Cancer cell chauh target thei enkawlna! Targeted Therapy chungchang zawng zawng hi a awlsam zawngin.

"Cancer" tih thumal i hriat hian i rilruah a lo lang leh ang chu "chemotherapy" tih hi a ni mai thei. Enkawl harsa leh hrehawm zia chu kan hre vek. Sam tla leh taksa nunna nei lo angin kan ngai fo thin. Mahse, medical science hian hma a sawn nasa hle a, cancer cell chauh target tur leh cell hriselte tihchhiat tlem thei tur enkawlna thar a siam chhuak tih i hria em? Chu chu vawiin a kan sawi tur treatment bik, advanced tak tak zinga mi a ni. A hming chu Targeted Therapy tih a ni.

A awlsam zawngin, Targeted Therapy chu eng nge ni?

Indo laia hmêlma chunga bomb thlak chu han mitthla teh. Bomb pangngai i thlak hian hmelma chauh ni lovin, ralthuam keng lo mipui leh an chhehvela in te pawh a chhe vek a ni. Chemotherapy pawh chutiang deuh chu a ni. Cancer cells te a that a, mahse kan taksaa cell hrisel tak tak, rang taka inthen darh (entir nan, hair cells, mouth cells) te pawh a tichhe thei bawk.

Mahse, sniper a awm tih han ngaihtuah teh, a target chu a en chiang a, hmelma chauh a kap thin. A chhehvela tumah hian harsatna an tawk lovang. Chu chu Targeted Therapy hian a ti thin.

He enkawlnaah hian i oncologist chuan i taksaa cell pangngai chu cancer cell-a chantirtu genetic mutation chu a zawng hmasa ber a ni. Tichuan, chu genetic mutation avanga cancer cell chunglam emaw, a chhunga emaw target bikte chu an hmuchhuak a, chu target chauh bei thei damdawi an thlang chhuak a ni.

Engtin chiah nge he enkawlna hian hna a thawh?

Hei hi hrethiam tur chuan cancer a lo awm dan hi i hrethiam hmasa phawt ang u.

Kan taksaa cell tin hian thupek hrang hrang kan nei vek a. DNA kan ti a. Chaw siam dan tur recipe book ang mai a ni. He lehkhabu-a thupêkte hian cell pakhat chu hun bituk chhûnga inṭhen darh tûr, ṭhang lian tûr leh thi tûrin a hrilh a ni.

Cancer a lo awm chuan eng emaw chhan vangin he recipe bu-a thupek hi a dik lo. Chu chu genes-ah hian inthlak danglamna (mutation) a awm tihna a ni. Tichuan cell te chu thunun theih lohvin an inthen tan ta a ni. Chu chu cancer a lo ni ta a ni.

Targeted Therapy-ah chuan doctor-te chuan he kalphung hi step khat hnu step khatin an hrethiam a:

1. Thupek dik lo zawn: A hmasa berin, test-te chuan i cancer cell-a genetic instruction dik lo, chu chu genetic mutation , chu eng nge ni tih chiang takin a hmu chhuak a ni.

2. 2. A rilru a hah lutuk chuan a rilru a buai em em a.Target thlan: A dawtah chuan, he thupek dik lo avang hian cancer cell chungah emaw, a chhungah emaw eng protein emaw molecule dang emaw bik nge lo awm tih kan hmuchhuak a. Chu chu kan "target" a ni.

3. Damdawi dik design: A dawtah chuan damdawi chu target hriat chhuah tawha inzawm turin siam a ni. He damdawi hian cancer cell chu a that thei a, cell inthen darh tura puitu signaling pathways te chu a block thei bawk.

Hetianga enkawlna hi chiang taka target a nih avangin cell hrisel tak takte chunga nghawng a neih chu a tlem hle.

Target therapy chi hrang hrangte chu engte nge ni?

Hetiang enkawl dan hi chi hrang hrang a awm a. An hnathawh dan azirin classified an ni. A chi hrang hrang thenkhat chu hetiang hi a ni:

• Small-molecule drugs: Hengte hi damdawi te tak te an nih avangin cancer cell chhungah a lut thei a, cell chhunga target te a bei thei a, cell thanna a titawp thei bawk.
• Immunotherapies: Hei hi a danglam deuh hlek a ni. Heta kan tih hi kan taksa hriselna (immune system) tihchak a, cancer cell tihchhiat hi a ni. He umbrella hnuaiah hian enkawlna dang tam tak a awm bawk.
• Monoclonal antibodies: Hengte hi kan taksain antibodies a siam ang chiah hian lab-a siam specialized proteins an ni. Cancer cell chunglama target-ah an inzawm thei a, immune system chu cancer tihchhiat turin signal an pe thei bawk.
• Antibody-drug conjugates: Hei hi hmanraw fing tak a ni. Hetah hian chemo damdawi chak tak chu monoclonal antibody-ah hian a inzawm a ni. Antibody hian cancer cell dik tak a hmuh a, a nghet tlat chuan damdawi chu cancer cell-ah direct-in a chhuak ta a ni. Parcel ang mai a ni a, hmun dik takah an rawn thawn a ni.

He enkawlna hmang hian eng cancer chi nge hlawhtling taka enkawl?

Targeted Therapy hi cancer zawng zawng tan hman theih a ni lo. Mahse, tunlai hian he enkawl dan hi cancer chi hrang hrang tan hlawhtling takin an hmang ta a ni. Chung zinga ṭhenkhat chu:

• Hnute cancer a ni
• Lung cancer a ni
• Prostate cancer a ni
• Thisen cancer (e.g. Multiple myeloma, Acute leukemia) te hi a tha hle a ni.
• Vun cancer (e.g. Melanoma) 1. A rilru a hah lutuk chuan a rilru a buai em em a.
• Colorectal cancer a ni
• Kidney cancer a ni
• Thyroid cancer a ni
• Lu leh kawng cancer a ni
• Cervical cancer a ni

He list hi nitin a pung zel a, zirchiannaah hian genetic variation thar leh anmahni target tu damdawi an hmuchhuak reng a ni.

Engtin nge enkawlna pek a nih a, eng nge i beisei theih ang?

Tunah hian targeted therapy damdawi chi hrang hrang 100 chuang a awm tawh a ni. He enkawlna i dawn dan hi i cancer chi hrang hrang, damdawi chi hrang hrang leh i doctor thutlukna a zirin a inang lo thei.

• Pill angin: Damdawi thenkhat chu pill angin a awm a, chu chu in lama i ei theih a ni.
• Injection angin: Ṭhenkhat chu taksaah injection angin an pe a.
• Intravenous (IV): A tam zawkah chuan he enkawlna hi taksaah hian vein hmangin, saline ang chi hmangin pek a ni.

Enkawl dan tur pawh a inang lo. Nitin, kar tin emaw, thla tin emaw enkawlna i ei a ngai mai thei. Enkawlna thenkhatah chuan hun rei tak a ngai a, thenkhat erawh chu hun bituk chhunga tihfel a ni thung.

I enkawl chhung hian i doctor chuan a check reng ang che. Thisen test leh CT scan hmangin enkawlna a thawh that dan leh i rilru put hmang a enfiah thei bawk. I enkawlna chhunga i harsatna tawh zawng zawng chu i doctor nen inbiakna hun i nei bawk ang.

Chemotherapy leh Targeted Therapy inkara danglamna pawimawh tak tak

Mi tam takin zawhna an neih chu heng method pahnih zingah hian eng method nge tha zawk tih hi a ni. Chu chu hrethiam tur chuan heng method pahnih inthlauhna hi han thlir ila.

A side effects te pawh i fimkhur ang u.

Targeted therapy hian cell hrisel tihchhiatna a ti tlem a, mahse side effect nei lo a ni lo. Damdawi hrang hrang leh mi hrang hrangah side effect a inang lo. Side effects awm fo thenkhat chu:

• Diarrhea: Thinrimna (loose stools) a awm.
• Vun lama harsatna: vun vawt, vun hring, vun hring.
• Elevated liver enzymes: Hei hi thisen test hmanga hriat theih a ni.
• Hypertension: Thisen sang a sang .
• Thisen zam: Thisen kalna kawng hrang hranga thisen zam (blood clots) lo awm theihna a ni.
• Lung natna: Damdawi thenkhat hian thinlung hnathawh a tichhe thei.
• Hliam dam rei lutuk.
• Gastrointestinal bleeding: Ekk emaw, bawlhhlawh dum emaw-ah thisen a awm.
• Sam rawng inthlak danglam.

Heng thute hi hre hlau suh. Heng zawng zawng hi i doctor chuan a hriattir ang che. Tin, heng side effects te control nan leh a nghawng tihziaawmna tur damdawi leh thurawn tul tak tak a pe bawk ang che. Harsatna i neih chuan doctor hnena hrilh hun sawn suh.