fayn fayn wan wit mɛrɛsin. Bɔt fɔ trit di taya we kin apin wit PBC kin stil bi prɔblɛm. Bɔrku pipul dɛn kin liv fɔ lɔng tɛm ɛn nɔr kin ambɔg dɛn ɛvride layf bikɔs ɔf PBC.

Bɔt nɔto ɔlman kin no se i gɛt PBC we i bigin. Ɛn sɔm pipul dɛn kin gɛt wan kayn sik we kin rili bad. Sayn dɛm lɛk fɔ taya bad bad wan ɛn di ay bilirubin lɛvɛl na di blɔd kin sho se di sik kin go bifo kwik kwik wan te i nɔ de wok fayn. If yu rich da stej de, yu go nid fɔ transplant yu liva fɔ mek yu kɔntinyu fɔ liv. Bɔt fɔ di wan dɛn we gɛt PBC we gɛt saksesful liva transplant, di prɔgnosis rili fayn.

Aw lɔŋ yu kin liv wit (PBC)?

Bɔrku tɛm, i kin tek bitwin 15 ɛn 20 ia fɔ mek di sik rich di say we i fɔ dɔn.

Di fɔs stej, we min se ivin if dɛn dɔn tɛst yu ɛn dɛn si se yu gɛt PBC, yu kin stil nɔ gɛt ɛni sayn fɔ lɔng tɛm. Na lɛk af pan pipul dɛn go bigin fɔ gɛt dis sik insay di nɛks fayv to tɛn ia.Wae yu dɔn gɛt dis sik, de avrej layf we yu kin liv na lɛk 10 ia. 65% pan di pipul dεm we gεt saksesful liva transplant de liv 10 ia.

Aw a kin tek kia ɔf misɛf we a gɛt (PBC)?

If yu it fayn it ɛn liv fayn layf, dat go ɛp fɔ mek yu liva gɛt wɛlbɔdi fɔ lɔng tɛm.

Fɔ ɛgzampul:

• Stɔp fɔ smok, drink rɔm, ɛn yuz drɔgs ɛn mɛrɛsin dɛn we nɔ rayt ɔ fɔ ɛnjɔy yusɛf.
• It smɔl tin dɛn we dɛn dɔn prosɛs ɛn we dɛn pak ɛn it mɔ tin dɛn we ful-ɔp.
• Ridyus di sɛtyuret fat ɛn it mɔ wɛlbɔdi ɔnsatyuret fat.
• Tek wan brisk waka ɛvride. Ɛksesaiz fɔ bia wet kin ɛp fɔ mek di bon dɛn kɔntinyu fɔ gɛt wɛlbɔdi.

Bɔrku pipul dɛm wae gɛt Primary Biliary Cholangitis kin liv fɔ lɔng tɛm ɛn nɔr gɛt ɛni big prɔblɛm. Bɔt if yu gɛt sik we de go bifo, ɛn sɔntɛnde kin kil yu, dat kin tek yu prɔblɛm. Tɔk to yu dɔktɔ bɔt aw fɔ ridyus yu bɔdi, maynd, ɛn filin . Dɔn bak, aks bɔt sɔpɔt nɛtwɔk dɛm wae de ɛp pipul dɛm wae de liv wit PBC. Mɛmba se yu ɔl yu wɛl bɔdi bɛtɛ pas jɔs di sik.

Mɛsej we dɛn kin kɛr go na os

Praymari Biliary Cholangitis (PBC) na wan sik we nɔ de mɛn we de afɛkt di bayl dakt dɛm na di liva. Dɛn tink se na wan ɔtoimyun kɔndishɔn de mek i kam. Pan ɔl we di sayn dɛn nɔ kin apin fɔs, sɔm sayn dɛn lɛk fɔ taya ɛn fɔ it di skin kin kam as tɛm de go. As di sik de go bifo , e kin mek yu gɛt sirosis ɛn liva nɔ de wok fayn.

Bɔt if dɛn no di sik kwik kwik wan ɛn yuz mɛrɛsin lɛk (UDCA), dɛn kin ebul fɔ kɔntrol di sik . Sɔm pipul dɛn kin ivin nid fɔ transplant dɛn liva.

De tin wae impɔtant pas ɔl na fɔ go to dɔktɔ ɛn adopt wɛl bɔdi layf if yu gɛt dɛn sik ya. Nɔto yu wan, nɔ fred fɔ tɔk bɔt dis ɛn gɛt ɛp.

` Praymari Biliary Cholangitis, PBC, liva sik, bayl dakt, sirosis, ɔtoimyun, taya, skin rash, liva sik, bayl dakt, sirosis, ɔtoimyun