Apoptosis chu eng nge ni? Kan taksa chhunga cell te thih dan mak tak mai!

Kan taksaa cell-te, a bik takin an tar emaw, an chhiat emaw hian eng nge thleng thin tih i ngaihtuah ngai em? Dik tak chuan kan taksa hian heng cell te hi a hriat chian theihna leh felfai taka paih chhuah theihna mak tak a nei a ni. Chu chu apoptosis kan tih chu a ni. A awlsam zawngin sawi ila, hei hi taksain a ruahman leh a thunun cell thihna kalphung a ni a, ‘programmed cell death’ nen a inang hle.

Engvangin nge he thil hi apoptosis an tih hi kan tan a pawimawh em em?

Ngaihtuah teh, kan taksaa cell ṭhenkhat chu an upa tawh a, a nih loh leh an DNA a chhe ta a ni. Heng cell te hi taksaah hian an awm chhunzawm zel a nih chuan thunun theih lohvin an inthen darh a, an pung zel mai thei a, cancer ang chi natna hlauhawm tak tak a thlen thei a ni. Hetiang process apoptosis an tih hian chutiang hlauhawmna tur venna kawngah min pui thin.

Hei hi in chhunga furniture hlui, chhe tawh tihbo ang mai a ni. Chu furniture neih chuan in chhungah buaina a siam thei ang bawkin, kan taksaa heng cell chhia kan neih hian harsatna a thlen thei a ni. Chuvangin, apoptosis hi kan taksa hriselna atana puitu thil pawimawh tak a ni.

Mahse, engkim hi ruahmanna angin a kal vek a ngai a ni. He apoptosis process-ah hian thil a dik lo a nih chuan, cell tam lutuk thih emaw, thi tur cell thi lo emaw pawh nise, chu chuan harsatna a thlen thei a ni.

• Apoptosis a tam lutuk chuan kan taksa mamawh cell hrisel te pawh a tichhe thei bawk. Entirnan, he dinhmun hi Alzheimer natna ang chi natnaah hmuh tur a awm.
• Apoptosis a lo awm dik loh chuan (a tlahniam): Cell chhia leh chhe tawhte chu taksaah an awm reng a, chutah chuan thunun theih lohvin an inthen darh a, an pung chho tan thin. Hei hian cancer ang chi natna a thlen thei a ni.

Apoptosis chungchang hriat i duh mai thei a, a chhan chu nangmah emaw i hriat mi emaw pawhin a vei tih hmuhchhuah a nih vang a ni. Microscope hmanga hmuh theih chauh cell chhunga heng thil tenawm tak takte hi engtin nge kan natna lan chhuah dan nen a inzawm theih tih hi ngaihtuah hi thil awmdan pangngai a ni. Mahse, apoptosis hriatthiamna hian i natna hmuhchhuah chhan ‘a chhan’ chu a hriatthiam tir thei che a ni. He hriatna hian i doctor nen i dinhmun leh enkawl dan tur chungchang i sawipui thei bawk.

Apoptosis hi eng nge thleng tak tak? A tum chu eng nge ni?

Apoptosis hi kan taksa tana thil pawimawh tak a ni. Kan pian hma pawhin a intan thin. Ngaihtuah teh, nausen pum chhunga nausen a lo thanglian lai hian, entirnan, kut zungtangte a lo pian that theih nan, a inkar cell thenkhat chu a hun takah an thih a ngai a ni. Chu chu apoptosis hian a puih a ni.

Kan pian hnuah pawh apoptosis hian hna pawimawh tak tak a thawk a:

• Kan taksa cell leh tissue hlui te hi a thara thlak reng a ngai a ni. Apoptosis hian hei hi a pui hle.
• Kan taksa hriselna (immune system) hian natna chi hrang hrang a do theih nan a pui thin.
• A chhe tawh, .Cell siam thar leh theih loh te chu taksa atanga lakchhuah an ni.
• Cell chhia te chu thunun theih loha an pung zel loh nan a veng a ni.
• Taksa tissue-a balance (`(Homeostasis)`) vawng reng turin a pui.

He thil apoptosis an tih hian engtin nge hna a thawh?

Hei hi thil kalphung buaithlak tak a ni a, mahse a awlsam zawngin hetiang hian a thleng thin. Kan taksaa protein bik thenkhat chuan he apoptosis process hi an tichhuak thin. Entirnan , protein pakhat `(p53 protein) tih hi a ni.

`p53` protein hnathawh dan chu hetiang hi a ni:

1. Pakhatnaah chuan he protein hian kan taksaa information dahkhawmtu ``genes'' te chu a tichak a, ``DNA'' chhia cell te siamthat a tum bawk.

2. Amaherawhchu, a chhiatna chu siam that theih loh khawpa tam a nih chuan chu protein chuan chu cell chu a inthen darh emaw, a pung emaw phal lovang.

3. Chu ai chuan chu protein chuan signal a thawn a, "Okay, tunah chuan he cell hian apoptosis process a tan a ngai a ni."

Apoptosis a lo intan chuan chemical inthlak danglamna hrang hrang a awm a, chu cell chu a inthen darh ta a ni. Tichuan, cell thi tur chuan cell dang phagocytes (kan taksa bawlhhlawh khawlkhawmtu ang chi thisen var chi khat) an tih hnenah signal a thawn a, "Lo kal la, heng ka chi hrang hrangte hi ei rawh," a ti a. Chutih rual chuan, cell thi mek hian a chhehvel tissue-te hnenah signal a thawn a, chu chuan inflammation tihziaawmna leh a dam chak zawk nan a pui bawk. A felfai khawp mai, a dik em?

Apoptosis tam lutuk hi a hlauhawm em?

Ni e, a dik tak zet. Apoptosis a lo awm tam lutuk chuan kan taksa mamawh cell hrisel te pawh an thi thei bawk. Hetianga cell thihna tam lutuk hi natna tam tak lo awm theihna nen a inzawm tlat a ni. Chung natna thenkhat chu:

• `(Alzheimer natna)` (Alzheimer natna) .
• `(Huntington natna)` (Huntington natna) .
• `(Amyotrophic lateral sclerosis (ALS))` (ALS natna) tih a ni a, a rilru a buai em em a, a rilru a hah em em bawk a.
• `(Parkinson natna)` (Parkinson natna) .
• `(AIDS)` (AIDS) tih hi a ni.
• Ulcerative colitis a awm thei
• `(Rheumatoid arthritis)` (Rheumatoid arthritis) a ni a, a rilru a hah lutuk a, a rilru a buai em em bawk a.

Chutiang dinhmunah chuan taksain a mamawh cell a tihchhiat avangin a natna lanchhuahna a lo awm thin.

Apoptosis a lo awm dik loh (a tlahniam) chuan eng nge thleng?

Kan sawi tawh ang khan apoptosis hi cell chhia tihbo nan emaw, cell control loh taka thanlenna tihtawp nan emaw a pawimawh hle. Chuvangin, hei hi a thleng dik lo a nih chuan, chu chu , apoptosis a thleng tawk lo a nih chuan, chu cell tha lo, chhia chu taksaah an awm reng ang a, thunun theih lohvin an inthen darh ang a, an pung ang.

Hei hi hnim hring ang a ni. Uluk taka thunun a nih loh chuan rang takin a darh ang a, huan pumpui a tichhe vek ang.

Hetianga cell pung dan pangngai lo hian cancer leh autoimmune disorder a thlen thin.Hriselna lama harsatna lian tak tak a awm thei.

Natna enkawlna kawngah apoptosis hian eng hna nge a thawh?

Zirchiangtute chuan apoptosis process inthlak danglamna hi natna thenkhat lo awmnaah a inrawlh tih an hmuchhuak a. Chuvângin, tûnah chuan apoptosis a tam lutuk chuan a titawp thei, a nih loh leh a mamawh hunah a tichak thei damdawi an zawng ta a ni .

Ngaihtuah teh, a chang chuan kan taksaa protein thenkhat chuan apoptosis hi a thlen tur laiin a titawp thin. Tichuan, cell chhia chu a awm reng thei a, cancer tumor-ah a lo thang lian thei a ni. Zirchiangtute chuan heng proteins te hnathawh titawp thei damdawi an zawng mek a ni. Tichuan apoptosis chu a thleng dik thei a, chu cell tha lo chu a chhe vek a ni.

Kan mamawh cell hrisel te thih loh nan apoptosis process tlem kan tihtlem duhna hmun dang pawh a awm bawk.

Hetianga apoptosis control thei enkawlna hian nakin lawkah natna tam tak enkawlna kawngah a pui thei ang. Hemi chungchang hi i doctor chuan a hrilh belh thei che a ni.

Apoptosis leh necrosis hi eng nge an danglamna?

Apoptosis ang bawkin necrosis hi cell thihna dang a ni. An pahnih inthlauhna ber chu apoptosis hian kan pian hma pawhin, embryonic stage (chu kut zungtang ang chi formations te kha i hre reng em?) lai pawhin min lo thanglian thei a ni. Mahse, necrosis hi embryonic development nen hian a inzawm lo. Kan pian hnu, natna chi hrang hrang, hliam, toxin, etc. avanga cell a tihchhiat hian a thleng tlangpui.

Researcher te chuan apoptosis leh necrosis hi thil pahnih inthlau tak niin an ngai thin. Apoptosis chu ruahmanna fel tak, ruahmanna fel tak neia cell thihna niin an ngai a, necrosis chu ruahmanna awm lo, buaina chhuak cell thihna a ni . Chu chu eng emaw chen chu a dik a ni. Necrosis-ah chuan cell thi mek chhunga thil awmte chu a luang chhuak a, a chhehvel tissue-ah a darh a, inflammation a thlen thei bawk. "Chaotic" process a ni deuh ber. Mahse apoptosis-ah chuan cell te chu an chhunga thil awmte chu paih chhuak lovin an thi ta a ni. Chu ai chuan cell piece te chu mumal takin an dah khawm a, phagocyte an tih cell te chu an rawn lut a, an ei ta a ni.

Mahse, zirchianna thar chuan heng thil kalphung pahnih hi inang lo deuh a awm tih hmuhchhuah a ni. Necrosis chi thenkhat, apoptosis ang chi te chu programmed (or regulated) necrosis a ni tih hmuhchhuah a ni. Entirnan necroptosis leh pyroptosis te hi a ni . A châng chuan apoptosis a hlawhchham chuan taksain necroptosis ang chi hmangin cell duh loh emaw, chhiatna thlen thei emaw a paih chhuak ṭhin. Chuvangin, heng cell thih dan hrang hrangte hian kan taksa venhimna atan an thawk dun a ni.

Engtin nge `Apoptosis` tih thumal hi an lam thin?

`Apoptosis` tih thumal hi sawi dan tlangpui pahnih a awm. Pakhat chu `App-up-toe-sis` a ni a, pakhat chu `App-uh-toe-sis` a ni a, a awmzia chu `p` ri pahnihna tel lo tihna a ni. Hemi chungchang hi i doctor hnenah i zawt thei a, i hriselna nena inzawm thumal dang pawh i zawt thei bawk. Thil lian tham a ni lo, a pawimawh ber chu a concept hriatthiam a ni.

A tawp berah chuan thil hriat reng tur

Apoptosis hi hmuh theih loh, mahse thil pawimawh tak a ni a, nitin kan taksa chhungah hian kan nung leh hrisel theih nan a thleng thin. He programmed cell death hian kan hriselna a pui mai bakah natna laka invenna a pui bawk.

Apoptosis i vei tih hmuhchhuah i nih chuan i doctor nen sawiho la, chutiang chuan i natna chungchang te, a nghawng dan te, leh enkawl dan tur te chiang taka i hriat theih nan.

Hetiang thil hi hriat chian hian i hriselna chungchanga thutlukna i siam hunah nasa takin a pui ang che tih hre reng ang che.

` Apoptosis, cell thihna, programmed cell thihna, taksa hnathawh dan, hriselna, natna, cancer