I thluak thisen kalna kawngah pawh hetiang harsatna hi i nei tawh em? (Cerebral Amyloid Angiopathy - CAA) Hemi chungchang hi han sawi ila!

A chang chuan kan lu a hah deuh thin a ni lawm ni? A nih loh leh kan hriatrengna hi a chak lo deuh niin a lang. Ṭhenkhat chuan hei hi kan upat deuh deuha thil thleng pangngai niin an ngai mai thei. Mahse, a chang chuan hei hi chu aia thuk deuh pawh a ni thei. Vawiin hian hetiang thil hi kan sawi dawn a ni. Chu chu `(Cerebral Amyloid Angiopathy)` emaw `(CAA)` tih hming pu dinhmun chungchang a ni.

`(Cerebral Amyloid Angiopathy - CAA)` tih hi eng nge ni?

A awlsam zawngin sawi ila, Cerebral Amyloid Angiopathy (CAA) hi kan thluaka thisen kalna kawng te tak teah protein pangngai lo a lo awm a, zawi zawiin a chak lo va, thisen a leak chhuak thin. Hei hi a chhan ber chu thluaka thisen kalna kawng bang a protein pangngai lo, amyloid an tih chu a awm khawm vang a ni. Tui pipe a inkhar ang maiin han ngaihtuah teh. Hun a kal zel a, he amyloid protein hian thisen kalna kawngte chu a ti hring a, a chak lo va, awlsam takin a tichhia a ni.

Hetianga thisen kalna kawng a chak loh chuan thluaka thisen a luang lut tan thin. A châng chuan heng leak te hi a tlem hle a, ``microbleeds'' ang chi hi a ni. Chu chu thisen tla te tak te tak tak a tla chhuak tihna a ni. Hengte hi a te lutuk a, a chang chuan symptom engmah kan hmu lo. Mahse a chang chuan hei hi ``intracranial hemorrhage'' thlengin a kal thei a, chu chu thluak chhunga thisen chhuak lian tak a ni. Hetiang thisen chhuak hi a lo awm chuan thluak tissue a tichhe thei a, harsatna lian tak a thlen thei bawk.

He dinhmun, ``CAA'' tia koh hi ``cognitive decline'' tih dinhmun thlentu lian ber a nih thu pawh hmuhchhuah a ni bawk. ``(Cognitive decline)'' tih hian kan ngaihtuahna thiamna, hriatrengna, ngaihvenna, ngaihtuahna leh harsatna chinfel thiamna te a tlahniam zauh zauh tihna a ni. Kan thluak ``processor'' chu ``a slow down'' ang mai a ni.Mithiamte sawi dan chuan kum 50 chunglam zinga 23% leh 29% inkar chuan he ``(CAA)'' condition hi a hniam lam emaw, a nasat lutuk emaw a ni thei. Chutiang chuan a tlem lo tihna a ni.

`(CAA)` natna lan chhuahna awm thei te chu engte nge ni?

Hetiang dinhmunah hian a lan chhuah dan hi mi zawng zawng tan a inang vek lo. Thluaka thisen engzat nge a leak tih ah a innghat a ni.

Mi thenkhat chuan ``CAA'' an nei thei tih hi han ngaihtuah teh. A chhan chu an thluaka thisen chhuak te tak te, hriat theih loh (``silent microbleeds'') chauh an nei a, chu chu hriat theih a ni lo. Tui khur te tak te atanga zawi zawiin a luang chhuak ang mai a ni a, mahse bucket khata khat tur khawpa lian leak a ni lo.

Mahse, thluak chhungah thisen chhuak tam tak a awm chuan thluak lam harsatna a awm thei a ni. Tin, mi thenkhat chuan ``CAA'' chungchang hi an thluak ``MRI'' scan an neih hian harsatna dang an neih chuan an hrechhuak thin.

Thisen chhuah a na zual chuan heng ang symptoms hi a lo lang thei a ni:

• Lu na nasa tak: Lu na pangngai a ni lo, a na deuh chauh.
• Buaina : Hmun, hun, leh tu nge awm tih te hi a buaithlak thin.
• Thusawi harsa : Thusawi thiam lo leh i sawi duh sawi harsa.
• Sudden weakness : Taksa sir lehlamah, kut emaw, ke emaw a chak lohna hriat nghal.
• Cognitive impairment : Hriatrengna a tlahniam a, thutlukna siam a harsa thin.
• Epilepsy symptoms (Seizure) : Fit ang deuh a ni thei.

A nasat ber ṭhenkhatah chuan thisen chhuak nasa tak avang hian coma-ah pawh a lut thei a ni.

`(CAA)` a awm hian eng nge thleng tak tak?

Cerebral amyloid angiopathy hi a takah chuan hemorrhagic stroke chi khat a ni a . Hetiang dinhmun hi i neih chuan protein danglam tak amyloid an tih chu a inzawm khawm a, i thluaka thisen kalna kawng chhungah a innghat a ni.

Kum tam tak chhung chu i thisen kalna kawngte chu a chak lo zauh zauh a, microscopic crack emaw fissure emaw a siam a, chu chuan i thluak chhungah thisen a luang lut thei a ni. Heng thisen kalna kawng atanga thisen a chhuah hian thluak tissue a tichhe thin.

A tam zawkah chuan he thisen chhuahna hi tire-in zawi zawiin boruak a chhuah tir ang maiin a lang. A tirah chuan danglamna lian tham i nei lovang.

Mi tam tak chuan a tir lamah chuan hriatrengna hloh leh buaina ang chi hi an ngai pawimawh lo. "Aw, hei hi i tar huna thil thleng mai a ni," tiin an ngaihtuah mai thei. Mahse hun a kal zel a, amyloid protein hian thisen kalna kawng a tichhe a, thluaka thisen a luang lut tam zel avangin a natna lan chhuah dan chu a zual sauh sauh a ni.

`(CAA)` hi siam nghal theih a ni em?

Chutiang chuan a lo thang chak lo tlangpui. Mahse, natna thlentu genetic mutations thenkhat i rochun chauhvin a thleng thei. Entirnan, hereditary coronary artery disease (CAA) chi khat awm tam ber chu stroke na tak, nunna atana hlauhawm tak a ni.

Heng stroke na tak takte hi a lan chhuah hmasak ber a ni. Stroke atanga damchhuak pawh ni se, a hnuah dementia , epilepsy , leh stroke nawn leh nawn lehin thluak a tichhe zual thei a ni. Hetiang chi thlahtu CAA vei tam zawk hi an natna lan chhuah atanga kum 10 chhungin an thi thin. Mahse hei bakah hian hereditary CAA hi a tlem hle tih pawh i hre reng tur a ni .

`(CAA)` din chhan te chu engte nge ni?

Mithiamte chuan a chhan dik tak an la hre lo a, mahse zirchiannaah chuan a hnuaia thilte hian a hlauhawmna a tipung thei tih hmuhchhuah a ni.

• Alzheimer natna: Alzheimer natna vei te hian hetiang hi an vei tam zawk. Hei hi natna pahnih hian protein amyloid a inrawlh vang a ni thei.
• Hnam:Research atanga a lan dan chuan he natna hi hnam thenkhatah a tam zawk a ni. Entirnan, zirchianna thenkhatah chuan CAA hi mipa hring zingah a tam zawk niin an sawi. Mahse, hei hi khawvel pum huap dinhmun a ni lo va, zirchianna neih belh a ngai a ni.
• Hypertension: Thisen sang hi heng thisen kalna kawngte hi extra pressure dahin CAA vei theihna a tipung bawk.

Engtin chiah nge `(CAA)` hi i hriat?

Hei hi a harsa ber a ni. Mi pakhat dam lai hian he natna hi 100% chiang taka finfiah theih dan tur a awm lo tak zet a ni. A finfiah theih dan awmchhun chu a thih hnua thluak tissue lak a, microscope hmanga enfiah hi a ni. Chu chu ``autopsy`` hmanga tih a ni.

Mahse, thih hmaa ``CAA'' tih finfiah theih ni lo mah se, doctor-te chuan natna hi a awm ngei ang tih ``presumptive diagnosis'' an siam thei a ni. Hei hi hetiang hmanga tih a ni:

• Magnetic Resonance Imaging (MRI) hmanga thluak scan: Hei hian thluaka thisen zam te te (microbleeds) a hmuchhuak thei.
• A `(PET)` scan (Positron Emission Tomography scan) with (Amyloid tracer labeling) : Hei hmang hian `(amyloid)` protein hi thluaka a awm em tih hriat theih a ni.

Heng test atanga information an hmuh atang hian doctor ten an nih theih leh theih loh (CAA) an rel thin.

`(CAA)` enkawlna tur a awm em?

Lungchhiatthlak takin hei hi damdawi chiang tak emaw, a thlen lohna tur kawng emaw a awm lo.

Chuvangin, i test-naah he natna hi i nei thei tih a hriat chuan i doctor chuan i thluak thisen chhuahna, thisen chhuah tam zawk, emaw, thisen awm tawhte chu a na zual theihna chance tihtlem a tum ang. Chu chu i symptoms te enkawl a, i natna chu a na zual loh nan control tihna a ni.

Entirna tlemte pe tur chuan:

• Thisen sang control dan: Chronic hypertension hian thluaka thisen chhuah theihna a tipung a. Test-ah ``CAA'' chhinchhiahna a awm a, thisen sang pawh i neih chuan i doctor chuan i hriselna zawng zawng leh thisen sang zawng zawng chu uluk takin a enfiah ang. I thisen sang tihhniam nan damdawi leh nunphung thlak danglam (ei leh in, exercise) te pawh an rawt thei bawk.
• Thisen tihthianghlimna hmanruaah fimkhur rawh: CAA i vei a, thisen zam natna (blood clotting disorder) avanga anticoagulant, warfarin emaw aspirin emaw i ei a nih chuan i thluak thisen chhuahna a ti na zual thei a ni. Hetiang natna hi i neih chuan i doctor chuan thisen tithianghlimtu ei kha bansan turin a hrilh thei che a , thisen zam venna kawng dang, him zawk a rawn rawt thei bawk. Chuvang chuan i damdawi ei zawng zawng chu i doctor hnenah hrilh vek a pawimawh.

Eng chen nge `(CAA)` nen hian i dam theih ang?

Hei hi mi tam takin an zawh thin a ni. Mahse, chhanna pakhat chauh pek erawh a har khawp mai. I dinhmun a zirin a danglam nasa hle.

I kum, tuna i natna lan chhuah dan, i hriselna zawng zawng, leh thluaka thisen chhuak nasa tak (e.g., zunthlum, cholesterol sang) i neih theihna tipungtu damdawi lam dinhmun dangte hian i dam rei tur chu a nghawng vek a ni.

I doctor hi i beisei tur hriatna tha ber a ni. I dinhmun chiang tak chu a hria ang a, chutiang chuan thurawn a pe thei ang che.

Engtin nge ka in enkawl ang?

(CAA) i nei tih i hriat chuan mahni in enkawl a pawimawh. I risk hriatthiam hi i in enkawl dan tur tha ber a ni.

Entirnan, test-naah ``(CAA)'' i nei tih a hriat a, mahse symptom lian tham i nei lo a nih chuan, i doctor chuan thisen sang ven dan tur emaw, a tul lo taka thisen tithianghlimtu hman loh dan tur emaw a hrilh thei che a ni. Hei hian a huam tel a ni:

• I thisen sang kha enfiah fo la, doctor-in a tih angin control rawh.
• Ei leh in hrisel ei rawh.
• Exercise neih fo thin ang che.
• Meizial i zu a nih chuan bansan rawh.

Engtikah nge Doctor ka hmuh ang?

I symptoms a zual chuan doctor pan nghal rawh.

Entirnan, CAA hian i hriatrengna leh ngaihtuahna thiamna a nghawng thei a ni. Nangmah emaw, i hriat miin emaw hriatrengna lama harsatna (thu theihnghilh, bo) emaw, a hma aia buai emaw, tawng harsa emaw i neih chuan, i doctor chuan thluak thisen thar a awm leh awm loh enfiah che a duh mai thei. Chuvangin heng inthlak danglamna te hi ngaihthah suh.

Engtikah nge emergency room-ah ka kal ang?

Hei hi a pawimawh hle. Symptoms a lo nasat thut a, lu na, buaina, tawng harsa, hriatna hloh emaw a lo awm chuan damdawi in pan nghal tur a ni.

A chhan chu hemorrhagic stroke i nei tawh mai thei a, chu chu thisen chhuahna avanga stroke a ni a, chu chuan thluak a tichhe vek thei emaw, thihna emaw a thlen thei a ni. Stroke hnua enkawl vat hi nunna chhanhim nan leh hun rei tak chhunga rualbanlote tihziaawmna atan a pawimawh hle.

Stroke vei tawhna vaukhânna chhinchhiahna ṭhenkhat chu hetiang hi a ni:

• Sagging of one side of the face: Hmai sir khat chu nuihzatthlak takin a chawi sang thei lo.
• Kut pakhat chak lohna: Kut pahnih hmalam pan tura tih a nih chuan kut pakhat chu a tla thla thin.
• Thusawi harsa: thumal a inzawm khawm a, sawi chu i hrethiam thei lo.
• Sudden severe headache: I nunah a hmaa a la awm ngai loh lu na tak a ni.

Heng symptoms te hi i hmuh chuan hun khawhral lo la, damdawi in pan nghal mai rawh.

Doctor hnenah eng zawhna nge ka zawh ang?

I test-naah (CAA) i nei thei tih a hriat chuan zawhna tam tak i neih hi thil pangngai a ni. Doctor i zawh theih tur zawhna thenkhat chu hetiang hi a ni:

• Ka MRI emaw PET scan emaw hian eng chiah nge a lan?
• Ka thluak chhungah thisen a chhuak em? Engtiang chiahin nge a nasat?
• He thisen chhuahna hi a zual zel thei ang em?
• Stroke ka neih theihna tur risk chu eng nge ni?
• Chu chuan engtin nge ka hriatrengna leh ka ngaihtuahna a nghawng ang?
• Eng nunphung tihdanglamna nge ka neih?
• Eng damdawi nge ka ei theih ang? Side effect an nei em?
• Engtiang chiahin nge ka test leh ang?

`(CAA)` pawh hi `(Dementia)` a ni em?

Ni lo, an inang lo. Mahse, an pahnih inkarah hian inzawmna a awm. Cerebral Amyloid Angiopathy hian thisen chhuak stroke a thlen thei a ni . Heng stroke te hian thluak cell te a tichhia a, chu chuan vascular dementia a thlen thei a ni . Dementia hi thluak hnathawh, hriatrengna, ngaihtuahna, tawng leh rorelna tichhe thei natna a ni. Chuvangin, CAA hi vascular dementia thlentu pakhat a ni thei.

A tawp berah chuan thil hriat reng tur (Take-Home Message) .

Cerebral Amyloid Angiopathy (CAA) hi natna khirh tak a ni a, protein amyloid chu thluaka thisen kalna kawngah a awm a, thisen a chhuak thei a ni.

• A hmaa a lan chhuah dan hi a fiah lo hle thei – hriatrengna hloh tlem, thu theihnghilh ang chi. Mahse hengte hi hun kal zelah a na zual thei a ni.
• Hei hi damdawi chiang tak a awm lo a , mahse a symptoms te chu enkawl theih a ni a, a natna hi control theih a ni. Thisen sang control leh nunphung hrisel zawm hi a pawimawh hle.
• I natna lan chhuah dan rinhlelh awm (a bik takin hriatrengna hloh, buaina, thluak lam inthlak danglam nghal) i neih chuan damdawi lam thurawn zawng nghal rawh.
• (CAA) hriat chian hian nang leh i hmangaih tak takte chu he dinhmun hi i hmachhawn thei ang.

He thu hi in tan a tangkai ngei ka beisei. Zawhna i neih chuan Doctor nen inbiakna neih hreh suh.

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