Intestine-a tumor te tak te lo awm thin te hi i zir dawn em ni? - Juvenile Polyposis Syndrome (JPS) natna nei tan chuan a chhuak thei lo.

Tu pawhin an ek chhungah thisen an hmuh chuan an hlau hle ang, a bik takin naupang tê têah chuan. A nih loh leh, pum na reng, pum na lutuk, leh rilru hah lutuk ang chi thilte i ngaihtuah em? Hengte hi a chang chuan kan sawi tur genetic condition Juvenile Polyposis Syndrome (JPS) tih chhinchhiahna a ni thei bawk. A hming hi a buaithlak deuh niin a lang mahse hlau suh. Hei hi thil awm dan tlangpui ni lo mahse, hriat reng a pawimawh. I hriatthiam theih khawpin a awlsam zawngin sawi ila.

A awlsam zawngin, Juvenile Polyposis Syndrome (JPS) hi eng nge ni?

A awlsam zawngin, JPS hi genetic condition a ni a, chu chuan kan digestive system (gastrointestinal (GI) tract) wall-ah polyp tih hming pu thil te te a siam a ni . Chûngte chu a hnah te tak tea chi te tak te innghah ang mai an ni.

Heng polyp te hi chaw ei kawng khawi hmunah pawh a lo awm thei a, mahse a tam ber chu:

• Intestine lian tak (colon) .
• Rectum (Rectum) atanga lo chhuak

Tin, a chang chuan pum chhung leh ril te tak teah te pawh an lo thang lian thei bawk. JPS vei chuan heng polyp hi engemaw zat a nei thei a, a chang chuan za aia tam pawh a nei thei bawk.

"Juvenile" kan tih hian hei hi naupang tê tê chauh natna a ni tihna em ni?

He zawhna hi mi tam takin an rilruah an nei a ni. "Juvenile" tih thumal kan hriat hian naupang tê tê leh puitling tleirawlte kan ngaihtuah a. Mahse, he thumal hi hetah hian damlo kum sawina atan hman a ni lo. Heng polyp te hi microscope hmanga an lan dan (an cell awm dan) atanga an vuah a ni.

Mahse, a pawimawh ber chu JPS natna lan chhuah dan hi kum 20 , chu chu naupan lai emaw, tleirawl lai emaw a lo lang tan fo thin a ni. Chuvangin, he hming hi eng emaw chen chu a inhmeh hle niin mi pakhatin a ngai mai thei.

JPS chi hrang hrang lian ber ber a awm em?

Ni e, JPS hi chi thum ah then theih a ni. Type tin hi a dang nen a inang lo deuh vek a. Eng nge an nih i en ang u.

He natna hi thlahtute atanga lo chhuak a ni em?

Ni e, JPS hi thlahtu natna a ni. Autosomal dominant takin a kai darh a ni. Tunah chuan he autosomal dominant hian eng nge a awmzia tih i ngaihtuah mai thei.

JPS vei zinga 75% vel chuan hetiang hian an nu leh pate hnen atangin an rochun thin. Mahse 25% vel chu chhungkaw zingah tumahin an la neih ngai loh genetic mutation thar avanga lo awm a ni. Chumi awmzia chu, chhungkuaa tumahin nei lo mah se, tu emaw chuan a tipung thei tihna a ni.

JPS natna lan chhuah dan chu engte nge ni?

JPS thil langsar ber chu a hmaa kan sawi tawh polyp te hi a ni. Hengte hi taksa chhungah an thang lian a, chuvangin pawn lam atang chuan kan hmu thei lo. Mahse, a tlem hle a, polyp thenkhat chu rectum pawnah hmuh tur a awm.

A tam zawkah chuan polyp te hi a lian emaw, a tam emaw a lo pung hian symptoms a lang thin. Heng polyps te hi kan ngaihtuah tur a ni.

Naupang thenkhatin an pian tirh atanga an neih theih mizia dang

JPS vei zinga 15% vel chuan polyp bakah hian an pian tirh lamah taksa lama harsatna dang an nei thei bawk. Chung zingah chuan:

• Cleft palate a awm
• Kut leh keah kut zungtang extra neih (Polydactyly) .
• Thluak, thinlung, mipat hmeichhiatna emaw, zun kawng (urinary system)-a hmasawnna dik lo
• Intestinal twisting (Malrotation) a awm thei lo.
• Vun chhunga thisen kalna kawng inthlak danglamna (Telangiectasia) .

JPS leh cancer hlauhawmna inzawmna a awm em?

Hei hi a pawimawh hle a, kan ngaihven a ngai hle. JPS vanga polyps lo awm hi a tir lamah chuan non-cancerous (benign) tumor angin an lo piang chhuak thin. Chu chu cancer vei an ni lo tihna a ni.

Mahse, JPS vei te hian midang aiin digestive system cancer an vei theihna a sang zawk. Hei hi he natna hlauhawm ber a ni. Risk hi 30% - 50% vel a ni thei.

Cancer hlauhawmna sang zawk nei:

• Colorectal cancer a ni
• Pum cancer a ni
• Pancreatic cancer natna a ni
• Small intestine cancer a ni

Engvangin nge JPS hi a lo awm? Scientific chhan chu eng nge ni?

JPS hi kan taksaa gene pahnih zinga pakhat BMPR1A leh SMAD4 -a mutation avanga lo awm a ni.

Heng gene pahnih hi kan cell hnathawh thununtu "supervisor" pahnih angin han ngaihtuah teh. An hna ber chu cell-te hnenah, "Okay, divide now" leh "Okay, stop dividing now" tih te hi a ni. Hei hi cell thanna an control dan a ni.

JPS-a thil thleng chu heng genes te hi an inthlak danglam chuan chu "supervisor" chuan hna a thawk tha lo. Tichuan cell te chu control theih lohvin an chhuak ta a ni. An inthen rang lutuk a, an chungah an inzawm khawm a, kan sawi tawh polyp te chu an siam ta a ni.

Engtin nge JPS hi hmuhchhuah a nih?

JPS symptoms i neih chuan i doctor chuan a enfiah hmasa ang che a, i symptoms te leh i chhungte zingah hetiang natna hi an nei tawh em tih te a zawt ang che. JPS vei nia hriat tur chuan a hnuaia mi pakhat tal i neih a ngai a ni:

Hei atan hian eng test nge tih thin?

Doctor chuan a natna hriat chian nan test engemaw zat a rawt ang:

• Colonoscopy emaw Endoscopy: Hei hi camera leh light hmanga tube te tak te, flexible tak dahin, intestine lian chhung chu enfiah a ni. Hei hian polyp a awm leh awm loh, khawiah nge a awm tih leh engzat nge a awm tih hriat theih nan a pui thei a ni. Pum enfiah nan chuan tube chu ka chhungah an dah lut a (Upper GI Endoscopy).

• Genetic blood test: Thisen sample lak a, JPS thlentu genetic mutations awm leh awm loh enfiah a ni.

JPS enkawlna tur engte nge ni?

JPS enkawlna tum ber chu polyp tihbo te, symptoms control te, cancer vei theihna tihziaawm te a ni. I doctor chuan i kum, i hriselna, polyp awm zat leh an awmna hmun a zirin i tan enkawlna tha ber tur a ruat ang.

Enkawl dan hrang hrang a awm a:

• Colonoscopy neih laiin polyp lakchhuah: Polyp tlemte chauh a awm chuan tube chhunga hmanraw bik kal tlang hmangin tan leh lakchhuah theih a ni.
• Polyp surgery hmanga lakchhuah: Polyp te hi a lian hle emaw, colonoscopy neih chhunga lakchhuah theih lohna hmuna awm emaw a nih chuan operation tih a ngai mai thei.
• Colon emaw, pum emaw section pakhat surgery hmanga lakchhuah: Hmun khatah polyp tam tak a awm chuan doctor-te chuan chu colon section pum pui chu lakchhuah an rel thei a ni.

Natna i vei tih hmuhchhuah a nih hnuah engtin nge i nun i enkawl?

JPS damdawi a awm lo. Chuvangin, vawi khat hmuhchhuah a nih tawh chuan a pawimawh ber chu a nunpui zir leh natna enkawl dan zir hi a ni. Chutianga tih theih dan tha ber chu medical screening neih fo hi a ni.

Engzat nge test ka neih ang?

• Test hmasa ber chu symptoms a lan tirh emaw kum 15 an tlin hmain emaw tih tur a ni .
• Examination hmasa berah harsatna a awm loh (polyps awm lo) chuan kum 3 danah enfiah thin a tawk .
• Polyp tam tak i neih tawh a, lakchhuah emaw, operation i neih emaw chuan kum tin screening neih thin tur a ni . Polyp hmuh leh a nih loh chuan kum 3 danah screening lamah i inthlak thei a, i doctor thurawn angin.

Inenkawl zawhah i taksa chu a dam theih nan hun i pek a ngai a ni. A tlangpuiin natna lan chhuah dan a reh a, i rilru a hahdam tan theih nan kar hnih vel a ngai thin.

Doctor hmuh i mamawh apiangin.

JPS symptoms i neih chuan, a bik takin i stool-a thisen awm , ngaihthah suh. Doctor pan vat rawh. Tin, i chhungte zingah polyps emaw JPS emaw history nei an awm chuan doctor hnenah hrilh ngei ang che. Hei hi thlahtute atanga lo piang natna a nih avangin chu information chu natna hriatchhuahna atan a pawimawh hle.