Yu dɔn ɛva gɛt "Sulfa" kayn mɛrɛsin frɔm dɔktɔ na yu layf? Sɔntɛm yu mɛmba, ɔ sɔntɛm yu dɔn ivin yɛri bɔt am. We bɔku pipul dɛn yɛri di wɔd "sulfa," dɛn kin tink se na di sem drɔg. Bɔt na rili wan jenɛrik nem fɔ wan big grup fɔ mɛrɛsin. So tide, lɛ wi tɔk bɔt wetin na dɛn sɔlfɔnamid ya, wetin dɛn de du, ɛn wetin na di impɔtant tin dɛn we yu nid fɔ no bɔt dɛn.
Wetin na dɛn sɔlfɔnamid ya rili?
Fɔ tɔk am simpul wan, sɔlfɔnamid na wan grup fɔ drɔgs we mɔtalman kin mek na lɛbɔtri (synthetic). Dɛn nɔto tin dɛn we kin apin na di wɔl. If yu luk di kemikal strɔkchɔ fɔ dɛn drɔgs ya, dɛn ɔl gɛt wan kɔmɔn pat we gɛt di ɛlimɛnt sɔlfɔ. Dis na di say we di nem "sulfonamide" kɔmɔt.
So aw dɛn drɔgs ya kin wok? Tink bɔt am, baktri dɛm we de kam insay wi bɔdi nid it fɔ liv ɛn fɔ skata. Wan pan di tin dɛn we dɛn bɔdi ya nid na fɔlet, ɔ vaytamɛn B9 . wetin dεn sכlfa dεm ya de du na fכ blok di baktri dεm fכ mek dis fכlet. I tan lɛk se yu angri we yu nɔ gɛt tin fɔ it. We di baktri nɔ gɛt folate, dɛn nɔ kin ebul fɔ sheb ɔ gro ɛn dɛn kin day smɔl smɔl.
Naw yu kin de tink se, "Wi nid folate tu, so i nɔ go ambɔg wi?" Dat na fayn kwɛstyɔn! Bɔt wi, dat na, mɔtalman, kin gɛt di folet we wi nid frɔm di it we wi de it. Wi nɔ de mek folate na wi bɔdi. So dɛn drɔgs ya nɔ de afɛkt wi sɛl dɛn dairekt wan da we de. Na dat mek dɛn na rili fayn we fɔ kil baktri dɛm.
Sɔlfa drɔgs impɔtant tide jɔs lɛk aw dɛn bin de da tɛm de.
Sɔlfonamides nɔto bin di fɔs antibayɔtiks we dɛn bin fɛn. Bɔt afta dɛn dɔn fɛn dɛn insay di 1930 dɛm, dɛn na bin di bɛst ɛn pawaful klas fɔ antibayɔtiks we bin de fɔ lɛk tɛn ia so. Bifo pipul dɛn lɛk penisilin, dɛn sɔlfa drɔgs ya bin ɛp fɔ ridyus di pipul dɛn we kin day bikɔs ɔf baktriyal infɛkshɔn.
Bɔt tide, dɛn nɔ jɔs de yuz sɔlfɔnamid fɔ mɛn baktriyal infɛkshɔn. Dɛn kin yuz dis klas ɔf mɛrɛsin fɔ trit bɔku difrɛn sik dɛn, lɛk dayabitis, ay blɔd prɛshɔn, HIV infɛkshɔn, ɛn sɔm kayn kansa.
Us ɔda drɔgs dɛn de insay di grup we dɛn kɔl sulfonamide?
Dis list lɔng smɔl, bɔt i go gi yu wan aidia bɔt ɔmɔs yus dɛn mɛrɛsin ya fɔ. Lɛ wi sheb dis to tu pat.
| Di Nem fɔ Drug | Di Kɔmɔn Yuz dɛn |
|---|---|
| 1. Antibayɔtik sɔlfonamid dɛn | |
| Sulfacetamide we gɛt di sik | As ɔntmɛnt fɔ akni ɔ as ay drɔp fɔ ay sik (kɔnjɔktiviti) . |
| Sɔlfadiazin (Silvaden®) we dɛn kɔl . | Fɔ mek yu nɔ gɛt infɛkshɔn pan wund dɛn we dɛn dɔn bɔn |
| Sɔlfasalazin (Azulfidin®) we dɛn kɔl . | Ɔlsɛrativ kɔlayt ɛn rεumatoid atraytis |
| Sulfamethoxazole (we de insay BactrimTM) . | Difrεn baktri infεkshכn dεm lεk urinary tract infεkshכn, respiratory infεkshכn |
| 2. Sɔlfonamid dɛn we nɔ gɛt antibayɔtik | |
| Furosemide (Lasix®), Bumetanid (Bumɛks®) ɛn di ɔda wan dɛn we de na di wɔl. | Diuretics fɔ ridyus wata we de stɔp (swɛlin) na di bɔdi ɛn ay blɔd prɛshɔn |
| Sɛlɛkɔksib (Sɛlɛbrɛks®) . | Fɔ jɔyn pen lɛk at at sik |
| Sumatriptan (Imitrex®) we de na di bɔdi. | Fɔ maygren ed we de at |
| Tolbutamid, Klɔrpropamid, we dɛn kɔl Klɔrpropamid | Fɔ tayp 2 dayabitis |
| Tamsulosin (Flɔmaks®) we dɛn kɔl . | Fɔ prɔblɛm dɛn we gɛt fɔ du wit di urinary we di prɔstat gland dɔn big (benign prostatic hyperplasia) . |
| Darunavir (Prezista®) we dɛn kɔl di . | Antiretroviral drɔg fɔ HIV infɛkshɔn |
Frɔm dis, yu kin si se pan ɔl we dɛn kɔl "sulfa" "sulfa", nɔto di sem tin, ɛn na wan rili brayt klas fɔ drɔgs.
Di stori bɔt ‘sulfa allergic’ na tru?
Yɛs, alɛji to sɔlfonamid drɔgs kin apin. Ɔlsay na di wɔl, bitwin 3 ɛn 8 pipul dɛn pan ɛvri 100 pipul dɛn nɔ gɛt alɛji fɔ wan mɛrɛsin we dɛn kɔl sɔlfa. Bɔt dis tan lɛk di rit we pipul dɛn kin gɛt alɛji to ɔda kɔmɔn antibayɔtiks lɛk penisilin.
Bɔt di impɔtant tin ya na dat jɔs bikɔs yu bin gɛt alɛji to wan sɔlfa drɔg, yu nɔ go gɛt alɛji to ɔl di ɔda sɔlfa drɔgs . Fɔ ɛgzampul, pɔsin we gɛt alɛji to di antibayɔtik Bactrim go mɔs bi se i nɔ gɛt alɛji to di pen kil we dɛn kɔl Celebrex. Na bikɔs di kemikal dɛn we di tu drɔgs dɛn gɛt difrɛn.
So, if yu dɔn ɛva gɛt alɛji to sɔlfa drɔg, mek shɔ se yu tɛl yu dɔktɔ so dat i go gi yu ɔda mɛrɛsin we nɔ bad.
Ɛni sayd ɛfɛkt ɔ risk de wit dis mɛrɛsin?
Lɛk ɛni mɛrɛsin, sɔlfɔnamid kin gɛt sɔm prɔblɛm dɛn ɛn sɔm prɔblɛm dɛn.
- Bacterial Resistance: As tɛm de go, sɔm baktri kin ‘adik’ to dɛn mɛrɛsin ya ɛn dɛn kin bi resistant to dɛn. Dɔn di mɛrɛsin kin stɔp fɔ wok pan da baktri de.
- Siriɔs sayd ɛfɛkt: Na smɔl tɛm nɔmɔ, sɔm pipul dɛn kin gɛt siriɔs riakshɔn na dɛn skin. Stevens-Johnson syndrome ɛn toxic epidermal necrolysis na tu kayn siriɔs, bɔt we nɔ kin apin so ɔltɛm. Bifo yu panik bɔt sɔntin lɛk dis, i go fayn fɔ mek yu tɔk to yu dɔktɔ bɔt di mɛrɛsin we yu de tek.
Bactrim na sɔlfonamid?
Yɛs, sɔm pat pan am. Di drɔg BactrimTM gɛt sulfamethoxazole, we na wan sulfonamide, ɛn ɔda drɔg we dɛn kɔl trimethoprim, we de wok di sem we.
Selebrex na sulfa drɔg bak?
Yɛs. Celecoxib (Celebrex®) na wan pen kil we de insay di sulfonamide klas.
Dis mɛrɛsin kin mek kristal dɛn fɔm na di urine?
Sɔm sɔlfa drɔgs kin mek kristal fɔm na di urine. Dis nɔto kɔmɔn sayd ɛfɛkt. If yu dɔktɔ gi yu wan, i go tɛl yu wetin fɔ du fɔ mek dis nɔ apin (fɔ ɛgzampul, drink bɔku wata). So nɔ wɔri bɔt am.
Salfonamides na wan klas ɔf drɔgs we dɛn dɔn tɛst fayn fayn wan ɛn we dɛn dɔn pruv ɛn we gɛt istri we dɔn pas 90 ia. Fɔs, dɛn bin de yuz dɛn fɔ baktriyal infɛkshɔn nɔmɔ, ɛn naw dɛn de yuz dɛn fɔ mɛn bɔku bɔku sik dɛn frɔm ed to fut.
Mɛsej we dɛn kin kɛr go na os
- Salfonamides, ɔ "sulfa," nɔto wan drɔg. Dɛn na big grup fɔ mɛrɛsin wae dɛn kin yuse fɔ trit difrɛn kayn sik dɛm, lɛk dayabitis, ay blɔd prɛshɔn, infɛkshɔn, ɛn pen.
- If yu dɔn ɛva gɛt alɛji to ɛni sɔlfa drɔg, mek shɔ se yu tɛl yu dɔktɔ bifo yu tek ɛni mɛrɛsin.
- Ɛni sɔlfa drɔg difrɛn. Jɔs bikɔs yu gɛt alɛji to wan, nɔ wɔri se yu go gɛt alɛji to ɔl di ɔda wan dɛn. Aks yu dɔktɔ bɔt dis.
- Tek ɛni mɛrɛsin jɔs pan dɔktɔ advays. If yu gɛt ɛnitin fɔ wɔri ɔr de fred bɔt di sayd ɛfɛkt dɛm, tɔk to yu dɔktɔ opin wan bɔt am.
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