Waliwo omuntu wo ow’oku lusegere alina enkyukakyuka zino? Ka tuyige ku bulwadde bwa Pick

Tutera okuwulira nga twewuunya bwe tulaba enkyukakyuka ezitasuubirwa mu nneeyisa n’enjogera y’abamu ku baagalwa baffe, si bwe kiri? Leero tugenda kwogera ku mbeera y’obujjanjabi eyinza okuba emabega w’enkyukakyuka ng’ezo. Wadde nga guno mulamwa mu ngeri enzibu, ka tugezeeko okugutegeera mu ngeri ennyangu.

Obulwadde bwa Pick kye ki? Kyawukana kitya ku bulwadde bwa Niemann-Pick?

Mu ngeri ennyangu, Obulwadde bwa Pick’s Disease mbeera ekosa obwongo, mpolampola ne butta obutoffaali. Kika kya bulwadde bw’okusannyalala obuyitibwa frontotemporal dementia (FTD) . Kisinga kulabibwa mu bantu abali wansi w’emyaka 65. Edda, obulwadde bw’okusannyalala obw’omu maaso (frontotemporal dementia) bwennyini era bwayitibwanga obulwadde bwa Pick. Naye kati, abasawo bakozesa erinnya lino mu mbeera zokka ng’emisingi egimu gituukiddwaako.

Kati oyinza okuba ng'olowooza nti, "Oh... obulwadde bwa Pick bwe bumu n'obulwadde bwa Niemann-Pick?" Nedda, ndwadde bbiri ez’enjawulo ddala. Newankubadde ekitundu kya "Pick" eky'erinnya mu butanwa kye kimu, endwadde zino zombi tezikwatagana.

• Obulwadde bwa Pick: Butuumiddwa erinnya lya Arnold Pick, omusawo w’obusimu era omusawo w’eby’omutwe Omuczech eyasooka okuzuula obulwadde buno mu 1892. Buno kika kya bulwadde bwa frontotemporal dementia (FTD), ekitegeeza nti bukosa bwongo bwo bwokka.
• Obulwadde bwa Niemann-Pick: Obulwadde buno bwatuumibwa erinnya ly’abasawo babiri Abagirimaani, Albert Niemann ne Ludwig Pick, era bumanyiddwa olw’okukuŋŋaanyizibwa kw’amasavu mu mubiri n’obuzibu mu ngeri gye gafugibwamu. Amasavu bwe gakuŋŋaanyizibwa, gasobola okukosa ebitundu by’omubiri bingi omuli obwongo, ekibumba, enseke, obusigo bw’amagumba n’amawuggwe.

Otegedde enjawulo eriwo? Ekimu kintu ekikoma ku bwongo, ate ekirala kikwata ku bitundu by’omubiri eby’enjawulo.

Ani afuna obulwadde buno? Kitera kitya?

Obulwadde bwa Pick butera okuzuulibwa ku myaka emito okusinga embeera endala ng’okubulwa amagezi. Businga kuzuulibwa mu bantu abali mu myaka 50 ne 60. Kyokka oluusi kiyinza okubeera mu bantu abato nga 20 oba 80.

Waliwo obukakafu obulaga nti obulwadde buno busobola okutambulira mu maka. Abanoonyereza bazudde enkyukakyuka z’obuzaale ezitakka wansi wa ssatu ezikwatagana nayo. Kyokka emirundi egisinga obulwadde buno buba bwa bulijjo. Kino kitegeeza nti omuntu asobola okubukulaakulanya nga talina byafaayo bya maka.

Kizibu okwogera ddala obulwadde buno bwe butera okubeerawo. Abakugu bateebereza nti buli bantu 100,000 abakwatibwa abalwadde bawera 15 ne 22. Wabula waliwo okubuusabuusa ku butuufu bw’ebibalo bino, kubanga obulwadde buno buzibu nnyo okubuzuula ng’oli mulamu, era oluusi ne bwe buba bumaze okufa, buba buzibu okubuzuula. Kale omuwendo gwennyini ogw’abalwadde guyinza okuba nga gusingako.

Obulwadde bwa Pick bukosa butya omubiri?

Obulwadde bwa Pick bulwadde bwa neurodegenerative, ekika ky’obulwadde bw’okusannyalala obuyitibwa frontotemporal dementia (FTD). Mu ngeri ennyangu, obutoffaali bw’obusimu (neurons) mu bwongo bugenda bulekera awo okukola. Ebitundu by’obwongo ebikoseddwa bitandika okukendeera (atrophy). Olwo, ofiirwa obusobozi ebitundu ebyo bwe byali bifuga. Wadde nga bulina ebifaanagana n’obulwadde bwa Alzheimer, obulwadde bwa Pick butera okutandika ku myaka emito, era waliwo enjawulo enkulu eziwerako.

Olw’okuba Obulwadde bwa Pick bukosa ebitundu ebimu byokka eby’obwongo, obubonero obukulu bwe bukyukakyuka mu nneeyisa oba mu lulimi . Ebiseera ebisinga, abantu abalina obulwadde bwa Pick’s Disease tebasobola kumanya nti balina ekizibu oba embeera. Kino kiri bwe kityo kubanga obwongo bwabwe tebusobola kukola ku mawulire agakwata ku mbeera yaabwe. Kino kiyitibwa "obutaba na kutegeera."

Bubonero ki obulaga obulwadde bwa Pick?

Obulwadde bwa Pick bubaawo mu ngeri bbiri enkulu: emu ye behavioral variant frontotemporal dementia (bvFTD) , ate endala ye primary progressive aphasia (PPA), ekosa ebitundu by’obwongo ebikwatagana n’olulimi.

Enkyukakyuka mu nneeyisa Obulwadde bw’okusannyalala mu maaso n’ekiseera (bvFTD) .

Obubonero bw’embeera eno eya bvFTD busobola okwawulwamu ebika mukaaga ebikulu:

• Okufiirwa ebiziyiza: "Okuziyiza" kye kitundu ky'obwongo ekitugamba nti "tokola kino." Ebitundu bino bwe byonooneddwa, tetusobola kwekomya kwogera oba kukola bintu bitasaana.
• Obutabeera na "filter" ku ebyo byogerwa: Okwogera ebiri mu birowoozo byo, oluusi mu ngeri erumya abalala, kiba kya mpisa, oba tekisaanira. Ng’ekyokulabirako, okuvuma omuntu mu bwangu ku lukuŋŋaana lw’amaka.
• Obutassa kitiibwa mu balala: Bayinza obutassa kitiibwa mu by’ekyama by’abalala, bayinza okubakwatako nga tebaagala, bayinza okugezaako okweyisa mu ngeri etasaana mu by’okwegatta, era bayinza okunyiiga oba okutabuka amangu ago.
• Ebikolwa n’enneeyisa mu ngeri ey’obulagajjavu: Kino kiyinza okuzingiramu okukozesa ssente mu ngeri etali ya buvunaanyizibwa, mpozzi n’okubba mu maduuka.

• Obutafaayo: Kino kiyinza okulabika ng’okwennyamira, naye kya njawulo katono.
• Okubulwa okwagala ekintu kyonna: Okubulwa okwagala ebintu bye wali onyumirwa (ebintu by’onyumirwa, okumala ebiseera n’emikwano).
• Okuva mu mbeera z‟abantu: Okwewala okubeera n‟emikwano n‟ab‟omu maka.
• Okukendeera mu kwerabirira: Obutafaayo ku kunaaba, okukyusa engoye, n’okubeera muyonjo.

• Okufiirwa okusaasira:Kino era kiyitibwa "okuzibikira mu nneewulira." Kifuuka kizibu okutegeera enneewulira z’abalala. Tebalaga buwagizi mu nnaku oba essanyu ly’abantu abalala nga bwe baali.

• Enneeyisa eziwalirizibwa: Abantu abalina obuzibu buno balaga enkola z’enneeyisa ez’enjawulo ennyo ku balala.
• Entambula eziddiŋŋana: Enfunda n’enfunda okukola entambula entonotono, gamba ng’okukuba mu ngalo, okukuba ebigere, n’okutambula ng’odda n’okudda.
• Enneeyisa enzibu oba ez’emikolo: okulaba firimu ze zimu emirundi n’emirundi, okusoma ebitabo bye bimu, okukung’aanya ebika by’ebintu bye bimu. Kuno kw’ogatta n’okukung’aanya ebintu.
• Okuddiŋŋana: Okuddiŋŋana amaloboozi, ebigambo, ne sentensi ze zimu emirundi n’emirundi.

• Enkyukakyuka mu mmere oba enneeyisa ezissa essira ku kamwa: Abantu abalina obulwadde buno bayinza okufuna embeera eyitibwa "hyperorality," nga eno y'okwagala okutali kwa bulijjo ku bintu ebikwata ku kamwa.
• Enkyukakyuka mu kulya: Abantu batera okunywa ennyo emmere gye baagala ennyo naddala emmere ey’akawoowo, swiiti n’omwenge. Kino kiyinza okuvaako omugejjo.
• Enneeyisa z’omu kamwa eziwalirizibwa: Okuwalirizibwa okunywa sigala, okulya ennyo, n’ebirala Era, okunoonyereza mu kamwa. Wadde nga kino kya bulijjo abaana abato okukikola nga bwe beetegereza ensi, si kya bulijjo abantu abakulu okukikola.
• Pica: Kino kwe kuwalirizibwa okulya ebintu ebitalya, ebitali bya biriisa (ensimbi, obucaafu, amayinja).

• Okufiirwa omulimu gw'abakulira naye obusobozi obulala nga tebufudde: "Omulimu gw'abakulira" kitegeeza obusobozi bw'okuteekateeka olunaku, okugonjoola ebizibu, n'okukola ebintu. Wadde ng’obusobozi buno bukosebwa mu bantu abalina obulwadde buno, obusobozi obulala, gamba ng’okujjukira n’okukola ku kulaba, tebukosebwa nnyo mu ntandikwa. Kino kye kintu ekikulu ekyawula obulwadde bw’okubulwa amagezi obw’omu maaso (frontotemporal dementia) ku bulwadde bwa Alzheimer.

Obulwadde bwa Primary Progressive Aphasia (PPA) .

PPA era esobola okuva ku bulwadde bwa Pick. Kino kireetera omuntu okufiirwa obukugu mu lulimi mpolampola, gamba ng’okusobola okwogera n’okutegeera abalala bye boogera. Wadde nga waliwo ebika ebikulu bisatu ebya PPA, ebika bibiri ebikulu ebiyinza okukwatagana n’obulwadde bwa Pick bye bino:

• Nonfluent variant PPA (nfvPPA): Mu kika kino, kizibu okukwataganya ebigambo n’okukozesa grammar entuufu. Wadde ng’ebigambo ebimu ne sentensi ennyangu bisobola okutegeerwa, sentensi enzibu zifuna obuzibu okuzitegeera.
• Enkyukakyuka y’amakulu PPA (svPPA):Ekika kino kizibuwalirwa okulonda ekigambo ekituufu oba okutegeera amakulu g’ebigambo. Ebintu ebimu ebyogeddwa biyinza obutaba na makulu, era kiba kizibu okutegeera abalala bye boogera. Wayinza okubaawo obuzibu mu kusoma n’okuwandiika, naye basobola okuddamu ebyo abalala bye boogera mu ngeri y’emu.

Teebereza, kitaawo afuuka wa njawulo mangu ku muntu gwe yali, n’aboggolera buli muntu, n’asaasaanya ssente mu ngeri etafaayo, oba n’akuba oluyimba lwe lumu olunaku lwonna. Oba, bw’oyogera naye, ebigambo bye bitabulatabula, n’awulira ng’ebyo by’oyogera tabitegedde. Bino bye byokulabirako by’ebintu bye tubadde twogera.

Kiki ekivaako embeera eno? Kisiigibwa?

Obulwadde bwa Pick kika kya bulwadde bwa frontotemporal dementia (FTD) obulina ensonga entongole ennyo. Obwongo bwaffe n'obutoffaali bw'obusimu birimu puloteyina ey'enjawulo eyitibwa tau . Puloteeni zino zeetaaga okuba n’enkula eyeetongodde, oba si ekyo tezijja kukola bulungi.

Puloteeni za tau bwe zitakola bulungi, ne zitabula wamu, ne zikuŋŋaanyizibwa munda mu busimu obuyitibwa neurons, obutoffaali obwo bwonoonebwa ne busaanawo. Obusimu obuyitibwa neurons obwonooneddwa buyitibwa "Pick cells." Zifuuka ezizimba era nga zifaanana nga bbaatule. Ebibumbe bya puloteyina za tau ebitabuddwa munda mu butoffaali biyitibwa "Pick bodies." Bino osobola okubiraba wansi wa microscope. Ekikulu, obutoffaali buno obwa Pick n’emibiri gya Pick tebirabibwa mu bulwadde bulala bwonna.

Lwaki puloteyina zino eza tau tezikola bubi kikyali kyama. Wadde ng’abanoonyereza bakwataganya enkyukakyuka ezimu mu buzaale ku kino, emirundi egisinga obulwadde buno tebusibuka.

Obulwadde buno tebusiigibwa. Tebusiigibwa okuva ku muntu omu okudda ku mulala. Wadde nga waliwo okusobola okuyisibwa mu milembe, tekibaawo mu mbeera ezisinga obungi.

Obulwadde bwa Pick buzuulibwa butya? Bigezo ki ebikolebwa?

Abasawo basobola okuzuula obulwadde bw’okusannyalala mu maaso (FTD) nga bayita mu kukebera omubiri n’obusimu, okukebera okuzuula n’okukuba ebifaananyi, era ebivaamu bisobola okuzuula oba FTD ey’enneeyisa oba ekika ekitono ekya PPA.

Wabula engeri yokka ey’okumanya obulungi oba obulwadde bw’okusannyalala obw’omu maaso (FTD) bw’omuntu buva ku bulwadde bwa Pick kwe kunoonya emibiri gya Pick n’obutoffaali bwa Pick mu bitundu by’obwongo bwe. Kino kiyinza okulabibwa nga twekenneenya sampuli y’ebitundu by’obwongo wansi wa microscope. Kino kitegeeza nti obulwadde bwa Pick busobola okuzuulibwa mu ngeri enkakafu ng’omuntu amaze okufa, mu kwekebejja omulambo.

Ebigezo nga bino bisobola okukolebwa okuzuula FTD:

• Okukebera omusaayi: Bino binoonya obubonero bw'eddagala obuyitibwa "biomarkers" obuyinza okuyamba okuzuula endwadde ezimu.
• Okukebera amazzi g’omu bwongo:Kino kikolebwa nga baggya amazzi mu mugongo (spinal tap / lumbar puncture).
• CT scan (Ekifaananyi ekikwata ku kompyuta - CT scan) .
• EEG (Ekipimo ky’amasannyalaze eky’obwongo) .
• Okukebera obuzaale
• MRI scan (Okukuba ebifaananyi mu ngeri ya magineeti - MRI) .
• Okukebera PET (Positron emission tomography - Okukebera mu ngeri ya PET) .

Waliwo obujjanjabi bw'obulwadde bwa Pick's Disease? Kisobola okuwona?

Ebyembi, tewali ddagala, bujjanjabi, oba kuziyiza bulwadde bwa Pick. Abasawo basobola okuwandiika eddagala okuyamba okuddukanya obubonero ng’okwennyamira, obutafaayo, n’enneeyisa ey’obukambwe. Kyokka olw’okuba obujjanjabi buno bwawukana okusinziira ku muntu, omusawo wo y’asinga okwogera naye.

Obulabe bw’okukwatibwa obulwadde buno busobola okukendeezebwa?

Obulwadde bwa Pick bubaawo mu ngeri ezitategeerekeka, ezitamanyiddwa. N’olwekyo, mu kiseera kino tewali ngeri yonna gye tuyinza kubuziyiza oba okukendeeza ku bulabe bw’okubufuna.

Omuntu alina obulwadde buno ayinza kusuubira biseera bya mu maaso bya ngeri ki?

Mu ngeri zonna eza FTD omuli n’obulwadde bwa Pick’s Disease, obwongo bweyongera mpolampola. Nga bwe kikola, ebitundu by’obwongo ebikoseddwa bifiirwa obusobozi bwabyo okukola. Mu bulwadde bwa Pick, kino kitera okukosa ebitundu by’obwongo ebifuga enneeyisa oba ebitundu by’obwongo ebikwasaganya okwogera n’obusobozi bw’okutegeera abalala bye boogera.

Ate era oyinza okubulwa amagezi ku mbeera gy’olimu. Kwe kugamba, oyinza okubulwa obusobozi bw’okutegeera obubonero n’ebikutuukako olw’obulwadde buno.

Abantu abalina obulwadde bw’okusannyalala mu maaso (FTD) mpolampola bafiirwa obusobozi bw’okubeera nga beetongodde. Obulwadde bwe bugenda bweyongera, bayinza okwetaaga okulabirira essaawa 24 okuva eri abaagalwa baabwe oba abakugu abatendeke. Kino kiyinza n’okukwetaagisa okulabirira okumala ebbanga eddene.

Abantu abalina FTD bayinza okufuna obuzibu mu kumira (dysphagia) , ekiyinza okukaluubiriza okulya, okunywa, n’okwogera. Kino kyongera obulabe bw’okufuna embeera nga ekifuba oba okulemererwa okussa.

Ebika byonna ebya FTD, omuli n’obulwadde bwa Pick, mbeera za bulamu bwonna. Obulwadde buno buba bwa maanyi, mpolampola busaanyaawo ebitundu ebikulu eby’obwongo. Ebizibu ebiyinza okuvaamu biyinza okuba eby’amaanyi era ne bituuka n’okufa. Olw’okuba obulamu bw’omuntu bwawukana okusinziira ku muntu, kizibu okwogera ddala engeri obulwadde buno gye bunaakukwatamu n’ebbanga lye bunaamala. Omusawo wo (oba omusawo ajjanjaba omwagalwa wo) asobola okukubuulira ebisingawo ku nsonga eno.

Oyinza otya okukozesa ekiraamo kyo bw’oba ​​tosobola kwesalirawo?

Bw’oba ​​ozuuliddwa ng’olina obulwadde bw’okusannyalala mu maaso (FTD) nga bukyali, kikulu okwogera n’omusawo wo, ab’omu maka go oba abaagalwa bo, n’abo be weesiga abasobola okukusalirawo ebikulu mu bwangu. Emboozi eno eyinza okuba enzibu, naye okwogera ku bintu bino nga bukyali okusinga okulwawo kijja kuyamba abaagalwa bo okumanya ky’oyagala singa oba tosobola kwogera ku nsonga zo oba okusalawo.

Ng’oggyeeko emboozi eyo, kikulu n’okubeera n’ebyo by’oyagala n’ebyo by’osazeewo mu buwandiike. Bw’oba ​​tosobola kwerabirira, oba bw’oba ​​tosobola kusalawo ku kulabirira kwo oba ku bulamu bwo, lowooza ku ky’okuteekateeka ebiwandiiko eby’amateeka. Osobola okufuna obuyambi okuva eri munnamateeka okuteekateeka ebiwandiiko bino, naye n’ebimu ku byo osobola okubiteekateeka ggwe kennyini (okusinziira ku mateeka agali mu kitundu kyo, biyinza okwetaagisa okukkirizibwa omuwandiisi w’ebitabo oba omukungu omulala).

Okola ki singa omuntu akuli ku lusegere alaga obubonero buno?

Abantu abalina FTD batera obutamanya bubonero bwabwe oba embeera yaabwe. Olw’okuba tebalaba nti balina ekizibu, tebakkiriza nti beetaaga kujjanjabibwa. Obutategeera buno buyinza okunyiiza n’okutiisa omuntu alina obubonero n’abo abasinga okumusemberera.

Singa omuntu akuli ku lusegere aba alaga obubonero bwa FTD oba embeera efaananako bwetyo, osobola okugezaako okuyamba mu ngeri zino:

• Buuza engeri gy’oyinza okuyambamu: Wadde ng’abantu abalina FTD balaga obubonero, bayinza obutakimanya nti buno bubonero bwa kizibu kya maanyi ku bwongo. Bw’obawuliriza, ng’owaayo obuwagizi bwo, basobola okuwulira nga balina akakwate ku bantu be beesiga, era bayinza n’okufuna okuzzibwamu amaanyi kwe beetaaga okulaba omusawo.
• Bakubirize okunoonya obuyambi: Wadde ng’obulwadde bw’okusannyalala mu maaso (FTD) mbeera etaliimu ddagala oba bujjanjabi, waliwo engeri y’okujjanjaba n’okuddukanya obumu ku bubonero. Kaweefube ono asobola okuyamba nnyo okutumbula omutindo gw’obulamu bw’omuntu alina embeera eno. Okulaba omusawo kiyinza okuyamba omuntu alina FTD okuzuula obulwadde. Obulabirizi obw‟enjawulo busobola okuwa obuweerero okuva ku bumu ku bubonero obutanyuma eri abantu abalina embeera eno n‟ab‟omu maka gaabwe.
• Sigala mukkakkamu era ebintu tobitwala nga bya buntu: Abantu abalina FTD batera obutaba na buyinza ku bye boogera oba bye bakola. Kino kiyinza okulabika ng’abagezaako okunyiiza, okuswaza oba okulumya abalala mu bugenderevu, naye mu butuufu kizibu kya bujjanjabi.
• Totya kusaba buyambi: Okulabirira omuntu alina FTD kiyinza okuba ekizibu ennyo naddala ng’embeera yeeyongera okwonooneka okumala ekiseera. Totya kusaba buyambi oba eby’obugagga. Ebitongole bingi ebya gavumenti n‟eby‟obwannannyini biwa enkola n‟obuweereza obw‟obuyambi, gamba ng‟okulabirira abantu abakulu mu lunaku, okulabirira abaana abawummudde, n‟okulabirira abakadde awaka abalina obukugu.
• Okulabirira okumala ebbanga eddene kuyinza okuba enkola esinga obulungi: Bangi, okulabirira omwagalwa waabwe alina FTD kiyinza okuwulira ng’omulimu ogw’ekiseera kyonna. Si buli muntu nti asobola okumalira ebiseera oba amaanyi mangi bwe gatyo okulabirira omuntu we. N’olwekyo, kikulu okulowooza oba omwagalwa wo yeetaaga okulabirirwa mu kifo ekirabirirwamu abantu abamaze ebbanga eddene nga kirimu ebifo eby’abasawo abalina obukugu. Wadde nga kino kiyinza okuba ekizibu okusalawo, okulabirira ng’okwo kuyinza okuba engeri esinga obulungi ey’okukakasa nti tebalina bulabe, beeyagaza, era nga balina abalabirira abalina ebisaanyizo era abatendeke.

N’ekisembayo, obubaka obutwala awaka

Obulwadde bwa Pick’s Disease mbeera eyitibwa frontotemporal dementia (FTD), nga eno kika kya kusannyalala nga kyonoona mpolampola obwongo ku myaka emito okusinga endwadde endala ez’obwongo ezikwatagana n’emyaka. FTD era ekosa ebitundu by’obwongo ebiyamba omuntu okutegeera obulungi n’obutasaana bw’enneeyisa ye. Kino kiyinza okuleeta okwetamwa, obutategeeragana, n’okutaataaganya ebirala eby’amaanyi mu bulamu bwa buli muntu yenna akwatibwako. Wadde ng’obubonero obumu busobola okujjanjabibwa, tewali ddagala liyinza kuzzaawo bulwadde bwennyini, era abantu abalina obulwadde buno batera okwetaaga okulabirirwa buli kiseera, essaawa 24.

Bw’oba ​​ggwe oba omuntu ali ku lusegere lwo afuna obubonero buno, ekisinga obulungi kwe kugenda mu basawo amagezi. Jjukira nti toli wekka, era waliwo ebifo w’oyinza okufuna obuyambi.

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