Eddagala eppya erilwaza obulwadde bwa sukaali obw’ekika ekisooka: Ka tuyige ku Tzield (Teplizumab)

Waliwo omuntu yenna mu maka go alina obulwadde bwa sukaali obw’ekika kya 1? Oba omusawo akugambye nti oli mu bulabe bw’okukwatibwa obulwadde buno? Bwe kiba bwe kityo, leero twogera ku ddagala eppya eriyinza okulwawo okutandika obubonero bwa sukaali emyaka egiwerako. Kino ddala kireetedde abantu bangi essuubi ddene. Ka tulabe eddagala lino kye liri n’engeri gye likola.

Ssukaali ow’ekika kya 1 n’omulimu gw’eddagala lya Tzield

Okusooka, ka tutegeere obulwadde bwa sukaali obw’ekika kya 1 kye ki. Mu butuufu bulwadde obuva ku busimu obuziyiza endwadde . Mu ngeri ennyangu, abaserikale b’omubiri, abalinga ‘eggye’ erikuuma omubiri gwaffe okuva ku ndwadde, mu nsobi batandika okulumba obutoffaali bwaffe obulungi. Mu ssukaali ow’ekika kya 1, ‘okulumba’ kuno kubaawo ku butoffaali bwa beta mu lubuto lwaffe.

Lowooza ku butoffaali buno obwa beta ng’amakolero amatono agakola obusimu obuyitibwa insulini, obwetaagisa ennyo mu mibiri gyaffe. Insulini ayamba obutoffaali okukyusa ssukaali (glucose) ali mu mmere gye tulya n’afuuka amaanyi. Kale, abaserikale b’omubiri bwe basaanyaawo obutoffaali buno obwa beta, okukola insulini kukendeera mpolampola.

Okuzikirizibwa kuno tekujja kubaawo omulundi gumu. Kijja kubaawo mu mitendera esatu.

• Omutendera 1: Abaserikale b’omubiri batandika okulumba obutoffaali bwa beta, naye nga bukyakola insulini emala.
• Omutendera 2: Okwonooneka kw’obutoffaali bwa Beta kweyongera, ssukaali mu musaayi atandika okufuuka ow’enjawulo katono, naye n’okutuusa kati tewakyali bubonero bwa bweru.
• Omutendera 3: Obutoffaali bwa beta obusinga busaanawo, era omubiri tegusobola kukola insulini emala. Ssukaali mu musaayi alinnya nnyo. Wano obubonero bwa sukaali, gamba ng’ennyonta esukkiridde n’okufulumya omusulo ennyo we bulabika.

Wano eddagala eriyitibwa Tzield (teplizumab-mzwv) we liyingirira Tzield ddagala lya biologic. Kiyinza okukendeeza ku sipiidi abaserikale b’omubiri gye balumba obutoffaali bwa beta obw’abantu abalina ssukaali ow’ekika kya 1 ow’omutendera ogw’okubiri . Kino kitegeeza nti kiyinza okulwawo okukula kw’obulwadde okutuuka ku mutendera ogw’okusatu, ng’obubonero bulabika era nga kyetaagisa okukuba amasasi ga insulini buli lunaku.

Lino ddagala eriweebwa okuyita mu musuwa (okufuyira mu misuwa, oba IV) . Omusomo guno ogw’obujjanjabi guweebwa omulundi gumu olunaku okumala ennaku 14 ez’omuddiring’anwa.

Obujjanjabi buno bwa Tzield bunsaanira?

Ssukaali ow’ekika kya 1 asobola okukwata omuntu yenna ku myaka gyonna era ng’alina obulamu bwonna. Obujjanjabi bwa Tzield buyinza okukusaanira singa oba otuukiriza ebisaanyizo bino:

• Bwoba olina obulwadde bwa sukaali obw'ekika kya 1 obwa stage 2 .
• Eri ggweBwoba tolina sukaali wa type 2 .
• Bwoba olina emyaka 8 n'okudda waggulu .

Okukakasa oba olina obulwadde bwa sukaali obw’ekika kya 1 mu mutendera ogw’okubiri, omusawo ajja kukukebera omusaayi mu ngeri ey’enjawulo. Ebisinga obukulu ku bino kwe kukebera okukebera obutoffaali obuziyiza endwadde ( autoantibodies ) ku butoffaali bwa beta n'okukebera okugumira ssukaali mu kamwa . Era bajja kukebera obutoffaali bwo mu musaayi n’enziyiza z’ekibumba balabe oba eddagala lino teririna bulabe gy’oli.

Ebikolwa by’eddagala lya Tzield byasomesebwa bitya?

Okunoonyereza okw’enjawulo okwatuumiddwa TN-10 kwakolebwa okunoonyereza ku migaso n’akabi akali mu ddagala lino. Ekibuuzo ekikulu kye yabuuza kyali nti, "Tzield asobola okuyimiriza oba okulwawo okukula kwa sukaali ow'ekika kya 1 okutuuka ku mutendera ogw'okusatu mu bantu abali mu bulabe obw'amaanyi?"

Abeetabye mu mpaka zino baawuddwamu ebibinja bibiri. Ekibinja ekimu kyaweebwa eddagala lya Tzield. Ekibinja ekirala kyaweebwa eddagala eriyitibwa placebo . Kwe kugamba, eddagala ly’omunnyo eryali lifaanana eddagala naye nga temuli ddagala lyonna. Abalwadde wadde abasawo tebaamanyi ani afuna ki.

Kyangu okulaba ebisaanyizo n’okuggyibwako ebisaanyizo by’okwetaba mu kunoonyereza okuva ku kipande wansi.

Biki ebivudde mu kunoonyereza kuno?

Oluvannyuma lw’ennaku 14 nga bajjanjabwa, abantu bano baagobererwa okumala emyaka nga 5. Ebyavaamu ddala bizzaamu amaanyi.

Mu ngeri ennyangu, kyatwala emyaka nga 4 abo abamira Tzield okufuna obubonero, ate abo abamira placebo ne bafuna obubonero mu myaka nga 2. Naddala mu mwaka ogusooka ogw’obujjanjabi, omuwendo omutono ennyo ku abo abaali bamira Tzield be baafuna obulwadde bwabwe obweyongera. Ku nkomerero y’okunoonyereza kuno, 57% ku abo abaali bamira Tzield baali bakyali balamu bulungi era nga tebalina bubonero bwonna bwa sukaali. Naye 28% bokka ku abo abamira placebo be baakola.

Biki ebiva mu Tzield?

Okufaananako n’eddagala lyonna, Tzield asobola okuba n’ebizibu ebivaamu. Naye teweeraliikiriranga, bino ebisinga bisobola okuddukanyizibwa.

Ebizibu ebitera okuvaamu:

• Okusiiyibwa ku lususu: Kino ebiseera ebisinga kiyinza okuba akabonero akalaga nti olina alergy. Ebiseera ebisinga, si kya maanyi era kijja kugenda ku bwakyo. Olususu lukuume nga lunnyogovu era weewale okukunya. Ebintu ng’okunaaba n’amazzi agannyogoga oba okunaaba mu oatmeal bisobola okuyamba. Yogerako n’omusawo wo ku nsonga eno. Ajja kumuwa eddagala bwe kiba kyetaagisa. Wabula , singa ekizimba kiwerekerwako okuzimba olulimi oba emimiro, oba bw’oba ​​olina obuzibu mu kussa, genda mu kisenge ky’abalwadde ab’amangu (ETU) mu ddwaaliro mu bwangu.

• Obutoffaali obweru obutono (Lymphopenia): Omuwendo gw’obutoffaali obweru bwo guyinza okukendeera okumala akaseera mu nnaku ezisooka ng’ofunye obujjanjabi. Kino kiyinza obutakukosa naye kiyinza okukuleetera okufuna yinfekisoni. Kino kijja kudda mu mbeera eya bulijjo mu wiiki ntono. Omusawo ajja kukulondoola buli kiseera kino.

• Omutwe: Omutwe ogulumwa ennyo guyinza okubaawo. Kitera okugenda ku bwakyo. Singa obulumi bw’omutwe busigala oba ne bufuuka obw’amaanyi, tegeeza omusawo wo.

Ebizibu eby’amaanyi by’olina okwegendereza:

• Obulwadde bw’okufulumya eddagala lya Cytokine:Kubanga eddagala erikosa abaserikale b’omubiri, nga Tzield, oluusi liyinza okuvaako ebirungo ebiziyiza endwadde bingi ebiyitibwa cytokines okufuluma mu musaayi omulundi gumu. Kino kiyinza okubaawo mu nnaku ezisooka ez’obujjanjabi. Obubonero ng’omusujja, okuziyira, okulumwa omubiri, n’okukoowa ennyo buyinza okubaawo. Omusawo wo ajja kukuwa eddagala eddala (e.g. paracetamol) nga tonnafuna bujjanjabi okukendeeza ku zino. Bw’oba ​​olina obubonero buno, tegeeza omusawo mu bwangu.

• Omuwendo gw’obutoffaali obweru obw’amaanyi gukendeera: Singa embeera eno efuuka ya maanyi, eyinza okuvaako yinfekisoni ez’amaanyi. Bw’oba ​​olina obubonero bw’obulwadde ng’omusujja, okusiiyibwa, okusesema, n’okukoowa ennyo , tegeeza omusawo mu bwangu.

Bino byonna si bye bizibu ebiyinza okuva mu Tzield. Bw’oba ​​olina obubonero bwonna obukutawaanya, kakasa nti olaba omusawo akuwe amagezi.

Omanya otya nti eddagala likola?

Ekigendererwa kya Tzield kwe kulwawo okutandika obubonero. N’olwekyo, oyinza obutalaba njawulo nnene ng’omaze okumira obujjanjabi. Buno bujjanjabi bwa nnaku 14 obw’omulundi gumu. Oluvannyuma lw’ekyo, omusawo ajja kukebera obulwadde bwa sukaali buli kiseera alabe bw’ali. Tolekera awo kumira bujjanjabi oba okukyusa enteekateeka nga tolina magezi ga musawo.

Waliwo obuzibu bwonna ku ddagala eddala?

Nga tonnatandika bujjanjabi bwa Tzield, kikulu nnyo okubuulira omusawo wo ku ddagala eddala lyonna ly’omira (omuli vitamiini, ebirungo ebiyamba omubiri, eddagala lya Ayurvedic oba ery’omuddo).

Okusingira ddala olina okwegendereza okufuna eddagala erigema ng’omira Tzield. Eddagala erimu erigema liyinza obutakola bulungi, ate erimu liyinza obutaba na bukuumi. Nolwekyo , nga tonnafuna ddagala lyonna erigema, tegeeza omusawo wo nti omira Tzield.