Cancer enkawl hnua he natna hi i hria em? (Cytokine tihchhuahna natna - CRS)

I hriat mi pakhat, chhûngkaw zînga mi pawh ni thei, cancer natna enkawl mek angin han ngaihtuah teh. A bik takin tunlaia enkawlna hmanraw changkang ber pakhat nen. Enkawl an tan atanga ni engemaw zat hnuah chuan khawsik sang tak an nei thut a, an taksa a na a, khawsik na tak nei ang maiin an inhria. Hei hi enkawlna avanga side effect pangngai mai mai niin kan ngai fo thin. Mahse, hei hi thil pawi zawk chhinchhiahna a ni thei. Hei hi damdawi lam natna Cytokine Release Syndrome (CRS) kan tih a ni.

A awlsam zawngin CRS chu eng nge ni?

Hei hi hrethiam tur chuan kan taksa immune system hi han ngaihtuah hmasa ila. Kan ram humhalhtu sipai ang mai a ni. He sipaite hian an sipaite (immune cells) inkara thuchah inhrilhhriatna tur palai an nei a. Chutiang bawkin, kan immune cell-te inbiakpawhna leh an hnathawh thunun theitu protein bik a awm a, chu chu cytokines . Hengte hi immune system hrisel tak neih nan a pawimawh hle.

Mahse, a châng chuan, a bîk takin cancer enkawlna ṭhenkhat, immunotherapy -ah chuan kan taksa chakna chu a tichak lutuk thei a ni. Hei hian heng messengers, cytokines an tih te hi thisenah a chhuah nghal a ni. Sipai pakhatin rampage an kalpui a, vawi khatah message sang tam tak an thawn chhuak ang mai a ni. Hei hi "cytokine storm" an ti \hin. Vawi khata cytokines tam tak a chhuah chuan taksa pum puiah inflammation a siam thin. Chu chu CRS kan tih chu a ni.

CRS thlentu berte chu engte nge ni?

CRS thlentu ber leh langsar ber chu tunlai cancer enkawlna atana hman thin thenkhat hi a ni.

• Immunotherapy: Hei hi a chhan tam ber a ni. CAR-T cell therapy leh bispecific antibodies ang chi enkawlna te hi CRS vei tan chuan a hlauhawm hle. Heng enkawlnate hian kan taksa hriselna (immune system) chu cancer cells do turin a tichak a ni. Hetiang a nih lai hian immune system hi a chang chuan a thawk nasa lutuk thin.
• A chhan dang: Genetic condition thenkhat emaw autoimmune disease nei te pawh an hlauhawm hle thei bawk. Entirnan, genetic condition pakhat Hemophagocytic lymphohistiocytosis (HLH) .

CRS natna lan chhuahna awm thei te chu engte nge ni?

CRS natna lan chhuah dan hi khawsik natna nen a inang thei a, chuvangin a chang chuan hriat a harsa thei hle. Mahse, heng symptoms te hi a na nghal vat thei bawk.

He dinhmun hi engtiang chiahin nge a pawi thei ang?

CRS hi natna khirh tak atanga nunna atana hlauhawm thlengin a awm thei a ni. Taksa pumpui a inflammation nasa lutuk hian taksa peng lian tak tak, kal, thin, lung leh thinlung te a tichhe thei a ni.

A hnuaia mite hi harsatna lian tham lo thleng thei thenkhat chu an ni:

• Thinlung a nghawng dan: Cardiomyopathy leh heart failure a lo awm thei.
• Lung a nghawng dan: Lung failure leh thisen oxygen level hniam tak tak a awm thei.
• Kidney leh Liver Failure: Heng taksa peng hrang hrangte a chhiat chuan hnathawh a titawp thei a ni.
• Capillary leak syndrome: Thisen kalna kawng te tak te atanga tui luang chhuak hian thisen sang chu hlauhawm takin a tlahniam thei a ni.

Doctor-te hian engtin nge hei hi an hmuh?

I enkawltu medical team te hian CRS chungchang hi an hre chiang hle a, chuvangin immunotherapy ang chi enkawlna i dawng a nih chuan i symptoms te chu uluk takin an lo enkawl dawn a ni.

Symptoms a lan chuan doctor chuan test eng emaw zat a ti ang a, a natna hi a finfiah ang.

• Complete Blood Count (CBC): Thisen cell inthlak danglamna a enfiah thin.
• Cytokine level: Thisen a cytokines awm zat tehna a ni.
• C-reactive protein test (CRP): He test hian taksaa inflammation level tehna atan a pui a ni.
• Kidney leh liver function endik: Heng taksa peng hrang hrangte hi a chhiat tawh em tih hriat chian.

A natna nasat dan azirin doctor-te chuan Grade 1 atanga 4-ah an dah a, a tam poh leh a nasat zawk thin. He stage hi khawsik, thisen sang, oxygen level, leh organ function te ngaihtuah a ni.

CRS enkawlna tur engte nge ni?

Enkawlna chu i natna lan chhuah dan nasat danah a innghat. Mild case tan chuan thil awlsam tak tak, khawsik tihziaawmna damdawi ang chi hi a tawk mai thei. Mahse, a natna a nasat chuan specialized treatment tam zawk a ngai mai thei.

Engtikah nge damdawi lam thurawn ka lak ang?

Hei hi a pawimawh ber a ni.

Cancer natna avanga immunotherapy i dawng a, enkawl hnuah khawsik emaw CRS symptom dang (ruh natna, buaina ang chi) i neih chuan tlem tal pawh tihkhawtlai a tha lo.

He dinhmun hi a na hle thuai thei. Chuvangin i doctor emaw damdawi in emaw hriattir nghal rawh. Enkawl i tan hma poh leh harsatna lian tham i neih theihna a hniam zawk.

Cancer i do lai hian hetiang thil hi i hriat chuan hlauhna leh lungngaihna i neih hi hriatthiam theih a ni. Mahse, i enkawltu medical team hian CRS hi an hre chiang hle tih hre reng ang che. Ngun takin an lo en reng che a ni. I taksaa inthlak danglamna eng pawh, a te ber pawh nise, hrilh hreh suh. I puihnain he dinhmun hi a nasat hmain enkawl theih a ni.