He thluak venghimtu kulh mak tak hi i hria em? (Thisen-Thinlung Damdawi) .

I thluak hi kulhpui hlu tak, sensitive tak angin ngaihtuah rawh. Tin, chu kulh chhunga lut zawng zawng enfiahtu, thil tha lo chu chhuah tir a, thil tha chauh luhtirtu kawngkhar vengtu pakhat a awm bawk a, chutiang bawkin vawiinah hian kan thluak chhehvela thisen kalna kawngkhar chhunga awm, thluak humhimtu, kawngkhar vengtu bik, a nih loh leh filter chungchang kan sawi dawn a ni. Damdawi lamah chuan hei hi Blood-Brain Barrier (BBB) ​​kan ti a.

A awlsam zawngin, Blood-Brain Barrier (BBB) ​​hi eng nge ni?

Hei hi daltu mai a ni lo. Dik tak chuan kan thluak vengtu ang mai a ni. He venhimna bang hi thluak vel thisen kalna kawng chhungah a awm a. A hnathawh ber chu thisena thil ṭha lo, hrik, leh chemical duh lohte thluaka a luh loh nan a ni . Tin, thluaka nutrients leh oxygen intake dik leh thluak atanga bawlhhlawh paih chhuah te a control bawk.

Kan taksa hmun dangah chuan kan thisen kalna kawng (hei hi endothelium cell kan ti) a cell te hian an inkarah hian gap te te an nei a. Mahse thluaka thisen kalna kawngah chuan heng cell te hi an inzawm tlat a, an inzawm khawm a, gap a awm lo. Plaster hmanga siam bang, khur nei lo ang mai a ni. Chuvangin molecule lian tak tak pawh, tuiah a inthiar mai mai thil pawh hi awlsam takin a kal tlang thei lo.

He security wall chhungah hian eng nge lut thei ang?

He bang bulah hian engkim a tawp vek lo. Thil thenkhat chu a paltlang thei a ni.

• Molecules tenau tak tak: Hei hi oxygen leh carbon dioxide ang chi molecule tenau te hian awlsam takin an paltlang thei a ni.
• Lipid-soluble: Heng protective wall cells pawn lam khuhna hi lipids atanga siam a nih avangin lipid-a inthiar theih thilte chu awlsam takin a kal tlang thei a ni.

Zu, anesthetics, leh caffeine ang chi thilte hian kan thluak a nghawng rang em em chhan hi han ngaihtuah teh. A chhan chu awlsam taka Blood-Brain Barrier an paltlang theih vang a ni. Tin, damdawi tam tak, antidepressant, anxiolytics, leh epilepsy damdawi te hi he inkharkhip hi paltlang a, thluak thleng thei tura siam a ni bawk.

Chumi awmzia chu, damdawi pakhatin thluak a nghawng nghal dawn a nih chuan Blood-Brain Barrier a paltlang thei tur a ni.

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He defence wall hi tihchak lohna tur dinhmunte chu engte nge ni?

He venhimna daltu hi chak tak ni mahse, a chang chuan a chak lo thei a, a "leak" tan thei bawk. Hei hi inflammation vang a ni ber.Hei hi hetiang dinhmunah hian a thleng thei a ni. He barrier hi a chak loh chuan thil tha lo, a tlangpuiin thluaka lut thei lote chu a lut thei a ni.

A hnuaia table-ah hian Blood-Brain Barrier tichak lo thei damdawi lam thil pawimawh thenkhat tarlan a ni.

Hei hi harsatna a nih theihna tur chhinchhiahna a awm em?

Dik tak chuan Blood-Brain Barrier-ah hian harsatna a awm tih hriattirna direct symptoms a awm lo. Kan hmuhte hi a nghawngtu natna hnuaia awm (entir nan, stroke emaw Alzheimer’s disease) chhinchhiahna a ni. Tunah hian he barrier dinhmun hi test dan tur chiang tak awm lo mah se, research level-ah chuan method hrang hrang zirchian mek a ni.

He invenna hlu tak hi nghet taka awm reng turin eng nge kan tih ang?

Blood-Brain Barrier hi direct-in kan enkawl thei lo nain, a tichak lotu thilte chu kan pumpelh thei a ni. Chumi awmzia chu nun hrisel neih hi thil tha ber a ni tihna a ni.

• Ei leh in inthlau tak leh taksa rihna hrisel tak vawng reng rawh: Thisen sang, zunthlum, leh cholesterol ang chi thilte hian kan thisen kalna kawng a tichhe thin. He chhiatna hian thluaka thisen kalna kawngte pawh a nghawng thei a ni. Chuvangin heng natnate hi ei leh in tha leh exercise tha tak hmanga thunun a pawimawh hle.
• Infection hi ngaihthah suh:A châng chuan beng, mit emaw, ha natna emaw enkawl ṭhat a nih loh chuan, thisen kaltlangin thluak lamah hrik a kal thei a ni. Chuvangin, natna hrik i neih chuan doctor pan nghal la, enkawl rawh.
• Safety gear ha rawh: Lu hliam hian he barrier hi direct-in a tichhia thei. Chuvang chuan bicycle emaw motor emaw i khalh dawnin helmet vuah ngei ngei tur a ni a, lirtheia i chuang dawnin seat belt kha bun tlat tur a ni .
• I natna khirh tak takte chu uluk takin enkawl rawh: Zunthlum, thisen sang, cholesterol ang chi natna i neih chuan i doctor-in damdawi a pekte chu dik tak leh a hun takah ei thin ang che. Tin, a hun takah clinic-ah kal la, i dinhmun enfiah bawk ang che.

He hriatna hi Doctor ten engtin nge an hman?

Blood-Brain Barrier chungchang hriatna hi doctor leh scientist te tan a tangkai hle. Harsatna leh remchang a ni bawk.

• Harsatna: A châng chuan, thluaka tumor emaw, natna hrik emaw damdawi chu he harsatna avang hian thluaka a lut thei lo. Barrier chuan damdawi chu "a chhe" niin a ngai. Hetiang a nih chuan, damdawi chu barrier kaltlangin thlen nan hian hmanraw bik ("Trojan horse" tih ang chi, molecule dang nena inzawm tlat) hman a ni.
• Case: Parkinson natna hi thluaka chemical dopamine a tlahniam chuan a lo awm thin. Dopamine hi damdawi anga direct-a pek ni mah se, he barrier hi a paltlang thei lo va, thluaka a lut thei lo. Chuvang chuan Doctor ten damdawi pakhat levodopa an tih chu an pe thin. He levodopa hian barrier chu a paltlang thei a ni. Vawikhat thluaka a luh chuan levodopa chu dopamine-ah a chang ta a ni. Hei hi ngaihtuahna ropui tak a ni lo maw?

Chu chu, damdawi thenkhat chu he daltu hi paltlang tura siam a ni tihna a ni. Damdawi dangte chu bypass tura siam a ni a, a chhan chu damdawi chu thluaka a luh chuan duh loh zawng side effect a thlen thei a ni.