I mit chhungah thisen kalna kawng thar a lo piang niin a lang em? He mit neovascularization chungchang hi kan sawi dawn em ni?

A chang chuan kan mit hian beisei loh harsatna a tawk thin a ni lawm ni? Vawilehkhatah kan mit a fiah lo va, a nih loh leh kan mit a sen a, a na bawk. Heng thil hnung lamah hian kan hriat tam loh condition a awm mai thei. Chutiang dinhmun pakhat chu ocular neovascularization, a nih loh leh mit chhunga thisen kalna kawng thar siam hi a ni.

Mit chhunga thisen kalna kawng thar siam dan chu eng nge ni? (Mit chhunga Neovascularization) tih a ni.

A awlsam zawngin, hei hi mit chhunga thisen kalna kawng thar a lo awm hian a ni. Mahse, heng thisen kalna kawngte hi an lo thang lian lo tur hmunah te, an thang lo tur angin an lo thang lian a, a châng chuan a tam lutuk bawk . Thlai ang maiin an thang lian thin. Heng thisen kalna thar inkarah hian fibrous tissue thar a lo awm thei bawk. Chutah chuan mit hmuhna a nghawng tan ta a ni.

Hei hi damdawi lama Neovascularization kan tih chu a ni a, mit chhunga thisen kalna kawng thar, duh loh tak tak siam chhuahna a ni. Hei hian mit chhungah inflammation leh scarring a thlen thei a, chu chuan a tawpah chuan mit hmuhna a tihtlem emaw, a hloh vek emaw a thlen thei a ni . A tam zawkah chuan he dinhmun hi hliam emaw, natna kal zel emaw avanga lo awm a ni .

Mit chhungah khawiah nge heng thisen kalna kawng tharte hi a lo awm theih ang?

Tunah chuan heng thisen kalna tharte hian mit peng engte nge an nghawng theih tih i en ang u. Mit hi taksa peng hrang hrang complex leh nalh tak a ni.

• Choroid: Hei hi mit (retina) leh mit var (sclera) inkar a awm a ni. Hei hi mit hnena thisen petu thisen kalna kawng tam zawk awmna hmun a ni.
• Retina: Hei hi mit chhunga êng lut chu electrical signal-ah a chantir a, thluaka a thawn chhuahna hmun a ni. Hei hian thil hmuh theihna min pe a ni.
• Macula: Hei hi retina lai takah a awm a. Kan hmaa direct-a thil awmte chu chiang taka hmuh theih turin min pui a ni.
• Iris: Hei hi mit a rawng pe theitu a ni. A laiah chuan circle dum te tak te, chu chu pupil , chu hetah hian a awm bawk.
• Cornea: Hei hi mit hmalam, glass ang maia chiang, window ang maia awm chu a ni.
• Conjunctiva: Hei hi mit vengtu membrane te tak te a ni.

Vascular layer-a thisen kalna kawng thar siam (Choroidal Neovascularization - CNV)

Tunah chuan he (Choroid), chu chu vascular layer-a thisen kalna kawng thar lo piang chhuak hi han en ila. Hei hi (Choroidal Neovascularization - CNV) an ti a.

Hei hi kum upa lam nena inzawm macular degeneration (AMD) vei te zingah a langsar ber. Doctor-te chuan a chhan chu AMD vei mi mit (retina) atanga siam, Vascular Endothelial Growth Factor (VEGF) an tih chemical level sang vang niin an ngai.

Heng thisen kalna kawng tharte hi a pangngai lo. An chak lo hle a, pipe chhe ang mai an ni.Hei hian tui, a chang chuan thisen pawh retina-ah a luang lut thei a ni. Balloon te tak te tuiin a khat angin ngaihtuah la, retina-ah hian blister a lo awm thei a ni.

Heng (CNV) thlentu hian central retina-ah thisen kalna kawng thar a siam thei bawk (Macular Neovascularization - MNV). Amaherawhchu, a chang chuan (MNV) hi chhan awm lovin a thleng thei. Chutiang hunah chuan (Idiopathic) an ti bawk a, chu chu "a chhan hriat loh" tihna a ni.

Corneal Neovascularization tih a ni

A dawtah chuan mitmeng (cornea)-a thisen kalna kawng thar lo awm dan tur kan sawi leh ang. Mit chhunga thil chiang tak chu cornea hi a ni tih hre reng ang che. A tlangpuiin thisen kalna kawng a nei lo tak zet a ni. Chuvang chuan a chiang em em a ni. Chuvangin, a chhungah thisen kalna kawng thar a lo awm chuan chu chiangna chu a tibuai thei a, vur ang maiin a lang thei bawk. Hei hian mit a ti fiah lo thei a ni.

He Corneal Neovascularization hi mit natna hrang hrang nen a inzawm a ni.

Retinal Neovascularization tih a ni

Retinal neovascularization chu retina chhunga thisen kalna kawng thar, pangngai lo tak tak siam a ni. Retina hi light-sensing cell awmna hmun a ni tih hre reng ang che. Hetiang dinhmun hi natna chi hrang hrang leh hliam hrang hrang avanga lo awm thei a ni. Heng thisen kalna kawng tharte hi a chak lo va, thisen a chhuak thei a, tui a leak thei bawk.

Iris-ah hian Neovascularization a awm a

Iris Neovascularization chu iris – mit chhunga mit rawng pe theitu thisen kalna kawng thar leh pangngai lo lo piang chhuak hi a ni. Rubeosis Iridis an ti bawk. Glaucoma chi khat na tak, Neovascular Glaucoma an tih nen a inzawm a ni. Glaucoma hi mit nerve tichhe thei natna a ni a, mit hmuhna tichhe theitu lian tak a ni.

Hetiang natna lan chhuah dan hi engte nge ni?

Tunah chuan mit chhunga thisen kalna kawng thar a lo awm hian eng symptom nge kan neih a, kan en ang. Heng symptoms te hi thisen kalna kawng thar siamna hmun azirin a danglam thei.

Choroid leh macula-ah thisen kalna kawng thar a lo awm chuan:

• Thil i hmuhte chu a dik lo leh a dik lo angin a lang thei , tui aṭanga thlir emaw, darthlalang dik lo emaw aṭanga en ang chi te.
• I hmalam i han en dik chuan i mit hmuhna lai takah hmun ruak emaw, hmun dum emaw i hmu mai thei.

Mit (cornea)-ah thisen kalna kawng thar a lo awm chuan (Corneal Vascularization):

Symptoms engmah i nei lo mai thei. Mahse, i tih chuan a hnuaia mite hi i tawng thei ang:

• Mit na a na.
• Mit a sen vek.
• Mit tui tak tak.
• Sensitivity to light (Photophobia) - Hei hian ni eng leh eng eng mawi tak tak ang chi thil en harsa tihna a ni.
• Contact lens i bun chuan darkar tlemte aia rei i bun thei lo mai thei.

Engvangin nge hetiang hi a lo awm? A chhan engte nge ni?

Okay, tunah hian engvangin nge hetiang hian mit chhungah thisen kalna kawng thar a lo awm tih hi han en ila, a chhan pawh eng nge ni. Heng formation awm chhan hi hmun tinah hian a inang lo deuh vek a.

Choroid leh macula-a thisen kalna kawng thar lo awm chhan:

• Macular degeneration: Hei hi a chhan ber a ni.
• Hmuh lohna nasa tak.
• Ocular histoplasmosis hi mit a fungal infection a ni.
• Mit hliam.
• Angioid streaks: Hengte hi retina layer pakhata crack lo awm ang mai a ni.
• Uveitis: Hei hi mit natna chi khat a ni a, mit chhung lam a ti na thei a, a sen thei a, mit a ti na thei bawk.

Cornea-a thisen kalna kawng thar lo awm chhan:

• Congenital diseases: Hengte hi pian tirh atanga lo awm thin natna te an ni.
• Mit trauma: Entirnan, chemical hmanga kang.
• Keratitis natna hrik kai theihna.
• Allergy nei te pawh a awm.
• Immune system leh inflammatory disorder te a awm bawk.
• Hun rei tak contact lens hman hian tissue oxygen tlakchhamna (Hypoxia) a thlen thei.
• Taksain corneal graft a hnawl.

Retina-a thisen kalna kawng thar lo awm chhan:

• Retinitis natna (retinitis) a ni.
• Retinopathy: Hei hian zunthlum kaihhnawih retinopathy, sickle cell retinopathy, leh retinopathy of prematurity te a huam a ni.
• I kawr chhunga thisen kalna kawng lian ber ber (carotid arteries)-a thisen kal tlem.
• Retinal vein occlusion: Hei hi mit lama thisen kalna kawngkhar a inkharkhip a ni.

Iris-a thisen kalna kawng thar lo awm chhan:

• Diabetes kaihhnawih mit natna (retinopathy) a awm.
• Central retinal vein a inkharkhip a ni.
• Ocular ischemic syndrome: Mit a thisen kal tlem avanga lo awm thin.
• Retinal detachment: Hei hi retina chu a supporting tissue atanga a inthen a ni.
• Uveitis natna a ni.

Engtin nge hei hi i hriat chian? Test te chu engte nge ni?

Awle, hetiang symptoms i neih chuan engtin nge doctor hian a hriat chian tak tak ang? Chumi atan chuan test engemaw zat a awm.

• Dilated slit lamp mit enfiahna:Hemiah hian mittui tlakna (eye drops) an hnawih a, mitmeng chu a lian a, mit chhung lam chu hmanraw bik, microscope ang chi hmangin uluk takin an enfiah thin.
• Optical Coherence Tomography (OCT): Hei hi mit chhung lam scan ang a ni. Mit chhunga layer awmte cross-sectional image chiang tak a la thei. Thisen kalna kawng thar leh tui leak ang chi thil a zawng thei.
• Fluorescein angiography emaw Indocyanine green angiography: Hei hian i kut vein pakhatah dye bik inject a, i mit chhunga thisen kalna kawngte thlalak lak a ni. Hei hian thisen kalna kawngkhar blockage leh leak ang chi thil chiang takin a lantir thei a ni.

Enkawlnate chu engte nge ni?

He natna enkawlna hi a chhan leh mit natna hmun a zirin a inang lo. Heng enkawlnaah hian damdawi leh/ emaw ablation te pawh a tel tlangpui a, chu chuan thisen kalna kawng thar, pangngai lo chu a tichhia a ni.

Damdawi chi hrang hrang: 1.1.

Chung zinga ṭhenkhat chu mit chhunga direct-a pek thin intravitreal injection te an ni. Hengte hian VEGF an tih chemical control-na leh thisen kalna kawng thar siam tihtlemna hmangin hna an thawk ber a ni.

• Bevacizumab (Avastin®) (Hei hi (off-label) hman a ni a, chu chu a pawmpui natna tan a ni lo va, a hlawkpui tih hriat a nih vang a ni tihna a ni)
• Brolucizumab (Beovu®) hmanga damdawi hman tur a ni
• Aflibercept (Eylea®) tih a ni
• Ranibizumab (Lucentis®) tih a ni
• Gene therapy: Hei hi enkawlna thar a ni a, zirchianna stage-ah a la awm reng a ni.
• MMP inhibitors: Entirnan, pill pakhat Doxycycline , chu chu mit (cornea)-a thisen kalna kawng thar lo thang lian tura pek thin a ni.

Tissue pangngai lo tihchhiat dan: 1.1.

• Laser ablation therapy: Hei hian laser beam hmangin thisen kalna kawng tharte chu "a kang" a, a tichhia a ni.
• Photodynamic therapy (PDT): Hei hi mit chhungah êng sensitive damdawi inject a, chutah chuan mit chhungah êng bik a eng a, chu chuan thisen kalna kawng dik lo chu thlan bik takin a tichhia a ni.
• Cauterization: Hetiang method hian thisen kalna kawng pangngai lo enkawl nan lumna hmangin a enkawl thin.

Tin, hre reng ang che: Heng enkawlnate hian side effect a nei thei. Entirnan, steroid leh anti-VEGF damdawi te hian side effect a nei thei a, chu chuan taksa pum a nghawng thei a ni. Tin, thisen kalna kawng an tihchhiat hian tissue hrisel pawh a chhe thei bawk. Chuvang chuan damdawi pakhat zel thatna leh that lohna te doctor nen sawiho a, i tana tha ber tur thlang thiam a pawimawh.

Hetiang dinhmun laka inven nan eng nge kan tih theih ang?

Hetiang dinhmun hi ven kim theih a nih loh laiin, kan mit enkawl tur leh a hlauhawmna tihziaawmna tur thil kan tih theih a awm a:

• Mit hmanga inhnaih hmainI kut chu sahbawn hmangin uluk takin silfai ang che.
• Contact lens i bun chuan hman dan leh tihfai dan tur dik tak zawm tur a ni. Hun bituk aia rei bun loh tur. Mut laiin la chhuak thin ang che.
• I mit hriselna atana pui thei tur ei leh in leh supplement chungchang i doctor zawt la. AMD vei tan chuan AREDS 2 tih hming pu supplement chi khat a awm a, chu chuan natna hi a tir lamah a titawp emaw a titawp thei a ni.
• Nunphung hrisel tak zawm rawh. Hei hian ei leh in inthlau tak ei te, exercise neih fo , leh zu in loh te a kawk a ni. Damdawi lam harsatna, zunthlum emaw thisen sang emaw i neih chuan control tha rawh.

Hetiang dinhmun nen hian eng nge beisei theih ang?

He thisen kalna kawng thar siam hi enkawl a nih loh chuan i mit chu a tlahniam zauh zauh ang a, a tawpah chuan a bo vek ang. Chu chuan i nunah nghawng lian tak a nei dawn a ni lawm ni?

Enkawlna a hlawhtling dawn em tih nghawngtu thil engemaw zat a awm. Chung zingah chuan thisen zam awmna hmun, a nasat dan, i kum leh hriselna lama harsatna dang i neih leh neih loh te a tel. A hmuhchhuah hma leh enkawl a nih chuan a rah chhuah a tha zawk.

Engtikah nge Doctor ka hmuh ang?

I mit a tlakchham thut a, mit na tak i neih emaw, i mit a kang a, êng hmuh harsa tak i neih chuan doctor pan nghal tur a ni. Tin, i mit hmuhnaah inthlak danglamna (e.g., mitdelna, hmun dum), emaw, harsatna awm thei nia i rinhlelh chhinchhiahna dang i hmuh chuan mit lam doctor pan nghal rawh.

Tin, mit doctor-in a rawt angin mit enfiah fo a pawimawh bawk. Mit lam natna thenkhat (e.g., zunthlum, chhungkaw history-a AMD) i neih chuan i kal fo a ngai mai thei.

Neovascularization'' leh Angiogenesis'' hi thil hrang hrang pahnih a ni em?

Hei hi thupui thuk deuh a ni a, mahse a awlsam zawngin sawi ila, (Angiogenesis) chu thisen kalna kawng awmsa atanga thisen kalna kawng thar a rawn inzar pharh chhuah dan a ni. (Vasculogenesis) chu thisen kalna kawng thar cell atanga intan (a bul atanga tan ang maia) a ni. (Neovascularization) hmang hian kawng hnih ah thisen kalna thar siam theih a ni. Chuvangin (Neovascularization) hi thumal zau deuh a ni a, heng thisen kalna kawng thar siam chi hrang hrang zawng zawng hi a huam vek thei a ni.

He thawnthu a\anga kan hriat reng tur pawimawh tak takte chu

Chuvangin, he natna Neovascularization of the Eye'' tih hi kan sawi nasa hle a, mit chhungah thisen kalna kawng thar a lo awm thin. Hei hi hlauhawm deuhin a lang thei a, mahse a hun takah hriatchhuah leh enkawl a nih chuan, chu natna chu enkawl theih a nih bakah mit hmuh theihna a awm theihna chance a sang hle.

• I mit hmuhna inthlak danglam thut, sen, na, emaw êng êng takah hmuh harsa i neih chuan tihkhawtlai suh. Mit lam doctor pan nghal rawh.
• Diabetes, hyperopia, emaw chhungkaw history-a AMD i neih chuan doctor-in a tih angin i mit enfiah fo ang che.
• I doctor-in damdawi a pek chu dik takin hmang la, a thupek zawm la, a laiah enkawlna chu titawp suh.
• Meizial zuk loh vek tur a ni. Meizial zuk hian mit hriselna a tichhe hle a, a bik takin AMD leh diabetic eye disease ang chi condition tan chuan a tichhe hle.
• Ei leh in hrisel leh exercise neih reng hi i mit tan chauh ni lovin, i taksa pum tan pawh a tha hle. Thlai hring, thei leh omega-3 tamna sangha te chu i eitur ah telh la.

I mit hi a hlu hle tih hre reng ang che. Khawvel hmuh theihna tura kan neih hlu ber an ni. Chuvangin, uluk taka enkawl hi i mawhphurhna a ni. I hriat lawk a, a tul anga hma i lak chuan harsatna tam tak i pumpelh thei a ni.