Yu kin gɛt dis ‘saylent’ prɔblɛm na yu blɔd? Lɛ wi lan bɔt Smoldering Multiple Myeloma (SMM)!

Sɔntɛnde, big prɔblɛm kin kam na wi bɔdi we nɔr kin gɛt ɛni ɔda sayn na do. Yu kin tink se, "O, aw dat go apin?" Wɛl, yes, i kin ebul. Tide wi go tɔk bɔt wan patikyula sik we kin kam kwayɛt wan, we nɔ kin sho ɛni sayn, bɔt we gɛt di potenshal fɔ divɛlɔp to siriɔs kansa tumara bambay. Dɔktɔ dɛn kɔl dis (Smoldering Multiple Myeloma - SMM) . Fɔ tɔk am simpul wan, dis tan lɛk di fɔs stej fɔ wan sik we dɛn kɔl "chronic multiple myeloma."

Wetin na Smoldering Multiple Myeloma (SMM)?

Fɔ tɔk am simpul wan, Smoldering Multiple Myeloma na wan sik we de afɛkt yu blɔd ɛn yu bon mɛro. Dis kin bi wan blɔd kansa we nɔ kin bɔku we dɛn kɔl aktif Multiple Myeloma (MM) . Naw yu kin de wɔnda, "Wetin na dis multiple myeloma?" Plasma sɛl na wan kayn wayt blɔd sɛl we de na wi imyun sistɛm. Dɛn wan ya de mek antibodi dɛm we de ɛp wi bɔdi fɔ fɛt sik. Bɔt sɔntɛnde, dɛn plasma sɛl dɛn ya kin chenj ɛn bi sɛl dɛn we nɔmal. Na da tɛm de wan sik we dɛn kɔl multiple myeloma kin apin.

So, SMM na di "saylent" stej bifo i bi kansa we dεn kכl mכltipכl maylכma, we nכ gεt εni simptom. Sɔntɛnde i kin tek sɔm ia fɔ mek SMM bi aktif maltipul mayloma. I sɔprayz fɔ no se sɔm pipul dɛn we gɛt SMM nɔ de ɛva gɛt aktif maltipul mayloma. Na dat mek dɔktɔ dɛn kin chɛk pipul dɛn we gɛt SMM ɔltɛm fɔ si sayn dɛn we de sho se i kin tɔn to aktif kansa.

Na (SMM) kansa?

Dis na smɔl triki kwɛstyɔn. SMM nɔ de trit am lɛk kansa per se. Bɔt bikɔs i kin tɔn to kansa we dɛn kɔl aktif maltipul mayloma, dɛn kin tek am se na kansa bifo kansa. Imajin se yu gɛt wan say we nɔ kɔmɔn na yu skin, we na mak we dɛn bɔn yu. Dat kin bi wan fɔs sayn fɔ gɛt kansa na yu skin, nɔto so? Na dat SMM bi. I min se yu gɛt sɔm chans fɔ gɛt mɔltipɛl mayloma. Na dat mek dɔktɔ dɛn kin wach pipul dɛn we gɛt dis sik gud gud wan .

Ɔda tin dɛn de we kin mek pɔsin gɛt dis sik we kin afɛkt mɔltipɛl mayloma?

Yɛs, ɔda wan de. Dɛn kɔl am Mɔnoklɔnal Gammopathy of Undetermined Significance (MGUS) . lεk SMM, dis na kכndyushכn we kin apin bifo mכltipכl maylכma de divεlכp. Dɔktɔ dɛn kin tek MGUS (dɛn kin kɔl am "M-gus") as prɛkursɔ fɔ multiple myeloma.

Aw (SMM) de afɛkt mi bɔdi? Wetin na di sayn dɛm we de sho se yu gɛt dis sik?

Na dis impɔtant tin: Bɔrku pipul dɛm wae gɛt (SMM) nɔr kin sho ɛni sayn.. Dat min se yu nɔ go fil ɛni prɔblɛm ɔ pen. Bɔku pipul dɛn kin no se dɛn gɛt SMM we dɛn kin du rutin blɔd tɛst fɔ ɔda rizin. Dɛn blɔd tɛst dɛn de kin sho se yu gɛt wan kayn prɔtin we nɔmal we dɛn kɔl M prɔtin , we na di plasma sɛl dɛn we nɔ de na yu bɔdi de mek.

di bכdi tεst dεm sho se dεn abnכmal plasma sεl dεm ya de prodyuz abnכmal imyun protin dεm (M protin dεm). Dɔn bak, if yu du bon mɛro bayɔpsi, dɔktɔ dɛn kin si dɛn abnɔmal plasma sɛl dɛn ya na di bon mɛro. Bɔt insay dis "smoldering" phase, mayloma nɔ de kɔz ɛni prɔblɛm na yu bɔdi, so pipul dɛm wae gɛt SMM nɔr kin gɛt ɛni simptom.

Udat kin gɛt (SMM)? Dis na sik we pipul dɛn kin gɛt?

Dis sik kin afɛkt pipul dɛm wae dɔn pas 60. De avrej ej wae dɛn kin gɛt dis sik na bitwin 62 ɛn 67 ia.

(SMM) nɔto kɔmɔn sik. Risach pipul dɛn se na lɛk wan pan ɛvri 100,000 pipul dɛn nɔmɔ i kin afɛkt. Bɔt, na lɛk sɛvin pan ɛvri 100,000 pipul dɛn nɔmɔ kin gɛt di sik we dɛn kɔl multiple myeloma. So, (SMM) na ivin rarer kondishon.

Wetin na di risk fɔ divɛlɔp (SMM) to aktiv mɔltipɛl mayloma?

Dis na impɔtant tin bak fɔ no. Insay di fɔs fayv ia afta dɛn dɔn no se dɛn gɛt SMM, lɛk 10% pan di pipul dɛn we gɛt SMM kin gɛt aktif maltipul mayloma ɛvri ia. Insay di nɛks fayv ia, da pasɛnt de go dɔŋ to 3% pan ia. Afta di fכs 10 ia, dis risk de dכn ivin fכ 1% pan ia.

Dis min se nɔto ɔlman we gɛt (SMM) go gɛt mɔltipɛl mayloma. Bɔt, prɔblɛm de, so i rili impɔtant fɔ de wach di dɔktɔ dɛn ɔltɛm.

Test de wae kin no fayn fayn wan if pɔrsin go gɛt multiple myeloma?

Bɔt i sɔri fɔ no se naw, no tɛst nɔ de we go ebul fɔ tɔk kɔrɛkt wan if pɔsin go gɛt mɔltipɛl mayloma. Dɔktɔ ɛn risach pipul dɛm de kɔntinyu fɔ analayz di jenɛtik chenj dɛm we gɛt fɔ du wit mɔltipɛl mayloma ɛn dɛn de luk fɔ si if dɛn go ebul fɔ no if pɔsin we gɛt SMM go gɛt mɔltipɛl mayloma.

Wetin na di rizin dɛn we mek (SMM) kɔmɔt?

Risach pipul dεm no se abnכmal plasma sεl dεm εn tin dεm we dεn kכl M protin na di mak fכ mכltipכl mayloma (MM) εn mכltipכl mayloma (MM). Bɔt dɛn stil nɔ no bɛtɛ bɛtɛ wan wetin kin mek di nɔmal, wɛlbɔdi plasma sɛl dɛn nɔ de wok. Dɛn de chɛk sɔm tin dɛn we kin mek dɛn gɛt dis sik:

• di jεnεtik mכtεshכn dεm: di risכch dεm de luk fכ if link de bitwin chenj dεm na sכm jin dεm (כnkojin - jin dεm we de mek sεl gro) εn mכltipכl mayloma (MM).
• Fat pasmak: Dɛn kin tink se if yu bɔdi fat pasmak, dat kin mek yu fat bak.

Aw fɔ no (SMM)? Us kayn tɛst dɛn kin du?

Dɔktɔ dɛn kin du bɔku tɛst fɔ no if yu gɛt dis sik. Mɛmba se if yu rutin blɔd ɛn/ɔ urine tɛst sho sayn dɛm fɔ M protin, dat kin bi di fɔs tin we go sho se yu gɛt mɔltipɛl mayloma. Dɔn di dɔktɔ dɛn go du sɔm beslayn tɛst fɔ si if yu sik de go bifo to mɔltipɛl mayloma. Dɛn tɛst ya kin bi:

• Complete Blood Count (CBC): Dis de sho di nɔmba fɔ di rɛd blɔd sɛl dɛn, wayt blɔd sɛl dɛn, ɛn di pletlɛt dɛn we yu bon mɛro de mek.
• Blɔd kemistri tɛst: Dis de chɛk yu kriaytinin lɛvɛl (fɔ chɛk aw yu kidni dɛn de wok fayn), albumin lɛvɛl (fɔ chɛk aw yu kidni ɛn liva de wok fayn), ɛn kalsiɔm lɛvɛl (fɔ chɛk if yu bon dɛn dɔn lɔs).
• kwantiti imyunoglobulin tεst: Dis bכdi tεst de mכsu di lεvεl dεm fכ di M protin dεm (imyun protin dεm) na yu bכdi.
• εlektrofכresis εn sεrum imyunofikshכn: dεn tεst dεm ya de luk fכ M protin dεm na yu bכdi.
• Yurin tɛst: Dɔktɔ dɛn kin aks yu fɔ gɛda urine na os fɔ 24 awa fɔ chɛk fɔ M protin.
• X-ray: Dɛn kin yuz ɛkstrem rayt fɔ si if bon dɛn dɔn pwɛl bikɔs ɔf di maltipul mayloma.
• Computed Tomography (CT) scan: Dis na ɔda we fɔ si di bon dɛn we dɔn pwɛl.
• Magnetic Resonance Imaging (MRI): Dis tɛst de yuz redio wev ɛn strɔng magnet fɔ mek ditayli pikchɔ dɛn bɔt yu bon ɛn yu spayna. Dɛn kin yuz dis tɛst fɔ luk fɔ pruf fɔ se di bon dɛn dɔn pwɛl kwik kwik wan.
• Bone marrow biopsies: Dɔktɔ dɛn kin tek wan sampul pan yu bon marrow ɛn analayz am fɔ si di pasɛnt we di nɔmal ɛn abnɔmal plasma sɛl dɛn de insay. Dɛn kin chɛk bak di bon mɛro sɛmpul fɔ chenj na yu DNA we kin mek yu gɛt kansa.

Wetin na di krayteria fɔ (SMM)?

We dɔktɔ dɛn de tɔk bɔt "krayteria," dɛn min di tɛst rizɔlt we mit di mɛdikal standad we dɛn nid fɔ mek dɛn no di sik. Di krayteria fɔ (SMM) na:

• wan bכdi tεst we sho wan lεvεl fכ M protin we pas 3g/dl (3 gram pan wan dεsilita bכdi).
• 24 awa urine test we sho 500 miligram ɔ mɔ prɔtin. Ɔ...
• di bon mכro bayopsi sho se di plasma sεl dεm de mek bitwin 10% εn 59% pan di tכtal bכdi sεl dεm na yu bon mכro. Ɛn...
• Nɔ sayn nɔ de fɔ se yu gɛt bon dɛn we nɔ kɔmɔn ɔ yu kidni dɔn pwɛl we yu gɛt mayloma, yu blɔd sɛl nɔmal, ɛn yu kalsiɔm lɛvɛl nɔmal.

Aw dɛn kin trit dis sik?

Naw, di standad tritmɛnt fɔ SMM na "watchful waiting." Dis kin min se dɔktɔ dɛn kin du tɛst ɔltɛm fɔ wach di lɛvɛl we di M protin de na yu blɔd ɛn di lɛvɛl we di plasma sɛl dɛn de na yu bon mɛrɔ. Lɛk sɛntinɛl, dɛn de wach fɔ si if di sik de wɔs.

Sɔm pipul dɛn kin gɛt ay risk fɔ gɛt aktif maltipul mayloma. If dɛn kayn tin ya, sɔm dɔktɔ dɛn kin se yu fɔ bigin fɔ trit di sik we dɛn kɔl multiple myeloma kwik kwik wan. If yu gɛt multiple myeloma (MM), yu dɔktɔ na di bɛst pɔsin fɔ gi yu di infɔmeshɔn ɛn di tritmɛnt we yu nid.

A kin ridyus di risk fɔ divɛlɔp (SMM)?

כnכfכs, naw dεn nכ no we fכ mek dεn nכ fכm (SMM).

Aw lɔŋ yu kin liv wit (SMM)?

Di we aw dis sik kin afɛkt ɔlman difrɛn. Sɔm pipul kin gɛt am bɔt nɔr kin ɛva gɛt multiple myeloma. Sɔm pipul dɛn kin gɛt mɔltipɛl mayloma mɔnt ɔ ia afta dɛn dɔn no se dɛn gɛt am. If yu de wɔri fɔ liv wit SMM, aks yu dɔktɔ wetin yu kin ɛkspɛkt. Na dɛn na di bɛst pipul dɛn fɔ gi yu patikyula infɔmeshɔn.

Aw lɔŋ yu kin liv wit mɔltipɛl mayloma?

Dis na prɔblɛm bak fɔ bɔku pipul dɛn. Na lɛk 40% to 82% pan di pipul dɛm we gɛt mɔltipɛl mayloma kin alayv fayv ia afta dɛn dɔn no se dɛn gɛt di sik. Dis kin dipen pan bɔrku tin, lɛk di kayn sik ɛn aw pɔrsin de du tritmɛnt.

Aw a go kia fɔ mi wɛlbɔdi biznɛs?

If yu gɛt mɔltipɛl mayloma, yu nɔ go nid tritmɛnt wantɛm wantɛm – ɔ ɛva. Yu dɔktɔ go tɛl yu fɔ kam insay fɔ mek dɛn chɛk yu ɔltɛm. Dis na fɔ chɛk if yu kɔndishɔn dɔn chenj to mɔltipɛl mayloma. Fɔ liv wit multiple myeloma kin mek yu strɛs ɛn mek yu wɔri . Yu go tink se, “O, a wish se a go du sɔntin bɔt dis.” Dat na nɔmal tin. Bɔt sɔm tin dɛn de we yu kin du fɔ kia fɔ yu ɔl yu wɛlbɔdi:

• It di it we balans fayn fayn wan. If yu nɔ shɔ bɔt dis, go to pɔsin we sabi bɔt it.
• If yu na pɔsin we de smok, duya tray fɔ lɛf fɔ smok.
• Gɛt inof rɛst.
• Protɛkt yusɛf frɔm infɛkshɔn. Aks yu dɔktɔ bɔt aw fɔ mek yu nɔ gɛt di sik.
• Ɛksesaiz ɔltɛm.Bɔt, tɔk to yu dɔktɔ fɔs ɛn aks us kayn ɛksɛsayz we fayn fɔ yu ɛn ɔmɔs yu fɔ du. I nɔ fayn fɔ du tumɔs bak.
• Pe atɛnshɔn to yu maynd wɛlbɔdi, bak. If yu de fil bad ɔr pwɛl hat bɔt yu sik, tɔk to yu dɔktɔ bɔt am. Mek shɔ se yu tɛl dɛn, mɔ if de pwɛl hat ɔr pwɛl hat kin pas tu wik ɔr de ambɔg yu ɛvride.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

If yu gɛt (SMM), na sɔm kwɛstyɔn dɛn ya yu kin aks yu dɔktɔ:

• Wetin mek dis bin apin to mi?
• Aw dis kin afɛkt mi layf ɛvride?
• Aw lɔŋ i kin tek fɔ mek di mכltipɛl mayloma bigin?
• Ɛni patikyula sayn dɛn de we kin sho se yu gɛt bɔku bɔku mayloma, ɛn a fɔ no bɔt dɛn?
• Tritmεnt de fכ mek di kכndyushכn (SMM) nכ de divεlכp to mכltipכl maylכma?

Fɔ dɔn, wetin fɔ mɛmba (Take-Home Message) .

Smoldering Multiple Myeloma (SMM) na wan prɛ-kansa kɔndishɔn we gɛt mɔltipɛl mayloma (MM). Bɔt nɔto ɔlman we gɛt SMM go gɛt aktif maltipul mayloma. Bɔku tɛm pipul dɛn we gɛt SMM kin want fɔ no if dɛn go gɛt aktif maltipul mayloma, ɛn if na so, ustɛm. Dis na kwɛstyɔn dɛn we rili at fɔ ansa. Dɔktɔ dɛn nɔ gɛt ɔl di ansa dɛn yet.

כltu, risεch we dεn jכs du sho se bay we dεn map chenj dεm na sכm jin dεm, i kin pכsibul fכ prεdikt to sכm mak if (SMM) go divεlכp to mכltipכl mayloma, εn if na so, usεn.

If yu gɛt dis sik, aks yu dɔktɔ if ɛni nyu tin de we gɛt fɔ du wit yu sik. Dɛn go gladi fɔ ɛp yu. Di tin we impɔtant pas ɔl na fɔ fala yu dɔktɔ in advays ɛn kɔntinyu fɔ gɛt strɔng maynd.

` Smoldering Multiple Myeloma, SMM, Multiple Myeloma, kansa, bכdi sik, bon mכro, M protin, blכd kεnsar, plasma sεl dεm