Vawiin zing khan chu pill i ei kha i kut a thlen theih nan eng chen nge a rei tih i ngaihtuah ngai em? Pakhatnaah chuan laboratory-ah zirchianna nasa tak an nei a. Tichuan ran chungah an test leh thin. Mahse mihringa hman tura pawm an nih hma chuan mihringah an enchhin a ngai a ni. Hei hi clinical trial kan tih chu a ni. A buaithlak hle a, a man pawh a to hle.
A awlsam zawngin, clinical trial chu eng nge ni?
A awlsam zawngin sawi ila, clinical trial hian hetiang hian hna a thawk a: Researcher-te chuan damdawi siam tharin a target natna vei damlote chu an la lut thin. Chumi hnuah chuan heng volunteer te hi random takin group hnih ah an then thin.
1. Group hmasa ber hnenah damdawi thar test tur pek an ni.
2. Group pahnihna , ``Control Group'' te chu active ingredient nei lo leh damdawi ang chiah chiah placebo pek an ni. Hei hi ``Placebo'' kan ti a.
He trial tawp lamah hian damdawi thar eitute natna lan chhuah dan chu placebo eitute aiin a ṭha zawk a nih chuan hei hian damdawi thar hi a thawk tha tih a tichiang a ni.
Chutiang trial-a harsatna lian ber pakhat chu trial atana fit dik tak damlo tling tak hmuh hi a ni. A chang chuan doctor te pawhin an damlote tana eng trial nge dik tih an hre lo. Tin, damlo tel duhte mizia chu trial-a thil tul nen a inmil lo thei bawk. Mahse, artificial intelligence (AI) hian he hna hi a ti awlsam thei hle.
I "Digital Twin" nen inhmu rawh.
I computer model, chu chu i digital copy i nei ang tih han ngaihtuah teh. Chu chu ``Digital Twin'' an tih chu a ni. Hengte hi computer-a thil awm tak tak emaw system emaw simulate tu ``Computer Model'' chauh an ni. Mahse number hmanga en chuan thil tak tak ang chiah hian an awm a ni. Entirna tha ber chu Apollo 13 spacecraft-a oxygen tank a puak khan NASA chuan khawvela siam spacecraft ang chiah ``Digital Twin'' hmangin siamthat hna a pui a ni.
Tunah chuan scientist te chuan mihring ``Digital Twin`` an siam thei tawh a, ``data`` tling tak pek an nih chuan. Hei hian artificial intelligence technology ``Machine Learning`` tih a hmang a ni. A awlsam zawngin, hei hian computer program pakhat chu data tam tak pek a, chuta zir chhuah tir a huam a ni.
Damlote Digital Twins hi heng Machine Learning model te hi clinical trial hmasa atanga data leh damlo tinte personal medical record hmanga training hmanga siam a ni. Chumi hnuah chuan model chuan damlo pakhat chu placebo pek a nih chuan trial kal zelah hriselna a inthlak dan tur a sawi lawk thei a ni.Chu chu chu damlo pakhat tan chuan computer hmanga control group (Simulated Control Group) siam a ni tihna a ni.
Tunah chuan hei hian engtin nge hna a thawh tih i en ang u. Damdawi thar dawngtu pawla tel turin "Samadhi" tih hming pu mi pakhat thlan ni ta ila. Samadhi-a ``Digital Twin,'' computer model chu control group-ah a awm a ni. Model hian Samadhi hi damdawi tak tak aiah ``Placebo'' pek ni ta se eng nge thleng dawn tih a sawi lawk a ni. A tawpah chuan Samadhi-a'n damdawi a chhanna tak tak leh model-in ``Placebo'' a ei a nih chuan a lo thleng dawn tih a sawi inthlauhna hi Samadhi tan damdawi hi engtiang chiahin nge a thawh hlawk tih tehna a ni.
Hetiang method hian a thatna lian ber pakhat chu clinical trial-a tel zawng zawng deuhthaw hian damdawi thar hi an dawng thei a, a chhan chu ``placebo'' hi an digital twin hnenah pek a nih vang a ni.
Traditional control team ai chuan ``Digital Twins'' hman a hlawkna chiang taka hmuh theih nan he table hi han en ila.
| Mihring ziarang | Traditional method hmanga tih a ni | Digital Twin hmanga tih dan |
|---|---|---|
| Control Group a ni | Mi tak tak atanga siam. A (Placebo) an hmu a. | Computer model (Digital Twins) atanga siam a ni. |
| Damlo tan advantage a ni | Placebo lak theihna chance 50% a awm. Chu chu damdawi thar chu i skip thei tihna a ni. | Mi tam tak chuan damdawi tak tak enchhin theihna hun remchang an nei a. |
| Volunteer mamawh zat | Mi tam zawk mamawh a ni (team pahnih tan). | Test hi mi tlemte nen tih theih a ni. |
| Hun leh senso | A sang hle mai. | nasa takin a tihtlem thei bawk. |
He technology hi tha viau mahse, harsatna a awm lo em ni?
He technology hian nakin hun atan thutiam ropui tak nei mahse, hman lar a la ni lo. Hei hi chhan tha tak a awm mai thei. ``(Machine Learning),'' lama mithiam Dr. Daniel Neal-a'n a sawi angin, heng model-te hian data tam tak an ring a ni. Tin, mimal hnen atanga data quality sang tak hmuh a harsa hle bawk.
"Miten an ei leh in leh exercise an tih dan ang chi thil chungchangah hian information an self-report fo thin. Mite hian thudik an sawi ngai lo. Exercise an tih tam lutuk hi an sawi tam lutuk a, junk food an ei zat pawh an sawi tlem duh hle.
Thil dang chu damdawi pakhatin a thlen theih side effects awm lo, beisei loh tak takte hi a ni. Chungte chu control group atana model ruahman hian a huam lo fo thin.
Mahse Dr. Neal-a hlauh ber chu he predictive model hi "business as usual" atanga siam a nih vang a ni. COVID-19 hripui ang chi thil thleng lian tak, beisei loh tak, mi zawng zawng nungchang tidanglamtu leh mi natna tidanglamtu hi han ngaihtuah teh. "Control model-te hian hei hi an ngaihtuah lo," a ti. Tichuan, heng control group-in an ngaihtuah loh thil thleng avang hian experiment hnuhnung ber result chu a danglam vek thei a ni.
Chuti a nih chuan hei hi hman theih a ni tak tak em? Nakin hun chu eng nge ni ang?
Healthcare-a digital technology hman dan lama mithiam Eric Topol chuan he ngaihtuahna hi ropui a ti hle a, mahse a hun hi a la dik lo hle. "Nakin lawkah clinical trial hi a danglam dawnin ka ring lo. A chhan chu data layer tam tak a mamawh a, health record chauh ni lovin, genome sequence, gut microbiome, environmental data te pawh a ni.
He technology lama hmahruaitu Unlearn.AI dintu Charles Fisher-a sawi dan chuan data privacy leh bias chungchanga harsatna awmte chinfel dan tur a awm tawh a ni. "Privacy hi a awlsam. Data anonymized tawh chauh hmangin kan thawk a ni."
Bias chungchang a sawi hian he thubuai hi chinfel kim lo mah se, zirchianna result nen a inzawm lo tih a sawi. Study te hi randomized a nih avangin data-ah bias engemaw zat awm mahse result a nghawng lo. Mahse, mithiam thenkhat chuan he ngaihdan hi an pawm lo. Anni chuan, .Mi tak tak chu computer model nen i tehkhin avangin chu model-ah chuan tihsual a awm chuan a result chu direct-in a nghawng thei a ni.
Mahse, Unlearn.AI hian damdawi siamtu company te nen thawkdunin, thluak lam natna Alzheimer’s, Parkinson’s, leh multiple sclerosis te clinical trial design turin an thawk dun tawh a ni. Heng natnate hi midang aiin data an neih tam avangin bul tanna tha tak atan an thlang a ni. Fisher chuan he method hi ni khat chu natna zawng zawngah hman theih a nih chuan damdawi thar market-a lo chhuah hun chhung chu nasa takin a tihtlem thei a ni, a ti.
Take-Home Thuchah a ni
- Digital twin hi damdawi thar test-na atana clinical trial-a hman thin damlo tak tak computer model a ni.
- Hei hian control group atan mi tak tak hmang lovin heng digital model te hi hman theih a ni ta a ni.
- Hetiang method hian a thatna lian tak chu trial-a tel tam zawkin damdawi test tak tak chu dawn theihna hun remchang an nei a ni.
- Mahse, harsatna a la awm a, chu chu data quality sang tak hmuh harsat leh beisei loh thil thleng model theih lohna te hi a ni.
- He technology hian damdawi lam hmalam hun atan thutiam ropui tak nei mahse, a la naupang hle. Thil ngaihtuah leh rinhlelhna i neih chuan i doctor nen inbiakna neih a pawimawh .
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