Chemotherapy hi cancer enkawlna atana hman tlanglawn leh sawi hlawh ber pakhat a ni. Hei hian kan thisen kaltlangin damdawi thawnin cancer cells te tihlum a, an lo thang lian zel tur tihtawp a huam a ni. Mahse, chemotherapy damdawi chi hrang hrang, hnathawh dan inang lo tak tak a awm tih i hria em? Antimetabolites hi chutiang damdawi chi khat bik a ni. A hming chu buaithlak tak angin lang mah se, an hnathawh dan chu mak tak a ni. Vawiin hian heng antimetabolites te hi kan sawi dawn a ni.
Engtin nge heng antimetabolites te hian cancer cell te hi an tihlum?
A awlsam zawngin, he damdawi hian a tih chu cancer cell-te chu a bum a , chu chu a tak tak ang chiah chiah chabi lem pek ang mai a ni.
Hei hi hrethiam tur chuan cancer cell pakhatin cell tam zawk a siam (divide) dan hi han en hmasa ila. Kan taksaa cell tin ang bawkin cancer cell-te hian DNA an tih hi an nei a. Hei hi cell-a "instruction book" emaw "blueprint" emaw angin ngaihtuah rawh. He ruahmanna hi cell hian a tih dan a ni a, a copy tam zawk a siam dan pawh a ni.
He DNA blueprint hi dik taka siam tur chuan cell hian thil pawimawh tak tak a mamawh a ni. In sakna tur hian brick leh cement a mamawh ang bawkin. Heng thil chi hrang hrangte hi metabolites kan ti a. Chungte chu a bik takin:
- Purines: Hengte hi DNA leh RNA siamtu pawimawh tak an ni.
- Pyrimidines: Hengte hi DNA leh RNA siamtu pawimawh tak an ni.
- Folic acid: Hei hi vitamin chi khat a ni a, cell inthen darhna atana chakna petu a ni.
Tunah chuan, antimetabolite damdawi hian a tih dan chu hetiang hi a ni. He damdawi molecule hi a chunga kan sawi tak thil tel tak tak (metabolites) nen hian a inang hle a ni. Chuvangin, cancer cell hian a DNA siam a tum hian he thil lem, damdawi hi a hmang a, a thil tel tak tak nia ngaiin a hmang thin.
Buhfai i siam lai han mitthla teh. Salt i ti a, i hmuh ang sugar i dah tel bawk. Chuti a nih chuan eng nge thleng? Rice pum pui thlum leh texture a buai em em a ni lawm ni? Chutiang bawkin cancer cell-in he thil lem a hman hian a DNA blueprint chu a dik lo vek a ni. Blueprint dik lo a awm chuan cell hian copy tam zawk a siam thei lo. A tawpah chuan cancer cell chu a inthen leh thei tawh lo va, a thi ta a ni.
Antimetabolite chi hrang hrangte chu engte nge ni?
A hmaa kan sawi tawh thil pawimawh pathumte kha i hre reng em? Heng damdawi te hi chi thum ah then a ni a, chu chu chu component pathum zingah eng component nge an target tih a zirin a ni.
- Purine antagonists: Hengte hian cancer cell te purine siam chu a titawp thin.
- Pyrimidine antagonists: Hengte hian cancer cell te chu pyrimidine siamna a titawp thin.
- Folic acid dotu (antifolates) te chu: 1.1.Chungte chuan cancer cell-te chu folic acid hmanga DNA siamna tur a veng a ni.
He damdawi hi eng cancer chi hrang hrangah nge hman a nih?
Antimetabolite damdawi hi cancer chi hrang hrang enkawl nan hman a ni. I doctor chuan i cancer chi hrang hrang, a stage leh a hmaa i enkawl tawh dan a zirin eng damdawi nge i tana tha ber tih a rel ang. Damdawi thenkhat chu cancer bakah hian natna dang (autoimmune diseases ang chi) enkawlna atan pawh hman a ni.
A hnuaia table-ah hian antimetabolite damdawi hman tlanglawn tak tak thenkhat leh an enkawl cancer chi hrang hrangte tarlan a ni.
| Ruihhlo Hming | Cancer enkawl dan chi hrang hrang |
|---|---|
| Fluorouracil (5-FU) hmanga siam a ni. | Hnute, ril, pum, pancreatic, leh vun cancer te |
| Capecitabine (Xeloda®) hmanga siam a ni. | Hnute, ril, pum, chaw kawng, leh pancreatic cancer te a awm thei |
| Gemcitabine (Gemzar®) hmanga tihdam theih a ni. | Hnute, lung (cell tenau lo), ovarian leh pancreatic cancer |
| Methotrexate hmanga siam a ni | Leukemia, lymphoma, hnute, lung, lu leh kawng cancer, ruh cancer (Osteosarcoma) te a ni. |
| Cytarabine hman a ni | Leukemia chi hrang hrang (Acute myeloid, ALL, CML) . |
| Hydroxyurea a awm thin | Leukemia (CML), lu leh kawng cancer |
Engtin nge he damdawi hi taksaah pek a nih?
Heng damdawi te hi pek dan chi hrang hrang a awm a, chu chu damdawi pek dan chi hrang hrang a zirin a ni.
- Intravenously (IV): Hei hi hmanraw hman tlanglawn ber a ni. Damdawi hi taksaah saline solution angin cannula emaw chemo port emaw, kut emaw, rilru emawa dah hmangin pek a ni. He enkawlna hi minute tlemte emaw, darkar tlemte emaw, ni engemaw zat emaw pawh a ni thei.
- Injection angin: Damdawi thenkhat chu vun hnuaia thau layer-ah injection angin an pe bawk.
- Tablet: Antimetabolite thenkhat chu tablet angin a awm bawk a, chu chu ei theih a ni.
- Topical cream angin: Vun cancer (basal cell carcinoma) enkawlna atana hman thin damdawi 5-FU hi topical cream angin a awm bawk.
Enkawlna avanga nghawng tha lo awm thei te chu engte nge ni?
Chemotherapy damdawi-a thil langsar tak chu cell inthen darh chak tak takte a target hi a ni. Cancer cell hi cell chi khat, a inthen darh chak em em a ni. Mahse buaina chu, kan taksaa cell hrisel thenkhat pawh hi an inthen darh chak hle. Entir nan:
- Hair follicle cells te chu a awm a
- Kawng leh chaw ei kawng chhunga cell awmte
- Vun cell te
- Thisen siamtu cell te
Antimetabolites damdawi hian cancer cell leh cell hrisel hi a thliar hrang thei lo. Chuvangin heng cell hrisel te pawh hi a chhe thei bawk. Chuvang chuan side effect a awm thin.
Side effects awm tam ber chu:
- Chauhna leh hahna
- Sam tlakchhamna
- Vun inthlak danglamna (e.g. rash ) .
- Nausea leh luak chhuak
- Diarrhea (ril a na) .
- Chaw chakna
Mahse heng side effects te hi mi zawng zawngah a inang vek lo. Damdawi pek i nih dan, a dose, etc. ah a innghat a , chuvangin enkawlna i tan hmain i doctor nen he thu hi sawi hmasak a pawimawh hle. Tunah chuan a side effects control nan damdawi tam tak a awm tawh a.
He enkawlna hian eng hlawkna leh hlauhawmna nge a neih?
A thatna te: 1.1.
Antimetabolites hlawkna ber chu cancer cells a that a, tumor thanna a titawp a ni. Hei hian cancer vei dam chhung a ti rei thei a, symptoms control-in nun a ti awlsam thei bawk.
Risk awm thei: 1.1.
A hlauhawm ber chu a hmaa kan sawi tawh ang khan a side effects te hi a ni. Tin, cancer enkawlna zawng zawng hian mi zawng zawng tan hna a thawk vek lo. Damdawi bik pakhat hian i cancer tan hna a thawk lo mai thei. Hun a kal zel a, cancer cell te hian damdawi chu an do thei lo thei a, damdawi chu a thawk tha lo thei bawk. Chutiang a nih chuan i doctor chuan chemotherapy damdawi dang emaw, enkawlna dang (e.g., radiation, immunotherapy) emaw a rawt thei ang.
Naupai, nau hnute i pek emaw, damdawi dang i neih chuan he enkawlna hi i tan hmain i doctor hnenah hriattir hmasa phawt ang che .
Take-Home Thuchah a ni
- Antimetabolites hi chemotherapy damdawi chi khat bik a ni a, cancer cell te chu an inthen darh loh nan "trick" a ni.
- Heng damdawi te hian cancer cell te hian an DNA siamna atana an mamawh raw materials (genetic blueprint) an hmuh loh nan hna an thawk a ni.
- Hengte hi cancer chi hrang hrang tam tak enkawlna atan hman a ni a, chu chu hnute, lung, leh leukemia te hi a ni.
- He damdawi hian cell hrisel tak tak, rang taka inthen darh te pawh a nghawng avangin sam tlakchham leh nausea ang chi side effects a awm thei a ni.
- Enkawlna chungchang zir hi a hlauhawm deuh thei. Mahse, i doctor hnenah damdawi i pek dan te, a thatna te, a chhiatna te, leh a side effect te zawt suh. Hriatthiamna tha tak neih hi enkawlna atana thil pawimawh tak a ni.
💬 Comments (0)
Comment a la awm lo. Hetah hian i comment hi a vawikhatna atan add rawh.
I comment kha add rawh