I tuihal reng bawk a, zun tam tak i pass reng bawk em? Nephrogenic Diabetes Insipidus chungchang hi han sawi ila.

Nilengin i tuihal bawk em? Tui engzat pawh in la, i la nei lo ang maiin i la inhria em? Tin, zun tam leh tam tak i zun a ngai bawk em? Hei hi thil pangngaiah i ngai mai thei, a nih loh leh zunthlum pawh i ti mai thei. Mahse, hei hi damdawi lama harsatna awm lo tak, ‘Nephrogenic Diabetes Insipidus’ an tih chhinchhiahna a ni thei bawk. Hemi chungchang hi awlsam takin, i hriatthiam theih dan tur angin sawi ila.

Nephrogenic Diabetes Insipidus hi eng nge ni?

A awlsam zawngin sawi ila, nephrogenic diabetes insipidus hi i kal (kidney)-in i taksaa tui awm zat a tihdanglam theih lohna a ni. Kan taksa hian hormone pakhat Antidiuretic Hormone, a tawi zawngin ADH an tih chu a siam chhuak a. Mi thenkhat chuan Vasopressin an ti bawk. He hormone, ADH hian kan kal (kidney) te hian zun atanga tui engzat nge a chhuah tur tih leh taksaah engzat nge a vawn tur tih a "hrilh" a ni.

Nephrogenic diabetes insipidus vei te kal hian he ADH hormone hi a chhang tha lo hle. Chu chu ADH hormone hian "tui vawng reng tur leh zun tihtlem" turin signal pe mahse, kal hian a ngaithla lo tihna a ni. Chutah thil thleng chu kal (kidney) hian a tul aia tam zun a siam chhuak thin. Hei hian rang takin, a chang chuan hlauhawm takin, tui tlakchhamna a thlen thei a, chu chu tui tlakchhamna a ni.

Hetiang dinhmun hi engtiang chiahin nge a awm?

Scientist-te chuan mi engzat nge nephrogenic diabetes insipidus vei tih chiang takin an hre lo a, mahse a natna hi a awm lo hle niin an ngai. Chu chu mi zawng zawngin kan vei loh natna a ni lo tihna a ni.

Diabetes Insipidus chi hrang hrang a awm em?

Ni e, zunthlum insipidus hi chi li a awm. Eng nge an nih i en ang u:

• Central Diabetes Insipidus: Hei hi i thluaka pituitary gland emaw hypothalamus emaw a chhiat chuan a thleng thin. Hengte hi i thluak peng hrang hrang, hormone ADH siamtu, dahkhawm leh chhuahtu te an ni. Hetiang chhiatna hian i taksain ADH chu a normal taka a tihregulate theih loh phah a ni.
• Nephrogenic Diabetes Insipidus: Tunlaia kan sawi tak zunthlum chi hrang hrangah hian kal (kidney) hian ADH hormone hi a chhang tha thei lo. ADH hormone awm mahse, kal (kidney) hian an ngaihsak lo niin a lang.
• Dipsogenic Diabetes Insipidus: ‘Primary Polydipsia’ an ti bawk a, hei hi i hypothalamus-a tuihal control mechanism a chhiat vang a ni. Hei hian tuihalna nasa tak a thlen a, tui in fo a ngai tih i hria a , zun tam lutuk bawk.
• Gestational Diabetes Insipidus: Hei hi naupai lai chauh a awm thin. A chang chuan nausen atanga enzyme siam hian ADH hormone a tichhia thin. Hei hi naute pian hnuah a bo thin.

Nephrogenic Diabetes Insipidus leh Diabetes Mellitus te hi eng nge an danglamna?

Hei hi thil pawimawh tak a ni a, mi tam takin an buaipui thin. "Diabetes" tih thumal kan hriat hian sugar kan ngaihtuah a, chu chu diabetes mellitus tihna a ni. Mahse, nephrogenic diabetes insipidus leh diabetes mellitus (zun tam lutuk leh tuihal lutuk ang chi) chhinchhiahna thenkhat chu inang mah se, heng natna pahnih hi a danglam vek a ni.

Diabetes Mellitus hi natna a tam zawk hle. Hormone insulin tlakchham vang emaw, taksain insulin a hman dik loh vang emaw, thisen sugar level sang lutuk vang a ni. Mahse, nephrogenic diabetes insipidus hi harsatna a ni a, chu chu kal (kidney)-in ADH hormone a chhan loh vang a ni a, thisen sugar level nen pawh inzawmna a nei lo Chuvangin, an pahnih hi inthlau lo ila a tha ber, a dik em?

Nephrogenic Diabetes Insipidus hi engte nge ni?

Kan kal (kidney) hian thisen a filter a, taksa atanga bawlhhlawh leh extra fluid te chu zun angin a paih chhuak thin. Hormone ADH (vasopressin) hian tui kan in zat leh kan zun kan chhuah zat inkara inthlauhna a awm theih nan a pui a ni.

Ngaihtuah teh, mi hrisel tak chuan a thawmhnaw a chhuah tam emaw, tui a in tlem emaw chuan ADH level a sang a, chu chuan kalte chu ‘zun tlem siam la, taksaa tui humhim rawh’ tiin a hrilh a ni. Chutiang bawkin taksaah tui a awm tlem chuan ADH level a tlahniam a, kal te chu ‘a pawi lo, tunah hian zun siam mai rawh’ tiin a hrilh thin.

Mahse, i taksain ADH a chhân lêt ṭhat loh chuan i kal (kidney) hian zun a siam tam lutuk a ni. Hei hi nephrogenic diabetes insipidus-ah chuan a thleng thin. He natna hi rochun (hereditary) emaw i nunah engtik lai pawhin a lo awm thei (acquired) .

Acquired nephrogenic diabetes insipidus a ni a, a rilru a hah lutuk a, a rilru a buai em em bawk

Hei hi a tam ber chi a ni. Thil pakhatin taksain ADH a chhanlet theihna a tihbuai hian a thleng thin. Entirnan, i kal (kidney) tichhe thei thil thenkhat avanga lo awm thei a ni. Chutiang dinhmunte chu:

• Amyloidosis – Hei hi protein pangngai lo tak chu kal (kidney) telin taksa peng hrang hranga a awm hian a ni.
• Cancer chi hrang hrang
• Kidney natna rei tak awm thei
• Kal natna, entirnan, pyelonephritis
• Polycystic kidney disease – Hei hi kal chhunga tui tamna cyst a lo awm hian a ni.
• Medullary sponge hmanga kal (kidney) a ni

Hei hi a nghawng chhan dang a awm bawk:

• Damdawi thenkhat: A bik takin lithium (rilru natna thenkhat tan hman thin) chu hun rei tak hman a nih chuan.
• Thisenah potassium level hniam (hypokalemia) .
• Thisen a calcium level sang (hypercalcemia) .
• Sickle cell atanga thisen tlakchhamna
• Sjögren’s syndrome – Hei hi immune system natna a ni.
• Urinary tract obstruction – entirnan, zun lung ang chi thil.

Hereditary nephrogenic diabetes natna nei lo a ni

Hei hi genes AVPR2 emaw AQP2 emaw a mutations avanga lo awm a ni. Heng genes te hian taksain zun ah tui engzat nge a dah tur tih a hrilh a. Heng genes te hi a chhiat chuan kal (kidney) te hian ADH hi an chhang thei lo. Nephrogenic diabetes insipidus, pianpui atanga lo chhuak, natna lan chhuah dan hi a dam chhung thla engemaw zat chhungin a lang tlangpui .

Nephrogenic Diabetes Insipidus natna lan chhuah dan chu engte nge ni?

Ngaihtuah teh, mi i hria a, Sumana ti ila. Sumana hi nilengin a tuihal hle tih a chiang. A bulah tui bottle lian tak nen hna a thawk a. Mahse, a in atanga darkar khat chhungin a tuihal leh ta a, toilet a kal fo a ngai bawk a, a zun nasa hle bawk. A châng chuan zan khatah vawi hnih emaw vawi thum emaw a tho a, zun chhuah tumin a tho ṭhin. ‘Tui ka in tam vang pawh a ni mai thei’ tiin a ngaihtuah a. Mahse hengte hi nephrogenic diabetes insipidus chhinchhiahna berte an ni.

Nephrogenic diabetes insipidus vei chuan a natna lan chhuahna a nei thei a:

• Tui tlakchhamna chhinchhiahna: Kawng a vawt, hmui a chhe, hah lutuk, luak chhuak, a chang chuan ding laia mit sen. Tui tel lova rei tak ni chhuak ang maiin han ngaihtuah teh.
• Polydipsia: Eng ang pawhin tui i in pawh nise tui tling lo ang maia inhriatna.
• Zun tam lutuk (Polyuria): Puitlingin ni khatah litre 3 aia tam (a tlangpuiin litre 5-20 inkar!) a zun a, naupangin ni khatah litre 2 aia tam a zun chuan rinhlelh awm tak a ni. Zun pawh hi a rawng a eng hle a, tui ang mai a ni.

Nausen naupangin he natna hi a neih chuan, thusawi dan an hriatthiam loh avangin heng ang symptoms hi an lantir thei a ni:

• Kawthalo
• Hlawhtling lo leh thau lutuk – Naute dang aiin a thau lo va, a sang lo bawk.
• Khawsik fo thin
• Hahdam lohna leh tap reng reng (Irritability) – naute chu a lungngai hle niin a lang.
• Chaw ei chak lohna, bawnghnute ei tlem
• Seizures – Hei hi chhinchhiahna hlauhawm tak a ni.
• Luak chhuak
• Wet diaper thlak fo a ngai.

Engtin nge Nephrogenic Diabetes Insipidus hi hmuhchhuah a nih?

Heng symptoms te hi i neih chuan doctor pan hmasak tur a ni. Zawhna a zawt ang che, a enfiah ang che, a tul chuan test order ang che:

• Thisen test: Taksa chhunga electrolytes, sodium ang chi, leh kal hnathawh dan enfiah thin ang che.
• Zun test dan: 1.1.Zun concentration (engtiang chiahin nge a dilute tih) en la, zun chhunga eng nge awm tih te en bawk ang che.
• Tui tlakchhamna test: Hei hi darkar engemaw zat chhung tui engmah in loh a ni a, chutah chuan darkar tin i rihna, zun chhuah dan, leh thisen leh zun awm zat enfiah thin a ni. Hei hi test harsa tak a ni a, mahse diagnosis atan chuan a pawimawh hle. Hei chauh hi kal (kidney) hian ADH a chhang let em tih dik taka hriat theihna a ni. He test hi damdawi inah medical supervision hnuaiah tih a ni.
• ADH hormone hmanga test: A chang chuan ADH hormone hi tui tlakchhamna test nen injection angin pek a ni a, chutah chuan zun concentration a inthlak em tih enfiah a ni. Nephrogenic diabetes insipidus-ah chuan ADH pek ni mahse zun concentration hi a danglam vak lo.
• I pituitary gland MRI scan (Magnetic resonance imaging): Central diabetes insipidus ang chi natna i rinhlelh chuan thluaka thil dik lo awm zawng zawng chu zawng rawh.
• Genetic testing: I chhungkuaa mi pakhatin zunthlum insipidus a neih chuan, emaw, inherited form a nih i rinhlelh chuan.

Nephrogenic Diabetes Insipidus hi damdawi tluantling a awm em?

Dik tak chuan tun dinhmunah hian nephrogenic diabetes insipidus hi damdawi kimchang a la awm lo.

Mahse, lungngai suh. A enkawl theih a ni. I doctor chuan i damdawi ei lai, harsatna thlentu (lithium ang chi) te chu a thlak danglam thei mai thei. Tin, a hnuaia dinhmun dang (kidney natna emaw calcium/potassium imbalance ang chi) a awm chuan, a enkawl dan dik chuan a chang chuan nephrogenic diabetes insipidus chu a tidanglam thei a, a titawp thei bawk.

Chuti a nih chuan engtin nge hei hi i enkawl?

A tihdanglam theih loh (entir nan, pianpui)-ah chuan enkawlna hian tui tlakchhamna venna leh nunphung tha tak neih a tum ber a ni. Hei hian a huam thei:

• Tui in fo tur: Hei hi a pawimawh ber a ni. Nilengin tui i in tur a ni a, tuihal i neih apiangin. Tui tam zawk in ngei ngei tur a ni, a bik takin ni lum lai te, exercise i tih lai te, i thawk hah lai te. Zanah pawh tui bottle khat i bulah dah thin ang che.
• Ei leh in lama inthlak danglamna:
• Chi tlem ei leh in: Chi ei tam hian tuihalna leh zun a tipung.
• Protein tlem ei leh in: A châng chuan protein tihtlem tura tih i ni thei a, a chhan chu protein ei laiin bawlhhlawh lo chhuakte paih chhuah nan tui a ngai bawk.
• Zun chhuah tlem thei damdawi: 1.1.
• Thiazide zunthlum damdawi: 1.1.Mak tak maiin heng diuretics te hi nephrogenic diabetes insipidus vei te hnena pek a nih chuan a takah chuan an zun chhuah zat a tihtlem phah a ni. A buaithlak deuh a, mahse an tangkai hle.
• Amiloride: Thiazides nen ei dun theih a ni a, a bik takin lithium avanga NDI lo awm tan chuan pek theih a ni.
• Prescription Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Entirnan, indomethacin tih hi a ni. Hengte hian kal (kidney) te chu ADH lakah tlem a sensitive deuh turin a pui thin.

Hetiang natna vei hian eng ei leh in nge a pumpelh tur?

I doctor chuan zu, caffeine telna in tur (coffee, tea, leh soft drink thenkhat ang chi), chi chi (pickles, sa hring, sausage, leh chips ang chi), leh protein tamna ei tur te chu tihtlem turin a hrilh thei che a, hengte hian i taksain tui a hloh tam thei a, tui i ei tam thei bawk.

Nephrogenic Diabetes Insipidus laka inven dan tur a awm em?

Hei hi venna tur ruahmanna (proven strategies) a awm lo. A bik takin congenital type hi a veng thei lo. Mahse, acquired type tan chuan:

• NDI thlen thei damdawi, lithium ang chi i ei a nih chuan i doctor nen inbiakna neih a pawimawh a, i kal hnathawh enfiah fo a pawimawh bawk.
• Hriselna lama harsatna awm thei (kidney disease, electrolyte imbalances) te chu rang tak leh uluk taka enkawl a nih chuan a hlauhawmna chu tihziaawm theih a ni.

Hetiang dinhmun hi ka neih chuan eng nge ka beisei ang?

Hei hi chanchin tha ber a ni. With proper treatment and a healthy lifestyle , nephrogenic diabetes insipidus vei te hian harsatna lian tham an nei tlem zawk tlangpui a, nun pangngai an hmang thei bawk. Hna i thawk thei a, nun chu a pangngai angin i hlim thei bawk.

Mahse, uluk taka enkawl loh chuan hei hian harsatna lian tak a thlen thei a ni. Eng nge an nih hi han thlir ila:

• Dehydration: Hei hi harsatna lian ber leh pawi ber a ni. Dehydration nasa tak chuan hriatna hloh, seizure, leh kidney failure a thlen thei.
• Electrolyte disturbance: Hei hi taksaa electrolyte (sodium leh potassium ang chi) awm zat inthlak danglamna a ni. Hei hian heart rate leh nerve function a nghawng thei a ni.
• Infection: Urinary Tract Infections (UTI) leh kal natna ang chi thil te.
• Nausen hmasawnna tlai, thluak chhiatna leh rilru lama harsatna nei te. Hei hi naupang tê tê tan chuan a hlauhawm hle. Chuvangin nausen hian heng symptoms te hi a neih chuan enkawl tan nghal tur a ni.
• Kidney failure: Control tha taka enkawl loh chuan hun rei tak chhung a thleng thei.
• Hydronephrosis: Bladder a khat reng avangin zun a back up a, kidney a lo hring chhuak thin.

Engtikah nge damdawi lam thurawn i lak ang?

I zun tam zia chungchangah rinhlelhna emaw, ngaihtuahna emaw i neih chuan, a bik takin zun tam lutuk nen i zun tam lutuk chuan doctor pan ngei ngei tur a ni.

Puitlingin ni khata zun a chhuah zat hi mi hrang hrangah a inang lo thei a, a bik takin tui an in zat a zirin a inang lo thei hle. Mahse ni khatah litre 2-3 aia tam i zun a nih chuan (definition thenkhatah chuan litre 3 aia tam i zun a nih chuan), emaw, i zun tam lutuk (ni khatah vawi sarih emaw vawi riat aia tam emaw) , chu chu harsatna chhinchhiahna a ni thei.

Doctor i hmuh hma hian tui i in zat leh zun engzat nge i siam tih (a theih chuan teh) diary-a ziah hmasak phawt a \angkai hle. Hei hian doctor tan i dinhmun a hriatthiam awlsam phah ang.

Chuti a nih chuan, he thawnthu atang hian eng thil nge kan hriat reng tur? (In lama hruai tur thuchah)

Nephrogenic Diabetes Insipidus hi thil awm lo tak a ni a, i kal hian i taksaa hormone ADH chu a chhang tha lo a, zun tam lutuk a siam thin. Hei hian tui tlakchhamna rang tak a thlen thei a ni.

• A lan chhuah dan ber chu tuihal lutuk leh zun tam lutuk, tui tam lutuk hi a ni .
• Hei hi zunthlum (diabetes mellitus) nen hian inthlau tur a ni lo; chutiang a nih chuan thisen sugar level chu a normal a ni.
• Hetiang dinhmun hi pian tirh lamah a awm thei a, a hnu lamah pawh a lo awm thei bawk.
• Damdawi famkim awm lo mah se, damdawi lam enkawlna dik leh nunphung thlak danglam (a bik takin tui in tam leh ei leh in thunun) chuan nun pangngai, hrisel takin i nung thei a ni.
• Nangmah emaw, i fa emaw hian heng symptoms te hi i nei nia i rinhlelh chuan doctor thurawn la nghal rawh. Hlauthawng suh, mahse a pawimawh ber chu hriattirna leh a tul anga hmalak hi a ni. Nangmah chauh i ni lo va, doctor-te pawhin an pui thei che a ni.

` Nephrogenic diabetes insipidus, kal natna, zun tam lutuk, tuihal lutuk, ADH, vasopressin, dehydration