Platelets zo ziri waggulu? Ka twogere ku bulwadde bwa Thrombocytosis!

Era ozuuliddwa nti olina obutoffaali obuyitibwa platelets bungi mu musaayi gwo? Oba omuntu gw’omanyi alina embeera eno? Kya bulijjo okuwulira ng’olina obunkenke obutonotono ng’owulira ekintu nga kino. Naye teweeraliikiriranga, leero tugenda kwogera ku mbeera eno eyitibwa Thrombocytosis mu ngeri ennyangu gy’osobola okutegeera.

Obulwadde bwa thrombocytosis kye ki? Mu ngeri ennyangu...

Mu ngeri ennyangu, obulwadde bwa thrombocytosis bwe buba ng’olina obutoffaali obuyitibwa platelets bungi mu musaayi gwo. Kati oyinza okuba ng’obuuza nti, “Puletelets kye ki?” Ekyo kibuuzo kikulu nnyo!

Platelets kika kya butoffaali obutono obusangibwa mu musaayi gwaffe. Omulimu gwazo omukulu kwe kukomya okuvaamu omusaayi nga waliwo omusaayi, gamba nga waliwo ekiwundu. Zikola nga ddaamu entono.

Naye kiki ekibaawo singa omuwendo gw’obutoffaali obuyitibwa platelets gweyongera nnyo? Omusaayi gwo guyinza okufuuka omugonvu ne gukwata. Mu mbeera ezimu ez’amaanyi, obutoffaali buno obuyitiridde busobola okuvaako okuzimba omusaayi okw’akabi okutondebwa munda mu misuwa. Kino kiyinza okwongera ku bulabe bw'embeera nga stroke oba heart attack .

Naye, si misango gyonna egya Thrombocytosis nti gya bulabe kyenkanyi. Obuzibu bw’embeera eno, n’okumanya oba weetaaga obujjanjabi oba nedda, kisinziira ku kivaako.

Waliwo ebika bibiri ebikulu eby’obulwadde bwa thrombocytosis:

Yee, abasawo bazudde ebika bibiri ebikulu eby’embeera eno. Ekyo ka twogereko katono.

1. Obulwadde bwa Essential Thrombocythemia (ET) oba Obulwadde bwa Thrombocytosis obusookerwako

Buno bulwadde bwa musaayi obutatera kulabika. Kibaawo ng’obusimu bwo obw’amagumba – ekkolero ly’obutoffaali bw’omusaayi munda mu magumba go – likola obutoffaali obuyitibwa platelets bungi nnyo. Lowooza ku kino, obutoffaali bw’omusaayi obusinga obungi mu mibiri gyaffe bukolebwa mu busimu buno obw’amagumba. Omuntu alina obulwadde bwa essential thrombocythemia aba n’okufulumya obutoffaali obuyitibwa platelets bungi mu ngeri etaali ya bulijjo olw’ekikyamu mu nkola eno ey’okukola obutoffaali bw’omusaayi.

Embeera eno eyitibwa ET (Essential Thrombocythemia) , etwalibwa ng’obulwadde obusinga okubeera mu kibinja ky’omusaayi ekiyitibwa Myeloproliferative Neoplasm (MPN) .

2. Obulwadde bwa Thrombocytosis obukola oba Secondary Thrombocytosis

Kino kye kika kya Thrombocytosis ekisinga okubeerawo. Kino omubiri gwo lwe gukola platelets eziwera nga guddamu embeera endala, yinfekisoni, obuvune, okulongoosebwa oba okuggyibwako ennywanto. Mu ngeri ennyangu, omubiri gwo gukola ekintu ekirala ne gwongera ku bungi bw’obutoffaali bwagwo. NoObulwadde bwa Reactive thrombocytosis butera okuba obw’akaseera obuseera, ekitegeeza nti ekivaako bwe kimala okugonjoolwa, omuwendo gw’obutoffaali obukola omusaayi gudda mu mbeera eya bulijjo.

Ani afuna obulwadde bwa thrombocytosis?

Embeera eno esinga kuzuulibwa mu bantu abasukka mu myaka 60. Ate era, kigambibwa nti ekika ekiyitibwa Essential Thrombocythemia (ET) kizuulibwa mu bakyala emirundi ebiri okusinga abasajja.

Biki ebivaako obulwadde bwa thrombocytosis?

Ensonga eziviirako ebika ebibiri bye twayogeddeko emabegako nazo za njawulo.

Ebivaako obulwadde bwa Essential Thrombocythemia (ET) .

Essential Thrombocythemia (ET) mbeera ya buzaale efunibwa. Si kintu ky’ozaalibwa nakyo. Kiva ku nkyukakyuka oba enkyukakyuka mu buzaale obumu obwenyigira mu kukola obutoffaali obuyitibwa platelets. Kino kireetera obusigo bw’amagumba bwo okukola obusimu obuyitibwa platelets bungi.

Abantu abasoba mu kitundu abalina obulwadde bwa Essential Thrombocythemia (ET) balina enkyukakyuka mu ggiini ya JAK2 . Enkyukakyuka mu buzaale bwa CALR oba MPL nazo za bulijjo.

Bannasayansi n’okutuusa kati tebannaba kusobola kuzuula kituufu kivaako enkyukakyuka zino ez’obuzaale, naye okunoonyereza ku nsonga eno kukyagenda mu maaso.

Ebivaako obulwadde bwa Reactive Thrombocytosis

Ekika kino kibaawo kubanga omubiri gwo gukola platelets nnyingi nga ziddamu embeera ez’enjawulo. Oba, oluusi, era kiyinza okuba nga kiva ku kuba nti platelets enkadde zikuŋŋaanyizibwa mu kifo ky’okusaanawo ku sipiidi eya bulijjo.

Bino bye bimu ku bintu ebiyinza okuvaako obulwadde bwa Reactive Thrombocytosis :

• Anemia , naddala okukendeera kw’omusaayi olw’obutaba na kyuma.
• Ebizibu ebirala eby’omusaayi.
• Ebika bya kookolo ebimu .
• Yinfekisoni, gamba ng’ekifuba .
• Embeera z’okuzimba – embeera ezireeta okuzimba mu mubiri, gamba ng’endwadde z’enkizi.
• Okukosebwa .
• Okulemererwa kw'ekibumba .
• Eddagala erimu.
• Okulongoosa naddala okulongoosa olubuto.
• Okuggyawo enseke .
• Okujjanjaba obutaba na vitamiini B12 .

Olukalala luno lulimu ebintu ebitonotono ebitera okuvaako ensonga eno. Wayinza okubaawo ebirala bingi ebivaako obulwadde bwa Reactive Thrombocytosis .

Bubonero ki obulaga obulwadde bwa thrombocytosis?

Ebiseera ebisinga, abantu abalina omuwendo gwa platelets omungi tebafuna bubonero bwonna, waakiri si mu mitendera egy’okusooka. Bw’oba ​​olina obulwadde bwa Reactive Thrombocytosis , oyinza okufuna obubonero bw’embeera y’obujjanjabi eyaliwo eyabuleeta.

Kyokka obubonero bwe bubaawo, butera okwekuusa ku kuvaamu omusaayi mu ngeri etaali ya bulijjo n’okuzimba omusaayi mu mubiri gwo. Oyinza okulaba obubonero nga:

• Okulumizibwa omutwe .
• Kyangu okunyiga.
• Okuwulira ng’anafuye, ng’oziyira oba ng’omutwe guzibye.
• Okuvaamu omusaayi mu nnyindo, mu kamwa n’ennyindo.
• Okuvaamu omusaayi mu lubuto oba mu byenda.

Abantu abamu abalina obulwadde bwa Essential Thrombocythemia (ET) bayinza okufuna embeera eyitibwa Erythromelalgia . Kino kireeta obulumi, okuzimba n’okumyuuka mu ngalo n’ebigere. Era bayinza okuziyira n’okuwunya mu ngalo n’ebigere.

Mu mbeera enzibu, thrombocytosis eyinza okuvaako omusaayi okuzimba mu lubuto mu ngeri etaali ya bulijjo (e.g., Budd-Chari syndrome ) era n’okwongera ku bulabe bw’okusannyalala oba okulwala omutima .

Obulwadde bwa thrombocytosis buzuulibwa butya?

Olw’okuba obulwadde bwa thrombocytosis tebutera kuleeta bubonero, ekisookera ddala ky’olina, bwe kiba nti okukebera omusaayi okwa bulijjo (e.g., Complete Blood Count – CBC ) kulaga nti omuwendo gwa platelet gweyongedde.

Thrombocytosis etegeezebwa ng’okubeera n’obutoffaali obusukka mu 450,000 buli microliter y’omusaayi. Singa omuwendo gw’omusaayi gwo guba mungi, omusawo wo ajja kulagira okukeberebwa omusaayi omulala mu wiiki ntono okulaba oba omuwendo gusigala nga guli waggulu. Omulundi gumu mu muwendo gw’obutoffaali obukola omusaayi (platelets) n’oluvannyuma n’edda mu mbeera eya bulijjo tekitera kuba kizibu. Kyokka, emiwendo egy’amaanyi egitaggwaawo giyinza okulaga embeera y’obujjanjabi eyaliwo.

Mu mbeera ya reactive thrombocytosis , okuzuula embeera enkulu eyagireeta (e.g., iron deficiency anemia , kookolo, yinfekisoni) kiyinza okuyamba abasawo okugizuula n’okugiddukanya. Wabula singa omusawo tasobola kuzuula kintu kya kubiri ng’ekyo, ajja kwongera okukeberebwa okulaba oba olina obulwadde bwa Essential Thrombocythemia (ET) .

Ebigezo bino biyinza okuli:

• Okusiiga omusaayi ogw’okumpi:Kino kikebera okulaba oba obusimu obuyitibwa platelets mu musaayi gwo bulabika nga tebuli bwa bulijjo.
• Okukebera DNA/obuzaale: Kino kisobola okuzuula enkyukakyuka mu buzaale nga JAK2 , ezitera okukwatagana ne ET (Essential Thrombocythemia) .
• Okukebera obusigo bw’amagumba: Kino kikebera obusimu bwo obutaba na butoffaali obutali bwa bulijjo.

Obulwadde bwa thrombocytosis bujjanjabwa butya?

Bw’oba ​​tolina bubonero bwonna, oyinza okwetaaga okwekebejjebwa bulijjo kwokka.

Obulwadde bwa reactive thrombocytosis (secondary thrombocytosis) emirundi mingi tekyetaagisa bujjanjabi. Ebiseera ebisinga, emiwendo gy’obutoffaali obukola omusaayi (platelets) gidda mu mbeera eya bulijjo ng’embeera eyavaako omuwendo gw’obutoffaali obutono (nga okulumwa, okukwatibwa yinfekisoni, oba engeri omuntu gy’akola ng’olongooseddwa) emaze okugonjoolwa. Kyokka bw’oba ​​olina obubonero, omusawo ajja kujjanjaba ekizibu ekikuviiriddeko.

Bw’oba ​​olina obulwadde bwa Essential Thrombocythemia (ET) era ng’olaba obubonero, omusawo ayinza okukuwa amagezi ku bujjanjabi obuwerako, gamba nga:

• Okumira aspirin omutono buli lunaku: Osobola okumira aspirin buli lunaku okuziyiza omusaayi okuzimba. Dozi eno entono ebiseera ebisinga tereetera lubuto kutabuka oba okuvaamu omusaayi. Wabula tomira aspirin buli kiseera nga toyogedde na musawo wo.
• Okumira eddagala erikendeeza ku muwendo gw’obutoffaali obukola omusaayi: Eddagala nga Hydroxyurea (amannya ga kkampuni: Droxia®, Hydrea®, Siklos®, Mylocel®) ne Anagrelide (erinnya ly’ekika: Agrilyn®) likendeeza ku kukola obutoffaali obukola omusaayi mu busimu bw’amagumba. Interferon alfa (erinnya ly’ekika: Multiferon®) eremesa obutoffaali obutali bwa bulijjo okwawukana n’okukula.
• Okubeera n’enkola ey’okuggyamu obutoffaali bwo: Singa obutoffaali bwo buba bungi nnyo ne kiba nti oli mu bulabe bw’okufuna okuzimba omusaayi mu kabi, omusawo ayinza okukuwa amagezi okukozesa enkola eyitibwa plateletpheresis . Kino kizingiramu okukozesa ekyuma okusengejja obutoffaali obuyitiridde okuva mu musaayi gwo. Kyokka, mu mbeera ezisinga obungi ez’obulwadde bwa thrombocytosis , plateletpheresis tekyetaagisa.

Ekikulu: Totandika oba toyimiriza bujjanjabi bwonna ku buno nga tolina magezi ga musawo. Buli kimu olina okukiteesaako n’omusawo wo era kikolebwe ng’akulembera.

Obulwadde bwa thrombocytosis busobola okuwona ddala?

Obulwadde bw’okuzimba obusimu obuyitibwa Essential Thrombocythemia (ET) .Mu kiseera kino tewali ddagala liwonya bulwadde bwa thrombocytopenia. Wabula omusawo asobola okukuyamba okuddukanya embeera eno okukendeeza ku bulabe bw’okuziyira omusaayi. Mu mbeera y’obulwadde bwa reactive thrombocytosis (obuva ku nsonga ez’okubiri), emiwendo gya platelet gitera okudda mu mbeera eya bulijjo oluvannyuma lw’ekizibu ekisookerwako okujjanjabwa.

Obulwadde bwa thrombocytosis busobola okuziyizibwa?

Embeera nnyingi ezireeta okuzimba omusaayi (thrombocytosis) teziyinza kuziyizibwa, omuli Essential Thrombocythemia (ET) .

Obulwadde bwa thrombocytosis butiisa obulamu?

Emiwendo gya platelet egy’amaanyi si gya bulabe eri obulamu, naye ebizibu ebiyinza okubaawo – gamba ng’okuzimba omusaayi oba okuvaamu omusaayi ennyo – biyinza okuba eby’akabi.

Ebisinga okuvaako obulwadde bwa thrombocytosis biba bya kaseera buseera, era tebitera kuleeta kuzimba musaayi mu ngeri ya maanyi. Mu Essential Thrombocythemia (ET) , akabi kali waggulu katono. Kyokka omusawo ajja kukulondoola nnyo, akuwandiikire eddagala eryetaagisa, era akole emitendera egyetaagisa okuziyiza omusaayi okuzimba mu ngeri ey’akabi. Kale teweeraliikiriranga.

Endowooza etya eri omuntu alina obulwadde bwa thrombocytosis?

Reactive thrombocytosis etera okuggwaawo ng’ekizibu ekisirikidde kijjanjabiddwa. Wadde ng’omuwendo gw’obutoffaali bw’omusaayi (platelets) guyinza okulinnya okumala akaseera katono (era nga kiyinzika okuba n’ekiseera ekiwanvu oluvannyuma lw’okuggyibwako enseke zo), ebiseera ebisinga obulwadde bwa thrombocytosis obw’okubiri tebuleeta kuzimba musaayi mu ngeri etaali ya bulijjo.

Essential Thrombocythemia (ET) , oba primary thrombocytosis, esobola okuleeta obuzibu obw’amaanyi okuvaamu omusaayi oba okuzimba omusaayi. Okumira eddagala okukuuma emiwendo gya platelet zo nga gya bulijjo kiyinza okuyamba okuziyiza kino. Kyokka oluvannyuma lw’emyaka mingi ng’olina obulwadde buno, obulwadde bw’amagumba (bone marrow fibrosis) (enkovu z’amagumba) busobola okubaawo. Abantu abatono abalina obulwadde bwa Essential Thrombocythemia (ET) nabo basobola okukwatibwa obulwadde bwa leukemia .

Ddi lwe nnina okulaba omusawo wange?

Goberera ddala ebiragiro by’omusawo wo ku mirundi gy’olina okugenda okwekebejjebwa abasawo n’okukeberebwa omusaayi okukebera omuwendo gw’obutoffaali obukola omusaayi.

Ddi lwe nnina okugenda mu kitongole ky’abalwadde ab’amangu (ETU) ?

Bw’olaba obubonero bw’okusannyalala oba okulwala omutima, kuba ku ssimu ya 1990 mu bwangu oba genda mu kisenge ky’abalwadde ab’amangu mu ddwaaliro erikuli okumpi. Bubonero buno bumanye.

Bibuuzo ki bye nnina okubuuza omusawo wange?

Osobola okubuuza omusawo ebibuuzo nga:

• Nsaana okweraliikirira nti obutoffaali bwange bungi?
• Nnaaba nneetaaga okwongera okukeberebwa okuddamu okukebera emiwendo gya platelet zange?
• Bikebere ki bye nja okwetaaga okukola okuzuula ekivaako obulwadde bwa Thrombocytosis bwange?
• Bujjanjabi ki bw’oteesa?
• Nkyukakyuka ki ze nsobola okukola mu bulamu bwange okusobola okuddukanya embeera eno?

Singa ebyava mu musaayi gwo biraga nti platelets zo nnyingi, tosattira. Platelets zo ziyinza okuba nnyingi olw’ensonga ezitali zimu. Ensonga zino nnyingi tezeetaaga bujjanjabi. Naye singa emiwendo gyo giba gya waggulu buli kiseera era ng’olina obubonero, omusawo ajja kugezaako okuzuula ekivaako. Okulondoola n’obwegendereza n’okukozesa eddagala ebiseera ebisinga bisobola okuziyiza ebizibu ebisinga okuba eby’amaanyi ebikwatagana n’obulwadde bwa thrombocytosis.

N’ekisembayo, ebintu by’olina okujjukira (Obubaka bw’okutwala awaka) .

Well, twayogedde nnyo ku Thrombocytosis leero, si bwe kiri? Nsuubira nti kino mukitegedde bulungi.

Ekisinga obukulu si kusattira singa okizuula nti emiwendo gy’obutoffaali gy’omubiri (platelets) giri waggulu. Si misango gyonna egya Thrombocytosis nti gya bulabe.

• Reactive Thrombocytosis kye kika ekisinga okumanyibwa, era kitera okuva ku nsonga endala ey’akaseera obuseera. Kino nakyo kijja kutereera ng’ekivaako ekyo kimaze okujjanjabwa.
• Essential Thrombocythemia (ET) kika kya rare ekiyinza okwetaagisa okujjanjabibwa okumala ebbanga eddene.
• Kakasa nti ogenda okukeberebwa n’obujjanjabi obutuufu ng’omusawo bw’akulagidde.
• Tobuusa maaso bubonero bwonna. Noonya mangu omusawo naddala ng’ovaamu omusaayi ogutali gwa bulijjo, okunyiga, okulumwa omutwe ennyo, okulumwa mu kifuba oba okukaluubirirwa okussa.
• Yogerako mu lwatu n’omusawo wo. Buuza ekibuuzo kyonna oba ekikweraliikiriza ky’olina.

Jjukira nti toli wekka. Bw’oba ​​olina obulagirizi obulungi n’obuwagizi bw’abasawo, osobola okuddukanya obulungi embeera eno n’obeera n’obulamu obulungi.