I platelets a sang em? Thrombocytosis chungchang hi han sawi ila!

I thisenah platelet sang tak i nei tih hmuhchhuah a ni bawk em? A nih loh leh i hriat mi pakhatin he natna hi a nei em? Hetiang thil i hriat hian tlem a hlauthawng deuh hi thil pangngai a ni. Mahse lungngai suh, vawiinah hian he natna Thrombocytosis an tih hi i hriatthiam theih tur awlsam takin kan sawi dawn a ni.

Thrombocytosis tih hi eng nge ni? A awlsam zawngin...

A awlsam zawngin sawi ila, thrombocytosis chu i thisenah platelet tam lutuk i neih hian a ni. Tunah chuan, “Platelet chu eng nge ni?” Chu chu zawhna pawimawh tak a ni!

Platelets hi kan thisena awm cell te tak te chi khat a ni. An hnathawh ber chu thisen chhuah lai, hliam awm lai ang chi, thisen chhuah tihtawp hi a ni. Dam te tak te ang maiin an che thin.

Mahse, platelet a pun lutuk chuan eng nge thleng ang? I thisen chu a thim thei a, a sticky thei bawk. Thil na tak tak thenkhatah chuan heng platelet tam lutuk hian thisen kalna kawng chhungah thisen zam hlauhawm tak a siam thei a ni. Hei hian stroke emaw heart attack emaw ang chi natna a thlen theihna a tipung thei a ni .

Mahse, Thrombocytosis vei zawng zawng hi a hlauhawm inang vek lo. A natna nasat dan te, enkawlna i mamawh leh mamawh loh te chu a chhan a zirin a ni.

Thrombocytosis hi chi hnih a awm a, chungte chu:

Ni e, doctor-te chuan he natna chi hnih lian tak an hmuchhuak a ni. Chumi chungchang chu tlem han sawi ila.

1. Thrombocythemia pawimawh tak (ET) emaw Primary Thrombocytosis emaw a awm thei

Hei hi thisen lama harsatna awm lo tak a ni. I ruhro – i ruh chhunga thisen cell factory – hian platelet tam lutuk a siam chhuah hian a thleng thin. Ngaihtuah teh, kan taksaa thisen cell tam zawk hi he ruhroah hian siam a ni. Essential thrombocythemia vei chuan he thisen cell siam danah hian chhiatna a neih avangin platelet a siam tam lutuk a, hei hi a danglam bik hle.

He natna hi ET (Essential Thrombocythemia) tia koh a ni a, thisen group Myeloproliferative Neoplasm (MPN) tia koh zinga natna tlanglawn ber nia ngaih a ni.

2. Reactive Thrombocytosis emaw Secondary Thrombocytosis emaw a awm thei

Hei hi Thrombocytosis chi khat a ni ber. Hei hi i taksain natna dang, natna hrik, hliam, operation emaw, i rilru a tihbo emaw avanga platelet tam zawk a siam hun a ni. A awlsam zawngin, i taksa hian thil dang a chhang let a, a platelet level a tisang a ni. HeiReactive thrombocytosis hi hun eng emaw chen atan a ni fo thin a, chu chu a chhan bulpui ber a chinfel hnuah platelet count chu a normal leh ta tihna a ni.

Tute nge thrombocytosis vei?

He natna hi kum 60 chunglam zingah hmuhchhuah a ni ber a, chubakah Essential Thrombocythemia (ET) tih chi khat chu hmeichhiaah mipa aiin a let hnih in a tam zawk tih an sawi bawk.

Thrombocytosis awm chhan hi engte nge ni?

A hmaa kan sawi chi hnihte chhan pawh a inang lo.

Essential Thrombocythemia (ET) awm chhan hrang hrangte .

Essential Thrombocythemia (ET) hi thlahtute atanga lo chhuak a ni. I pianpui thil a ni lo. Platelet siamna atana inrawlh gene thenkhat inthlak danglamna, a nih loh leh mutations avanga lo awm a ni. Hei hian i ruhroah platelet tam lutuk a siam chhuak thin.

Essential Thrombocythemia (ET) vei zinga a chanve aia tam chuan JAK2 gene-ah mutation an nei a. CALR emaw MPL genes-ah pawh mutation a awm fo bawk.

Scientist-te chuan heng gene mutations thlentu hi eng nge ni tih chiang takin an la hre thei lo a, mahse hemi chungchangah hian zirchianna an la nei chhunzawm zel a ni.

Reactive Thrombocytosis awm chhan te

Hetiang chi hi i taksain dinhmun hrang hrang avanga platelet a siam tam zawk vang a ni. A nih loh leh, a châng chuan, platelet hluite chu a rate pangngaia tihchhiat ai chuan a pung khâwm vâng pawh a ni thei bawk.

Reactive Thrombocytosis thlen thei thil thenkhat chu hetiang hi a ni :

• Anemia , a bik takin iron tlakchhamna avanga thisen tlakchhamna.
• Thisen lama harsatna dang.
• Cancer chi hrang hrang .
• Hri kai, pneumonia ang chi te .
• Inflammatory conditions – taksaa inflammation thlentu, rheumatoid arthritis ang chi.
• Inhliam .
• Kidney tha lo a awm .
• Damdawi thenkhat.
• Surgery, a bik takin pum surgery.
• Spleen lakchhuah a ni.
• Vitamin B12 tlakchhamna enkawl dan.

He list-ah hian a chhan tlangpui tlemte chauh a tel. Reactive Thrombocytosis thlentu dang tam tak a awm thei bawk .

Thrombocytosis natna lan chhuah dan chu engte nge ni?

Vawi tam tak chu platelet count sang tak nei te hian symptom engmah an nei lo va, a tir lamah pawh a tlem berah chuan an nei lo. Reactive Thrombocytosis , i neih chuan a thlentu damdawi lam dinhmun bulpui (underlying medical condition) symptoms i nei thei.

Mahse, symptoms a awm tak tak chuan i taksaa thisen chhuah dan pangngai lo leh thisen zam nen a inzawm fo thin. Symptoms i hmu thei ang:

• Lu na .
• A awlsam zawngin a hliam.
• Chak lo, luak chhuak emaw, lu hah emaw tih hriat.
• Hnar, hmui leh hmui atanga thisen chhuak.
• Pum emaw, intestines-a thisen chhuak.

Essential Thrombocythemia (ET) vei thenkhat chuan Erythromelalgia tih natna an nei thei a. Hei hian kut leh ke a ti na a, a ti na a, a sen bawk. Kut leh keah pawh rilru hah leh tingling an nei thei bawk.

A nasat chuan thrombocytosis hian pum chhunga thisen zam pangngai lo (e.g., Budd-Chari syndrome ) a thlen thei a, stroke emaw heart attack emaw a thlen theihna a tipung thei bawk.

Engtin nge thrombocytosis hi an hriat theih?

Thrombocytosis hian symptoms a thlen loh avangin, clue i neih hmasak ber chu thisen test pangngai (e.g., Complete Blood Count – CBC )-ah platelet count a sang tih hmuhchhuah a nih chuan a ni.

Thrombocytosis tih hi thisen microliter khatah platelet 450,000 chuang awm tihna a ni. I platelet count a sang a nih chuan i doctor chuan kar tlemte hnuah thisen test leh turin a ti mai thei a, chu chu a level a sang reng em tih a enfiah ang. Platelet count vawi khat tihpun a, a hnua a pangngaia a lo kir leh hi harsatna a ni tlangpui lo. Mahse, a level sang reng chuan a hnuaia damdawi lam dinhmun a kawk thei a ni.

Reactive thrombocytosis -ah chuan, a chhan bulpui (e.g., iron deficiency anemia , cancer, infection) hriatchhuah hian doctor-te chu a hriatchhuah leh enkawl danah a pui thei a ni. Mahse, doctor chuan chutiang secondary cause a hmuh theih loh chuan Essential Thrombocythemia (ET) i vei em tih test dang an ti leh ang.

Heng test-ah hian:

• Peripheral thisen chhuahna: 1.1.Hei hian i thisena platelet te chu a pangngai lo angin a lang em tih a enfiah thin.
• DNA/genetic tests: Hei hian JAK2 ang chi genetic mutations a hmuchhuak thei a, chu chu ET (Essential Thrombocythemia) nen a inzawm tlangpui a ni.
• Bone marrow biopsy: Hei hian i ruhroah cell pangngai lo a awm leh awm loh a enfiah thin.

Thrombocytosis hi engtin nge enkawl a nih?

Symptoms i neih loh chuan routine checkup chauh i mamawh mai thei.

Reactive thrombocytosis (secondary thrombocytosis) hi enkawl a ngai lo fo thin. A tlangpuiin, platelet count sang tak thlentu dinhmun (hliam, natna kai, emaw, operation avanga chhanna ang chi) a reh chuan platelet level chu a pangngaiah a kir leh thin. Mahse, symptom i neih chuan i doctor chuan a chhan bulpui chu a enkawl ang.

Essential Thrombocythemia (ET) i vei a, symptom i neih chuan i doctor chuan enkawlna engemaw zat a rawt thei a, chungte chu:

• Nitin aspirin dose tlem ei: Thisen zam a veng loh nan nitin aspirin i ei thei. Hetiang dose tlem hian pum a ti na lo va, thisen a chhuak lo bawk. Amaherawhchu, doctor nena inbiakna nei lovin aspirin hi ei fo loh tur a ni.
• Platelet level tihhniam thei damdawi ei: Hydroxyurea (brand name: Droxia®, Hydrea®, Siklos®, Mylocel®) leh Anagrelide (brand name: Agrilyn®) te ang chi damdawi ei hian ruhroah platelet siam a ti tlem a ni. Interferon alfa (brand name: Multiferon®) hian platelet pangngai lote chu a inthen darh a, a pung thei lo.
• I platelet lakchhuahna tur tih dan neih: I platelet level a san lutuk a, nunna atana hlauhawm thisen zam i neih theihna tur i nih chuan, i doctor chuan plateletpheresis tih tih a rawt thei ang. Hei hian i thisen atanga platelet tam lutuk filter chhuahna tur machine hman a huam a ni. Mahse, thrombocytosis -ah chuan plateletpheresis a ngai lo.

Pawimawh: Damdawi lam thurawn tel lo chuan heng enkawlna zinga pakhat mah hi tan emaw, tihtawp emaw loh tur a ni. Engkim hi i doctor nen sawihoin a kaihhruaina hnuaiah tih vek tur a ni.

Thrombocytosis hi a dam kim thei em?

Thrombocythemia pawimawh tak (ET) .Tunah hian thrombocytopenia hi damdawi a la awm lo. Mahse, i doctor chuan thisen zam i neih theihna tur a tihziaawm theih nan i dinhmun chu a enkawl thei che a ni. Reactive thrombocytosis (a chhan pahnihna avanga lo awm) a nih chuan a chhan bulpui enkawl a nih veleh platelet level chu a normal leh tlangpui.

Thrombocytosis hi a veng thei ang em?

Thrombocytosis thlentu dinhmun tam tak chu ven theih a ni lo a, chung zingah chuan Essential Thrombocythemia (ET) .

Thrombocytosis hian nunna a tichhe thei em?

Platelet level sang hi nunna atana hlauhawm a ni lo a, mahse harsatna awm thei – thisen zam emaw thisen chhuak nasa emaw ang chi – chu a hlauhawm thei hle.

Thrombocytosis thlentu tam zawk hi chu hun eng emaw chen atan a ni a, thisen zam na tak a thlen tam lo hle. Essential Thrombocythemia (ET) -ah chuan a hlauhawmna a sang deuh hlek a ni. Mahse, i doctor chuan ngun takin a lo en reng ang che a, damdawi mamawh a pe ang che a, thisen zam hlauhawm tak a awm loh nan a tul angin a ti ang. Chuvangin lungngai suh.

Thrombocytosis vei tan chuan eng nge a hmalam hun?

Reactive thrombocytosis hi a bulpui ber harsatna enkawl a nih chuan a reh tlangpui. I platelet count hi hun rei lote chhung (leh i spleen lakchhuah hnu rei tak pawh a ni thei) mahse secondary thrombocytosis hian thisen zam pangngai lo a siam lo tlangpui.

Essential Thrombocythemia (ET) , emaw primary thrombocytosis hian thisen chhuahna nasa tak emaw, thisen zam lutuk emaw a thlen thei a ni. I platelet level a normal theih nan damdawi ei hian hei hi a veng thei a ni. Amaherawhchu, kum tam tak he natna hi a neih hnuah, ruhro (bone marrow fibrosis) (bone marrow-a hliam) a awm thei a ni. Essential Thrombocythemia (ET) vei tlemte pawhin leukemia an vei thei bawk .

Engtikah nge ka doctor ka hmuh ang?

I doctor thupek dik tak zawm la, eng chen nge medical checkup i kal tur tih leh i platelet count enfiah nan thisen test i neih tur leh neih loh tur a ni.

Engtikah nge Emergency Department (ETU) ah ka kal ang ?

Stroke emaw heart attack emaw symptom i neih chuan 1990 call nghal la, hospital emergency room hnai ber pan rawh. Heng symptoms te hi fimkhur rawh.

Doctor hnenah eng zawhna nge ka zawh ang?

I doctor hnenah zawhna i zawt thei ang:

• Ka platelet level sang lutuk hi ka ngaihtuah tur em ni?
• Ka platelet level enfiah leh turin test tam zawk ka neih a ngai dawn em ni?
• Ka Thrombocytosis awm chhan hriat nan eng test nge ka tih a ngai ang?
• Eng enkawlna nge i rawt?
• Hetiang dinhmun hi enkawl turin ka nunphungah eng inthlak danglamna nge ka siam theih ang?

I thisen test result-in i platelet a sang tih a hriat chuan hlauthawng suh. I platelets hi chhan hrang hrang avangin a sang thei hle. Heng a chhan tam tak hi enkawl ngai a ni lo. Mahse i level a sang reng a, symptom i neih chuan i doctor chuan a chhan zawng chhuah a tum ang. Fimkhur taka enkawl leh damdawi ei hian thrombocytosis nena inzawm harsatna lian ber berte chu a veng thei tlangpui.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Awle, vawiin khan Thrombocytosis chungchang kan sawi nasa hle a ni lawm ni? Hemi chungchang hi in hriatthiam ka beisei.

A pawimawh ber chu i platelet level a sang tih i hriat chuan hlauthawng suh. Thrombocytosis vei zawng zawng hi a hlauhawm vek lo.

• Reactive Thrombocytosis hi a tam ber a, a tlangpuiin hun eng emaw chen atana thil dang vang a ni. Hei pawh hi chu chhan chu enkawl a nih veleh a tha lehzual ang.
• Essential Thrombocythemia (ET) hi a awm lo hle a, hun rei tak enkawl ngai a ni thei.
• Doctor-in a tih angin test leh enkawlna \ha tak tak i neih ngei ngei tur a ni.
• Symptoms engmah ngaihthah suh. Damdawi lam pan vat la, a bik takin thisen chhuak danglam tak, hliam tuar, lu na tak, rilru na, thawk harsa i neih chuan.
• I doctor nen zalen takin inbiakna nei rawh . Zawhna emaw, ngaihtuahna emaw i neih chuan zawt rawh.

Nangmah chauh i ni lo tih hre reng ang che. Damdawi lam kaihhruaina leh puihna dik tak i neih chuan he natna hi i enkawl tha thei a, nun hrisel tak i hmang thei bawk.