Abakuumi mu mibiri gyaffe: Monocytes zino ze ziruwa?

Bw’oba ​​wali otunuulidde lipoota y’okukebera omusaayi, osanga olabye amannya mangi. Mu zo, eyakukutte eriiso ye ‘Monocytes’. Mpozzi omusawo wo yalina kye yayogera ku nsonga eyo, oba oyinza okuba nga weebuuzizza kiki. Kale, monocytes zino ze ziruwa? Bikulu bitya eri emibiri gyaffe? Leero, tugenda kubyogerako mu ngeri ennyangu gy’osobola okutegeera.

Monocytes zino ze ziruwa?

Mu ngeri ennyangu, obutoffaali obuyitibwa monocytes kika kya butoffaali obweru (leukocyte) mu musaayi gwaffe. Teebereza nti omubiri gwo nsi nnene. Waliwo eggye erisobola okukuuma eggwanga lino okuva ku balabe (i.e. obuwuka obuleeta endwadde) abava ebweru. Eggye eryo lye baserikale baffe abaserikale b'omubiri . Kale, monocytes zino ziringa ekibinja ky’abajaasi ekikulu ennyo, abatendekeddwa mu ngeri ey’enjawulo mu ggye eryo.

Omulimu omukulu ogw’abajaasi bano kwe kunoonya n’okusaanyaawo abalabe nga akawuka, obuwuka, ffene, ne protozoa eziyingira mu mubiri. Tebikoma awo, wabula bikola n’okuzuula n’okumalawo obutoffaali mu mubiri gwaffe gwennyini obwakwatibwa edda obuwuka. Era, bwe kiba kizibu okulwana wekka, abaserikale bano aba monocyte baweereza obubaka eri abajaasi abalala mu magye (i.e. obutoffaali obulala obweru) nga bagamba nti, "Waliwo omulabe wano, mujje oyambe."

Osobola okunnyonnyola katono ku ngeri emirimu gyabwe gye gikolebwamu?

Abaserikale bano aba monocyte batandika obulamu bwabwe mu busimu bwaffe obw’amagumba. Kiringa essomero eritendeka amagye. Eyo gye batendekebwa obulungi ne beetegekera olutalo. Bwe zimala okukula obulungi, zitandika okutambula mu mubiri gwonna nga ziyita mu misuwa. Kiringa okugenda mu patrol.

Kuba akafaananyi ng’akawuka kayingidde mu mubiri gwaffe. Kiba ng’omulabe alumba ensi. Oba omuliro gukutte mu kibuga. Mu kiseera kino, akabonero akalabula kafulumizibwa. Amangu ddala ng’akabonero kano kawuliddwa, abaserikale ba monocyte abali okumpi bakola mangu. Naye bwe bagenda mu lutalo luno, bakyusa endabika yaabwe ne beeyawulamu ebika by’obutoffaali bibiri obukola emirimu ebiri egy’enjawulo.

1. Obutoffaali bwa dendritic - ababaka n’abakessi

2. Macrophages - Abalwanyi ku mwanjo

Kati katulabe buli omu ku bantu bano emirimu gy'akola.

Dendritic cells - ekifo eky’empuliziganya

Obutoffaali buno bulinga omukono gw’empuliziganya ogw’amagye, oba ekifo we bakubira essimu mu kitongole ekizikiriza omuliro. Omulimu gwabwe omukulu kwe kutegeera omulabe ng’atuuse, okutegeeza abaserikale abalala ab’amaanyi mu baserikale b’omubiri, n’okusaba obuyambi.

Obutoffaali buno obuyitibwa dendritic cells businga kusangibwa wansi w’olususu lwaffe, mu layers ez’omunda ez’ennyindo, amawuggwe, olubuto, n’ebyenda, kubanga bino bye bifo obuwuka we businga okuyingira mu mubiri.

Obuwuka bwe buyingira, obutoffaali buno bugenda ne bukuŋŋaanya antigen ku buwuka obwo. Antigen, mu ngeri ennyangu, eringa "identification card" y'obuwuka obwo. Kye kisobozesa abaserikale baffe abaserikale okutegeera nti "ono si muntu abeera mu mubiri gwaffe." Nga batwala endagamuntu eno, obutoffaali bwa dendritic bufulumya obubaka obw'enjawulo obw'eddagala (cytokines) obugamba obutoffaali obulala obweru nti, "Wano wajja omulabe ng'alina endagamuntu eno, mujje mulwanye mangu."

Macrophages - Abalwanyi ku mwanjo

Bano be bakomando abatuufu abagenda mu maaso ne balwana. Oluvannyuma lw’okufuna obubaka okuva mu butoffaali bwa dendritic, macrophages zigenda butereevu mulabe w’ali.

Macrophages zino kye zikola kwe kwetooloola obuwuka bw’omulabe ne bumira gwonna. Oluvannyuma lw’okugimira, bakozesa enziyiza ez’amaanyi ez’obutwa munda mu mibiri gyabwe okusaanuusa n’okusaanyaawo obuwuka buno. Era, "okuyonja" n'okugogola obutoffaali obufu n'ebitundu ebyonooneddwa oluvannyuma lw'okulwana gwe mulimu omulala omukulu ogw'obutoffaali buno obwa macrophage.

Monocytes zino zifaanana zitya?

Monocytes kye kika ky’obutoffaali obweru obusinga obunene mu musaayi gwaffe. Zisinga obunene bw’obutoffaali obumyufu obwa bulijjo emirundi nga ebiri. Bwe zitunuulirwa mu microscope, ziba nnene era nnyangu okuzitegeera.

Nucleus eri wakati mu butoffaali buno ya njawulo nnyo. Kitwala enkula ez’enjawulo. Akatoffaali bwe katambula mu mubiri gwonna, enkula ya nucleus esobola okukyuka. Ebimu ku bifaananyi ebikulu ebiyinza okulabibwa bye bino:

• Enkula y’ekinyeebwa ekiringa ekibumba
• Enkula y’embalaasi
• Enkula ekoona katono

Monocytes mmeka ze nnina okuba ne mu musaayi gwange? (Ekifo ekya bulijjo)

Mu muntu omukulu omulamu obulungi, monocytes zitwalibwa nga eza bulijjo singa zikola wakati wa 2% ne 8% ku muwendo gw’obutoffaali obweru bwonna. Mu kubala, kino kiri wakati wa monocytes 200 ne 800 buli microliter y’omusaayi.

Embeera ki ez’obujjanjabi eziyinza okuleeta enkyukakyuka mu muwendo gw’obutoffaali obuyitibwa monocyte?

Ebiseera ebisinga, omuwendo gwa monocytes gukendeera oba gweyongera ng’omubiri gwaffe gulwanyisa yinfekisoni oba obulwadde. Kino kitegeeza nti enkyukakyuka eno mu muwendo eyinza obutaba bulwadde, wabula akabonero k’obulwadde obulala. Oluusi, empisa zino nazo ziyinza okukyuka ng’ekizibu ekiva mu ddagala.

Omuwendo gw’obutoffaali obuyitibwa monocytes okweyongera (Monocytosis) .

Omuwendo gwa monocytes mu musaayi bwe guba mungi okusinga ogwa bulijjo, mu by’obusawo tuguyita monocytosis . Kino kiyinza okuba akabonero k’embeera z’obujjanjabi ez’enjawulo. Okugeza, kiyinza okuba embeera ey’okusiigibwa nga mononucleosis oba obulwadde bw’abaserikale b’omubiri nga lupus. Ezimu ku nsonga enkulu eziviirako obutoffaali obuyitibwa monocytes okweyongera ze zino:

• Endwadde z’abaserikale b’omubiri (autoimmune diseases).
• Obuzibu mu musaayi
• Kookolo
• Obulwadde bw’emisuwa n’emisuwa
• Situleesi etawona
• Yinfekisoni ez’ekiseera ekitono n’ez’ekiseera ekiwanvu
• Obuzibu bw’okuzimba
• Okufuna olubuto

Obulwadde bwa monocytopenia

Omuwendo omutono okusinga ogwa bulijjo ogwa monocytes mu musaayi guyitibwa monocytopenia . Ekintu kyonna ekikendeeza ku muwendo gw’obutoffaali obweru bwonna nakyo kiyinza okuvaako okukendeera kw’obutoffaali obuyitibwa monocytes. Waliwo ensonga eziwerako eziviirako kino:

• Okukendeera kw’omusaayi mu mubiri (Aplastic anemia).
• Obulwadde bw’omusaayi
• Ebisago eby’okwokya
• Okukwatibwa akawuka ka siriimu
• Obujjanjabi bw’eddagala erijjanjaba kookolo

Bikebere ki ebikebera emiwendo gya monocyte zange?

Okukebera omusaayi okwangu ennyo kukozesebwa okuzuula omuwendo gwa monocyte zo. Waliwo ebika bibiri ebikulu eby’okukebera ebikozesebwa mu kino.

Obubonero bubaawo olw’enkyukakyuka mu muwendo gw’obutoffaali obuyitibwa monocyte?

Wano abantu bangi we bakifuna mu bukyamu. Tojja kulaba bubonero bwonna olw’okuba nti omuwendo gwa monocyte gwo mutono oba mungi. Mu kifo ky’ekyo, obubonero bwonna bw’olaba buva ku mbeera y’obujjanjabi eyaliwo eyaviirako omuwendo gw’obutoffaali obuyitibwa monocyte okukyuka.

Nkomya ntya emiwendo gya monocyte gyange mu mbeera eya bulijjo?

Enkola z’obujjanjabi zisinziira ku kivaako emiwendo gy’obutoffaali bwo obw’omubiri (monocyte levels). Kino kitegeeza nti embeera eriwo erina okusooka okuzuulibwa n’okujjanjabibwa. Omusawo wo ajja kuba muntu asinga okukuwabula ku nsonga eno. Togezaako kwejjanjaba.

Okutwalira awamu, bino bye bimu ku bintu omusawo by’ayinza okuteesa okufuga emiwendo gya monocyte:

Nkuuma ntya obutoffaali bwange obwa monocyte nga bulamu bulungi?

Obutoffaali bwo obwa monocyte kitundu ku baserikale b’omubiri gwo. Kale, ekisinga obulungi kwe kukuuma abaserikale bwo bonna nga banywevu. Bino bye bimu ku bintu ebiyinza okukuyamba okukola ekyo:

• Weekuume okuva ku buvune ne yinfekisoni nga bwe kisoboka: Weewale okukwatibwa obuwuka obuteetaagisa.
• Lya emmere ennungi n’okukola dduyiro: Endya ennungi n’okukola emirimu gy’omubiri kyetaagisa nnyo eri abaserikale b’omubiri.
• Emize emirungi egy’obuyonjo: Ebintu ebyangu ng’okunaaba mu ngalo buli kiseera ne ssabbuuni bisobola okuleeta enjawulo nnene.
• Weewale okunywa sigala: Okunywa sigala kunafuya abaserikale b’omubiri.
• Okukendeeza ku situleesi: Situleesi esukkiridde ya bulabe eri abaserikale b’omubiri.
• Otulo otumala: Okwebaka kyetaagisa nnyo omubiri okudda engulu n’okuddaabiriza obutoffaali bw’abaserikale b’omubiri.

Mu nkomerero, obutoffaali obuyitibwa monocytes bwe bukuuma omubiri gwaffe mu kasirise. Bulijjo bakola okutukuuma endwadde. Kale okugoberera obulamu obulungi okusobola okubakuuma nga balamu kye kimu ku bintu ebinene bye tuyinza okukolera emibiri gyaffe.