Engtin nge kan taksa hian natna do turin thuchah te te a inthleng a, kan in tanpui dan hi i ngaihtuah ngai em? Kan taksa peng hrang hrang, thuruk thuruk te tak te ang maia che thin a awm a.
Cytokines hi chemical pawl khat, hetiang hna bik thawk thei an ni. Vawiin hian heng palai tenau tak tak, mahse pawimawh tak takte chanchin kan sawi dawn a ni.
Cytokines hi eng nge ni tak tak?
A awlsam zawngin sawi ila, cytokines hi protein chi khat a ni. Kan
immune system a information inbiakpawhna chemical messenger ang an ni . Kan immune system hi ram humhimtu sipai angin han ngaihtuah teh. He sipai hian
branch hrang hrang , sipai an nei. Chumi hnuah chuan tuin nge heng sipaite (i.e. immune cells) te hi, "Hetah hian hmelma a lo kal!" "Hetah hian kal la, inbei rawh!" "Hetiang hian inveng rawh!"? Chu chu heng
cytokines te hian an ti thin. Kan taksaah
natna hrik, virus, bacteria, allergen ang chi te an luh hian heng cytokines te hian kan immune cell te chu "hnathawh turin, heng invader te hi do turin" an hrilh thin. Chu mai pawh ni lovin, heng cytokines te hian kan taksa tana hlauhawm a awm loh lai pawhin kan taksa hriselna (immune system) a thawk tha a, a inrem tawn reng theih nan a pui bawk. Kan office kal tluang taka kalpui theihna tura message inthleng ang bawkin.
Eng chi cytokines nge awm?
He messenger chhungkaw zingah hian cytokines an tih hi chi hrang hrang an awm a. An vai hian immune cell te chu khawiah nge an kal tur tih leh eng nge an tih tur tih an hrilh vek a ni. Mahse chi hrang hrang a awm a, chu chu an hnathawh bik a zirin a ni. A chi hrang hrang tlemte han thlir ila.
- Chemokines: Hengte hi "kaihruaitu" an ni. GPS ang mai an ni. Anni hi immune cells te chu infection awmna hmun thlenga kaihruaitu an ni a, "Hetiang hian lo kal rawh" tiin an hrilh thin.
- Interferons: Heng hming tak tak hi "inrawlhna" tihna a ni. Inrawlh tih awmzia chu eng nge ni? Kan cell-a virus lut tur tihtawp a, virus tam zawk siam (‘replicating’) hmangin hna an thawk a ni. Virus awmna tur chhinchhiahna dah ang mai a ni a, chutah chuan, "Hetah hian kal tawh lo ang!"
- Interleukins: He hming hi "inter" (a inkar) leh "leukocyte" (thisen var) tih atanga lak a ni. Tun hma chuan heng chemical te hi thisen var (white blood cells) inkara inbiakpawhna chauh an nei niin an ngai thin. Mahse, tunah chuan cell dang siam chhuah an nih thu leh thisen var ni lo (non-white blood cells) inkara inbiakpawhna pawh an nei tih hmuhchhuah a ni ta.
- Tumor Necrosis Factor (TNF): Hei hi hming khauh tak ang maiin a ri a ni lawm ni? A hna ber chu a niIt controls inflammation , chu chu a hring leh a sen tihna a ni. Tin , immune cells te chu tumor cells tichhe turin signal a pe bawk .
- Colony-Stimulating Factors (CSF): Hengte hi kan taksaa "cell factory enkawltute" ang an ni. A chhan chu, cell chi khat bik blood stem cells (HSC) tih a awm a. Heng cell te hian thisen cell chi hrang hrang, thisen var, thisen sen, leh platelet te an siam thei a ni. He "production process" ( Hematopoiesis ) hi he "CSF" hian a pui a, chu chu stem cell te chu "he cell chi hi siam turin" a hrilh tihna a ni. Entirnan, " G-CSF " hian thisen var chi khat "Neutrophil" tih siam nan a pui a ni. Heng neutrophils te hi natna hrik dona kawngah an pawimawh hle.
Cytokine dang thenkhat chu a siamtu cell chi hrang hrang atanga hming vuah a ni.
- Lymphokines: A chhan chu thisen var chi khat lymphocyte an tih atanga siam a nih vang a ni.
- Monokines: A chhan chu thisen var chi khat, monocyte an tih atanga siam a nih vang a ni.
Cytokines hian kan taksa tan eng tanpuina nge a pek?
Cytokines chungchang kan sawi hian mi tam zawk chuan
inflammation . Inflammation kan ngaihtuah hian natna emaw, allergy emaw avanga lo awm thin, a thinrimna leh a sen thin te hi kan ngaihtuah thin. Mahse inflammation hi a takah chuan kan taksa immune cells te hian invaders te an do emaw, tissue hliam te an tidam emaw tihna a ni.
I kut zungtang i tan chuan a hmun chu a hring a, a sen vek tih han ngaihtuah teh, a dik em? Chu chu inflammation a ni. Chumi awmzia chu chutah chuan cytokines an thawn a, "Hetah hian harsatna a awm a, lo kal la, en la, hliam chu tidam rawh," an ti a, a kaihhnawih cell te chu rawn hruai lutin hna an thawk tan ta a ni.
Chuvangin, cytokines te hi chemical messenger ang an ni a, chu chuan cell te chu "engtin nge an awm ang" a hrilh thin. Anni hian thil chi hrang hrang signal an pe ber a:
- Cell activation: Cell te chu khawiah nge an kal tur tih leh eng nge an tih tur tih a hrilh thin. Entirnan, immune cells te chu infection awmna hmunah a hruai a, chuta hrik awmte chu a do thei a ni. Inflammation nena inzawm process tihpun emaw tihhniam emaw a signal bawk.
- Cell inthliarna: 1.1.Hei hi training school ang a ni. Cell puitling lote chu an la a, "hei hi i lo puitlin huna i nih duh cell chi chu a ni" ni turin an zirtir thin. Entirnan, cell naupang pakhat chu an la a, thisen var cell-ah an chantir a, chu chuan natna hrik do thei a ni.
- Cell proliferation: Hei hian "mi tam zawk nangmah ang siam" tihna a ni. Photocopy siam ang mai a ni. Entirnan, natna hrik dona atana thisen var tam zawk i mamawh hian i thisen var awmsa te chu "mi tam zawkin nangmah ang siam turin" signal i pe thin.
Chu mai pawh ni lovin, a chang chuan cytokines hian kan taksa cell te chu "cytokines tam zawk siam" turin signal a pe bawk. Tichuan inflammatory response chu a pung lehzual ta a ni.
Pro-inflammatory leh anti-inflammatory cytokines te hi eng nge an danglamna?
Kan immune system a thawk tha chuan cytokines hian a tul hunah inflammation a tichhuak a, chu chuan invader te a do a, tissue te a tidam thei a ni. Tichuan, "Okay, chu chu a tawk e, chu chu a ni," an ti a, an inflammation chu an tihtlem a, an titawp ta a ni. Car-
a accelerator (gas pedal) leh brake ang mai a ni.
- Pro-inflammatory cytokines: Hengte hi "gas pedal" te an ni. Heng tlangvalte hi inflammation tan leh tihpun tur signal pe thinte an ni. Kan taksaah hmelma a rawn luh chuan, "Mi zawng zawng, indona atan inbuatsaih rawh u!"
- Anti-inflammatory cytokines: Hengte hi "brake" an ni. Hengte hi inflammation tihtawp leh tihziaawmna tur signal petu an ni . A chhan chu, inflammation a pun lutuk chuan kan taksaa tissue tha te pawh a tichhe thei a ni. Chung chu a vengtu chu hengte hi an ni.
A dik tak chuan inflammation tihtawp hi a bul tan ang bawkin a pawimawh hle. Inflammation tam lutuk hian symptoms nuam lo tak tak a thlen thei a, hun rei tak chhung natna a thlen thei a, a chang chuan enkawl loh chuan nunna atana hlauhawm tak a ni thei bawk.
Engtin nge heng cytokines te hian hna an thawh?
Hei hi kawng awlsam takin a thleng thin. Cytokine chu
key angin ngaihtuah la, chu key nena inmil
`receptor` chu cell-ah hian a awm a ni. Cytokine (key) chu chu cell-a chu `receptor`-ah chuan a kal a, a fit chuan chu cell chuan "Eng nge tih ang?" Tichuan chu cell chuan chu thuchah ang chuan hna a thawk ta a ni. Entirna pakhat han en ila. Kan immune cell pakhatin taksa chhungah thil tha lo, virus ang chi a hriat chuan chu cell chuan cytokine a tichhuak thin. He cytokine hian thisen kal tlang emaw, tissue kaltlangin emaw a kal a, a nena inmil `receptor` nei cell a hmu chhuak thin. Cytokine chu chu `receptor`-ah chuan a binding chuan chu message dawngtu cell chuan instruction chu a dawng ta a ni. Chu cell chuan virus awmna hmunah chuan a kal ang a, a rawn bei tan mai thei. A nih loh leh, virus lut lo turin a invenna a tichak ang. Cytokines hian a chhuahtu cell hnenah emaw, a bul hnaia cell-ah te, a nih loh leh hla taka awm cell-ah te pawh thuchah a thawn thei a ni.
- Mahni cell-ah message thawn (`Autocrine signaling`):Cytokine hian a chhuahtu cell-a receptor pakhatah a binding a.
- Paracrine signaling: a bul hnaia cell awmte receptor-te nen a inzawm a.
- Endocrine signaling: Cytokines hi a chhuahtu cell atanga hla tak cell-a receptor te nen an inzawm a.
Kan taksa pum puiah hian cytokine `receptor nei cell a awm a. Dik tak chuan kan taksa peng tam takah hian heng `receptors` nei cell te hi a awm a, hei vang hian khawi hmunah pawh inflammation a awm thei a ni.
Khawi atanga lo chhuak nge cytokines? Tuin nge siam?
Kan taksaa cytokines awm tam ber chu
immune cells , thisen var (leukocytes) atanga siam a ni. Chung zinga ṭhenkhat chu:
- Macrophage te hi an ni
- Dendritic cells te chu a awm a
- Lymphocyte (T leh B lymphocyte) te hi a awm a.
- Monocytes te hi a awm a
- Neutrophils te pawh a awm
- Basophils te hi an ni
- Eosinophils a awm bawk
- Mast cells te chu a awm
Mahse immune cells chauh ni lo, kan taksaa cell chi dang tam tak hian cytokines an siam chhuak thei a ni. Entirna tlemte chu hetiang hi a ni:
- Endothelial cells: Kan thisen kalna kawng chhunga line siamtu cell.
- Epithelial cells: Kan taksa peng hrang hrang line siamtu cell.
- Fibroblasts: Connective tissue-a awm cell.
- Stromal cells: Connective tissue-a awm cell chi dang a ni.
- Schwann cells: Nerve cells (neurons) vel a awm.
Cytokine chi khat hi cell chi hrang hrangin an siam thei a ni.
Cytokines nen hian eng natna nge inzawm theih?
Cytokines hi kan taksa hriselna atana pawimawh tak a ni a, natna tam tak kan neih theih nen a inzawm tih an sawi bawk. A tlangpuiin cytokines hian natna hrik laka min fihlim theih nan a pui thin. Mahse, a chang chuan kan immune system hian cytokines a siam tam lutuk thei. Hei hi infection chhanna atan emaw
immunotherapy ang chi enkawlna pakhat atan emaw pawh a ni thei . Hei hi
cytokine release syndrome (CRS) emaw
cytokine storm emaw an ti a. Hei hian kan taksa system tam tak nghawng thei symptoms chi hrang hrang a thlen thei a ni. Enkawl loh chuan he natna hi nunna atana hlauhawm tak a ni thei. Cytokines a tam lutuk chuan inflammatory response a pung thin. Hetianga inflammation tam lutuk hian tissue te a tichhe thei a, natna hrang hrang a thlen thei a, chungte chu:
- Autoimmune diseases: Hei hi keimahni immune cell-te’n kan cell hrisel tak takte an beih sual hian a ni.
- Metabolic lama harsatna nei: 1.1.Metabolism nena inzawm harsatna, kan taksain ei tur chu chaknaah a chantir a, bawlhhlawh a paih chhuak thin.
- Ngawt
- Sepsis: Hei hi taksain inflammatory response a nasat em avangin taksa peng lian zawka thisen kal a tihtlem phah a ni. Sepsis hi medical emergency a ni a, thihna thlen thei a ni.
Mahse, lungngai suh. I taksaah cytokine level a sang a, i immune system a overactive a nih chuan i doctor chuan chu inflammation tihziaawmna tur treatment a pe thei ang.
Cytokine panel tih hi eng nge ni?
Doctor-te chuan i taksain cytokines a siam tam lutuk emaw, a tlem lutuk emaw tih chu an hre thei ang. Hei hi
cytokine panel an tih thil hmangin an ti thin . Hei hi thisen test awlsam tak a ni. I thisen sample an la a, inflammation nena inzawm cytokines level an enfiah thin. Cytokine level a san chuan inflammation a pung tihna a ni. Tichuan, a tul angin damdawi ei tan theih a ni.
He thawnthu a\anga kan hriat reng tur pawimawh tak takte chu
Chuvangin, tunah chuan kan taksaa immune system hrisel tak neih theihna tura cytokines a pawimawh zia chu i hrethiam tawh mai thei. Eng thil pawh ang bawkin
moderation hi a pawimawh ber a ni.
Cytokine signaling hi a zat dik leh dik taka a awm chuan hri kai lakah min veng thei a ni. Mahse, cytokine level a san lutuk chuan a chhuak inflammation tam lutuk chu enkawl loh chuan a hlauhawm thei hle.
Chuvang chuan he inbiakpawhna mak tak mai, kan taksa chhunga thil thleng hi kan hriat chian a pawimawh hle. Hemi chungchangah hian zawhna emaw rinhlelhna emaw i neih chuan doctor biak hreh ngai suh.
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