I doctor chuan damdawi chi khat MAOI an tih chu a pe che em? A nih loh leh khawi emaw laiah he damdawi hi i hre tawh a, eng nge a nih chiang taka hriat i duh em? MAOIs hi a takah chuan damdawi chi khat a ni a, rilru lam hriselna lama harsatna awm thei, depression ang chi enkawlna atana pek thin a ni. Amaherawhchu tunlai hian Doctor ten an recommend vak lo. Hei hi chhan bik engemaw zat a awm. Hemi chungchang hi a tir atang khan, awlsam takin, i hriatthiam theih angin i sawi ang u.
MAOI hi eng damdawi chi nge ni?
A awlsam zawngin sawi ila, MAOIs (Monoamine Oxidase Inhibitors) hi depression enkawlna atana damdawi chi hrang hrang hmuhchhuah hmasak ber a ni. Amaherawhchu, i hman hunah eng nge i ei tih i fimkhur hle a ngai a ni. Tin, damdawi dang side effect thenkhat leh harsatna a awm avangin doctor-te chuan a tawp ber atan an rawt fo thin a, chu chu antidepressant dangin hna a thawh loh laiin.
Chumi awmzia chu, SSRI ang chi damdawi thar zawk pek i nih a, i natna lan chhuah dan a lo tha lo a nih chuan i doctor chuan MAOI chu a dawt leh tur atan a ngai mai thei tihna a ni.
Khawvela MAOI hman ber chi hrang hrangte chu engte nge ni?
Tunah hian MAOI chi hrang hrang hman mek a awm a. Heng zawng zawng hi kan ramah a awm leh awm loh a inang lo thei a, mahse heng hmingte hi hriat chian a tha.
- Isocarboxazid (Marplan®) hmanga siam a ni.
- Phenelzine (Nardil®) hmanga siam a ni.
- Selegiline (Emsam®) hmanga siam a ni.
- Tranylcypromine (Parnate®) tih a ni.
MAOI damdawi hi eng condition atan nge pek a nih?
He damdawi hi depression tan bik ni mahse, rilru lam natna dang atan pawh hman a ni.
Official-in a pawmpui hman dan
Hengte hi thuneitute’n official-a he damdawi hi heng natnate tana \ha anga an pawm tawhte an ni.
- Major Depressive Disorder: Hetiang natna atan hian Isocarboxazid leh Tranylcypromine te hi pawm a ni.
- Treatment-resistant disorders: Phenelzine hi depression, panic disorder, leh social anxiety disorder, enkawlna dang dawng thei lo enkawlna atan hman a ni.
- Parkinson natna: Selegiline hi lungngaihna enkawlna atana hman a ni a, Parkinson natna damdawi dang nena adjunctive therapy atan pawh hman a ni.
"Off-label" tih a hmang
A châng chuan, doctor chuan official-a pawm loh natna pakhat atân an damdawi lam hriatna leh tawnhriat aṭangin he damdawi hi a pe thei a ni. Hei hi "off-label" hmanna an ti. Entir nan:
- Damdawi pakhat tranylcypromine an tih hi a chang chuan enkawlna dodal thei social anxiety leh panic disorder te tan an pe thin.
- Attention deficit hyperactivity disorder (ADHD) tan damdawi Selegiline hi pek a ni fo thin.
He damdawi hian taksa chhungah engtin nge hna a thawh?
Hei hi hriatthiam a awlsam hle. Kan thluak hian kan rilru put hmang, hlimna, leh ngaihvenna ang chi thilte thunun thei chemical a nei niin han ngaihtuah teh. Hengte hi neurotransmitter kan ti a . Chûngte chu thluak chhûnga thuchah kengtu palai tê tê ang an ni.
Tunah chuan kan taksa hian enzyme pakhat "Monoamine Oxidase" tih a nei ta. He enzyme hna chu chu messenger (neurotransmitters) te chu an hman zawh hnua tihchhiat leh paih chhuah hi a ni.
Depression nei chuan an thluak ah heng messenger te hi a hniam thei hle. MAOI damdawi pakhatin a tih chu chu ‘thianfai’ enzyme hnathawh chu rei lo te chhung atan a titawp (inhibit) a ni. Chuti a nih chuan eng nge thleng?
Thluaka neurotransmitter pawimawh engemawzat chu thluaka chhe lovin rei zawk an awm a, chu chu an level a sang tihna a ni.
MAOIs hian neurotransmitter a tihpun berte chu:
- Serotonin: Mood, mut, ei duhna, leh khawtlang nunphung atan a pawimawh hle.
- Norepinephrine: Fimkhur, ngaihtuahna fim leh thiltih nan a pawimawh.
- Dopamine: Hlimna, lungawina leh ngaihvenna nena inzawm.
- Tyramine: Hei hi neurotransmitter chi khat a ni bawk. Mahse a hna ber chu thisen sang control nana puih hi a ni. Hei hi MAOI i ei dawna i ei tur i fimkhur a ngaih chhan ber a ni. Tlem chuan chipchiar zawkin kan sawi dawn a ni.
MAOI leh SSRI te hi eng nge an danglamna?
SSRI (Selective Serotonin Reuptake Inhibitors) hi lungngaihna enkawlna atana hman thin damdawi chi dang a ni. Prozac leh Sertraline tih hming hi i hre tawh mai thei. An pahnih hian lungngaihna enkawlna atana hman damdawi ni mah se, an hnathawh dan a inang lo.
- SSRI: Hengte hi sniper ang mai an ni. Neurotransmitter serotonin chauh an target a ni . A level an tisang chauh a ni.
- MAOIs: Hengte hi shotgun ang mai an ni. Vawi khatah neurotransmitter engemaw zat (serotonin, norepinephrine, dopamine) an nghawng a ni.
SSRI damdawi hian side effect a neih tlem avangin leh ei leh in chungchangah dan bik a awm loh avangin doctor-te chuan SSRI damdawi hi an rawt hmasa ber thin.
MAOIs hian eng side effect nge a neih tlangpui?
Damdawi zawng zawng ang bawkin he damdawi hian side effect a nei thei. Mahse, mi zawng zawngin an hmu vek lo. Mi thenkhat chuan pakhat emaw pahnih emaw an dawng thei a, thenkhat chuan an tawng lo thei bawk. He damdawi i ei tan hnua harsatna thar i neih chuan i doctor nen sawiho rawh.
| Side effect awm fo thin | Hrilhfiahna |
|---|---|
| Luak chhuak emaw, lu hah emaw | Hei hi thisen sang hniam vang a ni thei. Hei hi ding emaw, ṭhut emaw atanga zawi zawia tho chhuakin a thunun theih a ni. |
| Kawng a vawt | Tui tam zawk in leh sugar-free gum ei hian hahdamna i hmu thei ang. |
| Luhai | Hei hi damdawi ei ruala ei hian tihziaawm theih a ni. |
| Flatulence emaw constipation emaw a awm thei | Hei hi i ei leh in leh tui i in zat a zirin a danglam thei. |
| Mutthilh theih lohna | Doctor chuan zanah damdawi ei turin a fuih mai thei. |
| Mu thei lo | Chutiang hunah chuan damdawi chu zing lamah ei turin an fuih mai thei. |
MAOI hman avanga hlauhawmna lian tak tak!
A bik takin he part hi i hriat chian a ngai a ni. MAOI hi fimkhur taka hman tur a ni.
1. Mahni intihhlum tumna a pung
Mahni intihhlum duhna emaw, nungchang emaw a pung thei a, a bik takin thalai kum 25 hnuai lam, he damdawi hi ei tan tirh emaw, a hman dan tur thlak emaw a ni thei.
He damdawi hi i ei tan hnua nangmah emaw i fa emaw chuan beiseina nei loin i inhriat tan chuan damdawi petu doctor chu biak nghal hreh suh.Sri Lanka rama national mental health helpline number, 1926 -ah pawh call-in tanpuina i dawng nghal thei bawk.
2. Serotonin Syndrome natna a ni
Hei hi thil awm lo tak, mahse nunna atana hlauhawm thei tak a ni. Taksa chhunga serotonin level hlauhawm taka a san chuan a thleng thin. He hlauhawmna hi serotonin level tisang thei damdawi dang (e.g., antidepressant dang, khuh syrup thenkhat, leh painkillers) i ei laiin MAOI i ei chuan a sang hle.
Chuvangin MAOI i ei tan hmain i doctor hnenah tuna i damdawi ei zawng zawng (vitamin leh traditional medicine te pawh tel) i hrilh hmasa tur a ni.
| Serotonin Syndrome natna lan chhuah dan | |
|---|---|
| A lan chhuah dan tlangpui |
|
| Symptom na tak leh hmanhmawhthlak tak tak a awm |
|
| Heng natna khirh tak tak te hi i neih chuan damdawi in hnai ber Emergency Department (ETU) ah kal nghal rawh! | |
3. Antidepressant Discontinuation Syndrome a awm thei
MAOI hi kar 6 aia rei i ei a, a hnua i chawlhsan nghal chuan withdrawal symptoms i nei thei. Hei hi ruihhlo ngawlvei a ni lo va, taksain a hman dan pangngaia damdawi a dawn dan tur a ni zawk.
Ziarang:
- Taksa na, hah, leh thawk hah, khawsik nei ang maiin
- Mu thei lo
- Luhai
- Luak chhuak thei
- I taksaah electric a kal ang maia inhriatna
- Lungkhamna, thinrimna
Doctor rawn hmasa lovin he damdawi hi eng thil vang pawha ei nghal vat loh tur a ni. Damdawi i ei tawh loh chuan thla khat vel chhung zawi zawiin ti la, a ei tur chu tihtlem la, i doctor enkawlna hnuaiah chauh ti rawh.
4. Chaw ei avanga thil hlauhawm (Tyramine Reaction) .
Hei hi MAOI-te nena risk pawimawh ber leh hlauhawm ber a ni.
Kan sawi tawh ang khan MAOI damdawi hian chemical tyramine tihchhiat tu enzyme chu a block a. Tyramine hi kan ei tur thenkhatah a awm tlangpui. Damdawi ei lo miah chuan taksa chu awlsam takin a chhe vek a, he tyramine hi a bo vek a ni.
Mahse MAOI ei mi pakhatin tyramine tamna ei tur a ei chuan taksain a tichhia thei lo. Tichuan thisena tyramine level chu hlauhawm takin a sang chho a, chu chuan thisen sang a tisang nghal (Hypertensive Crisis) . Hei hi a hlauhawm hle mai. A tlem berah chuan hei hian thluak thisen chhuahna leh thihna thlengin a thlen thei a ni.
MAOI ei huna ‘absolutely’ ei loh tur ei tur!
MAOI i ei a nih chuan a hnuaia list-a ei tur awmte hi i pumpelh vek tur a ni. Hemi chungchang hi i doctor nen sawiho la, hriat belh duh tan.
| Chaw chi hrang hrang | Thil pumpelh tur leh a chhan |
|---|---|
| Cheese | Cheese upa tawh tak takte chu pumpelh vek rawh. Entirnan: Cheddar, Blue cheese, Parmesan te hi a ni. (Hun kal zelah Tyramine level a sang chho zel). Cheese thar Cottage cheese, Mozzarella ang chi te hi a tha. |
| Sa leh sangha processed | Sausage, salami, sa hring, sa tihdam, leh sa/nga zuk leh hmuam. |
| Sauces te pawh a awm | Soy sauce leh fermented sauce dangte pawh a awm bawk. |
| Thlai leh thei chi hrang hrang fermented | Banana puitling tak tak , avocado, figs. Fava beans (legume chi khat) a ni. |
| Zu | Tap beer (draft beer) leh fermented beer te pawh a awm bawk. Wine thenkhatah pawh tyramine a tam hle bawk. |
| Thildang | Sourdough chhang, liver, etc. (tyramine hi a thar loh chuan a pung nghal vat). |
A pawimawh ber: Chaw ei tur chu a hmin veleh ei nghal rawh. A la awmte chu refrigerator-ah dah la, tihlum leh loh tur. Chaw a upa chhoh zel chuan tyramine level a sang chho thei a ni.
Damdawi hian eng chen nge a nghawng tih hriat nan a hman?
Damdawi hian a nghawng kimchang a hriat theih nan kar hnih atanga kar thum vel a ngai tlangpui. Chumi chhung chuan i symptoms-ah hmasawnna i hmu lo a nih chuan i doctor nen inbia ang che.
Engtikah nge doctor i biak ang?
MAOI i ei a nih chuan doctor i pan fo tur a ni a, damdawi hian hna a thawk em tih leh harsatna i neih leh neih loh en tur a ni. Chu bâkah, i doctor hnênah heng thilte hi sawipui ngei ang che:
- Side effects in a tibuai che a nih chuan.
- I symptoms a lo tha lo emaw, a nasat loh emaw chuan.
- Damdawi ei kha bansan a ngai nia i hriat chuan.
A tawp berah chuan MAOI ei mek i nih angin doctor i hmuh apiang (ha enkawltu pawh) hnenah he damdawi hi i ei tih hrilh a pawimawh hle a, anesthetics leh damdawi dang thenkhat hian MAOIs hi a ti hlauhawm thei a ni.
Take-Home Thuchah a ni
- MAOI hi lungngaihna damdawi chi khat a ni a, hman lar tawh lo mah se, a then phei chuan a hlawk hle.
- He damdawi ei lai hian Tyramine- awmna ei tur (aged cheese, processed meats, soy sauce ang chi) hi ei loh vek tur a ni. Hei hian nunna a tichhe thei a ni.
- Damdawi dang i ei tur chu doctor hnenah hriattir a pawimawh hle.
- Doctor rawn hmasa lovin damdawi ei kha bansan ngai suh.
- Serotonin syndrome (confusion, high fever, seizures) emaw, mahni intihhlum tumna emaw i neih chuan emergency room (ETU) ah kal nghal rawh.
- I enkawl healthcare professional zawng zawng hnenah MAOI i ei tih hrilh rawh.
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