Kan ruhro siamtu mi huaisen te tak te pahnih: Osteoblasts leh Osteoclasts te hi i zir mai ang u!

I ruhte kha i ngaihtuah ngai em? Thil chak tak, danglam ngai lo angin kan ngai fo thin. Mahse chutiang chu a ni lo. Kan ruhte hi tissue nung a ni a , kan taksa dang ang bawkin. Chutiang chuan i ngaihtuah lo mai thei, mahse an lo thang lian zel a, an chhe zel a, an thlak danglam zel bawk a, naupan lai atanga puitling thleng chauh ni lovin, kan dam chhung zawng hian! He hna mak tak thawk tura puitu cell chi hrang hrang pawimawh tak pahnih chu `Osteoblasts` leh `Osteoclasts` an ti a. Vawiin hian heng pahnih chungchang hi tlem han sawi leh ila, kan sawi dawn em ni?

`Osteoblast` te hi tute nge ni? Engtin nge an tih?

A awlsam zawngin `Osteoblasts` hi kan ruh siamtu "Mason Jars" an ni. A chang chuan `osteogenic cells` an ti bawk. Kan ruh tichaktu an ni a, ruh thar siamtu an ni bawk. `Osteoblasts` hian hna pawimawh pathum a nei a, chungte chu:

• Ruh thar siam ( ruh siam).
• Kan tar chhoh zel a, chu chu naupan lai atanga puitling kan nih chhoh zel chuan kan ruhte hi kan taksa pianzia nena inmil turin a inthlak a, chu chu `remodeling` an ti a ni.
• Ruh a tliak, a tliak, emaw, a hliam emaw a tihdam .

Ngaihtuah teh, kan ruh pakhat chu a lo thang lian a, eng emaw ti takin a inthlak a ngai a, a tihchhiat hnuah pawh a dam a ngai a nih chuan heng `Osteoblasts` cell te hi kan taksa chhunga chemical reaction hrang hrang, emaw, `hormone` hmanga tihchak an ni. Tichuan heng `Osteoblasts` cells te hi an inzawm khawm a, `bone matrix` tih hming puin mixture bik an siam a, an chhuah chhuak ta a ni. He `bone matrix` hi `collagen` leh `calcium` leh `phosphate` ang chi `protein` atanga siam a ni a, chungte chu kan ruh tan mineral pawimawh tak an ni. He hna hi kawng siam laia `concrete` leih ang mai a ni. Kawngpui thar tak a siam thei a ni. A nih loh leh chu `concrete` tho chu kawngpui hluiah chuan a chhe leh a chhe tawhte chu a luah khat thei bawk. Chutiang bawkin `Osteoblasts`, `Masons` te hian he `bone matrix` `concrete` hi hmang hian ruh thar siamin, ruh hlui chu an tichak a, ruh tliak te chu an tidam bawk. Chutianga ruh tissue thar siam a nih hnuah chuan `Osteoblasts` cell thenkhat chu chu ruh thara tel ve an ni ta a ni. Chumi hnuah chuan `Osteocytes` tia koh an ni. Chutiang a nih loh chuan an rawngbawlna a mamawh tawh loh chuan chu cell te chu an thi ta a ni.

`Osteocytes` an tih te hi tlem han zir ila?

Osteocyte te hi kan ruh chhunga "security guard" ang mai an ni.Duh. Kan ruh hi a tam zawk hi heng `Osteocytes` cells atanga siam a ni. Kan ruhte hi eng ang pressure emaw pressure emaw nge tih an en reng a ni. Kan kal emaw, kan tlan emaw, kan chawi emaw hian ruh tliak ang chi nghawng lian tak awm mahse heng `Osteocyte` te hian an hre thin. Chutih lai chuan `Osteoblasts` (si siamtu) leh `Osteoclasts` (a tichhia - a hnuah kan sawi leh ang) te hnenah pawh, "Hetah hian harsatna a awm a, lo kal la, lo siam tha rawh," tia signal thawn thin an ni. Entirnan, ruh a chhe emaw, a chhe emaw a nih chuan `Osteocytes` te hi chu hmuna cell dang rawn rang taka rawn hruai luttu, a chhe tawhte paih chhuaktu, ruh thar siam leh tihdamna tura puitu an ni.

Chuti a nih chuan `Osteoclasts` hi eng ang cell nge ni?

Osteoclasts hi kan ruh atanga cell hlui, chhe tawhte tithianghlimtu leh paih chhuaktu "cleaning crew" an ni. Demolition crew ang mai a ni. Osteoblast te tan ruh thar siamna tur hmun siamtu an ni.

Hriat reng dan awlsam tak chu: `Blast` hi `Builders` ang a ni a, `Clast` hi `Cleaners` ang a ni.

Osteoclasts hian enzyme bik a tichhuak thin. Heng enzyme te hian ruh hlui chu an tithianghlim a, an tichhia a ni. Ruh hlui chung lamah chemical reaction an siam a, chu chi hrang hrangte chu a tithianghlim a, tissue thar, chak zawk siamna tur hmun a siamsak a ni. Mahse osteoclasts hian ruh a tihthianghlim hian cartoon-a angin acid-in thir chi khat a ei bo ang mai a ni lo. Hetiang kalphung hi controlled tak leh precise tak a ni . Osteoclasts hian a hmaa kan sawi tawh osteocytes (security officer)-te'n "hei hi kan paih chhuah a ngai" tia an chhinchhiahna hmunte chauh a tithianghlim a ni. Osteoclasts atanga enzymes chhuak te hian ruh matrix chak tak chu a tichhia a, a chhunga thil awmte chu a la lut leh thin. Tichuan, ruh chung lamah khur te te a lo piang ta a ni. Chutiang khur chu a lo awm tawh chuan osteoblast (builder) te chu an rawn lut a, ruh tharin a ruh chu an luah khat ta a ni. Team effort ang mai a ni!

Heng `Osteoblasts` leh `Osteoclasts` cell te hi eng ang nge an nih?

Heng cell pahnih hi an te hle a, kan ruh pawn lam khuh (`bone lining`) leh ruh chhung ngeiah te an awm a ni.

• Osteoblasts hi a tlangpuiin cell te tak te, cube ang maia lian an ni.
• Osteoclasts hi ruh cell aiin a lian deuh hlek a. An pianzia chu spherical, dome ang mai an ni.

Heng cell hnathawh tichhe thei natna tlanglawn tak takte chu engte nge ni?

Osteoblasts leh osteoclasts te hi kan ruh peng pawimawh tak pahnih an ni. Chuvangin, kan ruh tichhe thei natna eng pawh hian heng cell te hnathawh hi a nghawng thei bawk. Kan ruhte hian chakna a siam theih lohna leh chakna a neih theih lohna tur harsatna lian ber ber thenkhat chu hetiang hi a ni:

• Osteoporosis (Osteoporosis ) - Hei hi ruh te chu a hring a, a chak lo a, a chhe awlsam a ni.
• Osteopenia - Hei hi ruh natna thlentu a ni. Ruh density chu a tlahniam tan ta a ni.
• Hyperparathyroidism - Parathyroid glands ten hormone an siam tam lutuk a, chu chuan ruh atanga calcium a hloh phah thin.
• `Paget’s disease of the bone (osteitis deformans)` - Hetiang dinhmunah hian ruh siamthatna kalphung a tibuai a, ruhte chu a chak lo va, a tichhe bawk.

Heng cell te hi hriat chian nan test bik a awm em?

I osteoblast emaw osteoclast emaw hnathawh that dan enfiahna tur test bik a awm lo tlangpui. Doctor-te chuan ruh pum hriselna an test tlangpui a, cell bik en ai chuan. Mahse, a chang chuan i osteoclasts te hnathawh that dan enfiah nan emaw, osteoporosis ang chi natna hriatchhuahna atan emaw thisen test (lab) te pawh tih theih a ni. I ruh hriselna enfiahna atana test hman tlanglawn thenkhat chu hetiang hi a ni:

• Bone density test (DXA scan) : Hei hian low-level X-ray hmangin i ruh a chak zia a teh thin. I tar chhoh zel angin i ruh a hring em tih hriat theih nan a pui thei a, osteopenia emaw osteoporosis emaw symptoms i neih leh neih loh hriat theih nan a pui thei bawk.
• Vitamin D test (` Vitamin D 25-hydroxy test`) : `Vitamin D` i dawng tlem em tih a enfiah thin.
• Calcium test : Hei hian i thisena calcium awm zat a enfiah a, darkar 24 chhunga i zun chhunga calcium awm zat a enfiah thei bawk.
• `Intact parathyroid hormone (IPTH)` test : Parathyroid hormone level a enfiah thin.
• Creatinine test : Hei hian i kal (kidney) te a thawk tha em tih a enfiah thin.

Kan ruhte a hrisel theih nan eng nge kan tih ang?

I ruh hrisel leh chak taka awm theih nan thil engemaw zat i tih theih a awm. I tih theih ṭhenkhat chu hetiang hi a ni:

• Eat a nutritious diet , a bik takin ei tur calcium leh vitamin D tamna ei rawh.
• Thil rit phur thei exercise ti rawh . Chu chu, i ruhte chunga rit tirtu exercise, kea kal , tlan, leh stairs chhoh te hi a ni.
• Meizial zuk hi pumpelh vek rawh . Meizial zuk hian ruh a tichhe nasa hle.
• Calcium leh vitamin D tling tawk ei rawh.I hmu tling em tih fimkhur rawh. A tul chuan damdawi lam thurawn hnuaiah supplement ei thin ang che.
• Medical checkup neih fo thin ang che . Natna emaw, danglamna emaw i hriat chuan doctor pan nghal rawh.

`Osteoblasts` leh `Osteocytes` te hi eng nge an danglamna?

`Osteoblasts` leh `Osteocytes` te hi kan ruh siam leh enkawltu cell an ni. Mahse a danglamna tlem a awm.

• Osteoblasts hi ruh thar siamtu, ruh awmsa tipungtu leh siam thattu cell te an ni. Ruh matrix chhuah tir a, tissue thar siamtu an ni.
• Osteocytes hi ruh puitling tissue chhunga cell awm a ni . Anni hi ruh chunga pressure leh stress awm dan hre chiangtu an ni a, osteoblast leh osteoclast te hnenah signal an thawn a, "Hetah hian harsatna a awm a, siamthat a ngai a ni," an ti thin.

A tawp berah chuan hriat reng tur (Take-Home Message) .

Tunah chuan heng cell te pahnih, `Osteoblasts` leh `Osteoclasts` tia koh te hian kan ruh hriselnaah nghawng lian tak an neih dan chu i hmu thei ta. An thawk ho reng a, kan ruhte chu a lo thang lian a, a siam thar a, a nghet reng bawk. Hla sak loh pasaltha ang mai an ni.

Kum 65 chunglam, hmeichhia, menopause paltlang tawh, leh damdawi lama harsatna nei tawhte tan chuan damdawi lam thurawn la a, damdawi lam checkup neih fo a pawimawh hle. Hei hian doctor-te chuan i ruh hriselna a enfiah thei a, ruh hloh emaw, ruh natna emaw a awm tih hriat hmasak theihna a siam bawk.

Chuvangin, i ruhte pawh enkawl ve rawh. Ei leh in that te, exercise lak te, nun hrisel tak neih te hi a pawimawh ber a ni!