Nang pawhin ni khatah vawi sawmhnih vel i tuihal a, i zun reng em? Hei hi Arginine Vasopressin natna / Zunthlum Insipidus a ni em?

Nang pawhin tuar theih loh tuihal i nei em? Tui in tam thei lo ang maiin i inhria em? Tin, ni khatah vawi tam tak, a chang chuan darkar khatah vawi khat emaw vawi hnih emaw pawh bathroom-ah i kal a ngai em? Zanah mut mumal lova zun tur i thawh a ngai a nih chuan hei hi thil ngaihthah tur a ni lo. Vawiin hian natna hmuh tur awm lo mahse enkawl theih, chutiang bawka natna lan chhuah dan kan sawi dawn a ni. Tun hma chuan hei hi ‘Diabetes Insipidus’ an ti thin.

Arginine Vasopressin Disorder hi eng nge ni?

A awlsam zawngin, he dinhmun hi i taksain zun a siam tam lutuk hian a ni. Chumi awmzia chu i taksain tui a vawng tha tawk lo tihna a ni. Hei hi a chhan ber chu hormone pakhat Arginine Vasopressin (AVP) tih harsatna vang a ni. Doctor-te chuan he hormone hi ``AVP`` tiin Antidiuretic Hormone (ADH) tiin an sawi bawk. He ``AVP`` hormone hian kan kal kaltlangin taksaa tui awm zat a inthlau reng theih nan hmun pawimawh tak a chang a ni.

Heng dinhmunte hi chi hnih a awm a, chungte chu:

1. AVP tlakchhamna (AVP-D): Hei hi i taksain hormone AVP a siam chhuah tlem vang a ni.

2. AVP resistance (AVP-R): Hei hi i kal (kidney)-in hormone AVP a chhân lêt ṭhat loh vang a ni. Chumi awmzia chu hormone awm mah se, kal (kidney) hian a hmang lo tihna a ni.

Hetiang natna lan chhuah dan hi engte nge ni?

AVP tlakchhamna leh AVP laka invenna chhinchhiahna lian ber berte chu:

• Zun chhuah fo ngai: Hei hi a lan chhuahna pawimawh tak chu nitin chauh ni lovin zan lamah pawh zun chhuah tura tho a ngai (Nocturia) .
• Zun rawng hring emaw, tui emaw tam tak pass: A tlangpuiin ni khatah mi pakhatin litre 1 leh litre 3 inkar a chhuah thin. Mahse, he natna vei hian ni khatah zun litre 20 thleng a chhuah thei a ni. Chu chu eng ang nge a nih tih han ngaihtuah teh!
• Tuihal lutuk (Polydipsia): Tui engzat pawh in la, i tuihalna ti reh lo ang maia inhriatna.

Heng symptoms te hi i taksaah thil engemaw a thawk tha lo tih hriattirna chak tak a ni. Damdawi lam thurawn lak vat a pawimawh hle.

Engtin nge heng chhinchhiahnate hian naupang tê tête chu a nghawng?

Hetiang dinhmun hi naupang tê têteah a awm a nih chuan a lan chhuah dân chu a danglam deuh thei a ni. Chung zinga ṭhenkhat chu:

• Tui tlakchhamna nasa tak .
• Ek khal.
• Luak chhuak.
• Khawsik fo thin.
• Thiltih buai leh thinrim tak tak lantir.
• Growth faltering / Hlawhtling lo.

Nausen emaw naupang tê emaw pawhin heng symptoms hi an neih chuan doctor pan nghal ngei ngei tur a ni.

Engvangin nge heng arginine vasopressin disorder te hi a lo awm?

A chhan pawh a inang lo va, a hmaa kan sawi tawh chi hrang hrang a zirin.

AVP tlakchham chhan `(AVP-D)`

Tun hma chuan central diabetes insipidus tia koh thin a ni a, hei hi hormone arginine vasopressin (AVP) tlakchham vang a ni. Hei hi a tam ber chi a ni.

Hei hi a chhan pawh a ni thei:

• Hypothalamus emaw pituitary gland (hengte hi thluaka hormone control tu pawimawh tak tak an ni) tihchhiat. Hetiang chhiatna hi operation emaw, lu hliam emaw avanga lo awm thei a ni.
• Genetic variation thenkhat (Inherited gene danglamna) 1.1.
• Tumor siam chhuahna .
• Damdawi lam thil thenkhat, sarcoidosis emaw tuberculosis emaw avanga inflammation / Granulomas .
• A châng chuan, a chhan chu hmuh theih a ni lo (idiopathic) . Chumi awmzia chu damlo zinga a chanve velah chuan a chhan hriat a ni lo tihna a ni.

AVP laka invenna (AVP-R) awm chhan .

Hetiang chi hi a hmain nephrogenic diabetes insipidus an ti thin a ni . Hetiang a nih chuan pituitary gland hian hormone AVP a siam chhuak a, mahse kal hian a chhang tha lo hle.

Hei hi chhan hrang hrang a awm a:

• Genetic change thenkhat.
• Zun kawng a block .
• Damdawi thenkhat hun rei tak hman , a bik takin lithium .
• Thisen a calcium level sang (Hypercalcemia) .
• Thisenah potassium level hniam (Hypokalemia) .

Naupai laia lo awm chi bik

Hei hi Gestational Arginine Vasopressin Disorder (gAVP-d) tih a ni. Hei hi a tlem hle. Naupai lai hian placenta hian hormone AVP tichhe thei enzyme a siam tam lutuk a.

Hetiang dinhmun hi i nei tam zawk a, eng emaw chhan vangin :

• Naupang twins emaw a aia tam emaw i phur a nih chuan .
• Liver hnathawh tichhe thei natna i neih chuan, preeclampsia emaw HELLP syndrome emaw ang chi .

Thu lawmawm tak chu he `gAVP-d` natna hi nau neih atanga kar hnih atanga kar thum hnuah a bo tlangpui.

Hetiang dinhmun hian eng harsatna nge a thlen?

AVP-D leh AVP-R te harsatna ber chu dehydration , taksa hnathawhna atana mamawh tui leh electrolyte hloh hi a ni.

A tlangpuiin i zun chhuah dan tur chu i mamawh aia tam in in i control thei a, mahse i in loh chuan i dehydrated nghal vat thei.

Dehydration hian nunna a tichhe thei a ni. Dehydration symptoms i neih chuan luak chhuak, luak chhuak, emaw hah lutuk emaw i neih chuan a rang thei ang bera damdawi in hnai ber pan rawh.

Engtin nge doctor-te hian hei hi an hriat chhuah?

Tuihal tuihal leh zun tamna symptoms hi thil dang tlanglawn tak atanga lo awm thei a nih avangin doctor-te chuan `AVP-D` emaw `AVP-R` emaw an hmuhchhuah hian natna dang an paih chhuak hmasa thin. Heng symptoms te hi i neih chuan i doctor chuan test eng emaw zat a order mai thei.

He natna hi hriat chian hunah chuan `AVP-D` nge `AVP-R` tih leh a chhan hriat a ngai a ni.

Diagnostic test te pawh a awm

• Tui tlakchhamna test: Hei hi AVP-D emaw AVP-R emaw hriat theihna rintlak ber a ni. He test neih chhung hian uluk takin an enkawl ang che, hei hian dehydration a thlen thei a ni. He test hi darkar engemaw zat chhung tui engmah in loh leh i taksain a chhan dan en a ni. Hetiang dinhmun hi i neih chuan zun tui, rawng hring tam tak i pass chhunzawm zel ang. Hetiang dinhmun hi i neih loh chuan zun concentrated, dark yellow tlemte chauh i pass ang.
• Copeptin thisen test: Copeptin hi hormone AVP atanga lo chhuak a ni.
• Blood glucose test: Hei hi diabetes mellitus enfiahna atana tih a ni a, chu pawh hian symptom inang chiah a nei bawk.
• Urinalysis: Hei hian zun chhunga osmolality ( zun concentration) leh ketones te a test thin.
• Imaging test MRI scan (MRI - Magnetic Resonance Imaging): Hengte hi pituitary gland emaw hypothalamus emaw a chhiatna a awm leh awm loh enfiah nan an ti thin.

Heng `AVP-D` leh `AVP-R` te hi engtin nge an enkawl?

Enkawlna chu `AVP-D` emaw `AVP-R` emaw i neih danah a innghat. Enkawlna eng pawh ni se, tui tlakchham loh nan tui tam tak in a pawimawh.

AVP-D (Thil tlakchhamna) enkawl dan

Desmopressin hi AVP-D enkawlna ber a ni. Hormone AVP ang bawka hnathawk thei damdawi a ni. A chi hrang hrang (e.g., hnar spray angin, pill angin) ei theih a ni.

Desmopressin hi naupai natna hlauhawm tak ``(gAVP-d)'' atan hman a ni fo. Mahse, a chang chuan naupai lai hian tui in tam zawkin a thunun theih a ni.

AVP-R (Resistance) hmanga enkawl dan

`AVP-R` enkawl hi a buaithlak deuh. A châng chuan hmanraw engemaw zat hman dun a ngai ṭhin. Entir nan:

• Thiazide hmanga zun chhuah thin(Hengte hi zun tamna damdawi chi khat ni mahse, hetiang dinhmunah hian hna an thawk dan a inang lo)
• Nonsteroidal anti-inflammatory drugs (NSAIDs) hmanga tihdam theih a ni.

`AVP-R` natna hi damdawi i ei avanga lo awm a nih chuan i doctor chuan damdawi dang a thlak danglamin a enkawl thei ang che.

Engtikah nge Doctor ka hmuh ang?

`AVP-D` emaw `AVP-R` emaw i neih chuan doctor pan fo a, thurawn lak a pawimawh hle. Chutiang chuan i doctor chuan i dinhmun enfiah turin test a ti thei a, i enkawlna chu a thawk tha em tih a enfiah thei bawk.

I doctor hnenah heng zawhnate hi zawh hi a \angkai hle mai thei:

• `AVP-D` nge `AVP-R` ka nei em?
• Hei hi eng nge a chhan?
• Hei hi natna rei tak (hun rei tak awm thei) nge hun rei lote chhunga awm?
• Eng enkawlna kawng nge ka neih?
• Ni khatah tui engzat nge ka in tur?
• Hetiang dinhmun hi enkawl turin eng nge ka tih belh theih ang?
• Ka chhungte pawh hian arginine vasopressin disorder vei an hlauhawm em?

`AVP-D` emaw `AVP-R` emaw ka neih chuan eng nge ka beisei theih ang?

`AVP-D` leh `AVP-R` dinhmun thlirletna (outcome) hi a tlangpuiin a tha hle. Inenkawlna mumal tak i la a, tui i in tam chuan harsatna lian tham i nei tur a ni lo.

Mahse, heng mite hi harsatna an tawk nasa zawk a ni:

• Nausen te
• Kum 65 chunglamte
• Rilru lam hriselna lama harsatna nei emaw, hmasawnna lama harsatna nei emaw

Chûng mite chuan an tuihalna hriat harsa an ti thei a, a nih loh leh hma an la thei lo mai thei bawk.

Engvangin nge tunah hian hei hi ‘Diabetes Insipidus’ tia koh a nih loh?

Kum 2022 khan damdawi lam pawl eng emaw zatin `Diabetes Insipidus` tih hming hi `Arginine Vasopressin Deficiency` leh `Arginine Vasopressin Resistance` tia thlak an rel a. Hei hi a chhan ber chu `Diabetes` tih thumal avanga buaina leh hriselna lama nghawng tha lo a neih vang a ni.

Mi tam zawkin "diabetes" an tih mai hian diabetes mellitus an sawina a ni. Thisen sugar level sang vang a ni. Tin, tuihal leh zun tam ang chi symptoms a nei bawk. Mahse, `AVP-D` leh `AVP-R` (hmanlai chuan `Diabetes Insipidus` tia koh) te aiin a tam zawk hle. Tin, zunthlum enkawl dan pawh `AVP-D` leh `AVP-R` enkawl dan nen a danglam vek bawk.

"Diabetes" tih thumal hi Greek tawng "diabetesine" atanga lo chhuak a ni a, chu chu "a kal tlang" tihna a ni. Chu hming chu diabetes ang bawkin taksa chhungah tui a kal chak lutuk avangin hman a ni a, chu chu heng arginine vasopressin natnaah hian a thleng thin a ni.

A tawp berah chuan ka hrilh a ngai a ni... (Take-Home Message)

`AVP-D` (arginine vasopressin tlakchhamna) emaw `AVP-R` (arginine vasopressin resistance) emaw i neih chuan i dam chhung hun tam zawk chu bathroom-ah i hmang ang maiin i inhria mai thei a, tui engzat pawhin i in pawhin i tuihalna a ti reh thei lo. Mahse thu lawmawm tak chu heng dinhmunte hi thunun theih a ni.

I doctor chuan i tana tha tur treatment plan a siam ang a, hydrated reng tur chuan ni khata tui i in tur zat a hrilh bawk ang che. Hlauthawng suh. I doctor puihna leh kaihhruaina la rawh. Hei hi "zunthlum" a ni lo tih hre reng ang che. Chuvang chuan diagnosis dik tak neih a pawimawh a, enkawlna dik tak neih a pawimawh. Nangmah chauh i ni lo, informed reng la, chak takin awm rawh.

` Arginine Vasopressin natna, Zunthlum Insipidus, AVP, ADH, Tuihal lutuk, Zun tam, Tui tlakchham, Polydipsia, Nocturia, Desmopressin, Kal, Hormone