Wali owuliddeko ku bulwadde bwa Lynch Syndrome? Erinnya lino liyinza okuba nga lipya katono gy’oli. Naye mbeera ya buzaale eyongera nnyo emikisa gy’okukwatibwa kookolo mu mibiri gyaffe. Kino kyongera obulabe bw'okukwatibwa kookolo naddala nga tonnaweza myaka 50. Kya bulijjo okuwulira ng'otya katono ng'owulira ebigambo "oyinza okufuna kookolo". Naye ekisinga obukulu kwe kuba ng’omanyi bulungi embeera ng’ezo. Kale leero kino tugenda kwogera mu ngeri ennyangu, mu ngeri gy’osobola okutegeera.
Mu ngeri ennyangu, Lynch Syndrome kye ki?
Teebereza nti omubiri gwaffe gulinga ekyuma ekizibu ennyo ekikola okusinziira ku kitabo ekinene eky’ebiragiro (DNA). Obuzaale bwaffe bulinga ennukuta eziri mu kitabo kino eky’okuyigiriza. Oluusi, wabaawo ensobi mu kitabo kino eky’ebiragiro, oba ‘ensobi mu kuwandiika’. Mu busawo, kino kiyitibwa enkyukakyuka mu buzaale.
Lynch syndrome mbeera ereetebwa enkyukakyuka mu buzaale. Omubiri gwaffe gulina ekika ky’obuzaale eky’enjawulo ekizuula n’okuddaabiriza ensobi mu DNA yaffe. Kino kiyitibwa obuzaale bwa ``mismatch repair (MMR)``. Kiba nga ''tiimu y'okuddaabiriza'' mu mubiri gwaffe. Omuntu alina obulwadde bwa Lynch syndrome alina ekikyamu mu emu ku buzaale mu ''ttiimu eno ey'okuddaabiriza''. N’olwekyo, ensobi eziri mu DNA teziddaabirizibwa bulungi. Obutoffaali obulina ensobi zino bukuŋŋaanyizibwa era ekiseera bwe kigenda kiyitawo, butera okufuuka kookolo.
Embeera eno esobola okukwata omuntu yenna. Kubanga mbeera ya buzaale. Oluusi osobola okusikira obuzaale buno obulema okuva ku maama wo oba kitaawo. Tekitera nnyo, enkyukakyuka eno ey’obuzaale esobola okukula mu mubiri gw’omuntu omupya nga tewali muntu yenna mu maka. Bw’otunuulira ebibalo ebiri mu nsi nga Amerika, kiteeberezebwa nti abantu nga omu ku buli bantu 279 alina embeera eno.
Bubonero ki omuntu alina obulwadde bwa Lynch syndrome bw’ayinza okufuna?
Ekikulu ky’olina okwetegereza wano kiri nti obulwadde bwa Lynch syndrome tebulina bubonero bwonna bwa njawulo. Wabula kabonero ka kookolo ava ku mbeera eno. Ku bino ebisinga okubeerawo ye kookolo w’olubuto n’omumwa gwa nnabaana.
Kale, wano waliwo obubonero obutera okulabika obuyinza okuba nga bukwatagana ne kookolo w’olubuto n’omumwa gwa nnabaana:
| Obubonero | Okunnyonnyola |
|---|---|
| Omusaayi mu musulo | Omusulo guyinza okuba omumyufu oba omuddugavu omuddugavu nga gutabuddwamu omusaayi. |
| Obulumi mu lubuto oba okuziyira | Olubuto olutera okulumwa oba obutabeera bulungi. |
| Enkyukakyuka mu mize gy’ekyenda | Okutandika amangu okuziyira oba ekiddukano, oba omusulo ogugonvu okusinga bulijjo. |
| Okukoowa ennyo | Okukoowa buli kiseera wadde ng’owummudde bulungi. |
| Okuzimba oba okuzimba | Okuwulira ng’ojjudde oba ng’ozimba ne bw’omala okulya katono. |
| Okuziyira oba okusiiyibwa | Okuziyira oba okusiiyibwa nga tolina kivaako kyeyoleka. |
Ekikulu si buli muntu nti obubonero buno abufuna. Oluusi kookolo ayinza obutalaga bubonero bwonna okutuusa ng’akula nnyo. N’olwekyo, bw’osigala ng’olina obubonero bumu oba obusingawo ku buno, kakasa nti olaba omusawo akuwe amagezi.
Bika ki ebya kookolo ebiyinza okuva ku mbeera eno?
Lynch syndrome si mbeera eggulawo oluggi lw’ekika kya kookolo kimu kyokka. Kyongera emikisa gy’okukwatibwa kookolo mu bitundu by’omubiri bingi eby’enjawulo. Ebitundu ebiri mu bulabe bisobola okwawukana okusinziira ku buzaale obukyamu. `MLHL`, `MSH2`, `MSH6`, `PMS2` ne `EPCAM` ze buzaale butaano obukulu obukwatibwako.
Wansi waliwo ebika bya kookolo obulwadde bwa Lynch syndrome byongera obulabe bw’okufuna.
| Ekika kya kookolo | Ekitundu ky’omubiri ekikwatagana |
|---|---|
| Kookolo w’olubuto olunene n’omumwa gwa nnabaana | Enkola y’okugaaya emmere |
| Kookolo w’omu nnabaana/Endometrial | Enkola y’okuzaala y’abakazi |
| Kookolo w’enkwaso | Enkola y’okuzaala y’abakazi |
| Kookolo w’olubuto | Enkola y’okugaaya emmere |
| Kookolo w’ekyenda ekitono | Enkola y’okugaaya emmere |
| Kookolo w’olubuto | Enkola y’okugaaya emmere |
| Kookolo w’omusulo ogwa waggulu | Enkola y’okufulumya omusulo |
| Kookolo w’obwongo | Enkola y’obusimu |
| Kookolo w’olususu | Omubiri |
Kookolo w’olubuto olunene aleetebwa obulwadde bwa Lynch syndrome wa njawulo katono. Zikula mangu nnyo okusinga kookolo atera okukula.Wadde nga kitwala emyaka nga 10 obulwadde bwa kookolo obutono obw’omuntu owa bulijjo okufuuka kookolo, omuntu alina obulwadde bwa Lynch syndrome kitwala omwaka mulamba oba ebiri.
Ate era olw’embeera eno, omuntu eyafuna kookolo w’olubuto n’omumwa gwa nnabaana n’awona alina emikisa mingi okuddamu okufuna kookolo ow’ekika kye kimu.
Lowooza ku kino, waliwo emikisa nga 15% egya kookolo okuddamu okukwatibwa mu myaka 10 oluvannyuma lwa kookolo asooka okulongoosebwa. Obulabe buno busobola okweyongera okutuuka ku bitundu 40% oluvannyuma lw’emyaka 20, ate okutuuka ku bitundu 60% oluvannyuma lw’emyaka 30. Kino kiraga engeri okwekebejja buli kiseera gye kukulu.
Kino kiyisibwa kitya okuyita mu milembe?
Lynch syndrome mbeera eyisibwa okuva ku mulembe okudda ku mulala mu ngeri ya ``autosomal dominant``. Kino kitegeeza kyokka nti ne bwe kiba nti omuzadde omu yekka , oba maama oba taata, alina obuzaale obulema, waliwo emikisa 50% nti omwana ajja kubusikira. Kino kitegeeza nti buli mwana alina emikisa 50% okugisikira ate 50% obutagisikira.
N’olwekyo, singa ggwe oba omuntu mu maka go azuuliddwa n’obulwadde bwa Lynch syndrome, kikulu nnyo okutegeeza ab’omu maka go abalala. Naddala baganda bo, abaana bo, n’abazadde bo balina okutegeezebwa ku kabi kano. Okubasindika mu kukeberebwa obuzaale n’okubudaabudibwa kiyinza n’okutaasa obulamu bwabwe.
Ntegeera ntya oba nnina embeera eno? Bigezo ki bye nnina okukola?
Engeri esinga okukakasa oba olina obulwadde bwa Lynch syndrome kwe kukebera obuzaale . Kino kitera okuzingiramu okutwala omusaayi. Oba buccal swab bagiggyibwa munda mu kamwa. Okukebera kuno kusobola okuzuula obulungi oba olina enkyukakyuka mu buzaale bwe twayogeddeko emabegako, gamba nga MLHL ne MSH2.
Bw’oba ozuuliddwa ng’olina obulwadde bwa Lynch syndrome, ekiddako ekikulu kwe kwekebejjebwa buli kiseera okuzuula kookolo nga bukyali. Omusawo wo ajja kukola enteekateeka y’okukebera ekusaanira.
| Ekigezo | Engeri y’okukikola n’obudde obusemba |
|---|---|
| Okukebera ekibumba | Okukebera ekyenda ekinene (colonoscopy) nkola nga mu kino bayingizibwamu ttanka ennyimpi nga eriko kkamera okuyita mu nseke okwekenneenya ekyenda ekinene. Ebiseera ebisinga kirungi buli mwaka oba ebiri . |
| Okukuba Ultrasound okuyita mu bukyala | Ku bakyala, kirungi okukebera ekisambi, ekizingiramu okuyingiza ekyuma ekisika okuyita mu bukyala n’okukebera nnabaana n’enkwaso, kirungi buli mwaka oba ebiri . |
| Okukebera omusulo | Funa okutegeera okusookerwako ku kookolo eyeekuusa ku kibumba ng’okebera omusulo. Kirungi kino okukikola buli mwaka . |
| Okukebera Endoscopy eya waggulu | Tubu erimu kkamera eyingizibwa mu kamwa okwekenneenya olubuto n’ekitundu eky’okungulu eky’ekyenda ekitono. Kirungi buli luvannyuma lwa myaka 3-5 . |
| Okukebera ebitundu by’omubiri (biopsy). | Singa wabaawo ebitundu ebiteeberezebwa oba ekizimba mu kiseera ky’okukebera waggulu, kaggyibwako akatundu akatono ne kakeberebwa obutoffaali bwa kookolo. |
Obulwadde bwa Lynch syndrome bujjanjabwa butya?
Mu kiseera kino tewali ddagala liwonya mbeera ya buzaale eya Lynch syndrome. N’olwekyo, essira erisinga okussa essira mu bujjanjabi kwe kuzuula n’okulongoosa okuggya obutoffaali bwa kookolo mu mubiri. Singa kookolo ono asobola okuzuulibwa n’aggyibwawo nga tannasaasaana mu bitundu by’omubiri ebirala, ebivaamu biba birungi nnyo.
Kino kyetaagisa ttiimu y’abasawo abakola emirimu egy’enjawulo. Ng’ekyokulabirako, abakugu mu by’omu lubuto, abalongoosa, abakugu mu by’abakyala, n’abasawo abajjanjaba kkansa bakolera wamu okujjanjaba embeera eno.
Abantu abamu naddala abakyala abamaze amaka gaabwe, basalawo okulongoosebwa nnabaana oba okuggyamu enkwaso nga tebannaba kufuna bulwadde bwonna okukendeeza ku bulabe bw’okufuna kookolo wa nnabaana oba enkwaso mu biseera eby’omu maaso. Mu ngeri y’emu, abo abali mu bulabe obw’amaanyi obwa kookolo w’olubuto olunene bayinza okusalawo okusalako kookolo w’olubuto olunene. Bino bisalawo bya muntu ku bubwe nnyo, era birina okukolebwa oluvannyuma lw’okukubaganya ebirowoozo ennyo n’omusawo wo.
Obulwadde bwa Lynch syndrome ne HNPCC kintu kimu?
Oyinza n’okuwulira erinnya `HNPCC (Hereditary Non-Polyposis Colorectal Cancer)`. Lynch syndrome ne HNPCC zitera okukozesebwa nga zikyusibwakyusibwa, naye waliwo enjawulo entono mu by’ekikugu wakati w’ebintu bino byombi.
Mu ngeri ennyangu, erinnya HNPCC likozesebwa okusinziira ku byafaayo by’amaka. Kwe kugamba, singa abantu abawerako mu maka baba bafunye kookolo ow’ekika kino, amaka ago kigambibwa nti galina HNPCC. Naye Lynch syndrome lye linnya eriweebwa oluvannyuma lw’enkyukakyuka y’obuzaale entongole egireeta okuzuulibwa. Kale, bonna ab’omu maka agalina HNPCC basobola okuba n’enkyukakyuka y’obuzaale bw’obulwadde bwa Lynch syndrome. Ate era omuntu afuna enkyukakyuka empya mu buzaale nga tewali muntu mulala yenna mu maka naye asobola okugambibwa nti alina obulwadde bwa Lynch syndrome.
Tewali ayagala kuwulira bigambo nti, "Olina kookolo." Omuntu alina obulwadde bwa Lynch syndrome ayinza okuba ng’alina okuwulira ebigambo ebyo mu kiseera ekimu mu bulamu bwe. Naye si y'enkomerero y'ensi. Bw’oba omanyi embeera yo, ng’okolagana n’omusawo wo, n’okukeberebwa kookolo buli kiseera, kookolo yenna asobola okuzuulibwa n’awona nga bukyali. Okuzuula amangu n’okujjanjaba y’engeri esinga obulungi ey’okubeera n’obulamu obulungi, obw’essanyu.
Obubaka Obutwala Awaka
- Lynch syndrome mbeera ya buzaale eyisibwa okuva ku mulembe okudda ku mulala era eyongera ku bulabe bwa kookolo.
- Ne bwe kiba nti omuzadde omu yekka alina obuzaale buno obulema, omwana alina emikisa gya 50% okubusikira.
- Singa ggwe oba omuntu mu maka go azuuliddwa ng’olina embeera eno, kikulu nnyo okutegeeza ab’omu maka abalala ab’oku lusegere ku nsonga eno.
- Wadde ng’embeera eno ey’obuzaale tesobola kuwona, engeri esinga obulungi ey’okuziyiza oba okuzuula kookolo nga bukyali kwe kwekebejja abasawo buli kiseera.
- Okuzuula kookolo amangu n’okujjanjaba kiyinza okuvaamu ebirungi ennyo era n’okukusobozesa okubeera n’obulamu obulungi.
- Bulijjo weebuuze ku musawo wo okuteekawo enteekateeka y’okukeberebwa ekusaanira n’okukola ku nsonga zonna ezikweraliikiriza.
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