Kizibu okussa mu bigambo ennaku gy’owulira ng’olaba omuntu ow’omu maka oba mukwano gwo ow’oku lusegere ng’agenda yeerabira mpolampola buli kimu n’atasobola kukola wadde emirimu gya buli lunaku ku lulwe. Obulwadde bwa Alzheimer mbeera bwetyo emenya omutima. N’okutuusa kati, wabaddewo ddagala lyokka erifuga obubonero, naye kati ensi eyogera ku bujjanjabi obupya obutunuulidde butereevu ekivaako obulwadde buno. Leero twogera ku ssuubi lino eppya, nga lino lye Anti-Amyloid therapy.
Mu ngeri ennyangu, obujjanjabi buno obwa Anti-Amyloid kye ki?
Mu bwongo bw’omuntu alina obulwadde bwa Alzheimer, ekika kya puloteyina ekiyitibwa `beta-amyloid` kikuŋŋaanyizibwa mu ngeri eteetaagisa. Kilowoozeeko ng’akasannyalazo akayita mu waya y’amasannyalaze, nga eno y’engeri amawulire gye gatambulamu wakati w’obusimu obuyitibwa neurons mu bwongo bwaffe. Puloteeni eyo eya `beta-amyloid` ekuŋŋaanyizibwa n’ekola `plaques` eziringa obusagwa wakati w’obutoffaali buno obw’obusimu. Kino olwo kitaataaganya entambula y’amawulire. Eno y’ensonga enkulu ereetera omuntu okubulwa okujjukira n’obutasobola kulowooza bulungi.
Ekika kino ekipya eky’eddagala, ekiyitibwa anti-amyloid, kikola nga kiggyawo ebikuta bya `beta-amyloid` ebikuŋŋaanyiziddwa mu bwongo. Ekyo kitegeeza nti elumba ekivaako obulwadde buno okusinga okunyigiriza obubonero buno. Essuubi liri nti singa tuggyawo ebikuta bino, obutoffaali bw’obwongo bujja kusobola okukola obulungi okumala ebbanga eddene.
Bino mu butuufu bibeera mu kibinja ky’obujjanjabi obuyitibwa `immunotherapy`. Okubeera omutuufu, eddagala lino liweebwa ng’ekika ky’ekirungo ekiziyiza obulwadde (monoclonal antibody) ekikoleddwa mu ngeri ey’enjawulo mu laboratory. Antibodies zino bwe ziyingira mu mibiri gyaffe, zisanga proteins ezo ez’obulabe `beta-amyloid`, ne zizikwatako, ne zizisaanyaawo.
Eddagala ebbiri erikulu eritta amyloid erikkirizibwa mu kiseera kino lye `donanemab (Kisunla)` ne `lecanemab-irmb (Leqembi)`. Waliwo n’eddagala eriyitibwa `aducanumab (Aduhelm),` kyokka kati kkampuni eyalikola liggyiddwa ku katale.
Obujjanjabi buno nfuna ntya? Waliwo ebizibu byonna ebivaamu?
Eddagala lino liweebwa nga liyita mu saline solution (IV infusion) mu musuwa. Kino kitwala essaawa nga emu. `Leqembi` etera okuweebwa buli luvannyuma lwa wiiki bbiri, ate `Kisunla` etera okuweebwa buli luvannyuma lwa wiiki nnya. Otandika n’akatono n’oyongera mpolampola okutuuka ku ddoozi omusawo gy’akulagidde.
Naye olina okumanya akabi akasinga okuva mu bujjanjabi buno. Kiyitibwa `ARIA (Amyloid-Related Imaging Abnormalities)`.
Mu ngeri ennyangu, kino kiyinza okuvaako okuzimba okumu mu bwongo oba obutundutundu obutonotono obw’omusaayi munda mu bwongo. Wadde nga kino kitera okugonjoola ku bwakyo, kikulu okukuuma kino eriiso. Eno y’ensonga lwaki olina okukeberebwa obwongo buli kiseera mu MRI mu kiseera kyonna eky’obujjanjabi buno.
| Ekika ky’ebizibu ebivaako | Okunnyonnyola |
|---|---|
| ARIA (akabi akanene) . | Okuzimba oba okuvaamu omusaayi omutono mu bwongo. Kino kiyinza okuvaako okulumwa omutwe, okuziyira, okuziyira, okutabulwa, n’obuzibu mu kulaba. |
| Ebizibu ebirala ebivaamu | - Obulwadde bwa allergy - Ebigwa - Embiro |
| Okufaayo okw’enjawulo | Bannasayansi bateebereza nti obujjanjabi buno buyinza okwongera obulabe bw’okuvaamu omusaayi mu bwongo singa buweebwa omuntu amira eddagala eriweweeza ku musaayi. Mazima ddala olina okwogera n’omusawo wo ku nsonga eno. |
Ddala eddagala lino likola litya?
Laba ekitundu ekizibu. Okunoonyereza kulaga nti eddagala lino lisobola okuggyawo ebipande bya `beta-amyloid` mu bwongo. Ekyo kintu kirungi.
Kyokka, wakyaliwo enjawulo mu ndowooza ku ngeri omulwadde gy’agenda okutereera mu butuufu okujjukira n’obusobozi bw’okukola emirimu gya buli lunaku oluvannyuma lw’okuggyawo ebipande ebyo. Okunoonyereza okumu kulaga nti bino bisobola okukendeeza katono obulwadde buno okukula. Ekyo tekitegeeza nti obulwadde buno buwonye ddala, wabula bukendeeza ku bulwadde buno okweyongera.
Bannasayansi balowooza nti ebivaamu ebisinga obunene bisobola okusuubirwa singa obujjanjabi buno butandikibwa mu mitendera egy’okusooka egy’obulwadde , ng’obwongo tebunnatuuka ku kwonooneka kwa maanyi.
Ani ayinza okufuna obujjanjabi buno?
Buno si bujjanjabi obuyinza okuweebwa buli mulwadde wa Alzheimer. Mu kiseera kino, bino bisemba ku bantu batono nnyo.
- Ku bantu abali mu ntandikwa y’obulwadde buno: Kwe kugamba, abo abalina obulwadde bwa Alzheimer obutandika amangu oba abo abalina embeera eyitibwa ‘mild cognitive impairment’. Tekinnamanyika oba kino kinaaba kya mugaso eri abantu abalina obulwadde obusingako.
- Ku abo abakakasibwa nti balina ebipande bya amyloid:Omusawo nga tannakuwa ddagala lino, balina okukakasa oba ddala ebikuta bino biri mu bwongo bwo. Kino kiyinza okuzingiramu okukebera PET oba okukuba ttaapu y’omugongo.
Ani atasobola kufuna bujjanjabi buno?
Eddagala lino terinnanoonyezebwa mu kugezesebwa kungi, n’olwekyo kiyinza okuba eky’akabi okuwa abantu abalina ebizibu by’obulamu bino wammanga obujjanjabi buno:
- Abantu abamira eddagala eriziyiza omusaayi okuzimba (okuggyako aspirin).
- Abo abaali bafunye obulwadde bw’omutima oba okusannyalala.
- Abantu abalina obuzibu mu kuvaamu omusaayi.
- Abantu abalina obulwadde bw’ekibumba oba ekibumba.
Ekirala, obujjanjabi buno bwa bbeeyi nnyo . Mu nsi nga Sri Lanka, kiyinza okuba ekizibu abantu bangi okufuna bino. Bino si bya bulijjo nnyo mu kiseera kino.
Obubaka Obutwala Awaka
- Anti-amyloid kika kya ddagala kipya eriggyawo ebikuta bya `beta-amyloid' ebikuŋŋaanyizibwa mu bwongo era nga bisobola okuleeta obulwadde bwa Alzheimer.
- Kino kigendereddwamu okujjanjaba ekivaako obulwadde buno okusinga obubonero.
- Kino kiyinza okuweebwa abalwadde bokka abali mu ntandikwa y’obulwadde buno era nga bakakasiddwa nti balina ebikuta mu bwongo.
- Olw’obulabe bw’okuzimba obwongo oba okuvaamu omusaayi mu ARIA, okulondoola buli kiseera nga bakozesa MRI scans kyetaagisa nnyo mu kiseera ky’obujjanjabi.
- Kitegeere nti obujjanjabi buno bukyali mu mutendera gw’okunoonyereza, bwa bbeeyi nnyo, era bufunibwa abantu batono bokka .
- Singa omwagalwa wo aba n’obubonero bw’obulwadde bwa Alzheimer, ekisinga obulungi kwe kwogera n’omusawo wo ku bisingawo n’engeri z’obujjanjabi ezikusaanira.
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