Thinlung chhunga protein mak tak tak awmte hi i zir dawn teh ang? (Thinlung lam Amyloidosis) tih a ni.

A chang chuan i chau emaw, thawk harsatna tlem i nei em? Heng thilte hi i ngaihven vak lo mai thei. Mahse a chang chuan hengte hi thinlung lam harsatna chhinchhiahna a ni thei. Vawiin hian thinlung tichhe thei dinhmun kan sawi dawn a, chu chu i hre lo mai thei , mahse hriat tlak tak a ni. Ngaihtuah buai suh, he thu hi awlsam tak leh i hriatthiam theih tur angin kan sawi dawn a ni.

Hei hi eng nge ni (Cardiac Amyloidosis)?

A awlsam zawngin sawi ila, `(Cardiac Amyloidosis)` hi kan taksaa protein pianzia dik lo, thinlung chhung leh a chhehvela awmte avanga lo awm a ni. Tui pipe-a inkharkhip ang maiin han ngaihtuah teh. Hetianga protein buildup hian i thinlungin thisen a pump theihna a ti tlem a ni. Chutah chuan thinlung chuan a thawkrim lehzual a ngai a ni. A tawpah chuan he extra effort hian thinlung a tichak lo thei a, a tichhe thei bawk a, `(Heart Failure)` a thlen thei a ni.

Hei hi chhan tam tak a awm thei. Mi ṭhenkhat chuan an nu leh pate aṭangin an rochun a, chu chu genetic a ni tihna a ni . Mi dangte chuan genetic link engmah nei lovin he natna hi an nei thei bawk. Natna dang, cancer ang chi te pawh a awm thei bawk. He natna, ``Amyloidosis`` tia koh hi tihdam kim theih ni lo mah se, chi thenkhat tan chuan enkawlna tha tak tak a awm.

Cardiac Amyloidosis chi hrang hrangte chu engte nge ni?

Kan taksaa protein awmte hi molecule chain sei tak an ni. Heng protein te hian thil tam tak ti turin min pui a, chung zingah chuan chakna min pe a, kan taksaah chemical reaction a kalpui a, system hrang hrang inkara thuchah a inhrilh tawn bawk. Mahse buaina a awm. Kan cell te hian heng protein chain te hi an pianzia dik tak an nih phawt chuan an hmang thei a ni. Protein misfolding disorder, amyloidosis ang chi hian heng protein te hi a ti twisted a, a fold dik lo va, a thawk tha thei lo bawk.

Protein a inrual lutuk chuan a inzawm khawm a, taksain a hmang thei lo. Kalna tur an neih loh chuan heng protein inzawmkhawmte hi an inzawm khawm a, an inzawm khawm a, taksa hmun hrang hrangah an inkhung khawm a ni.

Amyloidosis hian taksa chhunga system tam tak a nghawng thei a, a bik takin thinlung a nghawng thei a ni. Amyloidosis hi thinlung tichhe thei chi thum a awm a (chi dang pawh hian thinlung a nghawng thei a, mahse an tlem zawk hle).

AL (Light Chain) Amyloidosis natna a ni

Kan taksa hian a immune system-ah hian ``light chains`` an tih te hi a hmang thin. Hengte hian virus leh bacteria ang chi natna hrik lakah min venghim a ni. ``AL Amyloidosis`` hi kan ruhro chhunga cell te an thawk tha lo a, heng ``light chain'' te hi an siam tam lutuk hian a lo awm thin a ni. Hetiang chi hi kum 50 hnuah hmuhchhuah a ni tlangpui.

ATTR amyloidosis a ni

Transthyretin (TTR) hi protein a ni a, kan taksaah hian chemical thenkhat a kal kual thei a ni. Thyroid hormone leh vitamin A (retinol) a phurh chhuah avangin a hming a pu ta a ni. Tun hma chuan Thyroxine-binding prealbumin (TBPA) tia koh a ni a, mahse chu hming chu hman a ni tawh lo.

`ATTR Amyloidosis` symptoms hi a danglam hle. Kum 20 hnuai lam emaw, kum 70 hnuai lam emaw pawhin a lang thei. Subtype lian pahnih a awm a, chungte chu:

• Hereditary ATTR: Hei hi genetic condition a ni. Hei hian i nu emaw, i pa emaw, an pahnih emaw hnen atangin i rochun tihna a ni.
• Wild-type ATTR: Hei hi TTR protein chu a thawk tha lo tan mai mai a, genetic mutation engmah a awm lo. Hei hi kum 60 hnuah a thleng tlangpui a, a hmain Senile Systemic Amyloidosis emaw Senile Cardiac Amyloidosis emaw an ti thin a, mahse heng hmingte hi hman a ni tawh lo.

Dialysis nena inzawm amyloidosis a awm

Kidney natna avanga kum tam tak dialysis nei tawhte chu amyloidosis vei theihna a sang hle. Hei hi a chhan chu dialysis process-ah hian protein pakhat beta-2 microglobulin (beta-2 microglobulin) tih chu a tlangpuiin filter out a nih loh vang a ni. He protein hi beta-2Ms tia hriat a ni a, thinlung leh taksa peng dangah a awm khawm a.

Rare (Cardiac Amyloidosis) chi hrang hrang

Hei bakah hian ``Cardiac Amyloidosis'' subtype dang engemaw zat a awm a, mahse an tlem hle.

Hetiang hi tuin nge nei tam zawk?

He natna hi tu nge vei tih nghawngtu thil pawimawh engemaw zat a awm a:

• Kum: Mi thenkhatin kum 20 velah amyloidosis an vei thei a, mahse a tlangpuiin kum 40 hnuai lam zingah a tlem hle a, he natna hi kum 50 an tlin hnuah hmuhchhuah a ni ber a, a bik takin wild-type ATTR amyloidosis ang chi hi a ni.
• Gender: Hmeichhia aiin mipa hian cardiac amyloidosis an vei tam zawk. A bik takin wild-type ATTR amyloidosis-ah chuan hmeichhia pakhatah mipa 25 atanga 50 velin an vei belh a ni.
• Pian ram: Ram thenkhatah chuan chhungkaw ATTR amyloidosis thlentu genetic mutation hi a awm fo thin. Entirnan, Portugal, Japan, Sweden, Finland, leh Europe ram dang engemaw zat ang ram te.
• Hnam/chi: Chhungkaw ATTR amyloidosis thlentu genetic mutation dang chu West African hnam chhuak mipa hring zinga 4% vel ah hmuh a ni. Hei hian African American bakah Latin America leh Caribbean atanga lo kal mipa hringte pawh a huam tel a ni.
• Kum tam tak chhung dialysis tih chhunzawm zel: Dialysis i tih rei poh leh heng symptoms te hi i nei tam zawk thin.

He natna hi engtiang chiahin nge a hluar?

A tlangpuiin `(Amyloidosis)` hi natna hmuh tur awm lo tak a ni. Mahse, `(Amyloidosis)` chi thenkhat chu a dang aiin a tam zawk.

• AL Amyloidosis: United States-ah ringawt pawh hian kum tin AL Amyloidosis vei thar 4,000 vel an awm thin. Chu chu puitling 64,500 zinga pakhat vel a ni.
• Hereditary `ATTR Amyloidosis`: Hetiang natna hi West African hnam chhuak mipa hring zinga 4% thleng hmuh theih a ni. European hnam chhuak mite zingah chuan mi sang za zinga pakhat velin hmuh tur a awm. Amaherawhchu, a chunga kan sawi ramahte hian he zat hi a tam zawk hle. Entirnan, Portugal ramah chuan mi 538 zinga pakhat velin he natna hi an vei a ni.
• Wild-type ATTR Amyloidosis: Mithiamte chuan hei hi hriat chian loh a nih an ring a, chhut dan chuan mipa kum 80 chunglam 20% thleng a nghawng thei niin an sawi.
• Dialysis-related amyloidosis: Hei hi kum hnih atanga kum li chhung dialysis hmangtu zinga 20% vel ah a awm thin. Kum 13 emaw a aia rei emaw chhunga dialysis nei zawng zawngah a awm vek.

He natna hian engtin nge taksa a nghawng?

Cardiac Amyloidosis hi i thinlung insiam dan tidanglamtu leh a pump theihna tibuaitu natna a ni. A hnuaia mite hian a thleng thin:

• Thicken wall thickening: `(Amyloid)` proteins chu heart muscle-ah a awm chuan thinlung bang chu a thim a, thinlung chu a lian ta hle a ni. Chutiang a nih chuan thinlung hian taksa pum puia thisen pump turin a thawkrim zawk a ngai a ni. He extra effort hian a tawpah chuan `(Heart Failure)` a thlen thin.
• Cardiac amyloidosis hian thinlung rhythm mumal lo (arrhythmias), emaw, thinlunga electrical signal chak lo emaw a thlen thei bawk. Atrial fibrillation hi amyloidosis nena inzawm arrhythmia chi khat a ni.
• Amyloid deposits: Amyloid proteins hi waxy, sticky protein an ni a, awlsam takin an inzawm khawm a, clump lian tak tak an siam thin. Heng clump te hi heart valve-ah an tang a nih chuan valve chu a then a block thei a, thisen kal pawh a tikhawtlai thei a ni.

Eng nge a lan chhuah dan?

Amyloidosis thlen thei genetic mutation nei zawng zawng hian he natna hi an nei vek dawn lo. Mi thenkhat chuan an nei ngai lo. Mi dangte chuan an ti a, mahse chutiang chuan a na lo.

Cardiac Amyloidosis symptoms hi thinlung a ni tlangpui a, mahse taksa peng pawimawh dang, liver leh kidney te pawh a huam tel thei bawk. Cardiac Amyloidosis hnuhnung ber ah chuan heart failure na tak (a hnuaia tarlan) symptoms a awm thei.

A lan chhuah theih dan chu:

• Thâwk lak tawi: Hei hi i active lai emaw, i mut lai emaw a thleng thei.
• Fluid khawlkhawm avanga hliam: Hei hi ke, ke ruh, ke ruh leh pum chhungah hmuh tur a awm tlangpui.
• Chau:Ni engemaw zat emaw a aia rei emaw chhung chau lutuk tih hriat.
• Heart Palpitations: Engmah i beih ngai lova i thinlung a na ang maia i hriatna nuam lo tak a ni.
• Varicose veins in the neck: Hei hi thinlung a chak loh laiin a thleng thin a, a chhan chu pump tha a harsat vang a ni. He pressure sang hian kawr chhunga veins te pawh pressure a siam a, chu chuan a ti lian a ni.
• Hepatomegaly: Hei hi thinlung chak lohna avanga harsatna awm fo a ni bawk a, chutiang bawka kawr chhunga thisen kalna (veins) te pawh a inhawng thin. Thinlung atanga pressure sang hian liver chhunga thisen kalna kawngte chu pressure a siam bawk a, chu chuan organ chu a ti hring chhuak thin.
• Kidney problems: Kidney inflammation emaw kidney function tihdanglam ang chi thil.

Thil dang, ``Cardiac Amyloidosis'' chhinchhiahna ni thei, thinlung, thin, leh kal (kidney) nena inzawm lo:

• Thil danglam tak a hliam .
• Lei a hring chhuak.
• Carpal Tunnel Syndrome (Pulmonary Nerve Compression - Hei hi a hmaa hriattirna a ni thei a, a tam zawkah chuan natna a lo lan hma kum tam tak a ni).
• Lumbar Spinal Stenosis (a hnungzang hnuai lam a ruhro vel hmun a tawi).
• Mit hmuhna lama harsatna a awm.
• Hriatna lama harsatna leh bengchheng.
• Kut emaw ke emaw a hring emaw, a hrual emaw.

Cardiac Amyloidosis hi engte nge ni?

Amyloidosis chi hrang hrang awm chhan hrang hrang a awm a, mahse a tam zawk hi chu kan DNA nen a inzawm a ni .

Chhungkaw chaw siamna bu ang maiin han ngaihtuah teh. Kan cell te hnathawh dan tur te, protein thenkhat siam dan tur te a awm a. Nu leh pa atanga fate hnena DNA pek chhuah chu i nu leh pate’n chu recipe book chu i hnena kut chhuak ang mai a ni.

Genetic mutations hi i DNA recipe book-a typos ang mai a ni. Capital letter hian recipe a ti buai thei. Amyloidosis ang chi natnaah pawh a inang chiah chiah. I cell te hian an theih ang tawkin hna an thawk a, mahse recipe zawm dan chauh an hre thin. Heng typos te hi kawng hnih in i chungah a thleng thei.

Rochun a ni

Cardiac Amyloidosis hi chhungkaw natna a ni fo thin. Hei hian i rochun tihna a ni. Hei hi i nu leh pa pakhat emaw, pahnih emaw chuan an DNA-ah mutation an neih a, chu "recipe book"-a tihsual chu i DNA-ah copy a nih chuan a thleng thin.

Nei

Acquired diseases hi natna i rochun loh, mahse i nunah engtik lai pawha lo awm thin natna a ni. Wild-type ATTR amyloidosis leh dialysis-related amyloidosis te hi heng natna hmuhchhuah te hi entir nan an hmang ve ve a ni. Mahse heng zinga pakhat mah hi i DNA-a mutations nen a inzawm lo.

• Wild-type ATTR amyloidosis hi i taksain protein a siam dik vang a ni a, mahse hun kal zelah chu protein te chu a nghet lo (chuvang chuan he natna hi kum upa lam nena inzawm a nih vang a ni). A tâwpah chuan protein chu a fold dik lo mai mai a ni.
• Dialysis nena inzawm amyloidosis hi i taksaah protein pangngai, dialysis hmanga filter chhuah theih loh, i kal ang chi, a lo awm khawm hian a lo awm thin. Hun a kal zel a, chu protein chu harsatna thlen thei khawpin a pung chho zel a ni.

Hei hi hri kai theih a ni em?

Ni lo, `(Amyloidosis)` hi engti kawng mahin natna hrik kai theih a ni lo .

Engtin nge doctor hian hei hi a hriat chian? (Diagnosis) tih a ni.

Doctor chuan i natna lan chhuah dan te, taksa enfiahna (doctor chuan i taksa chu natna chhinchhiahna a en a, a hriat a, a ngaithla a), i chhungkaw medical history a zirin `(Cardiac Amyloidosis)` a ringhlel hmasa ang. Chumi hnuah chuan diagnostic test, imaging test, leh lab test te an ti ang a, `(Cardiac Amyloidosis)` i vei leh neih loh an finfiah ang.

I chhungkuaa mi pakhatin chhungkaw amyloidosis a neih chuan test thenkhat i mamawh lo mai thei a, test dang neih a ngai mai thei bawk. Genetic testing pawh tih theih a ni a, hei hian cardiac amyloidosis thlen thei genetic mutations i neih leh neih loh enfiah a ni thei bawk.

He natna hi hriat chian nan eng test nge tih thin?

I doctor chuan ``Cardiac Amyloidosis'' i vei nia a rinhlelh chuan a hnuaia test pakhat emaw a aia tam emaw hi a order thei ang.

Lab testing neih a ni

Heng test-ah hian tissue, thisen emaw taksa tui dang emaw sample lak a ni. Heng test tam takah hian Dye bik Congo red an tih chu hman a ni. He dye hian amyloid awmna hmunte chu lighting condition thenkhatah green-in a rawn eng chhuak thin.

• Tissue biopsy: Hetah hian doctor-te chuan hmun pakhat, heart muscle ang chi tissue sample tlemte an la a, lab-ah an test thin. Tissue sample pawh hmun dang atanga lak theih a ni a, mahse non-heart area atanga sample lak atanga positive result a awm chuan imaging test hmanga finfiah a ngai a ni.
• Thisen test: Cardiac amyloidosis chi thenkhatah chuan amyloid proteins thisenah a kal kual thin. Lab test hmangin heng protein te hi a hmuchhuak thei a ni.
• Urine testing: A then phei chuan amyloid proteins hi zun ah a awm thei. Heng protein te hi zun a awm leh awm loh test hian a natna hriat theihna kawngah pawh a pui thei bawk.

Imaging test te pawh a awm

Cardiac amyloidosis hian i thinlung a ti lian thei a, a pianzia a tidanglam thei a, chuvangin imaging test hian i natna chu a hriat theih nan a pui thei a ni. Test tih theih turte chu:

• Echocardiogram hmanga tihchhuah a ni.He test hi bat-in a kawng zawn nan sound a hmang ang mai a ni. High-frequency sound wave a hmang a ni. Aw chhuahna hmanrua chu rilru vunah dah a ni a, doctor-te chuan taksa chhunga thil awm hrang hrang aṭanga sound wave-te a rawn bounce dan enin thinlung chu "an hmu" thei a ni. Hei hi thinlung hmun thenkhat chu a danglam bik taka thim em tih hriat nan a tangkai hle.
• Scintigraphy: He test atan hian doctor-te chuan i thisenah tracer, radioactive tlemte (mahse hlauhawm lo) an inject thin. Tracer hian amyloid protein a khawlkhawmna hmunah a khawlkhawm thin. Chumi hnuah chuan heng hmunte hi SPECT scan (Single-Photon Emission Computed Tomography) tih imaging test hmangin awlsam takin hmuh theih a ni.
• Magnetic Resonance Imaging (MRI): He test hian magnet chak tak leh computer technology hmangin thinlung thlalak a siam a. MRI hi a chipchiar hle a, chuvangin doctor-te chuan thinlungah thickening emaw thil dang dang emaw an hmu thei a ni.

Electrocardiogram (ECG emaw EKG emaw) hmanga tih a ni.

ECG-ah chuan i rilru vunah sensor engemaw zat (a tlangpuiin 12) a awm a. Sensor-te hian i thinlunga electric current luang chu an hmuchhuak a, chu electric signal chakna chu paper emaw screen emaw-ah wave angin an lantir a ni. Doctor ang chi specialist trained-te chuan i thinlung hmun ṭhenkhatin electric a kalpui danah danglamna danglam tak a awm em tih chu wave chu an zir chiang thei a ni.

Genetic test neih a ni

Test dang result a zirin i doctor chuan genetic test neih a rawt thei bawk. Heng test te hian i DNA-a mutations awmte chu i amyloidosis thlentu ni thei tur a ni tih a hmuchhuak thei a ni.

Amyloidosis damdawi a awm em?

`(Cardiac Amyloidosis)` chi hrang hrang hi enkawl theih a ni a, mahse natna hi a dam kim thei ngai lo . `(Amyloidosis) chi hrang hrang a zirin enkawl dan pawh a inang lo. A tlangpuiin, natna hriat hmasak hi a pawimawh hle . `(Amyloidosis)` hi a hmaa man a nih chuan hun rei tak chhunga thinlung tihchhiatna chu a tlem thei hle. A hmaa hriatchhuah leh enkawl a nih loh chuan a chhe vek thei a ni. Lung chhiatna nghet tak siamthat theihna awmchhun chu `(Heart Transplant)` tih hi a ni.

AL amyloidosis a ni

AL Amyloidosis enkawlna hi cancer enkawl dan pangngai nen a inang tlangpui. Anni chu:

• Chemotherapy: Cancer ang bawkin chemotherapy hian plasma cell thawk tha lote a tichhia thei a ni.
• Stem cell transplant: He enkawlna hi chemotherapy nen a inzawm tlangpui a, plasma cell tha lo chu cell thar hmangin a thlak thin. Heng stem cells te hi i hnen atanga lak chhuah an ni tlangpui (autologous). I ta an nih avangin i taksa chuan a hre chiang a, a hnawl lo va, a chhe zawngin a chhang lo.
• Immunotherapy hmanga enkawlna:I immune system hian a tlangpuiin cell tha lote chu a hmuchhuak thei a, a tichhia thei bawk. Cancer emaw AL Amyloidosis ang chi natnaah chuan i immune system chuan chu cell te chu a dik lo tih a hre lo. Immunotherapy hian i immune system chu cell dik lote hriatchhuah leh tihchhiat turin a zirtir a ni.

ATTR amyloidosis a ni

Hetiang chi ``(Amyloidosis)`` hi i liver hian protein awlsam taka a chhe thei a siam hian a lo awm thin. He harsatna hi enkawlna zawng zawng tihtawp a ngai a ni. A hnuaia list-ah hian sorkar pawmpui enkawlna leh zirchianna kalpui mekte pawh a tel a ni.

• Liver transplant: Tun hma chuan liver transplant hi i liver-in protein dik lo a siam theih lohna tur kawng awmchhun a ni. Hei chauh hi duhthlan tur ni tawh lo mah se, hmanraw tangkai leh tangkai tak a la ni tho.
• Genetic silencers: ATTR Amyloidosis hi i DNA-a genetic mutation avanga lo awm a ni a, recipe book-a typo ang mai a ni. Genetic silencers hi damdawi, temporary recipe card ang maia thawk a ni. Instead of your cells following the wrong recipe, they give them new instructions so they can make the protein correctly.
• Stabilizers: Heng damdawi te hian TTR molecule te chu a fold dik lo emaw, a chhe thei lo emaw a titawp thin.
• Fibril inhibitors: Amyloid proteins te chu an inzawm khawm tan chuan fiber ang chi fibrils an tih chu an siam thin. Heng damdawi te hian fibrils siam hi a titawp thin.

Dialysis nena inzawm amyloidosis a awm

Hetiang `(Amyloidosis)` hi `(dialysis)` mamawhtute zingah a lo awm thin a, a chhan chu `(beta-2M)` protein a khawlkhawm vang a ni. A tlangpuiin i kal (kidney) hian chu protein chu a filter a, a paih chhuak thin a, mahse regular `(dialysis)` chuan chutiang chu a ti thei lo. Hei vang hian `(dialysis)` hmangtute hian he natna hi an vei theih nan kum tam tak a ngai a ni. Tunah hian enkawl dan kawng hnih a awm a, chungte chu:

• Kidney transplant: Kidney hrisel chuan dialysis i mamawh tawh lo tihna a ni a, kidney transplant chuan beta-2M protein tam lutuk chu a filter chhuak thei bawk. Kidney transplant hian dialysis kaihhnawih amyloidosis natna zual zel tur chu a titawp thei a, mahse zirchiangtute chuan taksaa amyloid protein lo awm tawh pawh a paih chhuak dawn em tih erawh an chiang lo.
• Special filters: Dialysis filter pangngai hian beta-2M proteins hi a paih chhuak thei lo a, mahse a then tal paih chhuak thei special filter a awm thung. Vanduaithlak takin heng filter te hian protein chu an filter chhuak vek lo va, an filter chhuak vek lo bawk. Chumi awmzia chu kum tam tak dialysis an tih hnuah pawh a tawpah chuan dialysis nena inzawm amyloidosis hi a lo awm thei tihna a ni.

Enkawlna bik ni lo

Cardiac Amyloidosis vei te tanpui thei tur enkawlna leh damdawi dang chi hrang hrang a awm bawk. Chungte chuan natna lan chhuah dan an enkawl tlangpui a, chungte chu:

• Heart transplant: Cardiac amyloidosis vanga thinlung chhiatna nasa tak nei te hian a chang chuan heart transplant an mamawh thin. He surgery hi amyloidosis chhan chu a reh emaw, enkawl emaw a nih hnuah tih a ni fo thin.
• Anti-arrhythmia damdawi: Heng damdawi te hian thinlung thawk mumal lo a veng thei a, a then chu a hlauhawm thei hle.
• Implantable devices: Heng hmanrua te hi pacemaker leh implantable cardioverter defibrillators (ICD) te a ni. Electric shock pein i heart rate an enkawl a, arrhythmia hlauhawm tak tak an veng bawk.
• Diuretic damdawi: Heng damdawi te hian a bik takin i kal hnathawh a tichak a, fluid retention (heart failure chhinchhiahna tlanglawn tak) a pui thin. Mahse, kal natna khirh tak ang chi natna i neih chuan heng damdawi te hi i ei loh tur a ni.
• Doxycycline : AL amyloidosis-a light chain te pawh hi i thinlung cell tan toxic a ni. Mithiamte’n an la hriatthiam kim loh chhan avangin antibiotic doxycycline hian chutiang toxic effects chu a do thei a ni.

Enkawlna hian side effect a nei em?

He natna enkawlna hian harsatna leh nghawng tha lo a neih dan hi a inang lo hle. A hnuaia tarlan te hi thil awm thei tlangpui thenkhat an ni. Mahse, i doctor chuan a harsatna te, a side effect te leh a hlauhawmna dangte chu a hrilhfiah tha zawk thei che a ni. Hei hi i dinhmun chu anmahni ngeiin an hriat vang a ni a, chuvangin an thu leh hla leh hrilhfiahna chu i dinhmun bik angin an siam rem thei a ni.

Engtiang chiahin nge enkawl hnuah ka dam leh ang?

Cardiac Amyloidosis enkawlna hi i natna lan chhuah dan enkawl danah chauh a ni tlangpui. Enkawlna thenkhat chuan hahdamna engemaw chen a pe thei a, mahse a nghawng chu rei lo te chhung chauh a ni. Thil engemaw takah chuan enkawlna hian side effect a thlen thei a, chu chuan hun engemaw chen chu a ti na thei a, mahse i doctor chuan chu side effects nasatzia tihziaawmna turin damdawi leh kaihhruaina a pe thei che a ni.

Hei hi ven theih a ni em? A nih loh leh a hlauhawmna chu tihziaawm theih a ni em?

Vanduaithlak takin amyloidosis hi ven theih a ni lo (pakhat tih loh chu a hnuaia mi hi en la). Non-inherited amyloidosis awm chhan hriat a nih loh avangin ven dan tur a awm lo. Hereditary amyloidosis pawh hi ven theih a ni lo, a chhan chu i nu leh pate hnen atanga i rochun DNA-ah a awm a ni.

A danglamna awm chhun chu cardiac amyloidosis a ni a, hei hi dialysis nen a inzawm a ni. Hetiang dinhmun hi hun rei tak dialysis i neih loh chuan, a nih loh leh beta-2M proteins buildup tihtawp nan special filter i hman chuan i ven theih a ni. Mahse, heng filter te hian buildup hi a titawp vek lo tlangpui a, chu chu natna lo awm tan tihkhawtlai theihna tur mai a ni fo tihna a ni.

He natna hi eng nge a hmalam hun?

Cardiac Amyloidosis hi natna zual zel a ni a, heart failure symptoms te chu a na zual zel a ni. A tawpah chuan he natna hian i thinlung chu a thawk thei tawh lo khawpin a tichak lo thei a ni. Enkawl loh chuan a hmalam hun chu a chhe hle.

Enkawlna tel lo chuan AL Amyloidosis vei te dam rei zawng chu thla riat aia tlem a ni. A natna khirh zualte tan chuan thla thum atanga thla ruk vel a ni thei. ATTR Amyloidosis vei tan chuan dam rei zawng chu kum hnih atanga kum nga vel a ni. ATTR Amyloidosis vei chhungkaw enkawl loh nei tan chuan thil awmdan chu a chhe zawk a, a vaiin kum hnih atanga kum thum vel an dam rei thei a ni.

Engtin nge ka in enkawl ang a, ka symptoms te hi ka enkawl ang?

Vanduaithlak takin amyloidosis i vei hnua i tanpui nghal theih tur thil tam tak a awm lo. I chhungkuaa mi tu emaw chuan he natna hi a vei a nih chuan i doctor nen genetic testing chungchang i sawipui tur a ni. Cardiac amyloidosis nena inzawm mutation nei zawng zawng hian he natna hi an vei vek dawn lo nain, i vei thei em tih hriat a pawimawh hle. Chutiang chuan a natna lan chhuah dan chu i hre chiang thei a, enkawlna i tan hma thei ang.

`(Cardiac Amyloidosis)` i vei a nih chuan damdawi leh enkawl dan chungchangah doctor thupek zawm a pawimawh hle. Heng damdawi tam tak hian kawng chiang takin hna a thawk a, a hnathawh dan tur dik tak atan chuan doctor-in a hrilh ang chiaha ei a pawimawh hle.

Engtikah nge doctor ka hmuh ang emaw, urgent care ka zawn ang?

Cardiac Amyloidosis i vei tih i hriat hnuah i doctor chuan regular follow-up visit a ruahman ang. I dinhmun a nasat dan azirin doctor pan fo a ngai mai thei.

I doctor chuan eng symptoms nge damdawi lam pan tir tur tih a hrilh bawk ang che. Mahse, a tlangpuiin a hnuaia symptoms te hi i neih chuan doctor ko rawh:

• Thut emaw, ding emawa luak chhuak emaw, muhil emaw tih: Hei hi ``Orthostatic Hypotension'' an ti a, hei hi a chhan chu thisen sang hniam hian i ding chhuah hian thluaka thisen kal a tihtlem vang a ni.
• Ke leh ke ruh emaw, pum emaw a hring: Hei hi tui tlakchham vang a ni tlangpui.
• Sudden, significant weight loss: Hei hi symptom pawimawh tak a ni a, a bik takin i taksa rihna tihtlem i tum loh hunah.

Engtikah nge ER (Emergency Room) ah ka kal ang?

Cardiac amyloidosis hian i thinlung hnathawh nasa takin a tibuai thei a, chuvangin symptom thenkhat chuan damdawi lam pan vat a ngai tih a tilang.A tul a ni. Chung zinga ṭhenkhat chu:

• Lung natna (heart pulpitations) tih hriatna.
• Lungphun danglam tak, chak, slow emaw, mumal lo emaw.
• Eng vang pawha thawk harsa.

A tawp berah chuan thu pawimawh tlemte (Take-Home Message) .

Cardiac Amyloidosis hi a takah chuan a buaithlak deuh a, mahse hriat a pawimawh hle.

He natna hi zawi zawiin a kal zel thei a, mahse, a hmaa hriatchhuah leh enkawl dan dik chuan i dam chhung hun rei zawk leh i nunphung tihchangtlunna kawngah kawng thui tak a zawh thei tih hre reng ang che.

A châng chuan organ transplant hian a natna chu a tidam thei a ni. Damdawi thar leh enkawlna thar avang hian he natna vei tam tak hian an natna lan chhuah dan an thunun thei a, natna a lo chhuah hnuah kum tam tak an dam thei a ni.

Hemi chungchangah hian rinhlelhna emaw zawhna emaw i neih chuan i doctor nen inbia ngei ang che . Thurawn dik tak an pe thei che a ni. Hlau suh, hriattirna dawng la, zawhna zawt rawh. Nangmah chauh i ni lo.

` Cardiac Amyloidosis, Cardiac Amyloidosis, Protein Deposition, Lung Natna, Lung Natna Symptoms, Amyloidosis Enkawlna, AL Amyloidosis, ATTR Amyloidosis, Lung Natna