I pum na pawh i nei fo em? I bawlhhlawh ah thisen a awm em? Ulcerative Colitis a ni thei ang em? Hemi chungchang hi han sawi ila!

I pum chhungah pawh i rilru a hah fo em, i pum a khat leh kang ang maiin? A chang chuan i bawlhhlawh nen thisen tlem i pass chuan tlem chuan i ngaihtuah tur a ni. Hei hi `(Ulcerative Colitis - UC)` tih natna lan chhuahna a ni thei. Lungngai suh, he thu hi awlsam takin, i hriatthiam theih dan tur angin kan sawi dawn a ni.

`(Ulcerative Colitis - UC)` tih hi eng nge ni? A awlsam zawngin...

A awlsam zawngin sawi ila, Ulcerative Colitis hi dam chhung zawnga natna a ni a, i colon leh rectum-ah inflammation leh ulcer a thlen thin. Natna pawl lian zawk Inflammatory Bowel Disease (IBD) an tih zingah a tel a ni. Crohn natna chungchang pawh i hre tawh mai thei, a dik em? Chu pawh chu IBD nen hian category khatah a tla ve bawk .

UC i neih hian thisen chhuak, pum na, leh zun tam ang chi thil i nei thei . Heng symptoms te hi a na zual fo thin tih hre reng ang che, chu chu "flare-ups" kan ti thin. Tin, chutah chuan symptom-free tak tak i nih theihna hun dang a awm bawk a, chu chu "remission" kan ti a ni.

`(UC)` chi hrang hrang a awm em?

Ni e, UC hi chi hrang hrang a awm. Hengte hi i colon chhunga khawiah nge swelling leh sores awmna a zirin classified a ni . A tam zawkah chuan i rectum tawp ber atanga tan a ni a, chu chu i hnute hnaih ber a ni. Chutah chuan a intan thei a, colon chhungah a darh thei bawk. Heng chi hrang hrangte hi hetiang hi a ni:

• Ulcerative proctitis: Hetah hian inflammation hi i rectum tawp ber ah chauh a awm thin.
• (Proctosigmoiditis): Hetah hian inflammation hi anus (rectum) tawp ber leh a hnuai lam, ‘S’ ang maia lian intestine (sigmoid colon) ah a awm a.
• (Left-sided colitis): A hming ang bawkin hei hian colon veilam a nghawng a ni.
• (Pancolitis): Chutiang a nih chuan, swelling leh lesions te chu colon pumpuiah a darh thei a ni .

He natna (UC) hi a na lo thei a, a na lo thei a, a na thei bawk , i natna lan chhuah dan azirin. Tin, na tak tak, mahse a tlem hle, ``fulminant ulcerative colitis'' tih chi pawh a awm bawk. A chang chuan nunna atana hlauhawm a ni thei a, damdawi lam pan vat a ngai bawk.

He natna hi engtiang chiahin nge `(Ulcerative Colitis)` an tih?

Crohn natna nena khaikhin chuan North America leh Europe-a mi 250 zinga pakhat velin heng natna zinga pakhat hi an vei nia chhut a ni. United States-ah ringawt pawh hian mi 900,000 vel chu UC vei nia chhut a ni. Hetiang dinhmun hi Sri Lanka-ah pawh hmuh tur a awm nasa hle.

Ulcerative Colitis natna lan chhuah dan chu engte nge ni?

UC symptoms hi hun kal zelah a na zual fo thin.Awle. A tirah chuan heng ang chi natna tenau, tenau te hi i hmu thei ang:

• Abdominal distension: Hei hi thisen nen a thleng thei a, a thleng lo thei bawk.
• Bowel movement tam zawk: Hei hi ni khatah vawi li emaw a aia tlem emaw a ni thei.
• Toilet-a kal duhna: Thil mamawh hmanhmawh tak, thunun harsa tak.
• (Tenesmus): Hei hi thumal mak deuh a ni lawm ni? A awlsam zawngin sawi ila, toilet kal ngai mahse kal thei lo ang maia inhriatna, i pum chhunga inkhung tlat ang maia inhriatna a ni.
• Pum na deuh emaw, tightness emaw a awm.

Nakinah chuan natna a zual zel chuan heng ang chi symptoms moderate emaw na tak emaw pawh a awm thei bawk:

• Toilet kal fo a ngai a, ni khatah vawi li aia tam kal a ngai.
• Thisen, mucus emaw, zunthlum emaw a awm. Hei hi ngaihtuah tur chhinchhiahna a ni ngei ang.
• Pum natna nasa tak.
• Chau lutuk (chau) tih hriat. Engmah tih theih loh khawpa chau lutuk nia inhria.
• A taksa rihna tlahniam nghal.
• Nauseous tih hriatna.
• Khawsik.

Dik tak chuan UC vei zinga a chanve vel chuan flare-ups neih laiin symptoms na lo tak tak an nei thin. Mahse mi dangte chuan khawsik, thisen chhuak, luak chhuak, leh pum na tak tak an nei fo thei.

Colon tih lohah hian symptom dang a awm em?

Ni e, mak ti suh, UC vei zinga 25% vel chuan colon pawnah, taksa hmun dangah symptoms an nei thei a ni . Hei hi a chhan chu colon-a inflammation hi a chang chuan taksa peng dang, ruh, ruh, mit, vun leh thin-ah te a darh thei a ni.

• Joint na leh a hring.
• Mit sen, inflammation, mit a hring.
• Vunah natna, hliam emaw, hliam emaw a awm.

Engvangin nge he `(Ulcerative Colitis)` hi a lo awm? Eng nge a chhan?

Hetiang dinhmun hi a chhan dik tak hi hriat a la ni lo. Mahse, doctor leh zirchiangtute chuan natna khirh tak niin an ngai a, risk factor tam tak a inzawm khawm a ni . A tam zawk chuan kan taksa immune system hnathawh dik lohna nen a inzawm tih an pawm .

Ngaihtuah teh, kan immune system hna ber chu pawn lam atanga lo chhuak hrik leh thil tha lo dang laka kan taksa venhim hi a ni. Mahse a chang chuan, he immune system hian kan taksa hrisel tak takte hi a rawn bei sual tan thin. Chutah chuan hetiang inflammation leh tissue chhiatna hi a thleng thin. `(UC)` ah chuan he attack hi colon chhungril lam ah a thleng thin.

Risk factors te chu engte nge ni? Tuin nge a nei tam zawk?

Tu pawhin Ulcerative Colitis vei thei mahse, mi thenkhat chu an hlauhawm zawk. Hêng thudikte hi i tân a inmil em tih en rawh:

• Kum: He natna hi thalai kum 15 leh 30 inkar, emaw, kum 60 hnu lama kum upa zawkte zingah a awm tam ber .
• Hnam leh chi: Zirchianna thenkhatah chuan mipa hring, a bik takin Ashkenazi Juda hnam chhuakte chu an hlauhawm zawk tih hmuhchhuah a ni. Mahse, hei hian Sri Lanka ang ram a nghawng nasat zia hriat chian nan zirchianna neih belh a ngai a ni.
• Genetics: Hei pawh hi thil pawimawh tak a ni. I chhungte hnai ber (i.e., nu leh pa, unau, naupang) tu emaw chuan UC emaw Crohn’s disease emaw a neih chuan he natna hi i vei theihna a sang zawk. UC vei zinga 20% vel chuan chhungkaw member pakhat, heng zinga pakhat vei hi an nei a ni.
• Gut microbiome: Kan chaw ei dan, a bik takin kan intestine lian takah hian microbes (bacteria, virus, fungi) maktaduai tam tak a awm a. He thil khawlkhawm hi ``gut microbiome'' an ti a. Kan intestine chhunga ecosystem te tak te ang mai a ni. Research atanga a lan dan chuan he microbial environment ah hian ``UC'' vei te chu he natna nei lo te nen khaikhin chuan danglamna nasa tak a awm a ni . A chhan dik tak hriat ni lo mah se, hei hian ``UC'' lo chhuahnaah pawh a pui niin an ngai.

Thil pakhat hriat reng tur chu i stress leh i ei leh in hian direct takin i UC a thlen lo tih hi a ni. Mahse, UC i neih tawh chuan heng thilte hian i symptoms a tizual thei a ni. Chuvangin, UC i vei tih hmuhchhuah a nih chuan i tih theih tha ber chu i triggers te kha uluk taka en reng a, a theih ang anga pumpelh hi a ni.

Ulcerative Colitis vang hian eng harsatna dang nge awm thei?

Ulcerative Colitis neih hian hriselna lama harsatna dang engemaw zat i neih theihna a tipung a ni. Chungte chu damdawi lam enkawlna leh enkawlna dang a ngai thei bawk.

• Anemia: Colon hliam avanga thisen chhuak chhunzawm zel, zawi zawia, a chang chuan rang taka thisen chhuak nasa lutuk hian taksaa thisen awm zat a ti tlem thei a, chu chuan thisen tlakchhamna (anemia) a thlen thei a, chu chu thisen sen (red blood cells) a tlahniam a ni.
• Colon cancer: UC vei, a bik takin kum tam tak chhung he natna vei tawhte chu midang aiin colon cancer vei an tam zawk. I risk chu i colon-a inflammation awmna leh UC i neih rei danah a innghat a ni. Hemi chungchang hi doctor nen inbiakna neih a pawimawh a, checkup pawh neih fo a pawimawh.
• Osteoporosis: Colon-a inflammation hian a chang chuan ruh leh ruh a nghawng thei a, ruh chak lohna a thlen thei a, hei hi osteoporosis an ti a ni.
• A rilru a buai em em a, a rilru a hah em em bawk a.Hei hi hming buaithlak deuh a ni. A awlsam zawngin sawi ila, colon-a inflammation chu liver-ah a darh chuan liver-a bile duct-te chu a hring thei a, a hliam thei bawk. He tissue chhia hian liver hnathawh a tichhe thei a ni.
• Naupangte thanlenna leh thanlenna lama harsatna: Naupang tê têin UC a neih chuan intestine lian hnathawh a tikhawtlai thei a, chu chuan taksain a ṭhanlenna leh a thanlenna atana thil pawimawh tak tak a lakluh theihna a ti tlem thei a ni. UC damdawi i ei lai hian i fate chu supplement dang bakah vitamin pek a ngai mai thei.

Complications emergency-a enkawl ngai te

Heng harsatnate hi a hlauhawm deuh a, hetiang thil hi a thleng a nih chuan damdawi inah dah nghal tur a ni a, emergency treatment (ER treatment) i dawng tur a ni.

• Dehydration na tak: Bowel movement tam lutuk hian i taksaah tui tam tak a hloh thei a, chu chuan dehydration nasa tak a thlen thei a ni. Chutiang a nih chuan damdawi inah IV fluid pek a ngai mai thei.
• Colon Perforation: Hei hi a hlauhawm hle a, a hlauhawm hle. Colon bang chhunga khur awm chu medical emergency a nih avangin operation nghal a ngai a ni.
• Thisen chhuak nasa: Hliam atanga thisen chhuak tam tak a awm chuan thisen pek a ngai mai thei.
• Toxic megacolon: Hei pawh hi thil awm lo mahse nunna atana hlauhawm tak a ni. Swelling na tak chuan colon hnathawh a titawp vek a, chu chuan colon a ti lian (megacolon) a, thisenah toxins a leak lut thin.
• Thisen zam: UC hian taksa thisen kalna kawng ( veins , arteries , leh capillaries)-ah thisen zam a siam theihna a tipung a ni. Heng clots te hi khawi hmunah nge an awm tih a zirin nunna atana hlauhawm tak an ni thei.

Engtin nge Ulcerative Colitis hi hmuhchhuah a nih? Eng test nge tih thin?

UC i vei nia i rinhlelh chuan i doctor chuan i natna lan chhuah dan a zawt hmasa ang che a, taksa enfiahna a nei ang che a, i chhungte zingah IBD nei an awm leh awm loh a zawt ang che. Tichuan, UC nena inmil symptom nei condition dang te chu paih chhuah nan leh UC finfiah nan test engemawzat an ti thei ang.

• Thisen test: I thisen sample lak a, thisen tlakchhamna (anemia) a awm leh awm loh enfiah theih a ni. Anemia hian colon emaw rectum emaw ah thisen a chhuak tihna a ni thei. Heng thisen test te hian a chhan dang, infection te pawh a zawng thei bawk.
• Stool samples: I stool sample pakhat chu infection, parasites, inflammation chhinchhiahna a awm em tih enfiah a ni ang.
• Imaging test: Colon leh rectum chhung lam en turin thlalak lak theih a ni.
• (Barium enema hmanga siam) .X-ray chi khat bik a ni. Colon chhunga swelling ang chi thil a hmuchhuak thei.
• CT scan (Computed Tomography scan) leh MRI (Magnetic Resonance Imaging) hmangin colon-ah hian a hring tih chiang takin a lang thei a, a bik takin UC vei nasat lutuk leh natna khirh tak takah chuan.
• X-ray pangngai hian harsatna hlauhawm tak tak, megacolon emaw, colon perforation emaw a awm leh awm loh a enfiah thei bawk.
• Endoscopic tests: Hei hi UC hriat theihna atana test ber leh chiang ber a ni. Endoscope chu tube te tak te, flexible tak a ni a, a tawp khatah camera te tak te a awm a. He tube hi i hnute kaltlangin dah a ni a, doctor chuan i colon chhungril chu a hmu thei ang. Tin, rinhlelhna hmun atanga tissue te tak te (biopsy) an la thei bawk a, lab-ah an thawn thei a, an natna hmuhchhuah chu an finfiah thei bawk. UC hriat theihna atana endoscopic test lian ber chu colonoscopy leh sigmoidoscopy te hi a ni .

Ulcerative Colitis hi engtin nge enkawl a nih?

UC enkawlna kawngah hian tum lian tak pahnih a awm a. Pakhat chu i symptoms (flare-ups) tihtlem a, remission-a dah che hi a ni. Tum dang chu remission i neih tawh chuan i remission chu vawng reng tur a ni. Hei hi damdawi hmanga tih a ni ber a , a chang chuan operation hmanga tih a ni bawk .

Damdawi chi hrang hrang

Doctor-te chuan damdawi chi hrang hrang (amah chauh emaw, a inzawm emaw) hmangin inflammation tihziaawmna leh colon-a hliam tihdam nan an hmang thin. Swelling leh inflammation a tlahniam chuan tissue te hian dam theihna chance an nei thin. Hei hian i natna lan chhuah dan a tiziaawm bawk a, i natna leh i ril a thunun bawk.

• (Aminosalicylates): Sulfasalazine (Azulfidine®) hi UC na lo leh na lo tak tan chuan pek thin a ni. Mahse, sulfa allergy i neih chuan doctor hnenah hrilh rawh. I doctor chuan sulfa ni lo aminosalicylate, mesalamine (Canasa®, Delzicol®, Asacol® HD, Pentasa®, Lialda®, Apriso®) te a pe thei ang.
• Corticosteroids: UC na tak i neih chuan corticosteroid, prednisone (Deltasone®) emaw budesonide (Entocort® EC, Uceris®) emaw pek i ni thei. Mahse, heng corticosteroids hian side effect lian tham engemaw zat a neih avangin doctor-te chuan hun rei lote chhung atan chauh an rawt a ni.
• Immunosuppressants: Heng damdawi te hi i taksa chakna (immune system) a overactive loh nan leh i taksa ngei pawh a beih loh nan control nan pek a ni a, chu chu immune system tihlum nan a ni. `(6-mercaptopurine (Purixan®, Purinethol®))`, `(azathioprine (Azasan® leh Imuran®))` emaw `(methotrexate (Trexall®))` emaw chu chutiang damdawi chu a ni.
• (Biologics) (Biologics) te: 1.1.Hengte hi damdawi thar deuh tak an ni a, a hlawk hle bawk. UC vei natna vei (moderate to severe case) enkawlna atan an hmang thin. Heng damdawi te hian inflammation-a inrawlh immune system hmun bikte hnathawh control-in hna an thawk a ni. Biologic damdawi te chu infliximab (Remicade®), adalimumab (Humira®), golimumab (Simponi®), vedolizumab (Entyvio®), leh ustekinumab (Stelara®) te an ni.
• (Janus kinase (JAK) inhibitors - small molecule drugs): `(Tofacitinib (Xeljanz®))` ang damdawi hian taksaa enzyme bik pakhat, inflammation thlentu hnathawh a titawp a, hna a thawk a ni. `(Upadacitinib (RinvoQ®))` hi `(JAK inhibitor) chi dang a ni.`

Inzai

Damdawi ei chung pawha symptoms control loh a nih chuan, emaw, UC hian harsatna nasa tak a thlen a nih chuan surgery hi a hnuhnung ber a ni thei. UC vei zinga 30% vel chuan an dam chhungin engtik lai pawhin operation an mamawh dawn a ni. Tin, UC vei naupang 20% ​​vel chuan operation an mamawh thei bawk.

UC tan hian surgery chi hnih a awm a. An pahnih hian proctocolectomy , tih procedure an nei a, chu chu i colon leh rectum zawng zawng emaw, a then emaw lak chhuah a ni.

1. (Proctocolectomy leh ileal pouch): Hei hi UC tan surgery tih dan tlangpui leh duh ber a ni. Hetiang tih danah hian surgeon chuan i colon leh i rectum tawp ber chu a la chhuak a, mahse i hnute chu a chhuahsan thung. Tichuan, i small intestine atanga a then chu pouch te tak te (ileal pouch) siamin i rectum nen inzawm tir a ni. Surgery atanga i dam hnuah he small intestine hian rectum thar angin hna a thawk a, chu chuan bowel movement pangngai i nei thei a ni.

2. (Proctocolectomy leh ileostomy): A chang chuan, ``ileal pouch'' siam theih a ni lo mai thei. Chutiang a nih chuan i medical team chuan permanent (ileostomy) (ileal pouch tel lovin) an rawt thei ang. Hei hian surgeon chuan i colon pum pui, i rectum hnuhnung ber leh i hnute chu a la chhuak vek a ni. Tichuan, i pum (belly) ah khur te tak te siamin i taksa pawn lamah pouch (ileal stoma) i bun a, chu chuan bawlhhlawh a khawlkhawm thin. He pouch hi i empty fo a ngai dawn a ni.

Ulcerative Colitis symptoms flare-ups te hi engtin nge kan ven theih ang?

UC i neih chuan i flare-ups tih tlem tum a pawimawh. Chutianga tih theih dan tha ber chu i triggers te hriatchhuah a, a theih ang anga pumpelh hi a ni. Trigger tlangpui laka invenna tur tips thenkhat chu hetiang hi a ni:

• Stress enkawl dan:Stress hi UC flare-ups thlentu lian tak a ni thei. Chuvangin, zan khatah darkar 7 tal mut tha la, exercise la la, i rilru ti thlamuang thei thil, meditation ang chi ti rawh.
• NSAIDs pumpelh: Khawsik emaw taksa na emaw i neih chuan acetaminophen (Tylenol®) ang chi damdawi ei thin ang che. Nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (Motrin®, Advil®) te hian UC symptoms a ti na zual thei a ni.
• I natna lan chhuahna tizual thei ei tur ei loh tur: Mi zawng zawng hi ei tur inang hian a nghawng vek lo. I tan i symptoms ti na zualtu chu midang tan chuan a inang lo mai thei. Mahse, UC vei tam tak chuan bawnghnute leh fiber tamna ei tur hian flare-up a thlen tih an hmuchhuak. I doctor emaw dietitian emaw nen inbia la, i tana tha tur leh i taksa mamawh nutrients i hloh lo tur meal plan siam rawh.

I natna lan chhuahna tizual thei thil, ei leh in leh dinhmun te chu diary te tak te siam a tha. I doctor hnena i sawi hian chutiang thilte pumpelh dan tur leh i dinhmun enkawl dan tur tha ber berte chu in rel dun thei a ni.

Ulcerative Colitis ka vei a nih chuan eng nge ka beisei ang?

Mi hrang hrangah hian a dinhmun (UC) hi a inang lo hle. Mi thenkhat chuan an nunah flare-up pakhat chauh an nei a, flare-up dang an nei ngai lo mai thei. Mi dangte chuan natna lan chhuah dan rei tak, thunun harsa tak tak an nei thei bawk.

Mahse, mi tam tak tan chuan symptoms a lo thleng a, a kal zel bawk. Chu chu, symptoms pung hun chhung (flare-ups) leh hun rei zawk, symptom awm lohna hun chhung (remissions) inkarah an inthlak danglam tihna a ni. UC vei zinga 30% vel ah chuan hun kal zelah a natna lan chhuah dan chu a zual zauh zauh a, a tam zawk a, a tawpah chuan operation neih a ngai ta a ni.

Mi tam zawk chuan an UC hi triggers te pumpelh a, an damdawi ei tur angin an enkawl thin. I hriselna enfiah turin doctor i pan fo tur a ni bawk. Entirnan, i doctor chuan colon cancer enfiah nan colonoscopy neih fo a rawt thei a, chu chu i risk a zirin a ni. I doctor chuan heng zawng zawng hi a hrilhfiah ang che.

Ulcerative Colitis hi a dam vek dawn em ni?

Hetiang dinhmun "damdawi" awmchhun chu i colon leh rectum lakchhuahna tur operation hi a ni. Mahse, kan sawi tawh ang khan mi tam zawk chuan damdawi hmangin an enkawl tha thei a, a tul chuan operation hmangin an enkawl thei a, nun pangngaiin an hmang thei bawk. UC enkawlna tum ber chu remission neih leh a rei thei ang bera vawn reng hi a ni. Hemi kawngah hian i medical team te chuan an pui ang che.

Engtikah nge ka doctor ka biak ang?

`(UC)` i neih chuan heng symptoms te hi i neih chuan doctor ko nghal la, damdawi in hnai ber pan rawh:

• Stool i pass lutuk a nih chuan, chawlhsan lovin.
• Anus atanga thisen chhuak a awm chuan, emaw, ek chhungah thisen zam a awm chuan.
• Natna nasa tak leh khawsik sang tak i neih fo chuan.

Hetiang symptoms hian i dinhmun a chhe zual thei tih a tilang a, chuvangin doctor thurawn lak vat a pawimawh hle.

Ka doctor hnenah eng nge ka zawh ang?

UC i neih chuan i doctor hnenah zawhna i neih apiang zawh hreh suh. I dinhmun i hriat tam poh leh i enkawl a awlsam zawk ang. Zawhna i zawh theih ṭhenkhat chu hetiang hi a ni:

• UC chi ka neih hian engtin nge ka hmalam hun hriselna (prognosis) a nghawng?
• UC atanga harsatna dang ka neih theihna tur risk chu eng nge ni?
• Eng treatment nge ka tan i recommend?
• Heng enkawlna atang hian eng risk emaw side effect nge ka beisei theih ang?
• Engtin nge flare-ups awm lo turin ka nunphung ka thlak danglam theih ang? (Ei leh in, exercise, stress management, etc. ang chi thil chungchang)
• Symptoms a na zual chuan in lamah eng nge ka tih theih ang?

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Ulcerative Colitis hi dam chhung zawnga natna a ni a, eng emaw chen chu a tichak lo thei hle. Mahse, damdawi lam enkawlna leh thurawn dik tak pek bakah, i nunphung a tul anga tihdanglamna i neih chuan i dinhmun chu i enkawl tha thei a, nun hrisel tak i hmang thei bawk.

I medical team te nen thawhhona tha tak neih a pawimawh hle. I damdawi ei tur chu doctor-in a tih angin ei la, a hun takah ei bawk ang che. Symptom nei lo i nih pawhin i damdawi ei kha bansan suh, hei hian i symptoms a ti na leh thei a, i dinhmun control a harsat phah thei bawk.

Complication i neih theihna tur leh chu chuan i care plan a nghawng dan tur hrethiam rawh. Entirnan, UC nei lo mi aiin thisen test emaw colonoscopy emaw i mamawh tam zawk mai thei. I remission vawng reng tur leh i hriselna zawng zawng vawng reng thei tur kawng tha ber berte chu i doctor nen sawiho rawh. Nangmah chauh i ni lo va, he zinkawngah hian doctor, nurse leh i hmangaih tak takte pawh an awm bawk.

` Ulcerative Colitis, Colon Ulcers, Pum natna, IBD, Crohn natna, Luak chhuak, Eksa chhunga thisen awm, Chaw ei dan