Hereditary gastric cancer tih hi i hre tawh em? (Hereditary Diffuse Gastric Cancer - HDGC) Hemi chungchang hi han sawi ila!

Vawiin hian mi tam takin an hriat loh dinhmun khirh tak chungchang kan sawi dawn a ni. Hei hi pum cancer chi khat, thlahtute atanga lo chhuak a ni. Doctor-te chuan `(Hereditary Diffuse Gastric Cancer)` emaw, a tawi zawngin `(HDGC)` emaw an ti a. I chhungkuaa tu emaw hian he natna hi a lo nei tawh a nih chuan, a nih loh leh a chungchang hriat belh i duh chuan he thuziak hi i tan a pawimawh hle ang. Ngaihtuah buai suh, awlsam takin sawi ila.

Hei hi eng nge ni `(HDGC)`?

A awlsam zawngin sawi ila, HDGC hi hereditary cancer risk condition a ni. Hei hian i dam chhungin pum cancer (Gastric cancer) i vei theihna chance chu 70% velin a pung tihna a ni. Chu mai pawh ni lovin, hmeichhia he natna hi rochuntute hian hnute cancer chi khat , Lobular Breast Cancer (LBC) vei theihna chance 42% zetin an pung bawk.

Hetiang `(HDGC)` natna vei te hian an nu leh pa pakhat hnen atangin mutated gene (`(mutated gene)`) an rochun thin. A tam zawkah chuan hei hi `(CDH1)` tih gene a ni. Mahse a chang chuan gene dang pawh a inrawlh thei. `(CDH1)` hi tumor titawptu gene (`(tumor suppressor gene)`) a ni. Hei hi mutation a nih chuan cancer control nan a thawk tha lo. Ngaihtuah teh, he gene hi kan taksaa police pakhat ang mai a ni a, cancer cells lo thang lian zel tur titawptu a ni. Chuti a nih chuan chu police chu a chak lo a nih chuan eng nge thleng ang? Hetah pawh hi chutiang chu a ni.

"Diffuse" gastric cancer chu eng nge ni?

Tunah chuan he `(Diffuse Gastric Cancer)` hi eng nge a nih i en ang u. Hei hi pum cancer chi khat a ni. Mahse, cancer dang ang bawka hmun khatah a lo thang lian ai chuan, he cancer hi chu pum chhung zawng zawngah cell pawl tenau takah a darh chhuak a ni. Tui luang chhuak bang bulah a darh ang mai a ni. Chumi avang chuan pum bang chu a thim a, a khauh bawk. Zawi zawiin pum chhung bang thuk zawkah a darh zel a.

Hetiang pum cancer chi hi standard imaging test-ah chiang taka hmuh theih a nih loh avangin hriat a harsa deuh a ni. Tin, natna a darh hnuah, a hnu lamah chauh a lan chhuah fo bawk. Chutih lai chuan cancer chu pum chhung bang kaltlangin a bul hnaia tissue, liver emaw ruh emaw-ah a darh (metastasized) tawh mai thei.

Hetiang dinhmun hi engtiang chiahin nge a awm?

`(HDGC)` natna chungchang sawi ila, mi sang sawm zinga mi panga atanga sawm velin an pian tirh atangin he natna hi an rochun thei niin an chhut. Pum cancer zawng zawng zinga 20% vel chu `(diffuse)` type a ni. Chutiang diffuse cancer zinga 2% vel chu hereditary `(HDGC) a ni.` Khawthlang ramte aiin Asia ramah chuan pum cancer hi a tam zawk tlangpui a, mahse he `(HDGC)` natna hi khawthlang ramteah chuan a tam zawk tih hmuhchhuah a ni.

`(HDGC)` condition symptoms te chu engte nge ni?

Kan sawi tawh ang khan he natna hi a darh (metastasized) hma chuan hetiang diffuse gastric cancer symptoms hi a lang lo mai thei. Chuvangin chhungkaw zingah he natna hi a thlen theih dan tur hriat a pawimawh hle. HDGC-ah chuan cancer dang aiin kum naupang zawkah a lo awm thin. Mi tam zawk hi kum 40 an tlin hmain hmuhchhuah an ni.

A lan chhuah dan ber chu:

• Pum natna (a bik takin pum veilam chunglam) .
• Pum natna, pum nasat
• Nausea leh luak chhuak
• Chaw chakna
• Rihna tihtlem
• Chauh lutuk, hah lutuk
• Chaw ei harsa
• Thisen in poop (`(Thisen in poop)`) a awm a.
• Thisen chhuak (`(Thisen chhuak)`) .
• Jaundice (mit leh vun sen) .

A châng chuan, nau piangsual cleft lip emaw cleft palate emaw an tih pawh hi he syndrome chhinchhiahna hmasa ber a ni thei bawk. Hei hi a chhan chu he genetic mutation hian he piansualna hi a thlen thei a ni. Mahse, a tam zawkah chuan cleft lip hi HDGC nen hian a inzawm lo. Mahse, chutiang piansualna neia piang i nih a, i chhungkuaa mi tu emaw chuan hetiang cancer chi hi a nei tawh a nih chuan i ringhlel deuh mai thei.

He `(HDGC)` siam chhan hi eng nge ni?

HDGC hi genetic disorder a ni a . A hmaa kan sawi tawh tumor-suppressing gene pakhata mutation awmin i DNA-a programming a tihdanglam hian a thleng thin. Tumor-suppressing genes hian cell te chu cell inthen darh leh than dan control turin a hrilh thin. Chuvangin heng genes te hian hna an thawh that loh chuan cancer a lo awm thei a ni.

He mutated gene hi i nu emaw i pa emaw hnen atangin i rochun a ni. Chutianga mutation rochun chu germline mutation an ti a . I reproductive cells genetic code a nghawng a ni.

Engtin nge he `(HDGC)` hi rochun a nih?

HDGC hi autosomal dominant condition a ni a, a rilru a hah hle . Chumi awmzia chu syndrome inherit tur chuan mutated gene copy pakhat chauh i neih a ngai tihna a ni. I nu emaw, i pa emaw hnen atangin rochun theih a ni. I nu leh pa zinga pakhatin mutation a neih chuan nang emaw i unaute emaw hian 50% in rochun theihna chance in nei a ni. Lu emaw, hmui emaw atanga pawisa lo chhuak chance ang maiin han ngaihtuah teh.

Gene mutation rochuntu zawng zawng hian cancer an vei vek em?

Ni lo, i nu leh pate hnen aṭanga i rochun genetic mutation hian cell tina cancer titawptu gene copy pakhat chauh a nghawng a ni. Mahse cell tin hian he gene hi copy pahnih an nei a, pakhat chu i nu atanga lak niin pakhat chu i pa atanga lak a ni. Chuvangin nu leh pa pahnih atanga mutation inang lo inherit lo mah la, a pangngaia hnathawk gene copy i la nei tho.

Cancer a lo awm theih nan mutation pahnihna (`(somatic mutation)`) .I dam chhungin cancer awmna tissue (i.e., pum chhunga lining emaw, hnute lobules emaw)-ah a awm tur a ni. He mutation pahnihna hian gene copy dang pawh a deactivate bawk. Chutah chuan cancer chu a lo thang lian tan ta a ni.

He mutation pahnihna hi eng nge a chhan?

Dik tak chuan hei hi a chhan dik tak kan hre lo. Mahse thil chi hrang hrangin hmun a chang thei. Environment exposure hian genetic diseases "triggering" ah hian chanvo a nei fo thin. Gene dang pawh a inrawlh thei bawk. HDGC gene kengtu chhungkaw thenkhatah chuan midang aiin cancer vei an tam zawk.

Environment risk factor thenkhat, stomach cancer lo awm chhan chu:

• Meizial zuk
• Zu in tam lutuk
• Sa sen (bawngsa, beram sa ang chi) ei tam lutuk .
• (H. pylori) infection (hei hi pumpui natna thlentu bacteria a ni) .

`(HDGC)` test dan hi engtin nge a awm?

Symptoms i la nei lo a nih pawhin, hlauhawma inngaih chhan tur a awm a nih chuan (entir nan, i chhungkuaa mi pakhatin heng cancer chi hrang hrang hi a vei tawh a nih chuan, emaw, genetic test-a `(CDH1)` gene-a mutation hmuhchhuah a nih chuan), doctor chuan `(HDGC)` test turin a refer thei che a ni.

I doctor chuan i chhungkaw history leh/ emaw genetic test result atanga i risk chu a chhut ang. I tissue-ah cancer hmahruaitu an zawng thei bawk. Entirnan, hnute chhunga Lobular Carcinoma In Situ (LCIS) tih natna emaw, chaw kawng lining-a signet-ring-type cell emaw an zawng mai thei. Hengte hi a hmaa inthlak danglamna, cancer lo ni thei a ni.

Engtin nge HDGC hi hmuhchhuah a nih?

Metastatic stomach cancer symptoms i neih chuan i doctor chuan i stomach wall-ah cancer a awm tih finfiahna a zawng ang. Tissue sample an la ang a, microscope hmangin an enfiah ang. Metastatic stomach cancer hmuhchhuah a nih chuan, leh i chhungkuaa mi tu emaw chuan hetiang cancer hi a nei tawh a nih chuan, i doctor chuan genetic testing neihpui turin a rawt thei che a ni .

Tunah hian HDGC vei zinga 40% velin he CDH1 mutation hi an nei tih hmuhchhuah a ni. Mutations dang pawh a tel thei a, mahse CDH1 hi kan hriat ber leh kan hriat theih ber a ni. I neih chuan HDGC hriat theihna kawng chiang tak a ni. Mahse, chhungkaw history-a hetiang diffuse gastric cancer chi khat i neih chuan CDH1 mutation i neih loh pawhin HDGC i vei tih hmuhchhuah a ni thei.

`(HDGC)` tih hriat nan eng test nge hman thin?

Heng test te hi natna hriat chian nan tih theih a ni:

• Genetic testing neih dan tur: 1.1.Hei hi thisen test a ni. I thisen sample lak a ni a, genetic natna nena inzawm genetic mutations a awm em tih enfiah a ni. Mi thenkhat chuan he test hi an nei thin a, a chhan chu chhungkaw history-a genetic diseases an neih vang a ni. Mi dangte chuan an chhungkaw hriselna chanchin an hriat loh vang emaw, anmahni hriat tur emaw, fa neih an tum vang emaw hian hetiang genetic test hi an nei thin.
• Upper endoscopy (EGD test): Hei hi i upper gastrointestinal tract (i.e., esophagus, stomach) chhung lam en a, tissue sample lak nan test a ni. Hei hi pum cancer hriat nan a pawimawh hle a, a bik takin he cancer chi khat, a darh tawh hi hriatchhuahna atan a pawimawh hle. Gastroenterologist (doctor, gastrointestinal diseases lama tui tak) chuan hetiang hian a ti thin. I hmuiah camera te tak te hmangin tube sei tak (endoscope) a dah lut a, i chaw kawng chu i pum chhungah a tla thla a. Tissue sample pawh tube kaltlangin lak theih a ni bawk. Mahse, heng hmanrua hmang pawh hian metastatic stomach cancer hmuh a harsa thei hle. A darh zau em avangin doctor chuan a hmu thei lo emaw, tissue sample-ah emaw a hmu thei lo mai thei. Chuvangin he cancer chi hi a zawngtu doctor chuan training bik leh tawnhriat bik a neih a ngai a ni.
• Breast MRI: Lobular breast cancer hi regular mammogram hmanga hriat theih a nih loh avangin doctor-te chuan MRI neih an rawt a ni. MRI-ah thil danglam bik a lan chuan chhinchhiahna a awm a, doctor dangin tissue sample a la bawk.
• Biopsy: Doctor chuan tissue sample a la a, microscope hmanga enfiah turin lab-ah a thawn a. He biopsy hian tissue sample-ah hian cancer cell a awm leh awm loh a finfiah thei a ni.

`(HDGC)` nei nia hriat a nih hnuah eng nge thleng?

Cancer i vei tawh a nih chuan i doctor chuan enkawl dan tur a sawipui ang che. Cancer i la nei lo a nih pawhin he syndrome hi i neih chuan i doctor chuan a chunga kan sawi tawh ang khan cancer screening test neih fo a rawt mai thei. Preventive surgery pawh hi i doctor nen i inbiakna tur dang a ni.

Engtin nge metastatic stomach cancer hi enkawl a nih?

Surgery hi cancer enkawlna hmasa ber a ni tlangpui a, operation hmanga tihbo theih a ni. HDGC i neih chuan i doctor chuan total gastrectomy . Hei hi a chhan chu HDGC hian hmuh hmaa hla takah a darh theihna a sang hle a ni.

Total gastrectomy-ah chuan surgeon chuan i pum zawng zawng a la chhuak a, i chaw kawng tawp chu i small intestine nen direct-in a thlunzawm a ni. Pum tel lova nun theih a ni a, mahse side effect engemaw zat a awm. Operation hnuah chuan enkawlna dang (adjuvant therapies) i nei thei a, chu chu radiation therapy emaw chemotherapy emaw a ni thei.

Hmeichhia `(HDGC)` vei te pawh hi lobular breast cancer (`(LBC)`) vei theihna hlauhawm an nih avangin, enkawl lai hian `(LBC)` symptoms hi an hriat reng a ngai a ni. `(LBC)` i neih chuan hnute cancer surgery atanga enkawl tan a ni tlangpui. Chumi hnuah chuan enkawlna dang pek belh a ni.

`(HDGC)` condition nei hian engzat nge dam rei zawng?

Dam rei zawng hi cancer hmuhchhuah leh enkawl hmasaknaah a innghat a ni. Screening neih fo pawhin hei hi a harsa thei hle. Metastatic stomach cancer hi man a, enkawl hmasak a nih chuan kum nga chhunga damchhuah zat chu 90% aia tam a ni. Mahse, a tlai deuha hmuh a nih chuan, pum chhung bang a rawn luhchilh hnuah chuan a rate chu 30% aia tlem lovah a tlahniam thin.

Chuvangin chhungkaw chanchin hriat chian a pawimawh em em a, hlauhawm i nih chuan damdawi lam thurawn lak a pawimawh hle kan ti.

`(HDGC)` ven dan tur a awm em?

`(CDH1)` gene mutation (cancer vei theihna sang zawk nena inzawm) i neih chuan, invenna kawng engemaw zat i tih theih a ni. He gene mutation bik nei lote tan chuan a hlauhawmna leh a tehfung chu chiang takin tarlan a ni lo. I doctor nen i mimal hlauhawmna leh duhthlan tur i sawi thei ang.

Prophylactic surgery tih a ni

Kum 20 tal HDGC vei nia hriat i nih a, hriselna lama harsatna lian tham dang i neih loh chuan i doctor chuan prophylactic total gastrectomy . Pum hloh hian i chaw ei kawngah nghawng engemaw zat nei thei mahse, heng side effects te hi pum cancer zual tawhte hmachhawn ai chuan enkawl a awlsam zawk.

Heng hmalakna peih lote tan chuan "wait-and-watch" approach hman theih a ni a, chu chu upper intestinal endoscopy leh random biopsy sample lak fo a ngai a ni. Mahse, hetiang taka uluk taka enkawl a nih pawhin HDGC hi a hma (enkawlna a hlawk ber hunah) hmuhchhuah a ni lo thei.

Total gastrectomy atanga nghawng tha lo awm thei te:

• Dumping syndrome: Chaw ei tur chu chaw kawng atanga ei leh in atanga direct in intestine a kal chuan a tlangpui aia rang zawkin small intestine a paltlang thin. Hei hian chaw ei kawng a hormone-ah inthlak danglamna lian tak a thlen thei a, chu chuan natna lan chhuahna, luak chhuak, ril\am, leh thisen sugar tlahniam te a thlen thei a ni. Heng symptoms te hi i ei leh in thlak danglam hian control theih a ni. Heng symptoms te hi hun kal zelah a reh ang.
• Malabsorption leh malnutrition: Pum hi lakchhuah a nih chuan chaw ei tura puitu acid leh enzyme awmna chu a bo ta a ni. Hei hian chaw chu a chhe tha lo thei lo va, taksain nutrients a hip lut thei lo bawk. Hei hian malnutrition a thlen thei a ni. Hei hi i ei leh in thlak danglam leh nutritional supplement ei hian a pui thei a ni.

Genetic counseling leh chhungkaw ruahmanna siam

CDH1 gene mutation nei tan chuan chhungkaw ruahmanna sawihonaah genetic counseling hi a \angkai hle thei a ni. Hei hian i fain HDGC natna a rochun theihna tur a hriatthiam theih nan a pui thei che a ni. Fa neih i tum a nih chuan, chu hlauhawmna enkawl dan tur pakhat chu selective In Vitro Fertilization (IVF) .

IVF-ah chuan nu leh pa hnen atangin egg leh sperm lakchhuah a ni a, lab-ah fertilized a ni. Embryo te an lo thanglian hnuah embryo tin atanga cell pakhat lak theih a ni a, CDH1 mutation test theih a ni. Nu leh pate chuan mutation nei lo embryo te chu thlangin nu nausen pum chhungah an dah thei a ni.

A tawp berah chuan eng nge kan hriat reng tur

Hereditary Diffuse Gastric Cancer Syndrome (HDGC) i vei tih hriat chu rilru na tak a ni thei a, thutlukna lian tak tak i siam a ngai mai thei bawk. Chûngte chuan nang leh i chhûngte a nghawng thei a ni. Hlauthawng lovin thil ngaihtuah chiang turin hun hmang rawh. Zawhna i mamawh ang zat zawt rawh. I medical team te chu he zinkawng zawh dan tur tha ber zawng turin an awm a ni. Awareness hi a hmasa ber a ni tih hre reng ang che. Nangmah chauh i ni lo.

` HDGC, hereditary cancer, pum cancer, CDH1 gene, pum cancer, hnute cancer, genetic test, endoscopy, gastrectomy, cancer venna