Ka tuyige ebisingawo ku Leptin, akuyamba mu nkukutu okufuga obuzito bwo.

Ffenna tweraliikirira obuzito bwaffe oluusi, si bwe kiri? Abantu abamu baagala kugejja, ate abalala baagala okukuuma omugejjo omulungi. Wali olowoozezzaako nti waliwo akakodyo akatono munda mu mibiri gyaffe akatuyamba okufuga obuzito bwaffe? Leptin y’emu ku bifuga eby’ekyama ng’ebyo. Leero, ka twogere ku leptin eno mu ngeri ennyangu gy’osobola okutegeera.

Leptin kye ki?

Mu ngeri ennyangu, leptin busimu obukolebwa obutoffaali bw’amasavu oba amasavu mu mubiri gwo . Kiringa enkola entono ey’okulaga obubonero obukuyamba okufuga obuzito bwo okumala ebbanga eddene. Ekyo kikola kitya? Leptin afuga enjala yo era akuyamba n’okuwulira ng’ojjudde oba okukkuta .

Lowooza ku kino: leptin eringa omubaka ategeeza obwongo bwo amasavu g’olina mu mubiri gwo. Bannasayansi baazuula leptin gye buvuddeko mu 1994. Kale wakyaliwo okunoonyereza kungi okugenda mu maaso, okutegeera ddala engeri gy’ekola. Leptin yanoonyezebwa dda olw’omulimu gwayo mu kuziyiza omugejjo, obulwadde bwa Alzheimer , obulamu bw’okuzaala, n’obutazaala .

Bw'owulira nti leptin y'efuga obuzito, oyinza okulowooza nti, "Oh... kale nteebereza nti nsaanye okuyiiya engeri y'okufuga leptin." Naye, okubeera omwesimbu, okukozesa obusimu buno si kyangu nga bw’olowooza.

Kiki ekituufu ekibaawo ku leptin?

Omulimu omukulu ogwa Leptin kwe kukuyamba okukuuma obuzito bw’omubiri gwo. Kwe kugamba, kiyamba okuleetawo enzikiriziganya ey’ekiseera ekiwanvu wakati w’obungi bw’emmere gy’olya n’amaanyi omubiri gwo ge gukozesa. Leptin ekulemesa okuwulira enjala buli kiseera. Era efuga obubonero bw’enjala obujja ng’omubiri tegwetaaga maanyi, oba kalori .

Leptin okusinga ekola nga ekosa ekitundu ky'obwongo bwo ekiyitibwa hypothalamus . Hypothalamus kifo kikulu nnyo mu kufuga enjala n’okukozesa amaanyi. Wabula waliwo ebirungo ebikwata leptin mu bitundu by’omubiri ebirala nabyo.

Ekikulu nti leptin tekoma ku kufuga njala yo okuva ku mmere emu okutuuka ku ndala. Wabula kiyamba okukyusa engeri gy’olyamu okumala ebbanga eddene, okufuga ensaasaanya y’amaanyi go, n’okukuyamba okukuuma omugejjo nga gutebenkedde.

Bw’oba ​​ogezaako okugejja, emiwendo gya leptin gyeyongera. Ekyo kikola kitya? Omubiri gwo bwe gukendeera amasavu, omuwendo gwa leptin gukendeera. Kino kiweereza akabonero eri omubiri gwo, nga kagamba nti, "Oh, silya kimala, enjala ennuma." Kino kikuleetera okuwulira enjala ennyo n’okuba n’okwegomba. Kino kiyinza okukuleetera okulya ennyo okusinga bw’osaanidde. Eno y’ensonga lwaki oluusi kiyinza okuba ekizibu okukuuma omugejjo.

Bannasayansi bakyasoma ku leptin. Balowooza nti era kikwata ku:

• Enkyukakyuka yo mu mubiri
• Enkola y’omubiri (endocrine system), kwe kugamba, enkola y’obusimu
• Enkola y’abaserikale b’omubiri

Emiwendo gya leptin gifugibwa gitya?

Leptin ekolebwa era n’efulumizibwa ebitundu by’omubiri gwo ebyeru ebiyitibwa adipose tissue oba obutoffaali bw’amasavu obweru. Obutoffaali buno obw’amasavu obweru kye kika ky’amasavu ekisinga mu mibiri gyaffe.

Olw’okuba leptin eva mu butoffaali bw’amasavu, obungi bwa leptin mu musaayi gwo bukwatagana butereevu n’obungi bw’amasavu mu mubiri gwo. Mu ngeri ennyangu, bw’oba ​​n’amasavu matono mu mubiri, oba olina leptin mutono. Bw’oba ​​n’amasavu amangi mu mubiri, olina leptin mungi.

Singa amasavu mu mubiri gwo geeyongera okumala ekiseera, emiwendo gya leptin gyeyongera. Okwawukana ku ekyo, singa amasavu mu mubiri gwo gakendeera, emiwendo gya leptin gikendeera.

Kiki ekibaawo singa emiwendo gya leptin gyeyongera?

Omuntu omugejjo ayinza okuba n’ekirungo kya leptin ekinene ennyo mu mubiri gwe. Kino kiyitibwa hyperleptinemia . Leptin bwe yeeyongera mu ngeri eno, embeera eyinza okubaawo ng’omubiri teguddamu ku leptin. Kino kiyitibwa okuziyiza leptin .

Embeera endala eziyinza okuba nga zeekuusa ku hyperleptinemia mulimu:

• Ennaku
• Omuze gw’emmere
• Obuzibu bw’obusimu obuyitibwa neurodegenerative disorders
• Obulwadde bw'ekibumba obulimu amasavu obutali bwa mwenge ( NAFLD ) .
• Obulwadde bwa Rabson-Mendenhall

Obuziyiza bwa Leptin kye ki?

Bw’oba ​​olina obuziyiza bwa leptin, obwongo bwo tebuddamu leptin mu ngeri eya bulijjo. Newankubadde leptin egenda mu maaso n'okusindika obubonero ku bwongo bwo, tofuna mpulira "ejjuvu". N’ekyavaamu, weeyongera okulya, wadde ng’amasavu mangi mu mubiri gwo.

Olw'obutaba na leptin buno obulabika, omubiri gwo gulowooza nti "ofa enjala." Okusobola okukuuma amaanyi, obwongo bwo bukendeeza ku maanyi go n’okukendeeza ku kalori z’oyokya ng’owummudde. Kino kitegeeza nti Basal Metabolic Rate (BMR) yo ekendeera.

Kale, okuziyiza leptin kukuleetera okuwulira enjala buli kiseera, era ne BMR yo ekendeera. Kino kyongera okugejja.

Mu kiseera kino bannassaayansi bagezaako okukola eddagala eriyinza okujjanjaba obulwadde bwa leptin.

Obubonero bw’okuziyiza leptin

Obubonero obukulu obw’okuziyiza leptin kwe kulumwa enjala buli kiseera, oba hyperphagia , n’okweyongera okulya emmere. Obubonero buno bubaawo ng’olina amasavu agasukkiridde mu mubiri, oboolyawo n’amasavu agasukkiridde.

Wabula obubonero buno buyinza okuva ku bintu ebirala bingi, so si kuziyiza leptin kwokka. Nga bannassaayansi bakyayiga ku leptin, kisoboka okuba nti obubonero obulala obw’okuziyiza leptin bujja kuzuulibwa mu biseera eby’omu maaso.

Kiki ekibaawo singa oba olina obulwadde bwa Leptin Deficiency?

Obutabeera na leptin, era emanyiddwa nga hypoleptinemia, mbeera etali ya bulijjo nnyo. Embeera enkulu ekwatagana ne kino y'obutaba na leptin obuzaaliranwa . Eno mbeera ya buzaale gy’ozaalibwa nayo. Kino kitegeeza nti amasavu go tegasobola kukola leptin.

Leptin bw’ebula, omubiri gwo gulowooza nti mu mubiri temuli masavu. Kino kivaamu enjala n’okwegomba okutafugibwa. Olw’ensonga eno, abaana abato abazaalibwa nga tebalina leptin bafuna omugejjo ogwa kiraasi III n’okulwawo okutuuka mu myaka gy’obuvubuka.

Embeera eno era ekwatagana n’endwadde endala eziwerako:

• Dyslipidemia (obutakwatagana mu masavu, gamba nga kolesterol ne triglycerides) .
• Obulwadde bw’ekibumba obulimu amasavu
• Obulwadde bwa bakitiriya obutera okukwatibwa
• Hyperinsulinemia (okukola insulini esukkiridde) .
• Hypogonadotropic hypogonadism (obusimu bw’okwegatta obutono) .

Okebera otya emiwendo gya leptin?

Okukebera omusaayi kuyinza okukebera omuwendo gwa leptin. Wabula abasawo tebatera kukebera bungi bwa leptin buli muntu. Balowooza ku kukola kukebera leptin mu mbeera zino zokka:

• Singa omwana wo omuto alina omugejjo gwa grade 3
• Bw’oba ​​omugejjo era ng’owulira enjala buli kiseera

Emiwendo gya leptin egya bulijjo gye giruwa?

Mu budde obutuufu, emiwendo gya leptin giyinza okuva ku:

• Ku bakyala: Nanograms 0.5 ku 15.2 buli mililita ( 0.5 ku 15.2 ng/mL ) .
• Ku basajja: Nanograms 0.5 ku 12.5 buli mililita ( 0.5 ku 12.5 ng/mL ) .

Wabula emiwendo gino egya bulijjo giyinza okwawukana katono okuva ku laabu okudda ku ndala. Kale, kakasa nti okebera range eyabulijjo ku lipoota yo ey’okukebera, oba buuza omusawo wo bw’oba ​​olina ekibuuzo kyonna ku bivudde mu kukebera kwo.

Nnyinza ntya okwongera ku muwendo gwa leptin?

Mu butuufu, tewali kinene ky’oyinza kukola kwongera ku muwendo gwa leptin okukendeeza ku njala oba okwagala okulya. Ekyo kiri bwe kityo kubanga emiwendo gya leptin gyo gikwatagana butereevu n’obungi bw’amasavu g’olina mu mubiri gwo.

Okunoonyereza okumu kwazuula nti abantu abatafuna tulo bumala balina ekirungo kya ghrelin (obusimu obulumwa enjala) mungi ate nga ne leptin mutono. N’olwekyo, otulo otumala kiyinza okuyamba okukuuma obusimu bwo nga buli mu bbalansi.

Bannasayansi balaze akakwate ku leptin ne triglycerides(Kino nakyo kika kya masavu ekiyitibwa lipids). Okunoonyereza okumu kulaga nti omuwendo gwa triglyceride bwe guba mungi, gukosa engeri leptin gy’ekola. Naye waliwo endowooza ez’enjawulo ku kunoonyereza kuno. Bannasayansi abamu balowooza nti emmere ekoleddwa okukendeeza ku triglycerides esobola okuyamba okwongera ku muwendo gwa leptin, naye abalala tebakkiriziganya na kino.

Mmere ki erimu ekirungo kya leptin ekingi?

Leptin busimu omubiri gwo bwe gukola, so si kiriisa nga vitamiini C oba puloteyina. N’olwekyo, tewali mmere yonna erimu leptin.

Olw’okuba leptin kintu kipya ekizuuliddwa, bannassaayansi bakyayiga ebisingawo ku nsonga eno naddala engeri gy’akosaamu omugejjo n’okugejja. Amasavu mu mubiri gwo bwe gaba matono, kiyinza okuba ekizibu okugejja kubanga omulimu gwa leptin mu kukola akabonero k'omubiri aka "enjala".

Obubaka Obutwala Awaka

Okay, kale okusinziira ku bye twogedde ku leptin, osobola okujjukira kino:

• Leptin busimu obukolebwa obutoffaali bwo obw'amasavu .
• Ekikulu ku kino kiri nti kikuyamba okufuga obuzito bwo mu bbanga eggwanvu era kikuwa okuwulira nga "ojjudde" .
• Amasavu mu mubiri gwo bwe geeyongera, leptin levels zeeyongera , ate amasavu mu mubiri gwo bwe gakendeera, leptin levels ekendeera.
• Okuziyiza leptin kwe kuba nti omubiri gulina leptin naye ng’obwongo tebuddamu bulungi. Kino kiyinza okuvaako omugejjo.
• Obutabeera na leptin tekitera kubaawo nnyo .
• Tewali mmere erimu leptin, kubanga ekolebwa mu mubiri.
• Obulamu obulungi naddala okwebaka obulungi , busobola okuyamba okutebenkeza obusimu.

Bw’oba ​​weeraliikirira omugejjo gwo oba nga weetaaga amagezi ku ngeri y’okugejja mu ngeri ennungi, yogerako n’omusawo wo. Osobola n’okulaba omusawo mukugu mu by’obusimu, omukugu mu by’endwadde z’omu lubuto, okukubaganya ebirowoozo ku nteekateeka z’okukendeeza ku buzito. Ekisinga obukulu kwe kusooka okufaayo ku bulamu bwo.

` Leptin, okufuga obuzito, obusimu, omugejjo, okuziyiza leptin, enjala, okukkuta