Engtin nge i taksain thisen zam (red blood cells) a siam? (Erythropoiesis) chungchang hi han sawi ila!

Kan taksa chhungah hian heng thisen sen, a nih loh leh thisen sen , hi engtin nge a lo awm tih i ngaihtuah ngai em? Hei hi kan nun atana thil mak, buaithlak leh pawimawh tak a ni tak zet a ni. Vawiin hian heng thisen sen (red blood cells) siam chhuah dan kan sawi dawn a, damdawi lamah chuan hei hi ( Erythropoiesis) kan ti a. Hei hi kan taksaa factory tlemte ang mai a ni a, thisen sen thar siam chhuak reng a ni.

Erythropoiesis chu eng nge ni? Engvangin nge kan tan a pawimawh?

A awlsam zawngin, (Erythropoiesis) chu i taksain thisen sen (red blood cells) a siam dan a ni (damdawi lamah chuan hei hi ``Erythrocytes'' kan ti bawk). Hetiang kalphung hi kan taksaah thisen sen (red blood cells) dik tak – tlem lutuk ni lo, tam lutuk lo. Heng thisen sen (red blood cells) te hi kan taksa tan a pawimawh zia hi han ngaihtuah teh!

Anni chu:

• Kan thawh hian oxygen chu lung chhungah a lut a, taksa chhunga tissue leh cell dang zawng zawngah a kal vek a ni. Kan taksaah postman te te ang mai a ni.
• Tin, kan taksa tissue-a carbon dioxide lo chhuak chu lungah a rawn kir leh a, chuta tang chuan kan thawk chhuah hian a chhuak leh thin.

Chuvangin i hmu em, heng thisen sen te tel lo chuan kan nung thei lo. Erythropoiesis an tih process hi a kal dik avangin kan hrisel a ni.

Erythropoiesis hi a takah chuan thil lian zawk pakhat a ni. Kan taksaa thisen cell chi thum siamna zawng zawng hi `` Hematopoiesis '' tih a ni.

• Thisen sen siam dan hi ``Erythropoiesis'' (tuna kan sawi tum hi) an ti a.
• Thisen var siam dan hi ``Leukopoiesis`` an ti a.
• Platelet (thisen chhuak tura puitu cell) siam chhuah hi ``Thrombopoiesis'' an ti a.

Khawiah nge hei (Erythropoiesis) hi a lo awm?

Heng thisen sen (red blood cells) siamna hmun hi hun kal zelah a inthlak danglam thin.

Nausen pum chhunga a awm laiin (Fetal erythropoiesis) .

Erythropoiesis hi kan pian hma, chu chu kan nu pum chhunga kan la awm lai atanga intan a ni.

• Kar thum vel a nih chuan: Hei hi a hmasa berin `` Yolk Sac'' an tih structure-ah a intan a, chu chuan embryo chu a chawm a ni.
• Thla hnih atanga thla thum hnuah: Chumi hnuah chuan nausen thin (liver and spleen) ah thisen sen (red blood cells) a lo piang chhuak thin.
• Thla nga vel: Hetiang thil hi embryo ruhroah a intan thin . Bone marrow hi kan ruh chhunga a nem, spongy part a ni.

Naupang leh puitling (Erythropoiesis) .

Kan pian hnuah thisen sen (red blood cells) hi kan...Ruhro ah chuan .

• Naupang: Naupan lai hian taksaa ruh tam tak ruhroah thisen sen (red blood cells) a lo piang chhuak thin a.
• Puitling: Kan lo puitlin chuan hei hi ruh thenkhatah chauh a thawk thin. Entirnan, pelvis, vertebrae, ribs, leh breastbone ang chi hmunah te.

Medullary leh Extramedullary erythropoiesis hi eng nge an danglamna?

Heng thumal pahnih hi a buaithlak deuhin lang mah se, hriatthiam a awlsam hle.

• `(Medullary)` tih awmzia chu ruhro nena inzawm thil tihna a ni. Chuvangin, `(Medullary erythropoiesis)` tih hian ruhro chhunga thisen sen (red blood cells) siam tihna a ni. Hei hi dinhmun pangngai a ni.
• Extramedullary erythropoiesis tih hian ruhro pawn lama thisen sen (red blood cells) siam a kawk a, chu chu liver leh spleen-ah te a ni.

Nausen stage-ah chuan hei hi (extramedullary erythropoiesis) hi a pangngai a ni. Mahse puitling chunga a lo thlen chuan ruhroah natna emaw, harsatna emaw eng emaw a awm tih chhinchhiahna a ni fo thin. Tichuan doctor-te chuan an en zui ta a ni.

Thisen sen (red blood cells) siam chhuahna stage hrang hrangte chu engte nge ni?

Red blood cell hi vawi khatah a lo piang vek lo va, stage engemaw zat kal tlanga zinkawng a ni. Caterpillar chu hnim hring a lo ni ta ang mai a ni.

Heng thisen cell zawng zawng hi basic cell pakhat atanga tan a ni. ``Hematopoietic stem cell'' (HSC) kan ti a ni. Hei hi ``master cell'' ang a ni.He HSC cell hi heng thisen sen, thisen var, platelet te zinga pakhat pawh a lo ni thei.

Thisen sen siam chhuah tur a nih chuan he HSC cell hi ``Common myeloid progenitor'' (CMP) an tih cell a lo ni hmasa ber thin. He CMP cell hi thisen sen (red blood cell), platelet emaw, thisen var chi hrang hrang emaw a lo ni thei bawk. A dawtah chuan CMP cell thisen sen lo ni tur chu ``Megakaryocyte-erythroid progenitor cell'' (MEP) ah a lo thang lian ta a ni.

Vawikhat MEP a nih chuan chu cell chu thisen sen (red blood cell) nih tumin a kal mek a ni. Chumi hnuah chuan stage engemaw zat a paltlang leh a:

• `(Proerythroblast)` (A rilru a buai em em a, a rilru a hah em em bawk a.
• `(Erythroblast)` (Erythroblast) tih a ni a, a chhuahna tur hmun tur chu a awm lo.
• `(Normoblast)` (Normoblast) tih hi a awm a.
• `(Reticulocyte)` (Reticulocyte) - Hei hi thisen sen naupang pakhat a ni.
• A tawpah chuan ``Erythrocyte'' puitling tak a lo ni ta a, chu chu kan hriat angin thisen sen (red blood cell) a lo ni ta a ni.

Heng thisen sen (red blood cells) siam kim tawhte hi ruhro (bone marrow) atang hian thisenah an chhuak thin. Chutah chuan an hna pawimawh ber - oxygen phurh kual leh carbon dioxide paih chhuah chu an tan ta a ni.

Hetiang hian eng chen nge hun a duh?

Thisen sen pakhat a lo pian kim theih nan kar khat vel a ngai tlangpui.

Thisen sen (red blood cell) dam chhung hi engzat nge ni ang?

Kan taksaah hian thisen sen pakhat chauh hi ni 120 vel a awm a.Chu chu. Tichuan, chu cell-te chu an thi a, an aiah cell thar a lo piang ta a ni. Hei hi a thleng fo thin cycle a ni.

Hei hi eng thilin nge thunun (Erythropoiesis)?

Kan taksa hian he process (Erythropoiesis) hi mak tak maiin a control a ni. A bulpui ber chu kan taksaa oxygen awm zat hi a ni.

Ngaihtuah teh, i tissue-te hian oxygen an hmu tlem a nih chuan (he dinhmun hi ``Hypoxia'' kan ti a) i taksa hian thisen sen (red blood cells) a siam chak nghal mai ang. A chhan chu thisen zam (red blood cells) a pun chuan tissue-a oxygen kal zat pawh a pung bawk.

He process (Erythropoiesis) hi hormone bik pakhatin a tichak a, chu chu a tichak tihna a ni. Chu chu `(Erythropoietin)` (EPO ) tih a ni.

Hei hi eng nge ni (Erythropoietin - EPO)?

Erythropoietin (EPO) hi hormone a ni a, thisen sen (red blood cells) siamchhuahna a tipung a ni. Hormone te hi kan taksaa thil tih hrang hrang inzawmkhawmtu chemical messenger ang a ni. Kan taksa mamawh EPO tam zawk hi kan kal atanga siam a ni .

Hei hi a lo awm dan chu hetiang hi a ni:

1. I thisen sen (red blood cell count) a tlem avangin i taksa tissue te hian oxygen an dawng tlem hle.

2. Chumi chhanna atan chuan i kal (kidney) hian hormone EPO a tichhuak tam zawk.

3. He EPO hormone hian i ruhro a tichak a, thisen sen (red blood cell) tam zawk siam turin a tichak a ni.

4. Thisen sen (red blood cells) a pun zel chuan a chhunga ``(Hemoglobin)`` (oxygen kengtu protein) awm zat pawh a pung zel bawk. Chu chu kal (kidney) te hian an hriat chuan EPO an secretion a ti tlem a ni.

5. Chutiang chuan kan taksaa thisen zam (red blood cells) awm zat chu level engemaw takah kan vawng reng a ni. He balance hi ``(Homeostasis)`` (homeostasis) kan ti a.

Kan kal (kidney) hian thisen sen (red blood cells) a lo awm loh nan EPO tlemte a tichhuak fo thin. Kan thisen sen 1% vel chu nitin an thih avangin, (Erythropoiesis) hian chu tlakchhamna chu a khum a ni.

Natna emaw, accident emaw avanga thisen sen (red blood cells) level a inthlak chuan kal (kidney) hian chutiang chuan EPO siamna a tipung emaw, a ti tlem emaw ang.

Erythropoiesis lama harsatna a awm chuan eng nge thleng?

Thisen sen siamna kawngah harsatna emaw, tlin lohna emaw a awm chuan thisen sen i nei tlem emaw, a tam emaw pawh a ni thei.

• Thisen sen (red blood cells) tlem: Hei hi anemia an ti a. Chumi awmzia chu i taksa tissue te hian oxygen an hmu tlem tihna a ni. Hei hian i chak lo thei a, i chau reng thei a, a châng chuan i vawt phah thei bawk . Anemia hi chi hrang hrang a awm a.
• Thisen sen (red blood cell count) pung: Hei hi `(Erythrocytosis)` (erythrocytosis) an ti a. Chutiang a nih chuan a chang chuan lu na leh hahna ang chi natna tenau te i nei thei bawk. Mahse, a chhan azirin, a châng chuan thisen zam ang chi harsatna lian tak tak a thlen thei a ni .

Eng dinhmun nge erythropoiesis tichhe thei?

Kan taksaa thisen zam (red blood cells) siam chhuah leh control-na tichhe thei natna leh thil dang tam tak a awm a.

Lung kaihhnawih natna

Hengte hian taksain oxygen a dawn zat a tihtlem thei a, hei hian EPO siamchhuahna a tidanglam thei a ni.

• Asthma natna a ni
• Chronic obstructive pulmonary disease (COPD) natna hrik pai thei lo (COPD) .

Thisen emaw ruhro emaw nghawng thei cancer

Chungte chuan thisen sen siamna kawngah direct-in a tibuai thei a ni.

• Leukemia natna (Leukemia) a ni
• Lymphoma natna (Lymphoma) a ni
• Myeloma natna a ni
• Myeloproliferative natna a awm thei

Chhan dang

• Nutritional deficiencies: A bik takin iron, vitamin B12, leh folate (folic acid) te tlakchhamna hian thisen sen (red blood cell) siam that lohna a thlen thei a ni. Hengte hi thisen sen (red blood cells) siamna atana mamawh building blocks te an ni.
• Hmun sang taka awm: Hmun sang takah chuan boruakah oxygen a tlem zawk. Chuvangin, insiamrem tur chuan taksain EPO a siam tam zawk a, thisen sen (red blood cell) siamchhuahna a tipung bawk.

Kan taksa hian kan dam chhungin thisen sen thar a siam chhuak thin. Cell hlui an thih chuan taksain heng inthlak danglamna te hi a hre chiang a, EPO siamchhuahna a tipung a, chu chuan thisen sen (red blood cells) siamchhuahna a tipung a ni. Kan tissue-a oxygen supply hrisel tak kan neih theih nan thisen sen (red blood cells) zat dik tak kan neih a ngai a ni. Vanneihthlak takin taksa hian he thil hi a control nghal vek a, kan lam atanga theihtawp chhuah ngai lovin. Mahse, he thil kalphung tibuaitu natna (erythropoiesis) i neih chuan i doctor chuan a enkawl thei a, a thunun thei bawk.

Hriat reng tur pawimawh ber berte (Take-Home Message) .

• Erythropoiesis hi kan taksaah thisen sen (red blood cells) siam chhuaktu thil pawimawh tak a ni.
• Heng thisen sen (red blood cells) te hi kan taksa pum puia oxygen phurtu leh carbon dioxide paih chhuaktu an ni.
• Hetiang thil hi kan ruhroah a thleng ber a ni .
• Hormone pakhat Erythropoietin (EPO) , chu chu kal atanga siam a ni ber a, hei hian he thil hi a thunun thei a ni.
• Hetiang kalphung chungchanga harsatna awm hian thisen tlakchhamna (thisen sen tlahniam) emaw, erythrocytosis (thisen sen pung) emaw a thlen thei a ni.
• Erythropoiesis dik tak hi nun hrisel neih nan a pawimawh hle. Hemi chungchangah hian zawhna emaw rinhlelhna emaw i neih chuan damdawi lam thurawn la ngei ang che .

Chuvangin, tunah chuan he thil mak tak (Erythropoiesis) tih hi hriatthiamna chiang tak i neih ka beisei. Kan taksa chhungrilah hian kan hriat loh thil tam tak a thleng a ni lawm ni?

` Thisen sen, erythropoiesis, ruhro, thisen tlakchhamna, oxygen, erythropoietin, kal