Hliam te tak te i nei a, ni rei lo te chhungin a lo vawt a, engmah thleng lo ang maiin a dam famkim tawh em? I nei ngei ang, a dik em? Chutih lai chuan hliam chu a dam tawh tih chauh kan ngaihtuah a. Mahse chu hliam tihdam nan chuan kan taksa chhunga thil mak tak tak thleng hi kan ngaihtuah ngai lo. Vawiin hian kan taksa chhunga thil thleng mak tak, kan dam khawchhuahna atana pawimawh tak, a chang chuan min nuih tir thei hial kan sawi dawn a ni. Hei hi angiogenesis kan ti a.
A awlsam zawngin, angiogenesis chu eng nge ni?
A awlsam hle mai. Angiogenesis chu kan taksaa thisen kalna kawng awm tawhte hmanga thisen kalna kawng thar, te tak te (capillaries) siam chhuahna a ni. Hei hi kan pian hma, kan nu pum chhungah a intan a, kan dam chhung zawng a la awm reng a ni.
Tunah chuan heng thisen kalna kawng te tak te, capillaries an tih te hian eng nge an tih tih i ngaihtuah mai thei. Dik tak chuan heng thisen kalna kawng te tak te te hian kan taksaa hna pawimawh ber pakhat an thawk a ni. Kan taksa peng leh taksa peng hrang hrangte mamawh thisen, ei tur tha leh oxygen phurtu ‘delivery service’ angin an thawk a ni.
Kan taksa khawi emaw laiah chuan tissue te hian oxygen an hmu tlem hle ang tih han ngaihtuah teh. Hetiang dinhmun hi hypoxia kan ti a. Oxygen a awm loh chuan chu lai hmuna cell te chu an hlauthawng a, "Min pui rawh! Hetah hian oxygen a tlem lo!" 'SOS' message thawn ang mai a ni. He ‘SOS’ thuchah hi kan dawn meuh chuan kan thisen kalna chhungril bang siamtu cell, endothelial cell an tih te chu an thawk chhuak a, thisen kalna kawng thar an siam tan ta a ni. Hei hi angiogenesis kalphung bul tanna a ni.
Engtin nge heng thisen kalna kawng tharte hi an lo pian? Kawng lian pahnih a awm!
Kan taksa hian heng thisen kalna kawng thar siam nan hian kawng lian pahnih a hmang a. An pahnih inthlauhna hrethiam turin heng chipchiar tak takte hi han thlir ila.
| Method hming | Engtin nge a nih | A awlsam zawngin... |
|---|---|---|
| Angiogenesis atanga lo chhuak (Sprouting Angiogenesis) a ni | Thisen kalna kawng awmsa atang hian hnah thar a lo thang chhuak thin. He hnah hi oxygen tlakchhamna hmun atanga lo chhuak chemical signal (e.g., VEGF an tih chemical) lam pan chuan a lo thang zauh zauh a. A tawpah chuan thisen kalna kawng thar tak a lo ni ta a ni. | Thingkung atanga hnah thar lo chhuak ang mai a ni. A hlui atang chuan thar a lo chhuak a, a lo thang lian zel a ni. |
| Intussusceptive Angiogenesis atanga lo chhuak a ni | Hetah hian hnah thar a lo chhuak lo. Chu ai chuan thisen kalna kawng pakhat chu a laiah a inthen darh a, thisen kalna kawng pahnih a lo ni ta zawk a ni. Endothelial cells te chu thisen kalna kawng chhungah an lut a, column an siam a, pahnih ah an then a ni. | Kawngpui lai takah lui (ditch) dahin kawngpui pahnih siam ang mai a ni. A awm chhun chu pahnih ah then a ni. |
Chuti a nih chuan hei hi Vasculogenesis nen a inang em?
Ni lo, hêng thumal pahnih hi a inang viau thei a, mahse, danglamna tê tê, mahse pawimawh tak a awm a ni. An pahnih hian thisen kalna kawng thar siamna a keng tel a ni. Mahse a danglamna chu anmahni bul tantu cell chi hrang hrangah a awm a ni.
- Angiogenesis: Hei hi thisen kalna kawng awm tawh, puitling kim tawh atanga thisen kalna kawng thar siamna hmun a ni.
- Vasculogenesis: Hei hi cell chi bik angioblast an tih atanga thisen kalna kawng thar siamna hmun a ni. Hengte hi cell puitling lo, thisen kalna kawng bang line-a awm cell-a la lo thanglian kim lo an ni.
A awlsam zawngin sawi ila, angiogenesis hi in hluiah pindan thar sak ang mai a ni. Vasculogenesis hi a bul atanga in sak ang mai a ni a, lungphum thar leh brick thar nen a ni.
Chuti a nih chuan, he angiogenesis hi thil tha nge thil tha lo?
Hei hi khandaih hriam pahnih nei tak a ni tak zet a ni. Hei hi a \ha leh \ha lo tih chu thisen kalna thar siam tharte hian tute nge an chawm tihah a innghat a ni.
Engtin nge angiogenesis hi a lo that theih?
Taksa hrisel takah chuan he kalphung hi kan dam khawchhuahna atan a pawimawh hle.
- Hliam a dam: I kut i tan hian hliam vel chu thisen kalna kawng thar a lo piang a, chu chuan a mamawh oxygen leh nutrients a pe a ni. Chuvang chuan hliam a dam thuai thin.
- Naupai lai: Nu pum chhunga nausen lo thang lian chuan a mamawh ei leh in leh oxygen mamawh zawng zawng chu nausen (placenta) kaltlangin a dawng vek a. He placenta hian a hnathawh that theih nan thisen kalna kawng thar a mamawh a.
- Exercise neih laiin: Exercise kan tih hian kan taksa peng hrang hrangte hian oxygen an mamawh tam zawk. Hetiang kalphung hian chu mamawh chu phuhruk turin a pui a ni.
- Hmeichhia thlasik lai: Hetiang kalphung hi nausen pum bang siam thar lehna atan pawh a pawimawh hle.
Hetiang hun lai hian angiogenesis hi kan nunna chhanhimtu leh hriselna atana min puitu mi huaisen ang mai a ni.
Hetiang kalphung thim tak - cancer tanpui dan tur
Hetiang kalphung ngei pawh hi kan hmelma a ni thei bawk. Chu chu cancer cells te tihpunna tura a puih hunah a ni.
Kan taksa chhunga cell te chu mi â ang maia thunun theih loha inthen darh tan hi cancer a ni tih kan hre vek. Heng cell inthen darh te hi an inzawm khawm a, tumor an siam thin. Kan taksaa tissue dang zawng zawng ang bawkin heng tumor te hian an dam khawchhuah theih nan, an lo thang lian a, taksa pum puia an darh theih nan ei tur, tui leh thisen supply an mamawh a ni.
Heta thil thleng hi a fing hle mai. Cancer cells te hian tissue hrisel ang bawkin heng ‘SOS’ chemical signals (VEGF ang chi) te hi an tichhuak tan thin. Heng signal te hian, "Thisen kan hmu tlem hle a, hetah hian thisen kalna kawng thar thawn vat rawh!"
He signal kan dawn hian kan taksa angiogenesis process chu a kick in a, tumor lam pan chuan thisen kalna kawng thar a siam tan ta a ni. Phên dangin sawi ila, cancer hian kan taksa ngeia thil awm dan pangngai chu a ‘hijack’ a ni.
Heng thisen kalna tharte hian tumor hi oxygen leh nutrients supply chhunzawm zel a pe a ni. Chuvang chuan tumor chu a thang chak zual sauh sauh a ni. Chu aia hlauhawm zawk chu cancer cells te hian heng thisen kalna kawng thar te hi an kal kual thei a, taksa hmun dangah an metastasize tan thei a ni.
Chuvang chuan angiogenesis an tih process hi cancer-ah hian a hlauhawm thei tih kan sawi a ni. Kan hmelma chawm, chawm ang mai a ni.
Hei hi tihtawp theih a ni lo em ni? Angiogenesis Inhibitors chungchang hi han sawi ila
Scientist-te chuan heng tumor-te hi a inthupzia an hriat chian hnu chuan a chinfel dan tur an zawng tan ta a ni. Chu zirchianna rah chhuah pakhat chu damdawi chi khat Angiogenesis Inhibitors tih a ni.
Heng damdawi te hian an tih ber chu cancer thisen kalna tur a titawp hi a ni. Hmelma riltam taka thihpui ang mai a ni.
Heng damdawi te hian kawng hrang hrangin hna an thawk a. Kawng lian tak pakhat chu cancer ‘SOS’ chemical signal leh a dawngtu thisen kalna kawng inbiakpawhna tihkhawtlai hi a ni. Static hian phone call a titawp ang bawkin, heng damdawi te hian cancer thuchah chu thisen kalna kawng a thlen loh nan a tikhawlo a ni. Hei hian thisen kalna kawng thar siam a titawp a, cancer hian a mamawh ei tur a hloh a, a thanna a tikhawtlai bawk.
Tunah chuan angiogenesis inhibitor damdawi engemaw zat chu US Food and Drug Administration (FDA) ang agency te chuan cancer enkawlna atan an pawm tawh a ni. Cancer enkawlna atana pawimawh tak an lo ni ta a ni.
Nangmah emaw i hriat emaw cancer vei a, he enkawlna chungchangah hian zawhna i neih chuan, i biak tur tha ber leh tling ber chu i enkawltu doctor a ni . Internet emaw hmun dangah emaw innghah ai chuan, i dinhmun hre chiang ber doctor hnen atanga thurawn lak a pawimawh hle.
Angiogenesis hi kan mit hmanga kan hmuh theih loh microscopic process a ni a, mahse kan taksa hnathawh makzia entir nan a tha hle. Kan taksa chungchâng, natnate, leh enkawl dân chungchânga hetianga kan hriat hian kan hrisêlna chungchânga thu tlûkna ṭha zâwk siam tûrin min ṭanpui thei a ni.
Take-Home Thuchah a ni
- Angiogenesis hi kan taksa chhunga thisen kalna awm tawh atanga thisen kalna kawng thar siam chhuahna pianphung a ni.
- Hetiang kalphung hi hliam dam leh naupai lai te taksa hrisel taka a thawh theih nan a pawimawh hle.
- Mahse, he thil kalphung tak hi a hlauhawm thei hle a, a chhan chu cancer cell-te chu ei leh in leh oxygen a pe a, taksa pum puiah an lo thanglian a, an darh zel theih nan a pui a ni.
- Angiogenesis inhibitor hi damdawi chi thar a ni a, tumor-a thisen kalna tur a tikhawlo a, cancer enkawlna a ni.
- I taksa hnathawh dan hriat chian hian i hriselna hriatthiamna a pe thei che a ni. Damdawi lam harsatna emaw, enkawlna emaw chungchangah ngaihtuahna i neih chuan i doctor nen inbia ang che.
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