By’olina okumanya ku androgens!

Wali owuliddeko ku androgens? Mpozzi yee, mpozzi nedda. Naye kibinja kya busimu obubeera mu mibiri gyaffe gyonna era nga kikulu nnyo mu nkula yaffe ey’okwegatta n’obulamu bwaffe. Androgens zino ziringa abaweereza abato abakola emabega w’empenda mu mibiri gyaffe. Leero tugenda kubyogerako mu ngeri ennyangu gy’osobola okutegeera.

Mu ngeri ennyangu, androgens kika kya busimu bw’okwegatta. Zitufuula okukula, era ziyamba n’obulamu bw’enkola yaffe ey’okuzaala n’okukula kw’emibiri gyaffe. Oyinza okulowooza nti abasajja bokka be balina. Naye mu butuufu, ffenna, ka tubeere basajja oba bakazi, tulina ebirungo ebiyitibwa androgens mu mibiri gyaffe. Kyokka mu butonde zikolebwa mu bungi mu basajja. Testosterone, bangi ku ffe gwe tuwuliddeko, nayo ye androgen enkulu.

Kati oyinza okuba nga weebuuza obusimu buno gye buva. Androgens zisinga kukolebwa ensigo mu nkola y’okuzaala ey’ekisajja n’enkwaso mu nkola y’okuzaala ey’omukazi. Okugatta ku ekyo, obusimu buno era bukolebwa endwadde z’ekibumba ezisangibwa waggulu w’ensigo zaffe. Androgens teziri awo zokka. Bakola omulimu munene mu kukuuma enkulaakulana yaffe ey’okwegatta n’obulamu bwaffe okutwalira awamu. Emitendera gyazo giyinza okukyuka olunaku lwonna. Ate era, obusimu buno bukyuka ku mitendera egy’enjawulo mu bulamu bwaffe, gamba nga mu myaka gy’obuvubuka n’okuva mu nsonga.

Bika ki ebya androgens ebiriwo?

Nga bwe twagambye emabegako, testosterone ye androgen enkulu ffenna gye tulina. Androgens endala nnyingi ziyamba okukola obusimu obulala. Okugeza, androgens zino wammanga ziyamba okukola testosterone ne estrogen:

• Ekirungo kya Androstenedione
• Ekirungo ekiziyiza amazzi mu mubiri (DHEA) .
• Ekirungo kya DHEA sulfate (DHEA sulfate - DHEAS) .

Androgen endala ye dihydrotestosterone (DHT) . Bw’ogenda okaddiwa, omubiri gwo gukyusa ebitundu nga 10% ku testosterone wo mu DHT buli lunaku. Okugatta ku ekyo, waliwo ebika ebirala bingi ebya androgen n’eddagala eriwerako erikwatagana ne androgen. Engeri emibiri gyaffe gye gikozesaamu obusimu buno nzibu nnyo, ng’ekyuma ekinene.

Mpeereza ki ebiyitibwa androgens bye biwa emibiri gyaffe?

Androgens mu ffenna, awatali kufaayo ku kikula kyaffe, ziyamba ku bintu bino:

• Obugumu bw’amagumba: Bino byetaagisa nnyo okukuuma amagumba gaffe nga ganywevu.
• Enkula y’ebinywa: Bino nabyo byetaagibwa okukula kw’ebinywa .
• Obuvubuka: Zino ze nkyukakyuka enkulu ezibaawo okuva mu buto okutuuka mu bukulu.
• Okukola obutoffaali obumyufu (Erythropoiesis): Era buyamba mu kukola obutoffaali obumyufu mu mubiri gwaffe.
• Obwagazi n’enkola y’okwegatta: Bino bikosa enkula y’enneewulira z’okwegatta n’okwegatta.

Kiki ekituufu ekituuka ku basajja abalina androgens?

Androgens mu mubiri gw’omusajja ziyamba ku:

• Eddoboozi enzito (okuwanvuya omuguwa gw’eddoboozi): Eddoboozi ery’obugonvu lye walina ng’okyali mwana muto likyuka, era eddoboozi ly’ekisajja ne livaayo olw’ensonga eno. Teebereza, mutabani wa mukwano gwo akyusa eddoboozi mu bwangu, n'olowooza nti, "Ow'oluganda, kati mulenzi munene," nedda? Ensonga lwaki ekyo kiri bwe kityo ye androgens.
• Okweyongera obuwanvu: Obusimu buno era bukosa obuwanvu.
• Enviiri okukula mu maaso, olususu lw’oku mutwe, mu kifuba, mu nnyindo, n’ebitundu by’ekyama: Ebintu ng’okukula kw’ekirevu n’okukula kw’enviiri mu kifuba.
• Enkula y’ensigo: Zino zeetaagisa nnyo mu kukola ensigo ezeetaagisa okukola omwana.

Engeri zino ez’omubiri zisinga kutandika mu myaka gy’obuvubuka. Naye eddagala lya testosterone lirina emirimu egy’enjawulo ku mitendera egy’enjawulo egy’obulamu. Bw’ofuuka omuntu omukulu, mu butonde eddagala lyo erya ‘testosterone’ likendeera ng’okaddiwa.

Androgens zikwata zitya ku bakyala?

Mu bakyala, eddagala eddala ery’omubiri likyusa ekirungo kya androgen testosterone ne kifuuka estradiol, ekika ky’obusimu obuyitibwa estrogen . Estradiol eno:

• Enkula y’engeri z’okwegatta ez’okubiri mu kiseera ky’obuvubuka: okugeza, enkula y’amabeere n’okugaziwa kw’ebisambi.
• Atereeza okugenda mu nsonga: Ayamba okukuuma enzirukanya y’ensonga eya bulijjo.
• Aids conception and pregnancy: Bino bikulu nnyo mu kufunyisa omwana olubuto n’okutwala obulungi olubuto.
• Kikendeeza ku kufiirwa amagumba - Osteoporosis: Ayamba okukendeeza ku bulabe bw’obulwadde bw’amagumba , embeera ebaawo ng’amagumba gamenyese naddala nga tukaddiwa.

Emiwendo gya estradiol mu mubiri gwo gikyuka ku mitendera egy’enjawulo mu bulamu bwo. Oluvannyuma lw’okuggwaamu amaanyi mu nsonga, nga kino kwe kukoma okugenda mu nsonga buli mwezi, omubiri gwo tegukola estradiol mungi.

Bizibu ki abasajja bye balina ku androgens?

Abasajja basinga kukosebwa mbeera eyitibwa male hypogonadism, nga eno y’okukendeera kw’obungi bwa androgen, oba testosterone. Kino kiyinza okuvaako obwagazi okukendeera n’okulemererwa okusituka.Obubonero nga: Bw’oba ​​olina ekintu nga kino, kikulu nnyo okwogera n’omusawo nga tokikuumye ku ggwe n’okweraliikirira.

Ku bantu abamu, androgens zisobola okuleeta kookolo w’enseke . Mu mbeera ng’ezo, oyinza okwetaaga okumira eddagala okukendeeza ku busimu obukola omubiri mu butonde obuyitibwa androgens. Abasawo obujjanjabi buno babuyita Androgen Deprivation Therapy (ADT) .

Androgens – naddala DHT (Dihydrotestosterone) – nazo zikwatagana n’ekiwalaata eky’omusajja , embeera eyitibwa androgenic alopecia . Obusimu buno era buyamba ku kiwalaata abantu bangi kye bayita ‘waxiness’.

Bizibu ki abakyala bye balina ku androgens?

Abakyala basinga kukosebwa bizibu by’okweyongera kw’emiwendo gya androgen (hyperandrogenism) . Ekisinga okuvaako kino y’embeera eyitibwa Polycystic Ovary Syndrome (PCOS) . Kino PCOS kintu ekirabibwa mu bakyala bangi ennaku zino. Obadde okimanyi nti PCOS oluusi esobola okuleeta okulwawo okufuna olubuto? Tekitera kubaawo, emiwendo gya androgen nagyo giyinza okweyongera olw’ebizimba mu nseke z’ekibumba oba enkwaso.

Abantu abalina PCOS, oba abo abalina ebirungo ebiyitibwa androgens ebingi, bayinza okufuna obubonero nga:

• Embalabe: Ensigo zirabika mu maaso, mu kifuba n’omugongo. Oluusi ebizimba bino biyinza okunyiiza ennyo.
• Amenorrhea oba irregular menstruation: Okugenda mu nsonga ezitabaawo mu kiseera ekituufu, oba okulwawo okumala emyezi.
• Enviiri ezisukkiridde okukula (hirsutism): Enviiri ezitayagala ku kalevu, mu kifuba ne mu lubuto, gamba ng’enviiri. Kino era kiyinza okukosa abakyala bangi mu birowoozo.
• Puleesa ne kolesterol omungi.
• Okukaluubirirwa okuzaala abaana (Obutazaala).
• Omugejjo: Okugejja ennyo.

Androgens – naddala DHT (Dihydrotestosterone) – nazo zisobola okukosa ekiwalaata ky’ekikazi . Abakyala abamu nabo bafuna enviiri ezigwa mu bitundutundu n’olususu lw’oku mutwe olufuuse ekiwalaata, nedda? Obusimu buno nakyo bulina kye bukola ku ekyo.

Bizibu ki ebiyinza okuva ku miwendo gya androgen mu baana abato?

Obuzibu obuva ku miwendo gya androgen mu baana buyinza okuvaako okulwawo okutuuka mu myaka gy’obuvubuka oba okuvubuka nga tebunnatuuka.Yee, kisoboka. Wayinza okubaawo ensonga eziwerako eziviirako buli emu ku zino. Ng’ekyokulabirako, abaana abamu balaga obubonero obw’okutuuka mu myaka gy’obuvubuka nga bukyali nnyo okusinga abalala. Era abaana abamu tebatuuka mu myaka gya buvubuka ne bwe baba batuuse mu myaka gy’obuvubuka. Bino byombi mbeera ezeetaaga okujjanjabibwa.

Emiwendo gya Androgen nagyo gikwatagana n'embeera eziyitibwa obuzibu mu nkula y'okwegatta . Kino kitegeeza ekibinja ky’embeera ez’enjawulo nga 60 ng’omuntu alina engeri z’ekisajja n’ez’omukazi. Embeera zino zibeera nzibu nnyo, n’olwekyo zeetaaga okufaayo okw’enjawulo okuva mu basawo.

Abasawo bapima batya emiwendo gya androgen?

Okukebera oba omukyala alina ekirungo kya androgen ekinene, abasawo batera okukozesa ekigezo ekiyitibwa Free Androgen Index (FAI) . FAI epimibwa nga bakwata omusaayi ne bapima bino wammanga:

• Omugatte gwa testosterone
• Testosterone ya bwereere
• Globulin esiba obusimu bw’okwegatta (SHBG) .

SHBG ye puloteyina etambuza ebirungo ebiyitibwa androgens (nga testosterone ne DHT) ne estrogen mu musaayi. Omusawo wo ajja kubala emiwendo gyo egya androgen ng’ageraageranya emiwendo gyo gyonna egya testosterone ne SHBG.

Ku basajja, abasawo batera okulagira okukeberebwa omusaayi gw’obusimu obuyitibwa testosterone okukebera oba testosterone mutono.

Naye jjukira nti okukebera omusaayi kuno kwokka tekuyinza kukubuulira buli kimu. Omusawo ajja kusalawo ng’asinziira ku bintu bingi omuli obubonero bwo n’okukeberebwa omusawo.

Kale, bubaka ki bwe tusaanidde okutwala awaka okuva mu bino byonna?

Androgens zeetaagisa nnyo mu bulamu bw’okuzaala n’obulamu obulungi okutwalira awamu bwaffe ffenna, abakyala, abasajja, abato n’abakulu. Naye bino okusobola okukola obulungi, kyetaagisa okubaawo bbalansi entuufu . Okufaananako minzaani, bwe kiba kizitowa nnyo ku ludda olumu, wabaawo ekizibu. Kitono nnyo, waliwo ekizibu; ekisusse, waliwo ekizibu.

Bw’oba ​​olina obubonero bw’obungi bw’ekirungo kya androgen ekitono oba ekinene, okugeza, nga bwe kyayogeddwako emabegako, obutaba na bwagazi, okukaluubirirwa okufuna obwagazi mu basajja, okugenda mu nsonga ezitali za bulijjo, enviiri ezisukkiridde okukula, embalabe mu bakyala, oba omwana okulwawo oba okukula amangu, kakasa nti olaba omusawo akuwe amagezi . Olwo omusawo asobola okukola ebigezo ebyetaagisa n’amanya ddala ekikuleetera obubonero. Tofaayo, emirundi mingi wabaawo obujjanjabi obulungi ku kino.

Jjukira nti ggwe osinga okumanya omubiri gwo. Bw’olaba enkyukakyuka oba obutali bwa bulijjo, kiba kya magezi okunoonya amagezi g’abasawo mu kifo ky’okububuusa amaaso.

` Androgens, Testosterone, Hormones, Obulamu bw'okuzaala, PCOS, Obulamu bw'abasajja, Obulamu bw'abakyala