Omwana wo olubuto lumuluma bubi? Kiyinza okuba obulwadde bwa Hemolytic Uremic Syndrome (HUS)!

Omwana wo omuto amaze ennaku ntono ng’afuna ekiddukano ng’olubuto lumuluma? Oyinza n’okulaba omusaayi mu kyo. Kya bulijjo ggwe ng’omuzadde okweraliikirira ennyo ng’ekyo kituuse. Bw’oba ​​n’obubonero nga buno, kiyinza okusinga okulumwa olubuto. Leero tugenda kwogera ku mbeera eyinza okuba ey’amaanyi, naye nga ejjanjabibwa nnyo singa etegeerekeka nga bukyali. Ekyo kye (Hemolytic Uremic Syndrome) , oba (HUS) mu bufunze.

Obulwadde bwa Hemolytic Uremic Syndrome (HUS) kye ki? Ka tukitegeere mu ngeri ennyangu.

Okay, kati katutunuulire kino (HUS) kye ki. Mu ngeri ennyangu, mbeera ng’emisuwa emitonotono mu nsigo zaffe gizibikira . Lowooza ku payipu y’amazzi okuzibikira amazzi ne galekera awo okukulukuta. Okuzibikira kuno kuleetera ebintu bisatu ebikulu okubaawo:

1. Obutoffaali bwo obumyufu busaanawo: Mu ddagala, kino kiyitibwa hemolytic anemia . Obutoffaali obumyufu bwe butambuza omukka gwa oxygen mu mibiri gyaffe gyonna. Kale bwe zisaanawo, omukka gwa oxygen omubiri gwe gwetaaga gukendeera.

2. Omuwendo gwa platelets mu musaayi gukendeera: Embeera eno eyitibwa thrombocytopenia . Platelets butoffaali butono obuyamba omusaayi gwaffe okuzimba nga tuvaamu omusaayi. Bino bwe bikendeera, kizibu okukomya omusaayi, era ebiwundu bisobola okubaawo mu mubiri gwonna.

3. Okwonooneka kw’ekibumba: Kino kye kintu ekisinga okuba eky’obulabe. Ensigo bwe zitakola bulungi, tezisobola kuggyamu kasasiro akuŋŋaanyizibwa mu mubiri. Kino era kiyitibwa (Acute Kidney Injury - AKI) .

Wadde nga HUS esobola okukwata omuntu yenna, esinga kuva ku bulwadde bwa bakitiriya naddala Escherichia coli , emanyiddwa ennyo nga E. coli . Obuwuuka buno bwe buvaako ekiddukano naddala ekiddukano ekiva mu musaayi. Wabula, obulwadde (syndrome) kwe kukungaanya obubonero, era HUS nayo esobola okubaawo olw’ensonga endala okuggyako E. coli.

Embeera eno (HUS) tesobola kukosa nsigo zokka, wabula oluusi ebitundu ebirala ng’omutima n’obwongo. Wabula businga kukwata nsigo.

Ekisinga obukulu: Ggwe oba omwana wo bw’oba ​​n’ekiddukano ekiva mu musaayi oba ng’ekiddukano okumala ennaku ezisukka mu ssatu, kakasa nti ogenda ew’omusawo. Singa tejjanjabibwa, HUS eyinza okufuuka ey’amaanyi era n’etuuka n’okutta omuntu.

Waliwo ebika bya HUS eby’enjawulo?

Yee, waliwo ebika ebikulu ebiwerako ebya (HUS). Ka tuyigeko katono ku bo:

1. "Typical" (HUS): Kino kye kika ekisinga okumanyibwa . Kisinga kuva ku bulwadde bwa bakitiriya naddala E. coli obukosa ekyenda kyaffe ekitono n’ekyenda ekinene.

2. "Atypical" (HUS) (aHUS): Kino kisingako katono.Kino kitera kuva ku nsonga z’obuzaale, ekitegeeza nti kisikira abazadde okutuuka ku baana.

3. "Secondary" (HUS): Ekika kino kibeerawo nga kikwatagana n'embeera endala ez'obujjanjabi. Okugeza, kiyinza okuva ku ddagala erimu, yinfekisoni endala oba olubuto.

Ka tuyige ebisingawo katono ku "Atypical" (HUS) (aHUS)

(aHUS) mbeera etali ya bulijjo nnyo. Era kiyinza okuleeta obubonero bwe bumu n’obwo obw’emabega:

• Okukendeera kw’obutoffaali obumyufu mu musaayi.
• Okukendeera kw’omuwendo gw’obutoffaali obukola omusaayi.
• Okulemererwa kw’ekibumba okw’amangu (okulemererwa kw’ekibumba okw’amangu) .
• Puleesa (hypertension) oba obutasobola kufuga puleesa.

Embeera eno (aHUS) etera okuba obuzibu mu buzaale . Kwe kugamba, kiva ku nkyukakyuka ezimu (enkyukakyuka) mu buzaale bwaffe. Kyokka, ne bwe kiba nti embeera eno ey’obuzaale ebaawo, eva ku yinfekisoni, endwadde oba obutonde.

(HUS) ya bulijjo etya?

Abantu abali wakati wa 5% ne 15% abafuna ekiddukano ekiva ku bakitiriya (E. coli) bajja kufuna HUS . Ekika ekiyitibwa (aHUS) tekitera kubaawo nnyo. Bubeera mu bantu nga omu ku buli bukadde.

Bubonero ki obukulu obulaga (HUS)?

Kikulu nnyo okuba ng’omanyi obubonero buno.

Obubonero obusooka okulabika:

• Ekiddukano: Ebiseera ebisinga kiwerekerwako omusaayi.
• Obulumi mu lubuto.
• Okuziyira n’okusiiyibwa.
• Okulumizibwa omutwe .
• Okuziyira n’omusujja.

Ebintu ebirala ebirabika:

• Okunyiga ebiwundu ebyangu.
• Olususu olumyufu (pallor): Munda mu nnyindo ne munda mu kamwa luyinza okufuuka olumyufu.
• Okusoberwa.
• Ensimbu.
• Embeera eziringa okusannyalala.
• Omutima okukuba amangu (arrhythmia).

Singa embeera ya (HUS) efuuka ya maanyi, obutoffaali obumyufu obusaanawo busobola okuleeta okuzimba omusaayi n’okwonoona ebitundu by’omubiri ng’ensigo. Olwo ensigo teziyinza kusengejja bulungi kasasiro. Kino kye tuyita (Acute Kidney Injury - AKI) . Buno bwe bubonero bwakyo:

• Omusaayi mu musulo (hematuria).
• Obutwa bweyongera mu musaayi: Kino kiyinza okuvaako obutabeera bulungi n’okuwulira ng’alwadde.
• Puleesa eri waggulu.
• Obuzibu mu kussa (dyspnea).
• Okuzimba: Okuzimba kuyinza okubaawo naddala mu magulu n’enkizi.
• Okukendeera kw’omusulo ogufuluma (oliguria).

Biki ebikulu ebivaako (HUS)?

Emisango egisinga egya HUS giva ku bika ebimu ebya obuwuka bwa E. coli. Obuwuuka buno bukola obutwa obuyitibwa Shiga toxin . Obutwa buno bwonoona obuwundo bw’ekyenda kyaffe ekitono ne buleeta ekiddukano. Obutwa buno era buyingira mu musaayi, ne busaanyaawo obutoffaali obumyufu n’okwonoona ensigo.

Otera okufuna obulwadde bwa E. coli okuva ku:

• Ennyama efumbiddwa bulungi: naddala ennyama y’ente, ennyama y’ente ensaanuuse.
• Amata n’ebyokunywa ebitaliimu pasteurized: Pasteurization nkola ya kufumbisa mpola era etta ebintu eby’obulabe nga bakitiriya.
• Ebibala n’enva endiirwa ebitayozeddwa, ebicaafu.

Ebika bino ebya E. coli ebikola obutwa era biyitibwa Shiga toxin-producing E. coli (STEC) . Ekika kya STEC ekisinga okubeera mu North America ye E. coli O157:H7 .

Tekitera nnyo, eddagala n'ebintu ebimu nabyo bisobola okuleeta "secondary (HUS)". Eby’okulabirako:

• Eddagala erijjanjaba eddagala: nga (bleomycin), (cisplatin), (gemcitabine).
• Eddagala eriweweeza ku busimu bw’omubiri: nga (cyclosporine), (tacrolimus).
• Quinine: Eddagala eriwonya omusujja.
• Ebiragalalagala ebimu : (oxymorphone), (ecstasy), (cocaine).

(HUS) esiigibwa?

Nedda, HUS si ya kusiigibwa.

Wabula obuwuka bwa E. coli busobola okusaasaanyizibwa. Obuwuuka buno busobola okusiigibwa nga buyita mu mmere oba ekyokunywa ekirimu obucaafu, oba nga bukwatagana n’omusulo gw’omuntu oba ekisolo ekirina ekiddukano ekirimu E. coli. N’olwekyo, kikulu okwegendereza ennyo obuyonjo.

Ani asinga okulwala (HUS)?

Wadde nga omuntu yenna asobola okulwala HUS, abantu bano wammanga bali mu bulabe bwa maanyi:

• Ku baana abali wansi w’emyaka 5.
• Ku abo abalina abaserikale b’omubiri abanafu (immunocompromised).
• Singa omuntu mu maka go abadde ne HUS emabegako (naddala aHUS).
• Bw’ofuna obulwadde bwa E. coli: Naddala okuva mu bintu ng’ennyama efumbiddwa bulungi n’amata agatali ga pasteurized.
• Okukwatagana obutereevu n’omuntu alina ekiddukano ekiva ku E. coli.

Omanya otya oba olina (HUS)? (Okuzuula obulwadde)

Bw’olaba omusawo, ajja kukola ebintu bino:

• Buuza ku byafaayo byo eby'obujjanjabi .
• Buuza ku byafaayo by'obujjanjabi bw'amaka go .
• Okukebera omubiri kukolebwa.

Singa ebintu bino bireeta okwekengera embeera ya HUS, omusawo ajja kulagira okukeberebwa okulala okuwerako.

Ebigezo bya ngeri ki ebikolebwa?

• Okwekenenya omusulo: Omusulo gwo guggyibwako ne gukeberebwa oba teguliimu puloteyina oba omusaayi.
• Okukebera omusaayi: Omusaayi gutwalibwa okukebera ebintu ng’obutoffaali obumyufu, obutoffaali obukola omusaayi, n’engeri ensigo n’ekibumba gye bikolamu obulungi.
• Okukebera omusulo: Sampuli y’omusulo bagiggyibwa ne bakeberebwa oba waliwo obuwuka obuleeta HUS, nga E. coli O157.
• Okukebera obuzaale: Oluusi, omusaayi gwo guyinza okusindikibwa okukeberebwa obuzaale. Kino kiyinza okuyamba okuzuula oba olina embeera y’obuzaale nga aHUS n’obujjanjabi ki obusinga okukuyamba.
• Kidney biopsy: Kino kizingiramu okukwata akatundu akatono ku kibumba n’okyekebejja mu microscope okulaba obungi bw’okwonooneka kw’ensigo n’ekyo ekizireese. Kino si buli muntu nti kyetaaga.

Okukebera kuyinza kutya okukakasa nti olina HUS?

• Okuva mu kukebera omusulo: Singa mu musulo mubaamu omusaayi oba puloteyina.
• Okukebera omusaayi: Singa obutoffaali obumyufu n’obutoffaali obukola omusaayi biba bitono, oba singa emiwendo egiraga enkola y’ekibumba (nga creatinine) giba gya waggulu.
• Okukebera omusulo: Singa obuwuka nga (E. coli O157) buzuulibwa.
• Okukebera ekibumba: Okwonooneka okwetongodde ku kibumba kuyinza okulabibwa.

(HUS) ejjanjabwa etya?

Singa ozuulibwa nti olina HUS, ojja kwetaaga okuweebwa ekitanda mu ddwaaliro n’okujjanjabibwa. Obujjanjabi bw’oyinza okukozesa mulimu:

• Amazzi agateekebwa mu misuwa (IV) ne/oba okuliisa mu ttanka (endya ey’omu lubuto): Kino kiyamba okuziyiza okuggwaamu amazzi mu mubiri n’okuwa ebiriisa ebyetaagisa.
• Eddagala:
• Bagezaako okukendeeza ku kwonooneka kw’ensigo nga bawa eddagala erikendeeza puleesa (antihypertensives) .
• Abantu abalina aHUS bayinza okuweebwa eddagala eryenjawulo nga eculizumab oba ravulizumab . Nga tonnatandika ddagala lino, kikulu okugemebwa endwadde za meningococcal ne pneumococcal , kuba eddagala lino lyongera obulabe bw’okufuna endwadde ezo.
• Oyinza okwetaaga okumira eddagala eritta obuwuka okumala waakiri wiiki bbiri.
• Okuteekebwamu omusaayi: Okuwa omuntu alina (HUS) obutoffaali obumyufu n’obutoffaali obukola omusaayi kikulu nnyo. Obutoffaali obumyufu bukendeeza ku bubonero bw’okukendeeza ku musaayi, gamba ng’okussa obubi n’omutima okukuba amangu. Platelets ziyamba omusaayi okuzimba obulungi, ne kikendeeza ku kuvaamu omusaayi n’okunyiga.

Singa ensigo eyonoonese nnyo, kiyinza okwetaagisa okulongoosa omusaayi okutuusa ng’ensigo zitereera. Singa ekibumba kiremererwa ddala olw’obulwadde bwa HUS, kiyinza okwetaagisa okukyusa ekibumba .

HUS esobola okuwona ddala?

Yee, abantu bangi bawona HUS awatali kwonoona bulamu bwabwe obw’olubeerera.

Wabula abantu abamu naddala abaana abato bayinza okufuna obulwadde bw’ekibumba obutawona (CKD) mu bitundu 20% okutuuka ku 50%. Obulwadde bw’ekibumba obw’omutendera ogw’enkomerero (ESK) busobola okukula mu bitundu 3% ku 5%. Okunoonyereza kulaga nti CKD ekosa abantu abakulu nga 45%.

Abantu abasoba mu 85% abafuna HUS baddamu mu bujjuvu enkola y’ekibumba kyabwe. Kyokka ne bwe banaawona ddala, emikisa emitono nti bajja kufuna puleesa oba obuzibu obulala mu kibumba mu biseera eby’omu maaso.

HUS esobola okuziyizibwa?

Bino bye bimu ku bintu by’oyinza okukola okuyamba okuziyiza obulwadde bwa E. coli, obukulu obuvaako HUS. Bino bikulu nnyo gy’oli n’ab’omu maka go:

• Weewale okuwuga mu bifo ebicaafu (ennyanja, emigga), naddala ng’olowooza nti amazzi galimu obuwuka bungi.
• Bw’oba ​​olina ekiddukano togenda kuwuga.
• Weewale okunywa ebyokunywa ebitali bya pasteurized (ebibisi) (amata, omubisi gw’ebibala).
• Bulijjo oyoze bulungi ebikozesebwa mu ffumbiro (ebiso, fooro, ebijiiko) n’ebifo we bategekera emmere (counters, cutting boards, amasowaani).
• Fumba bulungi amagi n’ennyama ensaanuuse okutuuka ku bbugumu ery’omunda erya diguli 71 (diguli 160), n’enkoko ku bbugumu ery’omunda erya diguli 74 (diguli 165).
• Bw’oba ​​oggyamu omuzira mu nnyama, giteeke mu microwave oba mu firiigi. Togiggyamu bbugumu mu kifo w’oteekateeka emmere oba mu mazzi agookya.
• Emmere embisi n’enfumbe gikuume nga zaawukana.
• Naaba bulungi mu ngalo ne ssabbuuni n’amazzi agookya nga tonnalya, ng’omaze okukozesa ekinabiro, ng’omaze okukyusa obuwale bw’abaana obutono, n’oluvannyuma lw’okukwata ku bisolo by’oku faamu.

Lowooza, bw’ogoberera emitendera gino egyangu, osobola okwekuuma embeera ey’amaanyi nga eno.

Kiki ky’oyinza okusuubira bw’oba ​​olina (HUS)?

Singa bazuuliddwa bulungi n’obujjanjabi, abantu abasinga obungi abalina HUS bawona mu bujjuvu awatali kwonoona bulamu bwabwe obw’olubeerera. Wabula waliwo akabi k’okufuna puleesa oba embeera endala ezikosa ensigo mu biseera eby’omu maaso.

Emisango egy’amaanyi egya HUS naddala singa gikwata ebitundu ebirala, gamba ng’obwongo, giyinza okutta singa tegijjanjabwa.

Emikisa ki egy’okuwona (HUS)?

Singa bazuuliddwa bulungi n’obujjanjabi, abantu abasoba mu 90% bawona HUS. Kale kikulu obutasattira n’okunoonya amangu abasawo amagezi bw’oba ​​olina obubonero.

Nze nneerabirira ntya?

Bw’oba ​​ggwe oba omwana wo olina ekiddukano eky’amaanyi, kikulu nnyo okugezaako okuzza amazzi mu mubiri gwo.Ebyokunywa ebizzaamu amazzi mu mubiri nga Jeevani bisobola okuyamba okukyusa amasannyalaze agabula. Abalongo n’abaana abato bayinza okwetaaga okuweebwa amata g’amabeere oba amata. Buuza omusawo ku ngeri esinga obulungi ey’okukuuma omwana wo ng’alina amazzi mu mubiri.

Ddi lwe nnina okulaba omusawo?

Laba omusawo mu bwangu bw’oba ​​olina obubonero buno:

• Ekiddukano ekivaamu omusaayi.
• Ekiddukano ekimala ennaku ezisukka mu ssatu.
• Okuzimba omubiri.
• Olususu olunyiga amangu.
• Obukoowu obw’amaanyi.

Bibuuzo ki bye nnina okubuuza omusawo?

Osobola okubuuza omusawo ebibuuzo bino:

• Okakasa otya oba nnina obulwadde bwa Hemolytic Uremic Syndrome?
• Nnafuna ntya obulwadde bwa Hemolytic Uremic Syndrome?
• Bwemba sirina bulwadde bwa Hemolytic Uremic Syndrome, mbeera ki endala ey’obujjanjabi gye nnyinza okuba nayo?
• Bujjanjabi ki bw’oteesa?
• Ensigo zange zinaayonooneka enkalakkalira?
• Nnafuna puleesa oba obuzibu obulala mu kibumba mu biseera eby’omu maaso?

Biki ebisatu eby’obulwadde bwa Hemolytic Uremic Syndrome?

Triad bwe bubonero obukulu busatu obugatta embeera y’obujjanjabi ezimu.

Enkola ya Hemolytic Uremic Syndrome triad erimu:

1. Okwonooneka kw’obutoffaali bwo obumyufu (microangiopathic hemolytic anemia) .

2. Okukendeera mpolampola mu muwendo gw’obutoffaali obukola omusaayi mu musaayi gwo (thrombocytopenia) .

3. Obuvune obw’amaanyi mu kibumba.

Bwemba nnina ekiddukano kitegeeza nti nnina obulwadde bwa Hemolytic Uremic Syndrome?

Olw’okuba olina ekiddukano tekitegeeza nti olina obulwadde bwa Hemolytic Uremic Syndrome. Wabula bw’oba ​​olina ekiddukano ekivaamu omusaayi, oba ekiddukano kyo bwe kiba kya maanyi (okutuuka ku ssa ly’ekiddukano eky’amazzi oba okumala ennaku ezisukka mu ssatu), mazima ddala wandibadde olaba omusawo.

Njawulo ki eri wakati wa (Hemolytic Uremic Syndrome) ne (Thrombotic Thrombocytopenic Purpura - TTP)?

Obulwadde bwa Hemolytic Uremic Syndrome (HUS) ne Thrombotic Thrombocytopenic Purpura (TTP) mbeera bbiri ezifaanagana. Mu TTP, ebizimba by’omusaayi bitondebwa mu misuwa emitono. Wadde ng’abasawo baali bagatta HUS ne TTP mu bibinja, kati zitwalibwa ng’embeera ez’enjawulo.

N’ekisembayo, ebintu by’olina okujjukira (Obubaka bw’okutwala awaka) .

Ekiddukano kitera okuba embeera ey’ekiseera ekitono, naye nga tekinyuma. Ebiseera ebisinga kitereera mu lunaku lumu oba bbiri. Wabula bw’oba ​​olina ekiddukano ekiva mu musaayi, oba ng’olina ekiddukano okumala ennaku ezisukka mu ssatu, wamu n’okuwulira ng’okooye, ng’ozirika oba okuyisa omusulo omutono ng’ogenda mu kinaabiro, kye kiseera okulaba omusawo amangu ago.

Embeera eyitibwa Hemolytic Uremic Syndrome esobola okwonoona ennyo ensigo zo n’okukosa ebitundu by’omubiri ebirala.Gy’okoma amangu okufuna obujjanjabi ku kino, gy’okoma okukendeera okwonooneka kw’ensigo zo okumala ebbanga eddene. N’olwekyo, beera mwegendereza obubonero, kuuma obuyonjo obulungi, era funa amagezi g’abasawo bw’oba ​​olina ekikweraliikiriza. Obulamu bwo bukulu nnyo gyoli!

` Hemolytic Uremic Syndrome, HUS, Obulwadde bw’ekibumba, Ekiddukano, E. coli, Obutoffaali obumyufu, Platelets, Obulamu bw’abaana