I doctor-in thisen sang damdawi emaw, mipa i nih chuan prostate tihpunna damdawi emaw a pe che em? Chutiang a nih chuan damdawi chu alpha-blocker a nih a rinawm. A hming hi a buaithlak deuhin a lang thei a, mahse hengte hi kan taksaa dinhmun thenkhat control nana hman lar tak damdawi chi khat a ni. Chuvangin vawiin hian heng alpha-blockers chungchang hi i hriatthiam theih tur awlsam takin i sawi dawn nia.
Engtin nge heng alpha-blocker te hian hna an thawh?
Hei hi hrethiam tur chuan kan taksa inbiakpawhna kalphung hi han ngaihtuah ila. Kan nervous system hi postal service ang a ni. Kan taksa peng hrang hrangah chemical message (chu chu ``Neurotransmitters'' kan tih) a thawn chhuak thin. Heng thuchahte dawng tur hian kan cell-te hian ''receptor'' bik an nei a. Chabi leh lock ang mai a ni. Chemical message (key) a lo thlen a, receptor (lock) dik takah a in fit chauhvin chu cell chu a thawk chhuak thin.
Alpha-receptors hi kan taksaa receptor chi khat a ni. Kan thisen kalna kawngah leh prostate gland ang hmunah te an awm ber. Heng alpha-receptor te hian thuchah an dawn chuan chu cell te chu an inzawm khawm tan thin. Entirnan, thisen kalna kawnga alpha-receptor te an thawh chuan thisen kalna kawngte chu a inzawm khawm a, thisen sang a sang chho thin.
Chuvangin, alpha-blocker-in a tih chu turtle-a chabi dik lo dah a, block ang mai a ni. He damdawi hian chu alpha-receptor-ah chuan a kal a, a inzawm a, thuchah dik tak an dawng thei lo. Chu chu, chu receptor te chu a `block` tihna a ni. Tichuan chu cell te chu an contract lo va, an relax ta a ni. Thisen kalna kawnga cell-te an relax chuan thisen kalna kawngte chu a zau a, thisen sang a tlahniam bawk. Prostate chhunga taksa ruhte a relax chuan zun a awlsam phah thin. Chu chu a thleng mai mai a ni.
Alpha-receptor chi hrang hrang leh an hnathawh dan
Alpha-receptor hi chi hnih a awm a, chungte chu alpha-1 (A1) leh alpha-2 (A2) te an ni. An pahnih hian hnathawh dan inang lo deuh an nei a.
| Receptor chi hrang hrang | Hmun leh hnathawh ber berte |
|---|---|
| Alpha-1 (A1) atanga lo chhuak a ni |
|
| Alpha-2 (A2) atanga lo chhuak a ni |
|
Alpha-blockers hi eng condition atan nge hman a nih?
Hetiang damdawi chi hi damdawi lam harsatna engemaw zat enkawlna atan hman a ni ber.
1. Thisen sang (Hypertension) .
Hei hi a hmanna ber a ni. Kan sawi tawh ang khan alpha-blockers hian thisen kalna kawng a ti hahdam a, thisen sang a tihniam bawk. Hemi atan hian damdawi Doxazosin, Prazosin, Terazosin te hi hman a ni tlangpui.
2. Prostatic Hyperplasia (BPH) natna hlauhawm tak (BPH) .
BPH hi mipa kum upat deuh deuha awm thin a ni. Hetiang dinhmunah hian prostate gland a lian a, urethra a press a, zun harsatna leh zun retention ang chi harsatna a thlen thin. Alpha-blockers Tamsulosin, Alfuzosin, leh Silodosin te hian prostate leh bladder neck ruh te a ti hahdam a, zun a awlsam phah hle.
3. Hman dan dang (Off-label hman dan) .
A châng chuan doctor-te chuan an thil tawn leh damdawi lam thil finfiahna a\angin damdawi chu a pawmpuina ni lo dinhmun dang atân damdawi an pe ṭhîn. Hei hi ‘off-label’ hmanna an ti a.
- Kidney Lung: Tamsulosin ang chi damdawi hi zun kawng chhunga lung te tak te tangte awlsam zawka kal theih nan pek thin a ni.
- Post-traumatic stress disorder (PTSD related nightmares): He natna enkawlna atan hian damdawi Prazosin hi hman a ni \hin.
- Pheochromocytoma: Hei hi tumor chi khat a ni a, adrenal glands-ah a lo thang lian a, hormone tam lutuk a siam chhuak thin. Heng tumor-te avanga thisen sang lutuk control nan Alpha-blockers pek thin a ni bawk.
Alpha-blockers hian eng side effect leh risk nge a neih?
Damdawi dang ang bawkin alpha-blockers hian side effect a nei thei a ni. Chuvang chuan doctor ten heng damdawi an pek hian an fimkhur hle a ni. I damdawi ei chi hrang hrang a zirin side effect i neih dan a inang lo thei.
Thil pawimawh tak pakhat chu "first-dose effect" hi a ni. Alpha-blocker pill hmasa ber i ei hian i thisen sang chu nasa takin a tlahniam nghal thei a ni. Hei hian luak chhuak , mit a fiah lo, leh i ding chhuah chuan tlu ang maiin a awm thei (orthostatic hypotension) . Hetiang hlauhawmna tihziaawm nan hian i doctor chuan mut hmain damdawi ei turin a hrilh tlangpui ang che a, a dose tlem atanga tan tur a ni.
Side effect awm fo thin thenkhat chu hetiang hi a ni:
- Luak chhuak emaw, mit hmuh fiah lo emaw (a bik takin ding lai) .
- Lu na
- Chau tih hriatna
- Hnar hnar (hnar congestion) a awm
- Thinlung thawk chak tak (tachycardia) .
- Mipat hmeichhiatna hman danah nghawng a neih dan: Mipa thenkhat chuan anejaculation an tih natna an nei thei. A tlem hle a, darkar 4 aia rei erection na tak (priapism) a awm thei. Hei hi emergency medical attention mamawh tak a ni.
He damdawi ei huna hriat reng tur thil
- Damdawi dang nena inzawmna: Alpha-blockers hian thisen sang damdawi dang, erectile dysfunction damdawi thenkhat leh damdawi dangte nen a inzawm thei a ni. Damdawi ei tur zawng zawng hi doctor hnenah hrilh vek a pawimawh.
- Zu in: Zu in hian side effects a tipung thei a, chu chu luak chhuak ang chi hi a ni .
- Cataract surgery: Cataract surgery neih i tum a nih chuan i mit surgeon hnenah alpha-blockers i ei tih i hriattir ngei tur a ni, heng damdawi te hian surgery neih chhung hian harsatna a thlen thei a ni.
- Damdawi chawlhsan: Doctor rawn hmasa lovin he damdawi hi ei nghal vat ngai suh. Chutianga tih chuan side effect na tak a thlen thei a, chu chu rebound hypertension te hi a ni. Damdawi ei kha i chawlhsan a ngai a nih chuan a him leh doctor thupek angin ti rawh.
Engtikah nge damdawi lam thurawn i lak ang?
Damdawi chungchanga zawhna i neih chuan, emaw, side effects avanga nitin hnathawh a harsat chuan doctor nen inbia ang che.
Mahse, a hnuaia symptoms te hi i neih chuan damdawi in Emergency Department (ETU) ah kal nghal rawh:
- Thil hriatna hloh emaw, muhil emaw
- A rilru a na (`(Angina)`) .
- Thâwk harsa
- Thinlung thawk chak emaw, mumal lo emaw (palpitations) .
- Darkar 4 aia rei erection na tak (`(Priapism)`) .
- Allergic reaction na tak chhinchhiahna (e.g., vun rawng, hnim hring, hmai/kawr hring, ei harsa) .
Take-Home Thuchah a ni
- Alpha-blockers hi thisen sang leh benign prostatic hyperplasia (BPH) ang chi natna enkawlna atana hmanraw pawimawh tak a ni.
- Chûngte chuan prostate gland thisen kalna leh ruhte chu a ti hahdam a ni.
- Damdawi ei tan tirh hian, a bik takin ei hmasak ber hnuah, luak chhuak a awm thei a, chuvangin zanah ei thin la, i doctor-in a tih angin ei thin ang che.
- Damdawi dang i ei zawng zawng chu i doctor hnenah hrilh rawh.
- Doctor thurawn tel lo chuan heng damdawi te hi ei nghal vat ngai suh.
- Side effect na tak i neih chuan doctor thurawn la nghal rawh.
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