Kizibu okuteeka mu bigambo okutya, okweraliikirira n’obutali bukakafu ebijja ng’ozuuliddwa nti olina kookolo w’amabeere. Naye ekisinga obukulu ky’olina okumanya nti obujjanjabi bwa kookolo bukulaakulana nnyo ennaku zino. Leero, tugenda kwogera ku bujjanjabi obumu obupya obw’engeri eyo, obw’omulembe. Kiyitibwa Datroway. Ka tulabe Datroway kye ki era oba esobola okukuyamba.
Datroway ddagala lya ngeri ki? Kikola kitya?
Mu ngeri ennyangu, Datroway bujjanjabi obugendereddwamu obukoleddwa nga bakozesa tekinologiya ow’omulembe. Mu busawo, kino tukiyita Antibody Drug Conjugate (ADC) . Kilowoozeeko ng’empeereza ey’enjawulo ey’okuweereza abantu. Molekyulu eno ey’eddagala ekolebwa ebitundu bisatu ebikulu.
1. Antibody: Eno ye "address finder" ya courier waffe. Kisanga puloteyina eyeetongodde (puloteyina eyitibwa Trop-2) ku ngulu w’obutoffaali bwa kookolo n’enywerera ku yo. Omulimu gwayo kwe kulonda okutta n’okukwata obutoffaali bwa kookolo bwokka, awatali kutuusa bulabe ku butoffaali bulamu.
2. Eddagala eriweweeza ku kookolo ( chemotherapy ): Eno ye "package" eri mu courier. Lino lye ddagala erisaanyaawo obutoffaali bwa kookolo.
3. Linker: Ekitundu kino kigatta antibody n’eddagala eriziyiza kookolo. Ebibiri bino bisibibwa wamu nga bitambula mu musaayi, oluvannyuma ne byawulwamu oluvannyuma lw’okuyingira mu katoffaali ka kookolo.
Kale, eddagala lya Datroway bwe liyingira mu mubiri, ekiziyiza ekirimu kizuula butereevu obutoffaali bwa kookolo ne kyekwata. Olwo, ekiyungo ekyo kimenyeka, ne kifulumya eddagala eriziyiza kookolo butereevu mu katoffaali ka kookolo. Mu ngeri eno, akatoffaali ka kookolo kasaanawo munda. Ekirungi ekisinga obunene ekiri mu nkola eno kwe kuba nti okwonooneka kw’obutoffaali obulamu kukendeera nnyo.
Obujjanjabi bwa Datroway buweebwa butya?
Datroway bujjanjabi obuweebwa mu ddwaaliro, mu ddwaaliro oba mu kifo awajjanjabirwa ng’olabirirwa omusawo wo. Kiweebwa nga saline solution okuyita mu musuwa (intravenous - IV infusion ) .
- Omuwendo: Omuwendo gw’eddagala ly’oweebwa gusalibwawo okusinziira ku buzito bw’omubiri gwo.
- Enteekateeka: Obujjanjabi buno butera okuweebwa buli luvannyuma lwa wiiki ssatu . Omusawo wo y’ajja okusalawo emisomo gy’olina okukola.
- Nga tonnaba kutegeka: Nga tebannaba kuweebwa saline, ojja kuweebwa eddagala eddala eriziyiza okuziyira, okusiiyibwa, n’okulwala alergy yonna eyinza okubaawo olw’omunnyo.
- Obudde bw’obujjanjabi:Obujjanjabi obusooka bumala eddakiika nga 90. Bw’oba tofunye buzibu bwonna obw’amaanyi omulundi ogusooka, obujjanjabi obuddirira busobola okuweebwa mu ddakiika ntono nga 30.
- Okwetegereza: Oluvannyuma lw’obujjanjabi bubiri obusooka, ojja kwetegereza abakozi b’ebyobujjanjabi waakiri okumala essaawa emu. Bwe waba tewali buzibu, ojja kwetegereza okumala eddakiika nga 30 mu bitundu ebiddako n’oluvannyuma n’okkirizibwa okudda eka.
Ntegeera ntya oba obujjanjabi buno bunsaanira?
Datroway si ddagala lya bika byonna ebya kookolo w'amabeere . Omusawo wo ajja kukuwa obujjanjabi buno singa kookolo wo atuukiriza ebisaanyizo bino wammanga:
- Kookolo alina okuba nga alina hormone receptor-positive ate nga HER2-negative .
- Kookolo bw’aba tasobola kuggyibwawo ddala n’okulongoosebwa (`unresectable`) oba ng’asaasaanidde mu bitundu by’omubiri ebirala (`metastatic`).
Ekisinga obukulu kiri nti okusobola okufuna obujjanjabi buno, olina okuba ng’omaze okufuna obujjanjabi obusinziira ku endocrine n’obujjanjabi obulala obw’eddagala.
N’olwekyo, ekisinga obulungi okusalawo oba obujjanjabi buno bukusaanira kukolebwa musawo wa kkansa akujjanjaba . Ajja kwetegereza ebiwandiiko byo byonna eby’obujjanjabi era asalewo kino.
Ebizibu ebivaamu n’engeri y’okubifuga?
Okufaananako n’obujjanjabi bwonna obwa kookolo, Datroway asobola okuleeta ebizibu ebimu. Naye ekirungi nti waliwo engeri y’okuddukanyaamu ebisinga ku bino. Ka tulabe ebikulu ebiyinza okuvaamu ebizibu n’ebyo by’oyinza okubikolako.
| Side effect | Engeri y’okuddukanyaamu |
|---|---|
| Ebizibu by’amaaso (Amaaso okukalu, okumyuuka, obulumi, obutalaba bulungi) | Kozesa amatondo g’amaaso agasiiga omusawo gy’akulagidde waakiri emirundi ena olunaku. Weewale okwambala lenzi ng’ojjanjabibwa. Buulira omusawo mu bwangu singa olaba enkyukakyuka oba obutabeera bulungi mu maaso go. Kirabika ojja kusindikibwa ew’omusawo w’amaaso. |
| Amabwa mu kamwa | Kuuma ice cube oba amazzi amatono aga ice mu kamwa ng’ogaba saline solution. Kozesa eddagala ery’enjawulo ery’okunaaba mu kamwa omusawo gy’akulagidde nga bw’akulagidde. Singa wabaawo amabwa gonna mu kamwa oba ne geeyongera, tegeeza omusawo mu bwangu. |
| Okuziyira n’okusiiyibwa | Limira eddagala eriweweeza ku kuziyira omusawo lye yakulagidde mu budde bwennyini, nga tonnafuna bujjanjabi n’oluvannyuma lw’okujjanjabibwa. |
Bino bye bisinga okuvaamu ebizibu. Bw’ofuna obuzibu obulala bwonna ng’oggyeeko bino, totya kwogera na musawo wo ku nsonga eyo.
Bintu ki by’olina okussaako essira ennyo?
Bw’oba omira obujjanjabi bwa Datroway, waliwo ebintu ebitonotono by’osaanidde okussaako essira mu ngeri ey’enjawulo.
Ebizibu ebikwatagana n’amawuggwe
Tekitera nnyo, abantu abamu bayinza okufuna okuzimba kw’amawuggwe (`Interstitial Lung Disease` oba `Pneumonitis`) olw’obujjanjabi buno. N’olwekyo, bw’ofuna obubonero ng’okusesema , okukaluubirirwa okussa, okuwunya, omusujja, oba okunyiga mu kifuba , tobuusa maaso era tegeeza omusawo wo mu bwangu . Bwe kiba kyetaagisa, omusawo ajja kutandika okugijjanjaba.
Okufuna embuto n’okuziyiza okuzaala
Eno nsonga nkulu nnyo.
- Obujjanjabi bwa Datroway buyinza okuba obw’obulabe eri omwana ali mu lubuto. N’olwekyo, ojja kukeberebwa olabe oba oli lubuto nga tonnatandika kujjanjaba.
- Bw’oba oli mukyala alina obusobozi bw’okuzaala, olina okukozesa engeri y’okuziyiza okuzaala ekola ennyo ng’ojjanjabwa n’okumala emyezi 7 oluvannyuma lw’okuweebwa ddoozi esembayo .
- Bw’oba oli musajja ate nga munno asobola okufuna olubuto, olina okukozesa enkola ennungi ey’okuziyiza okuzaala ng’ojjanjabwa n’okumala emyezi 4 oluvannyuma lw’okuweebwa ddoozi esembayo .
Bw’oba olina ekibuuzo kyonna ku nsonga eno, tolwawo kwogera na musawo wo.
Obubaka Obutwala Awaka
- Datroway bujjanjabi obugendereddwamu, obw’omulembe ku bika bya kookolo by’amabeere ebimu. Kiringa "guided missile" enoonya n'okusaanyaawo obutoffaali bwa kookolo.
- Obujjanjabi buno tebusaanira buli muntu. Omusawo wo akola ku bulwadde bwa kkansa y’ajja okusalawo oba nga kikusaanira.
- Obujjanjabi buno buweebwa nga saline solution okuyita mu musuwa, omulundi gumu buli luvannyuma lwa wiiki ssatu.
- Ebizibu ebiva mu maaso nga obuzibu mu maaso, amabwa mu kamwa, n’okuziyira biyinza okubaawo. Naye bino bisobola okufugibwa. Buulira mangu omusawo wo ku buzibu bwonna.
- Bw’ofuna obubonero ng’okukaluubirirwa okussa, tobubuusa maaso. Noonya abasawo amagezi mu bwangu.
- Kikulu nnyo okwewala okufuna olubuto ng’ojjanjabibwa n’okumala ekiseera ekigere oluvannyuma lw’okufuna olubuto.
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