Acetylcholine (ACh) kye ki? Tumanye ddala kye kikola ku mibiri gyaffe!

Wali owuliddeko ku acetylcholine , oba (ACh)? Oboolyawo omusawo wo akubuuliddeko, oba waliwo w’osomyeko. Kirungo kitono naye nga kikulu nnyo mu mubiri gwaffe. Kiba ng’omusawo omuto atambuza obubaka munda mu mubiri gwaffe. Kale, leero tugenda kwogera ku acetylcholine mu ngeri ennyangu gy’osobola okutegeera.

Acetylcholine kye ki ddala?

Mu ngeri ennyangu, acetylcholine kirungo kya busimu . Lowooza ku kino, obwongo bwo bwetaaga okuweereza obubaka obutonotono obw’amasannyalaze okutambuza omukono gwo, okulowooza, okujjukira ekintu, ebintu bino byonna. Acetylcholine mubaka wa kemiko ayamba okutambuza obubaka obwo okuyita mu butoffaali bw'obusimu .

Kino era kiyitibwa " excitatory " neurotransmitter . Omanyi ekyo kye ki? "Kizuukusa" akatoffaali k'obusimu, kwe kugamba, kakasitula, era ne kakafuula "okuweereza" obubaka amangu. Kiba ng'okukonkona ku mulyango gw'omuntu eyeebase n'ogamba nti, "Wano, twala ebbaluwa eno."

Erinnya acetylcholine liva ku bintu bibiri ebigikola. Ekimu kye kibinja kya acetyl . Kino kiva mu kirungo ekiyitibwa acetyl coenzyme A, ekikolebwa mu glucose ya sukaali. Ekirala kiriisa ekiyitibwa choline . Choline asangibwa mu butonde mu ensaano y’amagi, soya, ekibumba, enva endiirwa n’ebinyeebwa. Choline naye akolebwa mu kibumba kyaffe.

Acetylcholine yeenyigira mu mirimu mingi emikulu mu mubiri gwaffe naddala okutambula kw’ebinywa kyeyagalire.Kino kikola kinene mu bikolwa byaffe eby’okumanya, gamba ng’okutambuza ebitundu byaffe eby’omubiri n’okutambula. Kisitula obutoffaali bw’obusimu mu binywa byaffe, ekibireetera okukonziba. Si ekyo kyokka, naye era kikulu nnyo eri obutoffaali bw’obusimu mu bwongo bwaffe, n’enkola ng’okujjukira, okulowooza, n’okuyiga.

Acetylcholine (ACh) ekola etya?

Acetylcholine aterekebwa ku nkomerero z’obutoffaali bw’obusimu, okutuusa ng’obubaka bwetaaga okusindikibwa. “Siginini” bw’etuuka okuweereza obubaka, acetylcholine ono aterekeddwa afuluma. Bwe kimala okufulumizibwa, kitambula ne kiyingira mu bbanga ettono wakati w’obutoffaali bw’obusimu bubiri. Ekituli kino kiyitibwa enjatika y'obusimu obuyitibwa synaptic cleft .

Oluvannyuma lw’okusala enjatika y’obusimu obuyitibwa synaptic cleft, waliwo ebika bibiri eby’ebikwata acetylcholine by’esobola okwesiba. Bbo bali:

• Ebirungo ebikwata nicotinic
• Ebikwata ku muscarinic

Oluvannyuma lw’okusiba ku bikwata bino, obubaka bw’eddagala butambula ne bugenda mu katoffaali k’obusimu akaddako. Oluvannyuma lw’obubaka okusindikibwa, acetylcholine esigala mu cleft y’obusimu (synaptic cleft) tamala gagenda mu kasasiro. Enziyiza endala eyitibwa acetylcholinesterase ejja n’emenya acetylcholine eno wansi mu bitundu ebigikola, choline ne acetate. Olwo ebitundu bino ebimenyese ne biddamu okunyigibwa, ne biddamu okukozesebwa, ne bikozesebwa okutambuza obubaka obulala obw’eddagala. Enkola ennungamu ennyo!

Kiki ekituuka ku acetylcholine (ACh)?

Acetylcholine alina emigaso mingi eri emibiri gyaffe. Katutunuulire ebikulu.

Ebika byombi eby'ebikwata ( receptors ) byenyigira mu kujjukira kwaffe . Kwe kugamba, bikulu mu kujjukira okw’ekiseera ekiwanvu, okujjukira okw’ekiseera ekitono, okutondebwa kw’ebijjukizo, okunyweza kwabyo, n’okubiggyamu. Munda mu bwongo, acetylcholine yeenyigira mu bintu ebirala. Kitumbula okukubiriza, okwagala/okufaayo, okuyiga, n‟otulo otu REM (omutendera gw‟otulo mwe tuloota).

Embeera ki ezibeerawo nga acetylcholine (ACh) ekendedde?

Omubisi gwa acetylcholine omutono oba obutaba nabwo, kiyinza okuvaako endwadde eziwerako. Ebikulu ku bino bye bino:

• Obulwadde bwa Alzheimer : Abantu abalina obulwadde bwa Alzheimer tebalina acetylcholine emala mu bwongo. N’ekyavaamu, okubulwa okujjukira kabonero akakulu.
• Lambert-Eaton myasthenic syndrome : Obulwadde buno buva ku kukendeera kw’okufulumya eddagala lya acetylcholine okuva mu butoffaali bw’obusimu.
• Myasthenia gravis : Buno bulwadde bwa autoimmune obuleetera ebinywa by’amagumba okunafuwa amangu oluvannyuma lw’okukozesa enfunda eziwera.

Eddagala ki erigenderera acetylcholine (ACh)?

Cholinesterase inhibitors kibiina kya ddagala erikola nga liziyiza enzyme emenya acetylcholine n’okwongera ku mirimu gy’ebikwata acetylcholine. Zikozesebwa okujjanjaba obulwadde bwa Alzheimer ne myasthenia gravis. Eddagala lino erya Donepezil (Aricept®), Rivastigmine (Exelon®), ne Galantamine (Razadyne®) lye limu ku ddagala lino.

Mmere ki erimu choline ayamba okukola acetylcholine (ACh)?

Choline, ekiriisa ekikyuka ne kifuuka acetylcholine, kisangibwa mu mmere nnyingi. Okugeza nga:

• Ekibumba ky’ente
• Amagi (naddala ebikuta) .
• Ennyama y’ente top round
• Soya ayokeddwa, ebinyeebwa by’ekibumba eby’omu bipipa
• Ebbeere ly’enkoko eryokeddwa
• Ebyennyanja bya Cod `(Cod)`
• Quinoa afumbiddwa
• Ffene wa shiitake afumbiddwa, broccoli afumbiddwa ne Brussels sprouts
• Amata (1%) `(Amata (1%))`, yogati wa vanilla atalina masavu `(wogati wa vanilla atalina masavu)`

Gezaako okugatta emmere zino mu mmere yo. Endya ennungi kikulu nnyo eri obulamu obulungi.