DHT kye ki? Kikwata kitya ku mubiri gwo? (Obulwadde bwa Dihydrotestosterone) .

Wali owuliddeko ku DHT oba Dihydrotestosterone ? Mpozzi yee, mpozzi nedda. Naye kino kintu kikulu nnyo eri omubiri gwaffe naddala eri obulamu bw'abasajja. Kale, leero tugenda kwogera ku DHT eno mu ngeri ennyangu gy’osobola okutegeera.

DHT (dihydrotestosterone) kye ki? Mu ngeri ennyangu...

Mu ngeri ennyangu, DHT busimu bwa njawulo obuyamba okukulaakulanya engeri z’abasajja ez’okwegatta . Omanyi obusimu bulinga obubaka obutono obufuga buli mulimu mu mubiri gwaffe. DHT era eri mu kibinja ky’obusimu obuyitibwa Androgen. Androgen lye linnya eriweebwa obusimu obuleeta empisa z’abasajja.

Lowooza ku kino, DHT etandika okukola mu mubiri gw'omusajja okuva lw'abeera mu lubuto. Olwo, omulimu gwa DHT gukyuka mu biseera eby’enjawulo mu bulamu bwe. Wadde nga bannassaayansi tebakakasa bulungi ngeri DHT gy’ekwatamu abakyala, balowooza nti eyinza okukosa okukula kw’enviiri ku mubiri ne mu bifo eby’obwannannyini.

Androgen enkulu mu musajja omukulu ye testosterone . Ebitundu nga 10% ku testosterone ono bikyusibwa ne bifuuka DHT buli lunaku . Enkola eno ebeerawo mu lususu okwetoloola ebitundu by’ekyama ne mu nseke z’enseke mu basajja. Mu bakyala kino kibeerawo mu lususu. Era kibeera mu bifo ng’ekibumba kyaffe. Olw’okuba mu butonde abasajja balina eddagala lya ‘testosterone’ mu mibiri gyabwe, n’omuwendo gwa DHT gwabwe guli waggulu nnyo.

Mu butuufu DHT ekola ki ku mibiri gyaffe?

DHT ekola ebintu eby’enjawulo ku mitendera egy’enjawulo mu bulamu bw’omusajja. Kikulu nnyo naddala mu kiseera ky'okukula kw'omwana ali mu lubuto n'okukula .

Wabula obutafaananako testosterone, DHT tekola kinene mu kukuuma emirimu gy’omubiri mu musajja omukulu. Mu bukulu, DHT esinga kulabibwa mu mbeera nga okugaziwa kw’enseke n’okugwa kw’enviiri mu ngeri y’ekisajja.

Omulimu gwa DHT mu kiseera ky’omutendera gw’embuto

Ng’ali mu lubuto, ebitundu by’okwegatta by’omwana bikula ng’ekisajja oba ekikazi okusinziira ku mbeera y’obusimu entongole. Mu mbeera y’omulenzi, DHT ekolagana n’obusimu obulala (nga mw’otwalidde n’obusimu obuyitibwa testosterone ) okuziyiza okukula kw’engeri z’ekikula ky’abakyala n’okutumbula enkula y’engeri z’ekikula ky’abasajja .

DHT yeetaagibwa nnyo mu nkula y’ebitundu by’ekyama eby’ebweru eby’omusajja, obusajja n’ensigo, mu mwana ali mu lubuto. DHT era eyamba mu nkula y’endwadde z’enseke.

DHT mu kiseera ky’obuvubuka

Omulenzi bw’atuuka mu myaka gy’obuvubuka, DHT eyamba obusajja n’ensigo okwongera okukula. Si ekyo kyokka, naye ne DHT y’esinga okuvunaanyizibwa ku:

• Ku maasoOkukula ekirevu.
• Okukula enviiri z’omubiri.
• Okukula kw’enviiri mu bitundu by’obwannannyini.
• Okukula kw’enseke .

Kiki ekibaawo singa emiwendo gya DHT gyeyongera?

Embeera z‟obulamu ezimu zikwatagana n‟emiwendo gya DHT okulinnya. Ka tulabe kiki kye bali:

• Obulwadde bw’okuzimba enseke ezitali za bulijjo (BPH) .
• Kookolo w’enseke
• Androgenetic alopecia (okugwa kw’enviiri z’abasajja ) .
• Obulwadde bw’enkwaso eziyitibwa Polycystic Ovarian Syndrome (mu bakyala) `(Polycystic Ovarian Syndrome - PCOS)`

Obulwadde bwa Benign Prostatic Hyperplasia (BPH) ne DHT

Benign Prostatic Hyperplasia (BPH) kwe kugaziwa kw’endwadde yo ey’enseke. Embeera eno etera nnyo mu basajja abasukka mu myaka 50 .

Enseke yo esobola okukola DHT mungi. DHT eno esitula enkola eya bulijjo ey’endwadde z’enseke, era etera okuleetera enseke okugaziwa. BPH eno esobola okuleeta obuzibu ng'okukaluubirirwa okufulumya omusulo n'obutakola bulungi mu kwegatta .

Kookolo w’enseke ne DHT

Abantu abalina kookolo w’enseke batera okuba n’ekirungo kya DHT ekinene. Kookolo w’enseke ayinza okuva ku DHT okweyongera mu nseke yo, ng’ogasseeko enkyukakyuka ezimu mu buzaale ezireetera obutoffaali bw’enseke okukula mu ngeri etafugibwa.

Androgenetic alopecia (okugwa kw’enviiri) ne DHT

Androgenic alopecia kye tutera okuyita ekiwalaata eky'ekika ky'abasajja . Mu mbeera eno, enviiri zigwa okuva waggulu n’emmanju w’omutwe. Ekiseera bwe kigenda kiyitawo, enviiri zikendeera.

Ekimu ku bivaako enviiri zino okugwa kwe kwongera okukola DHT mu bitundu by’enviiri zo. Waliwo n’ebirala ebivaako embeera eno, gamba ng’obuzaale obuva ku buzaale. DHT bwe yeeyongera, enviiri zikendeera, enzirukanya y’okukula kw’enviiri ekendeera, era okukkakkana ng’enviiri zigwa.

PCOS ne DHT

Obulwadde bwa Polycystic Ovarian Syndrome (PCOS) bulwadde obutakwatagana mu busimu obukwata abakyala. Kibaawo ng’enkwaso zaabwe zikola obusimu bwa androgen bungi omuli n’obusimu obuyitibwa testosterone. Kino kivaako emiwendo gya DHT okulinnya. Kino kiyinza okuleeta obubonero obw’enjawulo, omuli okugenda mu nsonga obutali bwa bulijjo, enviiri z’omubiri okukula ennyo (hirsutism), n’embalabe .

Kiki ekibaawo singa emiwendo gya DHT gikendeera?

Embeera ezimu zikwatagana n’emiwendo gya DHT emitono. Ka tulabe kiki kye bali:

• Obutabeera na 5-alpha reductase `(obutaba na 5-alpha reductase)`
• Testosterone omutono / hypogonadism y’omusajja

DHT esinga ku ya bulijjo esinga kukwata basajja. Bannasayansi abamu balowooza nti emiwendo gya DHT egya wansi mu bawala giyinza okulwawo okutuuka mu myaka gy’obuvubuka.

Obutabeera na 5-alpha reductase ne DHT

5-alpha reductase ye enzyme eyamba okukyusa testosterone okufuuka DHT. Enkyukakyuka mu buzaale ekosa okukola enziyiza eno eyinza okuvaako emiwendo gya DHT okubeera wansi oba obutabaawo. Kino kiyitibwa obutaba na 5-alpha reductase. Eno mbeera esikira okuva mu bazadde okutuuka ku baana (an autosomal recessive pattern) .

Obutabeera na 5-alpha reductase bukosa enkula y’okwegatta mu baana abazaalibwa mu buzaale abasajja (abo abalina XY chromosomes). Abalongo abasajja abazaalibwa nga balina obuzibu buno batera okwoleka engeri zino wammanga:

• Ebitundu by’ekyama eby’ebweru tebikula mu bujjuvu.
• Okubeerawo kw’ensigo ezikola munda mu mubiri (nga tezivuddeyo).
• Enseke entono oba ezitaliiwo.

Ekikulu: Mu mbeera ez’amaanyi ez’obutaba na 5-alpha reductase, abalongo abasajja mu buzaale abalina XY chromosomes bayinza okuba n’ebitundu by’ekyama eby’ebweru eby’ekikazi. Wabula DHT ekendedde tekosa nkula ya nsigo (zikyayinza okukola ensigo) n’ebitundu by’ekyama eby’omunda. Kino kyawukana ku mbeera eyitibwa Androgen Insensitivity Syndrome. Abantu abalina embeera eno balina ensigo eza bulijjo n’obusimu obuyitibwa testosterone obwa bulijjo oba obw’amaanyi, naye tebalina bikozesebwa bya androgen, kale tebafuna mpisa za kwegatta za kubiri, ate era tebazaala nnyo.

Abalenzi abalina obuzibu bw’obuzaale 5-alpha reductase deficiency tebafuna nviiri mu maaso nga batuuse mu myaka gy’obuvubuka. Wabula emibiri gyabwe gikyakola ekirungo kya ‘testosterone’ ekivaako ebintu ng’eddoboozi okuzimba, ebinywa okukula n’obusajja okugaziwa.

Omusuwa gwa testosterone omutono ne DHT

Testosterone mu mubiri gwo y’ekyusa n’efuuka DHT. Kale, singa testosterone yo eba ntono, DHT nayo ejja kuba wansi okusinga eya bulijjo. Erinnya eddala erigamba nti testosterone omutono ye male hypogonadism.

Waliwo ebika bibiri ebikulu eby’obulwadde bwa hypogonadism obw’abasajja: obwa classical (obubeerawo ng’azaalibwa oba oluvannyuma lw’obulamu) n’obutandikira ekikeerezi. Okusinziira ku myaka gyo, obulwadde bw’ekisajja obuyitibwa hypogonadism buyinza okuleeta ebizibu eby’enjawulo.

Nsaana okulaba omusawo ku miwendo gya DHT?

Bw’oba ​​olowooza nti ggwe oba omwana wo muyinza okuba n’embeera evudde ku DHT entono oba ennene, kakasa nti oyogera n’omusawo.Olwo asobola okukola ebigezo ebyetaagisa oba okukusindika ew’omuntu mukugu mu nkola y’endwadde z’omu lubuto, gamba ng’omusawo w’endwadde z’omu lubuto.

Dihydrotestosterone oba DHT yeetaagibwa nnyo mu nkula y’abasajja mu kwegatta. Naye singa emiwendo gyayo giba waggulu nnyo oba wansi nnyo, kiyinza okuleeta obuzibu ng’ebitundu by’ekyama eby’ebweru obutakula, enseke okugaziwa, n’enviiri okugwa. Bw’oba ​​olina ekikweraliikiriza ku miwendo gya DHT, tolwawo kwogera na musawo wo. Basobola okuddukanya ebigezo ne bakuwa amagezi ku bujjanjabi obuyinza okukuyamba.

Ebintu ebikulu by’olina okujjukira okuva mu kitundu kino (Take-Home Message)

• DHT busimu bwa androgen obusinga okuyamba okukulaakulanya engeri z'okwegatta kw'abasajja .
• DHT kikulu nnyo mu nkula y’ebitundu by’ekyama eby’ebweru eby’omusajja mu kiseera ky’omwana ali mu lubuto n’okukula kw’enviiri mu maaso n’enviiri z’omubiri mu kiseera ky’obuvubuka.
• DHT okubeera waggulu kiyinza okuvaako embeera nga benign prostatic hyperplasia (BPH), kookolo w’enseke, okugwa kw’enviiri mu basajja, ne PCOS mu bakyala.
• Singa emiwendo gya DHT giba mitono, embeera nga 5-alpha reductase deficiency ziyinza okukosa enkula y’abasajja mu kwegatta.
• Bw’oba ​​olina okubuusabuusa oba okweraliikirira kwonna ku miwendo gyo egya DHT, kirungi okugenda mu basawo amagezi .

Nsuubira kati olina okutegeera okulungi ku DHT. Okumanya ebintu nga bino kikulu nnyo eri obulamu bwo!

` DHT, dihydrotestosterone, obusimu, obulamu bw’abasajja, testosterone, prostate, okugwa kw’enviiri, PCOS