"Chemotherapy" emaw "chemo" tih tawngkam hian mi tam tak tan hlauhna leh lungkhamna a thlen thin. Nangmah emaw, i hmangaih tak emaw hnenah he enkawlna chungchang hi doctor-in a hrilh tawh pawh a ni mai thei. A nih loh leh, chu mi chungchâng hriat belh duhna i nei mai mai pawh a ni thei. A chhan chu eng pawh ni se, he hming i hriat huna i rilrua hlauhna lo lang chu a dik a ni. Mahse a nihna takah chuan chemotherapy hi cancer dona kawnga ralthuam chak leh tangkai ber pakhat a ni. Chuvangin vawiin hian kan hlauhthawn thenkhat chu dah bo ila, a nihna tak tak, a hnathawh dan leh engvangin nge side effect a awm tih te chu awlsam tak leh dik takin sawi ila.
Chemotherapy hi eng nge ni tak tak?
A awlsam zawngin sawi ila, Chemotherapy hi damdawi chi khat, cancer cell tihhlum emaw, a lo thang chak lohna tura pek emaw a ni. Hengte hi damdawi chak tak tak an ni. Anni hi "chemo drugs" an ti a.
Hei hian engtin nge hna a thawh tih hrethiam tur chuan kan taksa chhunga cell awmte hi han thlir hmasa ila. Kan taksa hi cell maktaduai tam tak atanga siam a ni. Cell hriselte chu a tul hunah an inthen darh a, cell thar an siam a, an mamawh tawh loh hunah an thi bawk. Hei hi kalphung mumal tak a ni. Hei hi `Cell Cycle` kan ti a.
Mahse cancer cells hi chu bunch danglam tak, sawi lawk theih loh zawk an ni. Hetiang order hian hna an thawk lo. Thunun theih lohvin an inthen darh zel a, an thang lian zel a, mahse an thi lo. He inthenna thunun theih loh hi tumor siamtu a ni. Hengte hian tissue hrisel pawh a tichhe thei bawk.
Hetah hian chemotherapy a lo lut a, chemotherapy tum ber chu cell rang taka inthen darh hi a ni. Cancer cell hi cell chi khat, inthen darh rang tak a nih avangin chemotherapy hi heng cancer cell-te hnenah hian a kal nghal a ni. Chu cell te inthen darhna chu a titawp a, a tichhia bawk. Chu chu cancer cell thar siam chhuah a titawp tihna a ni.
Chemotherapy hi cancer tan chauh hman a ni em?
A tam zawkah chuan, a ni. Chemotherapy hi cancer enkawlna ber a ni. I medical oncologist chuan enkawlna dang bakah chemotherapy a rawt thei bawk. Entir nan:
- Surgery: Tumor chu a tan chhuah leh lakchhuah hmain a tihtlem nan chemotherapy pek theih a ni. Operation hnua cancer cell la awm zawng zawng tihhlum nan chemotherapy pek theih a ni bawk.
- Radiation Therapy: Chemotherapy ruala radiation therapy pek hian enkawlna hlawhtlinna a tipung thei a ni.
- Enkawlna dang: A chang chuan tunlai enkawlna `Immunotherapy` emaw `Targeted Therapy` emaw nen pek dun a ni.
Mahse chemotherapy hi cancer tan chauh ni lovin, damdawi dang engemaw zat tan pawh hman a nih thu a awm.
- Autoimmune Natna: 1.1.Heng natnaah hian kan taksa invenna (immune system) hian kan taksa hrisel tak takte hi a rawn bei sual a ni. Chemotherapy damdawi hian heng overactive defense cells te hi an than chhoh dan a control a, taksa tichhe thei tur chu a ti tlem a ni.
- Thisen lama harsatna: Thisen lama harsatna thenkhatah chuan kan ruhro hian thisen cell pangngai lo a siam chhuak thin. Chutiang hunah chuan stem cell transplant a ngai mai thei. Chumi hma chuan heng cell pangngai lote hi tihchhiat a, cell hrisel thar tan hmun siam turin chemotherapy an pe thin.
Chemotherapy damdawi chi hrang hrangte chu engte nge ni?
"Chemo" tia sawi ni mah se, damdawi pakhat chauh a ni lo. Chemo damdawi chi hrang hrang a awm a. Eng thil atanga siam nge an nih tih leh cancer cell an tihlum dan a zirin chi hrang hrangah an inthen a ni. I doctor chuan i cancer chi hrang hrang, a darh zau zia (stage) leh i hriselna zawng zawng a zirin i tana tha ber damdawi emaw, damdawi inkawp emaw chu a thlang ang.
A châng chuan damdawi pakhat chauh ni lovin, damdawi eng emaw zat an pe khawm ṭhin. Hei hi combination chemotherapy kan ti a ni . Hei hi enkawl dan a hlawk zawk nan tih a ni. A chhan chu damdawi tin hian cancer cell te hi kawng hrang hrangin an bei thin a ni. Tin, taksain damdawi inang a do theih loh nan a pui bawk.
A hnuaia table-ah hian chemotherapy damdawi chi hrang hrang chi hrang hrang tarlan a ni.
| Chemo group hming | Engtin nge hna an thawh? | Entirna thenkhat |
|---|---|---|
| Alkylating Agents te pawh a awm | Chungte chuan cancer cell DNA a tichhia a, an inthen darh thei lo. Brain tumor enkawlna atana hman chi bik pawh he pawlah hian a tel ve bawk. | Cyclophosphamide, Carboplatin, Cisplatin te a awm bawk |
| Antimetabolites a awm bawk | Chungte chuan cancer cell chu an bum thin. Cell inthenna atana mamawh DNA siamna atana mamawh raw materials angin an insiam a, chu process chu an tibuai ta a ni. Kulh siamna tur brick dik lo pek ang mai a ni. | A rilru a hah lutuk chuan a rilru a buai em em a. 5-fluorouracil, Gemcitabine |
| Topoisomerase tihkhawtlai a ni | Cancer cells hian enzyme bik (`Topoisomerase`) an nei a, chu chuan DNA chu a inthen darh hunah a replicate theih nan a pui thin. Heng damdawi te hian chu enzyme hnathawh chu a titawp thin. | Etoposide, Irinotecan, Topotecan tih te hi a awm a |
| Mitotic Inhibitor te hi a awm a | Hengte hi thlai atanga siam a ni fo thin. Chuvangin 'plant alkaloids' an ti bawk. An tih chu cancer cell inthen darh a, cell pahnih siamna process (`Mitosis`) chu tihtawp a ni. | Paclitaxel, Docetaxel, Vincristine te a awm bawk |
| Antitumor Antibiotics damdawi a ni | Chungte chuan cancer cell chhunga DNA awm chu a replicate loh nan a titawp bawk. A chang chuan DNA pawh an tichhe thin. Hengte hi infection atana kan ei tlangpui antibiotics ang a ni lo. | A rilru a hah lutuk chuan a rilru a buai em em a, a rilru a hah lutuk chuan a rilru a buai em em bawk a |
A pawimawh ber chu damdawi chi hrang hrang leh a hmingte ngaihtuah buai a ngai lo. I doctor chuan eng damdawi nge i tana tha ber tih a rel ang a, chiang takin a hrilhfiah ang che.
Mi zawng zawngin kan hlauhthawn thin side effects te hi han sawi ila.
Chemo chungchang kan sawi hian a side effects sawi loh hi thil theih a ni lo. Hei hi mi tam tak ti hlauthawngtu a ni. Chuti a nih chuan engvangin nge heng side effects te hi a lo awm?
Chemotherapy hian cell inthen chak tak takte a target tih kan sawi tawh kha hre reng ang che . Cancer cell chauh ni lo, kan taksaa cell hrisel thenkhat te pawh hi an inthen darh thuai thin. Entir nan:
- Kan sam bul hnaia cell awmte
- Kawng leh chaw ei kawng chhunga cell awmte
- Ruhro chhunga thisen siamtu cell
Chemotherapy damdawi hian cancer cell leh cell hrisel inthlauhna a hre thei lo. Chuvangin cancer cells te an beih lai hian heng cell hrisel inthen chak tak takte hi an tichhe bawk. Chuvang chuan side effect a awm thin.
Mahse hetah hian a tha ber chu kan cell hrisel te hi he chhiatna atang hian an lo dam leh thei hi a ni. Mahse cancer cell te hian an ti thei lo, an thi mai thin.
Side effect awm fo thin
Chemotherapy i dawn chi hrang hrang a zirin side effect a inang lo thei. Mi zawng zawng hian side effect inang an nei vek lo. A tlangpuiin:
- Chauhna: Hei hi mi tam takin an tawn thin a ni.
- Nausea leh Vomiting: Mahse tunah chuan hei hi control turin damdawi tha tak tak a awm ta.
- Sam tlakchham: Chemo damdawi zawng zawng hian sam a tikehsawm vek lo. An ti a nih pawhin enkawlna an zawh hnuah sam a lo sei leh ang.
- Kawngpui na: Ka chhungah hliam te te a lo awm thei.
- Chaw ei chakna hloh: Chaw thlum hi a danglam thei.
- Diarrhea emaw constipation emaw a awm thei
- Thisen cell zat tlahniam: Ruhro (bone marrow) a nghawng a, chu chuan thisen sen a tlahniam a, thisen tlakchhamna a thlen a, thisen var a tlahniam a, neutropenia a thlen bawk. Neutropenia a lo awm chuan taksain natna hrik a do theihna a tlahniam a, chu chuan natna hrik a thlen a awlsam phah a ni.
A pawimawh ber: Heng side effects te avang hian enkawlna hi chawlhsan suh. Heng side effect zawng zawng hi enkawl leh tihtlem dan tur leh damdawi a awm. I doctor leh nursing staff te chuan theihtawp an chhuah ang che.
Engtik hunah nge doctor nen kan inbia ang?
Chemo treatment i neih chhung hian i doctor nen inbiakpawhna tha tak neih a pawimawh. I rilru hahna emaw, side effect emaw i neih apiang chu i doctor hnenah hrilh hlau suh.
- Side effect tuar theih loh i neih chuan min hrilh nghal rawh.
- Nausea leh natna damdawi hian hna a thawk lo em tih min hrilh teh.
- Khawsik emaw, khawsik emaw ang chi natna i neih chuan min hriattir nghal ang che.
I doctor chuan damdawi dang a pe thei a, i chemotherapy dose emaw schedule emaw a thlak thei bawk. He zinkawng hi nangmah chauhin i paltlang lo tih hre reng ang che.
Take-Home Thuchah a ni
- Chemotherapy hi cancer dona atana damdawi chak tak leh tangkai tak a ni. A tul lovah hlau suh.
- Cell inthen chak tak tak, cancer cell ang chi te chu target-in hna a thawk a ni.
- Side effects a awm chhan chu cell hrisel, rang taka inthen darh te pawh a nghawng vang a ni. Mahse heng side effect tam zawk hi chu hun eng emaw chen atan a ni a, enkawl theih a ni.
- I doctor nen i rilru hahna eng pawh chu zalen takin sawipui rawh. I tanpui turin an inpeih reng a ni.
- Doctor thupek dik taka zawm a, enkawlna hun ruat saah pawh tel a pawimawh hle.
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